UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:NCOR1-CDRT4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NCOR1-CDRT4
FusionPDB ID: 57828
FusionGDB2.0 ID: 57828
HgeneTgene
Gene symbol

NCOR1

CDRT4

Gene ID

9611

284040

Gene namenuclear receptor corepressor 1CMT1A duplicated region transcript 4
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR-
Cytomap

17p12-p11.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1CMT1A duplicated region transcript 4 protein
Modification date2020031320200327
UniProtAcc

O75376

Q8N9R6

Ensembl transtripts involved in fusion geneENST idsENST00000268712, ENST00000395851, 
ENST00000395848, ENST00000395857, 
ENST00000583226, 		ENST00000312177, 
ENST00000519354, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score30 X 30 X 13=117005 X 2 X 5=50
# samples 336
** MAII scorelog2(33/11700*10)=-5.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NCOR1 [Title/Abstract] AND CDRT4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NCOR1(15989596)-CDRT4(15343599), # samples:2
Anticipated loss of major functional domain due to fusion event.NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check buttonFusion gene breakpoints across NCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDRT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E5-A2PC-01ANCOR1chr17

15989596

-CDRT4chr17

15341517

-
ChimerDB4BLCATCGA-E5-A2PC-01ANCOR1chr17

15989596

-CDRT4chr17

15343599

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268712NCOR1chr1715989596-ENST00000312177CDRT4chr1715341517-5621343523435241096

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268712ENST00000312177NCOR1chr1715989596-CDRT4chr1715341517-0.0013325640.9986675

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57828_57828_1_NCOR1-CDRT4_NCOR1_chr17_15989596_ENST00000268712_CDRT4_chr17_15341517_ENST00000312177_length(amino acids)=1096AA_BP=1067
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQDSQKTLDFPGSYL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:15989596/chr17:15343599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

CDRT4

Q8N9R6

FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346174_2161059.02441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346299_3281059.02441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346501_5571059.02441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245174_2161075.02338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245299_3281075.02338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245501_5571075.02338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461032_10351059.02441.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-234658_641059.02441.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346593_6031059.02441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346607_6171059.02441.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451032_10351075.02338.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-224558_641075.02338.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245593_6031075.02338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245607_6171075.02338.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346435_4861059.02441.0DomainSANT 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346623_6741059.02441.0DomainSANT 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245435_4861075.02338.0DomainSANT 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245623_6741075.02338.0DomainSANT 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119174_2160915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119299_3280915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119501_5570915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461707_17121059.02441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461952_19631059.02441.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191032_10350915.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191707_17120915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191952_19630915.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-11958_640915.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119593_6030915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119607_6170915.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451707_17121075.02338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451952_19631075.02338.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119435_4860915.0DomainSANT 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119623_6740915.0DomainSANT 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461933_19371059.02441.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462055_20591059.02441.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462263_22671059.02441.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191933_19370915.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192055_20590915.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192263_22670915.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451933_19371075.02338.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452055_20591075.02338.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452263_22671075.02338.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462032_21151059.02441.0RegionID1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462212_22731059.02441.0RegionID2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192032_21150915.0RegionID1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192212_22730915.0RegionID2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452032_21151075.02338.0RegionID1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452212_22731075.02338.0RegionID2


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NCOR1
CDRT4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461501_24401059.02441.0C1D
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191501_24400915.0C1D
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451501_24401075.02338.0C1D
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346988_18161059.02441.0ETO
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119988_18160915.0ETO
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245988_18161075.02338.0ETO
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119254_3120915.0SIN3A/B
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191_3730915.0ZBTB33 and HEXIM1


Top

Related Drugs to NCOR1-CDRT4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to NCOR1-CDRT4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource