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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NCOR1-CCDC144A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NCOR1-CCDC144A
FusionPDB ID: 57826
FusionGDB2.0 ID: 57826
HgeneTgene
Gene symbol

NCOR1

CCDC144A

Gene ID

9611

9720

Gene namenuclear receptor corepressor 1coiled-coil domain containing 144A
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR-
Cytomap

17p12-p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1coiled-coil domain-containing protein 144A
Modification date2020031320200313
UniProtAcc

O75376

A2RUR9

Ensembl transtripts involved in fusion geneENST idsENST00000268712, ENST00000395857, 
ENST00000395848, ENST00000395851, 
ENST00000583226, 		ENST00000340621, 
ENST00000436374, ENST00000360524, 
ENST00000399273, ENST00000443444, 
ENST00000456009, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score30 X 30 X 13=1170010 X 13 X 5=650
# samples 3313
** MAII scorelog2(33/11700*10)=-5.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/650*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NCOR1 [Title/Abstract] AND CCDC144A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NCOR1(15964714)-CCDC144A(16664738), # samples:2
Anticipated loss of major functional domain due to fusion event.NCOR1-CCDC144A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CCDC144A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CCDC144A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CCDC144A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CCDC144A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-CCDC144A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR1-CCDC144A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check buttonFusion gene breakpoints across NCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC144A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VP-A876-01ANCOR1chr17

15964715

-CCDC144Achr17

16664739

+
ChimerDB4PRADTCGA-VP-A876NCOR1chr17

15964714

-CCDC144Achr17

16664738

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268712NCOR1chr1715964715-ENST00000399273CCDC144Achr1716664739+11293613923461431969
ENST00000268712NCOR1chr1715964715-ENST00000443444CCDC144Achr1716664739+11539613923461431969
ENST00000268712NCOR1chr1715964715-ENST00000456009CCDC144Achr1716664739+6934613923461431969
ENST00000268712NCOR1chr1715964715-ENST00000360524CCDC144Achr1716664739+8521613923461431969
ENST00000268712NCOR1chr1715964714-ENST00000399273CCDC144Achr1716664738+11293613923461431969
ENST00000268712NCOR1chr1715964714-ENST00000443444CCDC144Achr1716664738+11539613923461431969
ENST00000268712NCOR1chr1715964714-ENST00000456009CCDC144Achr1716664738+6934613923461431969
ENST00000268712NCOR1chr1715964714-ENST00000360524CCDC144Achr1716664738+8521613923461431969

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268712ENST00000399273NCOR1chr1715964715-CCDC144Achr1716664739+0.0005336740.99946636
ENST00000268712ENST00000443444NCOR1chr1715964715-CCDC144Achr1716664739+0.0008505040.99914944
ENST00000268712ENST00000456009NCOR1chr1715964715-CCDC144Achr1716664739+0.0027687410.9972313
ENST00000268712ENST00000360524NCOR1chr1715964715-CCDC144Achr1716664739+0.0011617740.99883825
ENST00000268712ENST00000399273NCOR1chr1715964714-CCDC144Achr1716664738+0.0005336740.99946636
ENST00000268712ENST00000443444NCOR1chr1715964714-CCDC144Achr1716664738+0.0008505040.99914944
ENST00000268712ENST00000456009NCOR1chr1715964714-CCDC144Achr1716664738+0.0027687410.9972313
ENST00000268712ENST00000360524NCOR1chr1715964714-CCDC144Achr1716664738+0.0011617740.99883825

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57826_57826_1_NCOR1-CCDC144A_NCOR1_chr17_15964714_ENST00000268712_CCDC144A_chr17_16664738_ENST00000360524_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

--------------------------------------------------------------

>57826_57826_2_NCOR1-CCDC144A_NCOR1_chr17_15964714_ENST00000268712_CCDC144A_chr17_16664738_ENST00000399273_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

--------------------------------------------------------------

>57826_57826_3_NCOR1-CCDC144A_NCOR1_chr17_15964714_ENST00000268712_CCDC144A_chr17_16664738_ENST00000443444_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

--------------------------------------------------------------

>57826_57826_4_NCOR1-CCDC144A_NCOR1_chr17_15964714_ENST00000268712_CCDC144A_chr17_16664738_ENST00000456009_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

--------------------------------------------------------------

>57826_57826_5_NCOR1-CCDC144A_NCOR1_chr17_15964715_ENST00000268712_CCDC144A_chr17_16664739_ENST00000360524_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

--------------------------------------------------------------

>57826_57826_6_NCOR1-CCDC144A_NCOR1_chr17_15964715_ENST00000268712_CCDC144A_chr17_16664739_ENST00000399273_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

--------------------------------------------------------------

>57826_57826_7_NCOR1-CCDC144A_NCOR1_chr17_15964715_ENST00000268712_CCDC144A_chr17_16664739_ENST00000443444_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

--------------------------------------------------------------

>57826_57826_8_NCOR1-CCDC144A_NCOR1_chr17_15964715_ENST00000268712_CCDC144A_chr17_16664739_ENST00000456009_length(amino acids)=1969AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQA
SYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLR
GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEG
NIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGIT
TIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVER
GKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLT
PTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQT
ILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGH
PTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQ
LRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:15964714/chr17:16664738)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

CCDC144A

A2RUR9

FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-3746174_2161960.33333333333332441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-3746299_3281960.33333333333332441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-3746501_5571960.33333333333332441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-3746174_2161960.33333333333332441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-3746299_3281960.33333333333332441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-3746501_5571960.33333333333332441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37461032_10351960.33333333333332441.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37461707_17121960.33333333333332441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37461952_19631960.33333333333332441.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-374658_641960.33333333333332441.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-3746593_6031960.33333333333332441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-3746607_6171960.33333333333332441.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37461032_10351960.33333333333332441.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37461707_17121960.33333333333332441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37461952_19631960.33333333333332441.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-374658_641960.33333333333332441.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-3746593_6031960.33333333333332441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-3746607_6171960.33333333333332441.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-3746435_4861960.33333333333332441.0DomainSANT 1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-3746623_6741960.33333333333332441.0DomainSANT 2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-3746435_4861960.33333333333332441.0DomainSANT 1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-3746623_6741960.33333333333332441.0DomainSANT 2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37461933_19371960.33333333333332441.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37461933_19371960.33333333333332441.0MotifNote=CORNR box 1
TgeneCCDC144Achr17:15964714chr17:16664738ENST0000036052411181155_13091124.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST0000044344411271155_13091124.01924.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST0000045600911151155_1309890.01155.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST0000036052411181155_13091124.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST0000044344411271155_13091124.01924.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST0000045600911151155_1309890.01155.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST0000036052411181394_14001124.01428.0Compositional biasNote=Poly-Ser
TgeneCCDC144Achr17:15964714chr17:16664738ENST0000044344411271394_14001124.01924.6666666666667Compositional biasNote=Poly-Ser
TgeneCCDC144Achr17:15964714chr17:16664738ENST0000045600911151394_1400890.01155.0Compositional biasNote=Poly-Ser
TgeneCCDC144Achr17:15964715chr17:16664739ENST0000036052411181394_14001124.01428.0Compositional biasNote=Poly-Ser
TgeneCCDC144Achr17:15964715chr17:16664739ENST0000044344411271394_14001124.01924.6666666666667Compositional biasNote=Poly-Ser
TgeneCCDC144Achr17:15964715chr17:16664739ENST0000045600911151394_1400890.01155.0Compositional biasNote=Poly-Ser

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119174_2160915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119299_3280915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119501_5570915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145174_21602338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145299_32802338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145501_55702338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119174_2160915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119299_3280915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119501_5570915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145174_21602338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145299_32802338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145501_55702338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1191032_10350915.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1191707_17120915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1191952_19630915.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-11958_640915.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119593_6030915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119607_6170915.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1451032_103502338.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1451707_171202338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1451952_196302338.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-14558_6402338.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145593_60302338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145607_61702338.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1191032_10350915.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1191707_17120915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1191952_19630915.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-11958_640915.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119593_6030915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119607_6170915.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1451032_103502338.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1451707_171202338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1451952_196302338.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-14558_6402338.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145593_60302338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145607_61702338.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119435_4860915.0DomainSANT 1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119623_6740915.0DomainSANT 2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145435_48602338.0DomainSANT 1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145623_67402338.0DomainSANT 2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119435_4860915.0DomainSANT 1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119623_6740915.0DomainSANT 2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145435_48602338.0DomainSANT 1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145623_67402338.0DomainSANT 2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37462055_20591960.33333333333332441.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37462263_22671960.33333333333332441.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1191933_19370915.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1192055_20590915.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1192263_22670915.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1451933_193702338.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1452055_205902338.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1452263_226702338.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37462055_20591960.33333333333332441.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37462263_22671960.33333333333332441.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1191933_19370915.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1192055_20590915.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1192263_22670915.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1451933_193702338.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1452055_205902338.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1452263_226702338.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37462032_21151960.33333333333332441.0RegionID1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37462212_22731960.33333333333332441.0RegionID2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1192032_21150915.0RegionID1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1192212_22730915.0RegionID2
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1452032_211502338.0RegionID1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1452212_227302338.0RegionID2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37462032_21151960.33333333333332441.0RegionID1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37462212_22731960.33333333333332441.0RegionID2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1192032_21150915.0RegionID1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1192212_22730915.0RegionID2
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1452032_211502338.0RegionID1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1452212_227302338.0RegionID2
TgeneCCDC144Achr17:15964714chr17:16664738ENST000003605241118490_5451124.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST000003605241118648_11291124.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST000004434441127490_5451124.01924.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST000004434441127648_11291124.01924.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST000004560091115490_545890.01155.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964714chr17:16664738ENST000004560091115648_1129890.01155.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST000003605241118490_5451124.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST000003605241118648_11291124.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST000004434441127490_5451124.01924.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST000004434441127648_11291124.01924.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST000004560091115490_545890.01155.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC144Achr17:15964715chr17:16664739ENST000004560091115648_1129890.01155.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NCOR1
CCDC144A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR1chr17:15964714chr17:16664738ENST00000268712-37461501_24401960.33333333333332441.0C1D
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1191501_24400915.0C1D
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1451501_244002338.0C1D
HgeneNCOR1chr17:15964715chr17:16664739ENST00000268712-37461501_24401960.33333333333332441.0C1D
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1191501_24400915.0C1D
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1451501_244002338.0C1D
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119988_18160915.0ETO
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145988_181602338.0ETO
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119988_18160915.0ETO
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145988_181602338.0ETO
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-119254_3120915.0SIN3A/B
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-145254_31202338.0SIN3A/B
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-119254_3120915.0SIN3A/B
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-145254_31202338.0SIN3A/B
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395848-1191_3730915.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:15964714chr17:16664738ENST00000395851-1451_37302338.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395848-1191_3730915.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:15964715chr17:16664739ENST00000395851-1451_37302338.0ZBTB33 and HEXIM1


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Related Drugs to NCOR1-CCDC144A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NCOR1-CCDC144A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource