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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NDRG1-ERG

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NDRG1-ERG
FusionPDB ID: 57964
FusionGDB2.0 ID: 57964
HgeneTgene
Gene symbol

NDRG1

ERG

Gene ID

10397

2078

Gene nameN-myc downstream regulated 1ETS transcription factor ERG
SynonymsCAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5erg-3|p55
Cytomap

8q24.22

21q22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive proteintranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian
Modification date2020032820200320
UniProtAcc

Q92597

Q9Y282

Ensembl transtripts involved in fusion geneENST idsENST00000323851, ENST00000354944, 
ENST00000414097, ENST00000537882, 
ENST00000518066, ENST00000518176, 
ENST00000521414, ENST00000522476, 
ENST00000288319, ENST00000398897, 
ENST00000398905, ENST00000398907, 
ENST00000398910, ENST00000398911, 
ENST00000398919, ENST00000417133, 
ENST00000429727, ENST00000442448, 
ENST00000453032, ENST00000485493, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 21 X 12=680421 X 74 X 12=18648
# samples 4096
** MAII scorelog2(40/6804*10)=-4.08831123588866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(96/18648*10)=-4.27984269352035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NDRG1 [Title/Abstract] AND ERG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NDRG1(134292474)-ERG(39817543), # samples:6
Anticipated loss of major functional domain due to fusion event.NDRG1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NDRG1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NDRG1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NDRG1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NDRG1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NDRG1-ERG seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NDRG1-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NDRG1-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NDRG1-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check buttonFusion gene breakpoints across NDRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7314-01ANDRG1chr8

134292474

-ERGchr21

39817543

-
ChimerDB4PRADTCGA-EJ-7314-01ANDRG1chr8

134292478

-ERGchr21

39817547

-
ChimerDB4PRADTCGA-EJ-7314-11ANDRG1chr8

134292474

-ERGchr21

39817543

-
ChimerDB4PRADTCGA-EJ-7314NDRG1chr8

134292478

-ERGchr21

39817547

-
ChimerDB4PRADTCGA-KK-A8I6-01ANDRG1chr8

134292474

-ERGchr21

39817543

-
ChimerDB4PRADTCGA-KK-A8I6-01ANDRG1chr8

134292474

-ERGchr21

39942835

-
ChimerDB4PRADTCGA-KK-A8I6-01ANDRG1chr8

134292478

-ERGchr21

39817547

-
ChimerDB4PRADTCGA-KK-A8I6NDRG1chr8

134292474

-ERGchr21

39817544

-
ChimerDB4PRADTCGA-KK-A8I6NDRG1chr8

134292478

-ERGchr21

39817547

-
ChimerDB4PRADTCGA-V1-A8WW-01ANDRG1chr8

134292474

-ERGchr21

39817543

-
ChimerDB4PRADTCGA-V1-A8WWNDRG1chr8

134292474

-ERGchr21

39817543

-
ChimerDB4PRADTCGA-V1-A8WWNDRG1chr8

134292474

-ERGchr21

39817544

-
ChimerKB3..NDRG1chr8

134292474

-ERGchr21

39817544

-
ChimerKB3..NDRG1chr8

205649521

-ERGchr21

39775631

-
ChiTaRS5.0N/AFJ627786NDRG1chr8

134292474

-ERGchr21

39817547

-
ChiTaRS5.0N/AFJ627787NDRG1chr8

134296491

-ERGchr21

39817546

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323851NDRG1chr8134292474-ENST00000398907ERGchr2139817544-49502211221573483
ENST00000323851NDRG1chr8134292474-ENST00000398905ERGchr2139817544-49472211221570482
ENST00000323851NDRG1chr8134292474-ENST00000288319ERGchr2139817544-50192211221642506
ENST00000354944NDRG1chr8134292474-ENST00000398907ERGchr2139817544-49652361371588483
ENST00000354944NDRG1chr8134292474-ENST00000398905ERGchr2139817544-49622361371585482
ENST00000354944NDRG1chr8134292474-ENST00000288319ERGchr2139817544-50342361371657506
ENST00000323851NDRG1chr8134292478-ENST00000398907ERGchr2139817547-49502211221573483
ENST00000323851NDRG1chr8134292478-ENST00000398905ERGchr2139817547-49472211221570482
ENST00000323851NDRG1chr8134292478-ENST00000288319ERGchr2139817547-50192211221642506
ENST00000354944NDRG1chr8134292478-ENST00000398907ERGchr2139817547-49652361371588483
ENST00000354944NDRG1chr8134292478-ENST00000398905ERGchr2139817547-49622361371585482
ENST00000354944NDRG1chr8134292478-ENST00000288319ERGchr2139817547-50342361371657506
ENST00000323851NDRG1chr8134292474-ENST00000398907ERGchr2139817543-49502211221573483
ENST00000323851NDRG1chr8134292474-ENST00000398905ERGchr2139817543-49472211221570482
ENST00000323851NDRG1chr8134292474-ENST00000288319ERGchr2139817543-50192211221642506
ENST00000354944NDRG1chr8134292474-ENST00000398907ERGchr2139817543-49652361371588483
ENST00000354944NDRG1chr8134292474-ENST00000398905ERGchr2139817543-49622361371585482
ENST00000354944NDRG1chr8134292474-ENST00000288319ERGchr2139817543-50342361371657506
ENST00000323851NDRG1chr8134292474-ENST00000398907ERGchr2139817544-49502211221573483
ENST00000323851NDRG1chr8134292474-ENST00000398905ERGchr2139817544-49472211221570482
ENST00000323851NDRG1chr8134292474-ENST00000288319ERGchr2139817544-50192211221642506
ENST00000354944NDRG1chr8134292474-ENST00000398907ERGchr2139817544-49652361371588483
ENST00000354944NDRG1chr8134292474-ENST00000398905ERGchr2139817544-49622361371585482
ENST00000354944NDRG1chr8134292474-ENST00000288319ERGchr2139817544-50342361371657506
ENST00000323851NDRG1chr8134292474-ENST00000398907ERGchr2139817547-49502211221573483
ENST00000323851NDRG1chr8134292474-ENST00000398905ERGchr2139817547-49472211221570482
ENST00000323851NDRG1chr8134292474-ENST00000288319ERGchr2139817547-50192211221642506
ENST00000354944NDRG1chr8134292474-ENST00000398907ERGchr2139817547-49652361371588483
ENST00000354944NDRG1chr8134292474-ENST00000398905ERGchr2139817547-49622361371585482
ENST00000354944NDRG1chr8134292474-ENST00000288319ERGchr2139817547-50342361371657506
ENST00000323851NDRG1chr8134296491-ENST00000398907ERGchr2139817546-49141851221537471
ENST00000323851NDRG1chr8134296491-ENST00000398905ERGchr2139817546-49111851221534470
ENST00000323851NDRG1chr8134296491-ENST00000288319ERGchr2139817546-49831851221606494
ENST00000354944NDRG1chr8134296491-ENST00000398907ERGchr2139817546-49292001371552471
ENST00000354944NDRG1chr8134296491-ENST00000398905ERGchr2139817546-49262001371549470
ENST00000354944NDRG1chr8134296491-ENST00000288319ERGchr2139817546-49982001371621494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323851ENST00000398907NDRG1chr8134292478-ERGchr2139817547-0.0003768670.99962306
ENST00000323851ENST00000398905NDRG1chr8134292478-ERGchr2139817547-0.000559690.99944025
ENST00000323851ENST00000288319NDRG1chr8134292478-ERGchr2139817547-0.0004952840.9995047
ENST00000354944ENST00000398907NDRG1chr8134292478-ERGchr2139817547-0.0003933590.99960667
ENST00000354944ENST00000398905NDRG1chr8134292478-ERGchr2139817547-0.0005817030.99941826
ENST00000354944ENST00000288319NDRG1chr8134292478-ERGchr2139817547-0.0005146560.9994854
ENST00000323851ENST00000398907NDRG1chr8134292474-ERGchr2139817543-0.0003768670.99962306
ENST00000323851ENST00000398905NDRG1chr8134292474-ERGchr2139817543-0.000559690.99944025
ENST00000323851ENST00000288319NDRG1chr8134292474-ERGchr2139817543-0.0004952840.9995047
ENST00000354944ENST00000398907NDRG1chr8134292474-ERGchr2139817543-0.0003933590.99960667
ENST00000354944ENST00000398905NDRG1chr8134292474-ERGchr2139817543-0.0005817030.99941826
ENST00000354944ENST00000288319NDRG1chr8134292474-ERGchr2139817543-0.0005146560.9994854
ENST00000323851ENST00000398907NDRG1chr8134292474-ERGchr2139817544-0.0003768670.99962306
ENST00000323851ENST00000398905NDRG1chr8134292474-ERGchr2139817544-0.000559690.99944025
ENST00000323851ENST00000288319NDRG1chr8134292474-ERGchr2139817544-0.0004952840.9995047
ENST00000354944ENST00000398907NDRG1chr8134292474-ERGchr2139817544-0.0003933590.99960667
ENST00000354944ENST00000398905NDRG1chr8134292474-ERGchr2139817544-0.0005817030.99941826
ENST00000354944ENST00000288319NDRG1chr8134292474-ERGchr2139817544-0.0005146560.9994854
ENST00000323851ENST00000398907NDRG1chr8134292474-ERGchr2139817547-0.0003768670.99962306
ENST00000323851ENST00000398905NDRG1chr8134292474-ERGchr2139817547-0.000559690.99944025
ENST00000323851ENST00000288319NDRG1chr8134292474-ERGchr2139817547-0.0004952840.9995047
ENST00000354944ENST00000398907NDRG1chr8134292474-ERGchr2139817547-0.0003933590.99960667
ENST00000354944ENST00000398905NDRG1chr8134292474-ERGchr2139817547-0.0005817030.99941826
ENST00000354944ENST00000288319NDRG1chr8134292474-ERGchr2139817547-0.0005146560.9994854
ENST00000323851ENST00000398907NDRG1chr8134296491-ERGchr2139817546-0.0014992070.9985008
ENST00000323851ENST00000398905NDRG1chr8134296491-ERGchr2139817546-0.0014969490.9985031
ENST00000323851ENST00000288319NDRG1chr8134296491-ERGchr2139817546-0.0013808960.9986191
ENST00000354944ENST00000398907NDRG1chr8134296491-ERGchr2139817546-0.0015648990.9984351
ENST00000354944ENST00000398905NDRG1chr8134296491-ERGchr2139817546-0.0015555210.9984445
ENST00000354944ENST00000288319NDRG1chr8134296491-ERGchr2139817546-0.0014355210.99856454

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57964_57964_1_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817543_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_2_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817543_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_3_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817543_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

--------------------------------------------------------------

>57964_57964_4_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817544_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_5_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817544_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_6_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817544_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

--------------------------------------------------------------

>57964_57964_7_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817547_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_8_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817547_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_9_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000323851_ERG_chr21_39817547_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

--------------------------------------------------------------

>57964_57964_10_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817543_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_11_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817543_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_12_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817543_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

--------------------------------------------------------------

>57964_57964_13_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817544_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_14_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817544_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_15_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817544_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

--------------------------------------------------------------

>57964_57964_16_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817547_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_17_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817547_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_18_NDRG1-ERG_NDRG1_chr8_134292474_ENST00000354944_ERG_chr21_39817547_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

--------------------------------------------------------------

>57964_57964_19_NDRG1-ERG_NDRG1_chr8_134292478_ENST00000323851_ERG_chr21_39817547_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_20_NDRG1-ERG_NDRG1_chr8_134292478_ENST00000323851_ERG_chr21_39817547_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_21_NDRG1-ERG_NDRG1_chr8_134292478_ENST00000323851_ERG_chr21_39817547_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

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>57964_57964_22_NDRG1-ERG_NDRG1_chr8_134292478_ENST00000354944_ERG_chr21_39817547_ENST00000288319_length(amino acids)=506AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA

--------------------------------------------------------------

>57964_57964_23_NDRG1-ERG_NDRG1_chr8_134292478_ENST00000354944_ERG_chr21_39817547_ENST00000398905_length(amino acids)=482AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPT
PQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>57964_57964_24_NDRG1-ERG_NDRG1_chr8_134292478_ENST00000354944_ERG_chr21_39817547_ENST00000398907_length(amino acids)=483AA_BP=32
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPAR
VTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP
DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQR
ITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKS
KPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF

--------------------------------------------------------------

>57964_57964_25_NDRG1-ERG_NDRG1_chr8_134296491_ENST00000323851_ERG_chr21_39817546_ENST00000288319_length(amino acids)=494AA_BP=21
MSREMQDVDLAEVKPLVEKGEEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQV
NGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDG
KELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPP
RRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPD
EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHP

--------------------------------------------------------------

>57964_57964_26_NDRG1-ERG_NDRG1_chr8_134296491_ENST00000323851_ERG_chr21_39817546_ENST00000398905_length(amino acids)=470AA_BP=21
MSREMQDVDLAEVKPLVEKGEEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQV
NGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDG
KELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPST
VPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRAL
RYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGG

--------------------------------------------------------------

>57964_57964_27_NDRG1-ERG_NDRG1_chr8_134296491_ENST00000323851_ERG_chr21_39817546_ENST00000398907_length(amino acids)=471AA_BP=21
MSREMQDVDLAEVKPLVEKGEEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQV
NGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDG
KELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPS
TVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRA
LRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTG

--------------------------------------------------------------

>57964_57964_28_NDRG1-ERG_NDRG1_chr8_134296491_ENST00000354944_ERG_chr21_39817546_ENST00000288319_length(amino acids)=494AA_BP=21
MSREMQDVDLAEVKPLVEKGEEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQV
NGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDG
KELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPP
RRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPD
EVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHP

--------------------------------------------------------------

>57964_57964_29_NDRG1-ERG_NDRG1_chr8_134296491_ENST00000354944_ERG_chr21_39817546_ENST00000398905_length(amino acids)=470AA_BP=21
MSREMQDVDLAEVKPLVEKGEEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQV
NGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDG
KELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPST
VPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRAL
RYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGG

--------------------------------------------------------------

>57964_57964_30_NDRG1-ERG_NDRG1_chr8_134296491_ENST00000354944_ERG_chr21_39817546_ENST00000398907_length(amino acids)=471AA_BP=21
MSREMQDVDLAEVKPLVEKGEEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQV
NGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDG
KELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPS
TVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRA
LRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:134292474/chr21:39817543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG1

Q92597

ERG

Q9Y282

FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneERGchr8:134292474chr21:39817543ENST00000288319010311_3916.0480.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817543ENST0000039889709311_3910364.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817543ENST00000398911110311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817543ENST00000398919212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817543ENST00000417133212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817543ENST00000442448211311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817543ENST0000045303209311_3910388.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817544ENST00000288319010311_3916.0480.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817544ENST0000039889709311_3910364.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817544ENST00000398911110311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817544ENST00000398919212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817544ENST00000417133212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817544ENST00000442448211311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817544ENST0000045303209311_3910388.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817547ENST00000288319010311_3916.0480.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817547ENST0000039889709311_3910364.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817547ENST00000398911110311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817547ENST00000398919212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817547ENST00000417133212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817547ENST00000442448211311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817547ENST0000045303209311_3910388.0DNA bindingETS
TgeneERGchr8:134292478chr21:39817547ENST00000288319010311_3916.0480.0DNA bindingETS
TgeneERGchr8:134292478chr21:39817547ENST0000039889709311_3910364.0DNA bindingETS
TgeneERGchr8:134292478chr21:39817547ENST00000398911110311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292478chr21:39817547ENST00000398919212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292478chr21:39817547ENST00000417133212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134292478chr21:39817547ENST00000442448211311_39113.0463.0DNA bindingETS
TgeneERGchr8:134292478chr21:39817547ENST0000045303209311_3910388.0DNA bindingETS
TgeneERGchr8:134296491chr21:39817546ENST00000288319010311_3916.0480.0DNA bindingETS
TgeneERGchr8:134296491chr21:39817546ENST0000039889709311_3910364.0DNA bindingETS
TgeneERGchr8:134296491chr21:39817546ENST00000398911110311_39113.0463.0DNA bindingETS
TgeneERGchr8:134296491chr21:39817546ENST00000398919212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134296491chr21:39817546ENST00000417133212311_39113.0487.0DNA bindingETS
TgeneERGchr8:134296491chr21:39817546ENST00000442448211311_39113.0463.0DNA bindingETS
TgeneERGchr8:134296491chr21:39817546ENST0000045303209311_3910388.0DNA bindingETS
TgeneERGchr8:134292474chr21:39817543ENST00000288319010113_1996.0480.0DomainPNT
TgeneERGchr8:134292474chr21:39817543ENST0000039889709113_1990364.0DomainPNT
TgeneERGchr8:134292474chr21:39817543ENST00000398911110113_19913.0463.0DomainPNT
TgeneERGchr8:134292474chr21:39817543ENST00000398919212113_19913.0487.0DomainPNT
TgeneERGchr8:134292474chr21:39817543ENST00000417133212113_19913.0487.0DomainPNT
TgeneERGchr8:134292474chr21:39817543ENST00000442448211113_19913.0463.0DomainPNT
TgeneERGchr8:134292474chr21:39817543ENST0000045303209113_1990388.0DomainPNT
TgeneERGchr8:134292474chr21:39817544ENST00000288319010113_1996.0480.0DomainPNT
TgeneERGchr8:134292474chr21:39817544ENST0000039889709113_1990364.0DomainPNT
TgeneERGchr8:134292474chr21:39817544ENST00000398911110113_19913.0463.0DomainPNT
TgeneERGchr8:134292474chr21:39817544ENST00000398919212113_19913.0487.0DomainPNT
TgeneERGchr8:134292474chr21:39817544ENST00000417133212113_19913.0487.0DomainPNT
TgeneERGchr8:134292474chr21:39817544ENST00000442448211113_19913.0463.0DomainPNT
TgeneERGchr8:134292474chr21:39817544ENST0000045303209113_1990388.0DomainPNT
TgeneERGchr8:134292474chr21:39817547ENST00000288319010113_1996.0480.0DomainPNT
TgeneERGchr8:134292474chr21:39817547ENST0000039889709113_1990364.0DomainPNT
TgeneERGchr8:134292474chr21:39817547ENST00000398911110113_19913.0463.0DomainPNT
TgeneERGchr8:134292474chr21:39817547ENST00000398919212113_19913.0487.0DomainPNT
TgeneERGchr8:134292474chr21:39817547ENST00000417133212113_19913.0487.0DomainPNT
TgeneERGchr8:134292474chr21:39817547ENST00000442448211113_19913.0463.0DomainPNT
TgeneERGchr8:134292474chr21:39817547ENST0000045303209113_1990388.0DomainPNT
TgeneERGchr8:134292478chr21:39817547ENST00000288319010113_1996.0480.0DomainPNT
TgeneERGchr8:134292478chr21:39817547ENST0000039889709113_1990364.0DomainPNT
TgeneERGchr8:134292478chr21:39817547ENST00000398911110113_19913.0463.0DomainPNT
TgeneERGchr8:134292478chr21:39817547ENST00000398919212113_19913.0487.0DomainPNT
TgeneERGchr8:134292478chr21:39817547ENST00000417133212113_19913.0487.0DomainPNT
TgeneERGchr8:134292478chr21:39817547ENST00000442448211113_19913.0463.0DomainPNT
TgeneERGchr8:134292478chr21:39817547ENST0000045303209113_1990388.0DomainPNT
TgeneERGchr8:134296491chr21:39817546ENST00000288319010113_1996.0480.0DomainPNT
TgeneERGchr8:134296491chr21:39817546ENST0000039889709113_1990364.0DomainPNT
TgeneERGchr8:134296491chr21:39817546ENST00000398911110113_19913.0463.0DomainPNT
TgeneERGchr8:134296491chr21:39817546ENST00000398919212113_19913.0487.0DomainPNT
TgeneERGchr8:134296491chr21:39817546ENST00000417133212113_19913.0487.0DomainPNT
TgeneERGchr8:134296491chr21:39817546ENST00000442448211113_19913.0463.0DomainPNT
TgeneERGchr8:134296491chr21:39817546ENST0000045303209113_1990388.0DomainPNT

