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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NDEL1-PDGFRB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NDEL1-PDGFRB
FusionPDB ID: 57940
FusionGDB2.0 ID: 57940
HgeneTgene
Gene symbol

NDEL1

PDGFRB

Gene ID

81565

5159

Gene namenudE neurodevelopment protein 1 like 1platelet derived growth factor receptor beta
SynonymsEOPA|MITAP1|NDE1L1|NDE2|NUDELCD140B|IBGC4|IMF1|JTK12|KOGS|PDGFR|PDGFR-1|PDGFR1|PENTT
Cytomap

17p13.1

5q32

Type of geneprotein-codingprotein-coding
Descriptionnuclear distribution protein nudE-like 1endooligopeptidase Amitosin-associated protein 1mitosin-associated protein MITAP1nudE nuclear distribution E homolog-like 1nudE nuclear distribution gene E homolog-like 1protein Nudelplatelet-derived growth factor receptor betaActivated tyrosine kinase PDGFRBCD140 antigen-like family member BNDEL1-PDGFRBPDGF-R-betaPDGFR-betabeta-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 1platelet-deriv
Modification date2020032720200329
UniProtAcc

Q9GZM8

P09619

Ensembl transtripts involved in fusion geneENST idsENST00000299734, ENST00000334527, 
ENST00000380025, ENST00000402554, 
ENST00000583066, ENST00000585098, 
ENST00000523456, ENST00000261799, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 7 X 8=56028 X 26 X 6=4368
# samples 1015
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/4368*10)=-4.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NDEL1 [Title/Abstract] AND PDGFRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NDEL1(8354271)-PDGFRB(149506179), # samples:1
Anticipated loss of major functional domain due to fusion event.NDEL1-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NDEL1-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NDEL1-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NDEL1-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDGFRB

GO:0007165

signal transduction

10821867

TgenePDGFRB

GO:0010863

positive regulation of phospholipase C activity

1653029

TgenePDGFRB

GO:0018108

peptidyl-tyrosine phosphorylation

1653029|2536956|2850496

TgenePDGFRB

GO:0030335

positive regulation of cell migration

17470632

TgenePDGFRB

GO:0032516

positive regulation of phosphoprotein phosphatase activity

7691811

TgenePDGFRB

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

TgenePDGFRB

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

1314164

TgenePDGFRB

GO:0046777

protein autophosphorylation

1314164|2536956|2850496

TgenePDGFRB

GO:0048008

platelet-derived growth factor receptor signaling pathway

1314164|2536956

TgenePDGFRB

GO:0060326

cell chemotaxis

2554309|17991872


check buttonFusion gene breakpoints across NDEL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDGFRB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ALT626076NDEL1chr17

8354271

+PDGFRBchr5

149506179

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000334527NDEL1chr178354271+ENST00000261799PDGFRBchr5149506179-45658971072638843
ENST00000299734NDEL1chr178354271+ENST00000261799PDGFRBchr5149506179-45658971072638843
ENST00000380025NDEL1chr178354271+ENST00000261799PDGFRBchr5149506179-4526858682599843
ENST00000402554NDEL1chr178354271+ENST00000261799PDGFRBchr5149506179-4518850602591843

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334527ENST00000261799NDEL1chr178354271+PDGFRBchr5149506179-0.0057846270.9942154
ENST00000299734ENST00000261799NDEL1chr178354271+PDGFRBchr5149506179-0.0057846270.9942154
ENST00000380025ENST00000261799NDEL1chr178354271+PDGFRBchr5149506179-0.0058727220.9941273
ENST00000402554ENST00000261799NDEL1chr178354271+PDGFRBchr5149506179-0.0058416720.9941584

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57940_57940_1_NDEL1-PDGFRB_NDEL1_chr17_8354271_ENST00000299734_PDGFRB_chr5_149506179_ENST00000261799_length(amino acids)=843AA_BP=261
MGGPGRAGGGETSVERRRTCAFDTLEAFLIMDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ
RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERN
AFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKALPFKVV
VISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLS
HSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSA
ELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDL
VGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILL
WEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHP
AILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPE

--------------------------------------------------------------

>57940_57940_2_NDEL1-PDGFRB_NDEL1_chr17_8354271_ENST00000334527_PDGFRB_chr5_149506179_ENST00000261799_length(amino acids)=843AA_BP=261
MGGPGRAGGGETSVERRRTCAFDTLEAFLIMDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ
RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERN
AFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKALPFKVV
VISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLS
HSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSA
ELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDL
VGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILL
WEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHP
AILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPE

--------------------------------------------------------------

>57940_57940_3_NDEL1-PDGFRB_NDEL1_chr17_8354271_ENST00000380025_PDGFRB_chr5_149506179_ENST00000261799_length(amino acids)=843AA_BP=261
MGGPGRAGGGETSVERRRTCAFDTLEAFLIMDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ
RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERN
AFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKALPFKVV
VISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLS
HSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSA
ELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDL
VGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILL
WEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHP
AILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPE

--------------------------------------------------------------

>57940_57940_4_NDEL1-PDGFRB_NDEL1_chr17_8354271_ENST00000402554_PDGFRB_chr5_149506179_ENST00000261799_length(amino acids)=843AA_BP=261
MGGPGRAGGGETSVERRRTCAFDTLEAFLIMDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ
RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERN
AFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKALPFKVV
VISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLS
HSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSA
ELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDL
VGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILL
WEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHP
AILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:8354271/chr5:149506179)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDEL1

Q9GZM8

PDGFRB

P09619

FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). {ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710}.FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDEL1chr17:8354271chr5:149506179ENST00000299734+6928_190233.33333333333334368.0Coiled coilOntology_term=ECO:0000255
HgeneNDEL1chr17:8354271chr5:149506179ENST00000334527+6928_190233.33333333333334346.0Coiled coilOntology_term=ECO:0000255
HgeneNDEL1chr17:8354271chr5:149506179ENST00000402554+61028_190233.33333333333334329.0Coiled coilOntology_term=ECO:0000255
HgeneNDEL1chr17:8354271chr5:149506179ENST00000299734+6956_166233.33333333333334368.0RegionSelf-association
HgeneNDEL1chr17:8354271chr5:149506179ENST00000334527+6956_166233.33333333333334346.0RegionSelf-association
HgeneNDEL1chr17:8354271chr5:149506179ENST00000402554+61056_166233.33333333333334329.0RegionSelf-association
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923600_962526.33333333333341107.0DomainProtein kinase
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923606_614526.33333333333341107.0Nucleotide bindingATP
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923554_1106526.33333333333341107.0Topological domainCytoplasmic
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923533_553526.33333333333341107.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923129_210526.33333333333341107.0DomainNote=Ig-like C2-type 2
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923214_309526.33333333333341107.0DomainNote=Ig-like C2-type 3
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923331_403526.33333333333341107.0DomainNote=Ig-like C2-type 4
TgenePDGFRBchr17:8354271chr5:149506179ENST0000026179992333_120526.33333333333341107.0DomainNote=Ig-like C2-type 1
TgenePDGFRBchr17:8354271chr5:149506179ENST00000261799923416_524526.33333333333341107.0DomainNote=Ig-like C2-type 5
TgenePDGFRBchr17:8354271chr5:149506179ENST0000026179992333_532526.33333333333341107.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NDEL1
PDGFRBall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNDEL1chr17:8354271chr5:149506179ENST00000299734+69175_345233.33333333333334368.0CENPF
HgeneNDEL1chr17:8354271chr5:149506179ENST00000334527+69175_345233.33333333333334346.0CENPF
HgeneNDEL1chr17:8354271chr5:149506179ENST00000402554+610175_345233.33333333333334329.0CENPF
HgeneNDEL1chr17:8354271chr5:149506179ENST00000299734+69241_280233.33333333333334368.0DISC1
HgeneNDEL1chr17:8354271chr5:149506179ENST00000334527+69241_280233.33333333333334346.0DISC1
HgeneNDEL1chr17:8354271chr5:149506179ENST00000402554+610241_280233.33333333333334329.0DISC1
HgeneNDEL1chr17:8354271chr5:149506179ENST00000299734+69195_256233.33333333333334368.0KATNA1
HgeneNDEL1chr17:8354271chr5:149506179ENST00000334527+69195_256233.33333333333334346.0KATNA1
HgeneNDEL1chr17:8354271chr5:149506179ENST00000402554+610195_256233.33333333333334329.0KATNA1
HgeneNDEL1chr17:8354271chr5:149506179ENST00000299734+69191_345233.33333333333334368.0NEFL
HgeneNDEL1chr17:8354271chr5:149506179ENST00000334527+69191_345233.33333333333334346.0NEFL
HgeneNDEL1chr17:8354271chr5:149506179ENST00000402554+610191_345233.33333333333334329.0NEFL
HgeneNDEL1chr17:8354271chr5:149506179ENST00000299734+69189_256233.33333333333334368.0YWHAE
HgeneNDEL1chr17:8354271chr5:149506179ENST00000334527+69189_256233.33333333333334346.0YWHAE
HgeneNDEL1chr17:8354271chr5:149506179ENST00000402554+610189_256233.33333333333334329.0YWHAE


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Related Drugs to NDEL1-PDGFRB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NDEL1-PDGFRB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDGFRBC3554321BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 46CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePDGFRBC0393590Fahr's syndrome (disorder)3GENOMICS_ENGLAND;ORPHANET
TgenePDGFRBC4225270Kosaki overgrowth syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePDGFRBC4551572MYOFIBROMATOSIS, INFANTILE, 13GENOMICS_ENGLAND;UNIPROT
TgenePDGFRBC0013421Dystonia2GENOMICS_ENGLAND
TgenePDGFRBC0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
TgenePDGFRBC0023893Liver Cirrhosis, Experimental2CTD_human
TgenePDGFRBC0036341Schizophrenia2PSYGENET
TgenePDGFRBC0432284Infantile myofibromatosis2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgenePDGFRBC0004782Basal Ganglia Diseases1CTD_human
TgenePDGFRBC0006663Calcinosis1CTD_human
TgenePDGFRBC0015371Extrapyramidal Disorders1CTD_human
TgenePDGFRBC0036337Schizoaffective Disorder1PSYGENET
TgenePDGFRBC0206648Myofibromatosis1GENOMICS_ENGLAND
TgenePDGFRBC0263628Tumoral calcinosis1CTD_human
TgenePDGFRBC0521174Microcalcification1CTD_human
TgenePDGFRBC0750951Lenticulostriate Disorders1CTD_human
TgenePDGFRBC1333046Myeloproliferative Neoplasm, Unclassifiable1ORPHANET
TgenePDGFRBC1866182Penttinen-Aula syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePDGFRBC3472621Myeloid neoplasm with beta-type platelet-derived growth factor receptor gene rearrangement1ORPHANET
TgenePDGFRBC3714756Intellectual Disability1GENOMICS_ENGLAND