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDRG1chr8:134292474chr21:39817543ENST00000323851-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817543ENST00000414097-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817543ENST00000522476-114339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817543ENST00000537882-315339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817544ENST00000323851-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817544ENST00000414097-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817544ENST00000522476-114339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817544ENST00000537882-315339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817547ENST00000323851-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817547ENST00000414097-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817547ENST00000522476-114339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817547ENST00000537882-315339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292478chr21:39817547ENST00000323851-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292478chr21:39817547ENST00000414097-316339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292478chr21:39817547ENST00000522476-114339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292478chr21:39817547ENST00000537882-315339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296491chr21:39817546ENST00000323851-216339_36821.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296491chr21:39817546ENST00000414097-216339_36821.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296491chr21:39817546ENST00000522476-114339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296491chr21:39817546ENST00000537882-215339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134292474chr21:39817543ENST00000323851-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817543ENST00000323851-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817543ENST00000323851-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817543ENST00000414097-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817543ENST00000414097-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817543ENST00000414097-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817543ENST00000522476-114339_3480329.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817543ENST00000522476-114349_3580329.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817543ENST00000522476-114359_3680329.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817543ENST00000537882-315339_3480314.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817543ENST00000537882-315349_3580314.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817543ENST00000537882-315359_3680314.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817544ENST00000323851-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817544ENST00000323851-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817544ENST00000323851-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817544ENST00000414097-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817544ENST00000414097-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817544ENST00000414097-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817544ENST00000522476-114339_3480329.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817544ENST00000522476-114349_3580329.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817544ENST00000522476-114359_3680329.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817544ENST00000537882-315339_3480314.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817544ENST00000537882-315349_3580314.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817544ENST00000537882-315359_3680314.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817547ENST00000323851-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817547ENST00000323851-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817547ENST00000323851-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817547ENST00000414097-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817547ENST00000414097-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817547ENST00000414097-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817547ENST00000522476-114339_3480329.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817547ENST00000522476-114349_3580329.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817547ENST00000522476-114359_3680329.0RepeatNote=3
HgeneNDRG1chr8:134292474chr21:39817547ENST00000537882-315339_3480314.0RepeatNote=1
HgeneNDRG1chr8:134292474chr21:39817547ENST00000537882-315349_3580314.0RepeatNote=2
HgeneNDRG1chr8:134292474chr21:39817547ENST00000537882-315359_3680314.0RepeatNote=3
HgeneNDRG1chr8:134292478chr21:39817547ENST00000323851-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292478chr21:39817547ENST00000323851-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292478chr21:39817547ENST00000323851-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292478chr21:39817547ENST00000414097-316339_34833.0395.0RepeatNote=1
HgeneNDRG1chr8:134292478chr21:39817547ENST00000414097-316349_35833.0395.0RepeatNote=2
HgeneNDRG1chr8:134292478chr21:39817547ENST00000414097-316359_36833.0395.0RepeatNote=3
HgeneNDRG1chr8:134292478chr21:39817547ENST00000522476-114339_3480329.0RepeatNote=1
HgeneNDRG1chr8:134292478chr21:39817547ENST00000522476-114349_3580329.0RepeatNote=2
HgeneNDRG1chr8:134292478chr21:39817547ENST00000522476-114359_3680329.0RepeatNote=3
HgeneNDRG1chr8:134292478chr21:39817547ENST00000537882-315339_3480314.0RepeatNote=1
HgeneNDRG1chr8:134292478chr21:39817547ENST00000537882-315349_3580314.0RepeatNote=2
HgeneNDRG1chr8:134292478chr21:39817547ENST00000537882-315359_3680314.0RepeatNote=3
HgeneNDRG1chr8:134296491chr21:39817546ENST00000323851-216339_34821.0395.0RepeatNote=1
HgeneNDRG1chr8:134296491chr21:39817546ENST00000323851-216349_35821.0395.0RepeatNote=2
HgeneNDRG1chr8:134296491chr21:39817546ENST00000323851-216359_36821.0395.0RepeatNote=3
HgeneNDRG1chr8:134296491chr21:39817546ENST00000414097-216339_34821.0395.0RepeatNote=1
HgeneNDRG1chr8:134296491chr21:39817546ENST00000414097-216349_35821.0395.0RepeatNote=2
HgeneNDRG1chr8:134296491chr21:39817546ENST00000414097-216359_36821.0395.0RepeatNote=3
HgeneNDRG1chr8:134296491chr21:39817546ENST00000522476-114339_3480329.0RepeatNote=1
HgeneNDRG1chr8:134296491chr21:39817546ENST00000522476-114349_3580329.0RepeatNote=2
HgeneNDRG1chr8:134296491chr21:39817546ENST00000522476-114359_3680329.0RepeatNote=3
HgeneNDRG1chr8:134296491chr21:39817546ENST00000537882-215339_3480314.0RepeatNote=1
HgeneNDRG1chr8:134296491chr21:39817546ENST00000537882-215349_3580314.0RepeatNote=2
HgeneNDRG1chr8:134296491chr21:39817546ENST00000537882-215359_3680314.0RepeatNote=3


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (268) >>>268.pdbFusion protein BP residue: 32
CIF file (268) >>>268.cif		NDRG1chr8134292474-ERGchr2139817544-
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAY
GTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPS
QVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNER
RVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARN
TDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILG
PTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEV
ARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQ
ALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA
482
3D view using mol* of 268 (AA BP:32)
PDB file (272) >>>272.pdbFusion protein BP residue: 32
CIF file (272) >>>272.cif		NDRG1chr8134292474-ERGchr2139817544-
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAY
GTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPS
QVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNER
RVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARN
TGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKTEDQRPQLDPYQIL
GPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDE
VARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIA
QALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFF
483
3D view using mol* of 272 (AA BP:32)
PDB file (316) >>>316.pdbFusion protein BP residue: 32
CIF file (316) >>>316.cif		NDRG1chr8134292474-ERGchr2139817544-
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEALSVVSEDQSLFECAY
GTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPS
QVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNER
RVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARN
TGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAA
QPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSD
SSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYY
DKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHA
HPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS
506
3D view using mol* of 316 (AA BP:32)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NDRG1_pLDDT.png
all structure
all structure
ERG_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NDRG1_ERG_268_PAE.png (AA BP:32)
all structure
NDRG1_ERG_268_pLDDT.png (AA BP:32)
all structure
NDRG1_ERG_268_pLDDT_and_active_sites.png (AA BP:32)
all structure
NDRG1_ERG_268_violinplot.png (AA BP:32)
all structure
NDRG1_ERG_272_pLDDT.png (AA BP:32)
all structure
NDRG1_ERG_272_pLDDT_and_active_sites.png (AA BP:32)
all structure
NDRG1_ERG_272_violinplot.png (AA BP:32)
all structure
NDRG1_ERG_316_pLDDT.png (AA BP:32)
all structure
NDRG1_ERG_316_pLDDT_and_active_sites.png (AA BP:32)
all structure
NDRG1_ERG_316_violinplot.png (AA BP:32)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
NDRG1_ERG_268.png
all structure
NDRG1_ERG_272.png
all structure
NDRG1_ERG_316.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
2680.9972081.04653.0720.6420.6470.8530.6790.8830.7680.926Chain A: 172,176,177,179,210,213,214,217,220,221,2
32,233,236,237,239,240,241,242,243,244,245,246,247
,248,293,294,297,298,301,302,305,306,395,396,399,4
00,402,403
2721.0152391.048526.1620.5520.6910.8450.7670.9410.8150.527Chain A: 24,25,27,28,29,31,32,33,34,35,36,309,312,
314,315,316,317,318,319,355,359,361,364,368,369,37
1,372,375,376,379,381,401,402,404,405,406
3161.0031291.058606.0810.7720.6350.7160.5340.8080.6610.604Chain A: 14,15,16,17,18,19,20,21,35,36,39,176,177,
210,213,214,217,221,328,329,330,331,332,335,337,33
8,339,340,342,378,382,387,391,392,394,395,398,399,
426

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3, EP300, APEX1, PVT1, E7, TRIM8, MEF2D, SMARCE1, FOXP1, RERE, NFIB, FLI1, NFIA, BCL9, ARID1A, KMT2D, ZNF609, TRIM24, KDM6A, MITF, SS18L1, NCOR1, PIAS1, ATXN1L, HIVEP1, GATA4, SMARCA2, SMARCA4, ATXN1, MLLT10, LMO4, TLE1, TLE3, AES, SMARCB1, NCOA6, GSE1, SS18, NCOA2, QSER1, ARID4B, BCL7A, PRRC2B, NIPBL, TET2, ZNF746, ELMSAN1, SMARCD3, ATF7IP, BCOR, C15orf39, PAXIP1, ASXL2, C11orf30, LDB1, ZFHX4, FOXP4, RYBP, KMT2C, ARID1B, KDM2B, SMARCC2, MORC4, BCL7C, MAML1, DPF1, DPF3, DPF2, CREBBP, SMARCC1, SMARCD2, ISL2, SMARCD1, ZNF521, CIC, ARID3A, BCL7B, PYGO2, PCGF1, PAGR1, DNTTIP1, HIPK2, CPVL, ZNF703, FBRS, KIAA1551, FBRSL1, HMG20A, TCF7L2, GLTSCR1, CHD7, TCF20, TRPS1, ZNF608, PRR12, SATB2, ZNF148, ZNF281, RAD54L2, NCOR2, NCOA3, PSMB5, DBN1, NFIC,
NDRG1ARL4D, PHYHIP, S100B, HSP90AA1, HSPA5, VCP, CANX, PSMC3, PSMC2, PSMD2, XRCC6, RUVBL2, ILF3, SEC23A, COPB2, CLTC, AP2M1, AP1M2, MME, CTNNB1, ACTG1, KIF5B, PPP2R2A, TLE3, HSD17B4, CNDP2, DARS, DLST, ACSL3, FASN, MAOA, LDHA, PKM, RPN2, TARS, SHMT2, SLC25A6, ATP1A1, EEF2, EEF1G, EIF2S3, EIF3E, PABPC1, RPS3, RPS6, RPL24, RPL3, RPS16, RPS8, RPS20, RPS9, RPL4, RPS26, NCL, HNRNPF, HNRNPU, HNRNPH1, DDX1, DDX5, UPF1, EWSR1, CDH1, ANXA5, CLNS1A, IGBP1, SPAG9, MLH1, ACOT7, DDX39B, GSR, DPP3, EIF4H, FTO, KYNU, MVD, NAMPT, PEPD, PGD, BCL2L11, HSPA4, CUL2, TAF9, SGK1, SUZ12, EED, NDRG2, DHX15, G6PD, GART, HIP1R, CCDC22, CLIC4, NAA50, RTCB, SH2D4A, THUMPD1, TIMM13, TSG101, USP14, XPO1, NIF3L1, NTMT1, TARDBP, UFM1, TMEM17, ERBB3, FXYD1, PDE4DIP, S1PR2, FAM60A, CDK15, TRIM25, HNRNPL, MYC, SKP2, RABAC1, GSK3B, NR4A1, YAP1, RTN1, Apoa1, Apoa2, Rabac1, Arl6ip1, APOA1, APOA2, RAB4A, ZBTB38, EZR, TGOLN2, LAMP1, PPM1F, HRAS, NRAS, KRAS, RFFL, DYNC1I2, CUL4A, CTBP2, ORF3a, PRKCB, RAB5A, SH2D3C, M, Rnf183, HULC, ARF6, C11orf52, CAV1, LAMTOR1, LYN, MARCKS, OCLN, RAB11A, RAB2A, RAB35, RAB9A, RHOB, STX4, STX6, STX7, ZFPL1, HTRA4, NAA40, ST6GALNAC6, OR2A4, HOXC5, RPL35A, FXYD3, SRRT, PPP2R2B, NAA11, YWHAH, GOT1, STX17, WIF1, GOLGA2, ATP1B1, COL10A1, CERS3, OPTN, SSBP2, ATP1B3, C2orf73, NTNG1, FGF12, OSGEP, CCR1, TIMMDC1, CEP19, MBNL1, CRCP, PINK1, NRSN1, CCDC53, SSUH2, DNAJB6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NDRG1all structure
ERGall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NDRG1-ERG


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NDRG1-ERG


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
NDRG1ERGProstate AdenocarcinomaMyCancerGenome
NDRG1ERGAngiosarcomaMyCancerGenome
NDRG1ERGClear Cell Renal Cell CarcinomaMyCancerGenome
NDRG1ERGDedifferentiated LiposarcomaMyCancerGenome
NDRG1ERGEsophagogastric CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDRG1C0027627Neoplasm Metastasis2CTD_human
HgeneNDRG1C1832334CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNDRG1C0004114Astrocytoma1CTD_human
HgeneNDRG1C0006142Malignant neoplasm of breast1CTD_human
HgeneNDRG1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneNDRG1C0007134Renal Cell Carcinoma1CTD_human
HgeneNDRG1C0017636Glioblastoma1CTD_human
HgeneNDRG1C0022665Kidney Neoplasm1CTD_human
HgeneNDRG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNDRG1C0023903Liver neoplasms1CTD_human
HgeneNDRG1C0025202melanoma1CTD_human
HgeneNDRG1C0026640Mouth Neoplasms1CTD_human
HgeneNDRG1C0029295Oropharyngeal Neoplasms1CTD_human
HgeneNDRG1C0033578Prostatic Neoplasms1CTD_human
HgeneNDRG1C0149925Small cell carcinoma of lung1CTD_human
HgeneNDRG1C0153381Malignant neoplasm of mouth1CTD_human
HgeneNDRG1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneNDRG1C0206658Smooth Muscle Tumor1CTD_human
HgeneNDRG1C0206734Hemangioblastoma1CTD_human
HgeneNDRG1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneNDRG1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneNDRG1C0280785Diffuse Astrocytoma1CTD_human
HgeneNDRG1C0334579Anaplastic astrocytoma1CTD_human
HgeneNDRG1C0334580Protoplasmic astrocytoma1CTD_human
HgeneNDRG1C0334581Gemistocytic astrocytoma1CTD_human
HgeneNDRG1C0334582Fibrillary Astrocytoma1CTD_human
HgeneNDRG1C0334583Pilocytic Astrocytoma1CTD_human
HgeneNDRG1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNDRG1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneNDRG1C0345904Malignant neoplasm of liver1CTD_human
HgeneNDRG1C0376358Malignant neoplasm of prostate1CTD_human
HgeneNDRG1C0547065Mixed oligoastrocytoma1CTD_human
HgeneNDRG1C0678222Breast Carcinoma1CTD_human
HgeneNDRG1C0740457Malignant neoplasm of kidney1CTD_human
HgeneNDRG1C0750935Cerebral Astrocytoma1CTD_human
HgeneNDRG1C0750936Intracranial Astrocytoma1CTD_human
HgeneNDRG1C0751692Multiple Hemangioblastomas1CTD_human
HgeneNDRG1C0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneNDRG1C1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneNDRG1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNDRG1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneNDRG1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneNDRG1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneNDRG1C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneNDRG1C1458155Mammary Neoplasms1CTD_human
HgeneNDRG1C1621958Glioblastoma Multiforme1CTD_human
HgeneNDRG1C1704230Grade I Astrocytoma1CTD_human
HgeneNDRG1C2349952Oropharyngeal Carcinoma1CTD_human
HgeneNDRG1C4704874Mammary Carcinoma, Human1CTD_human
TgeneERGC0033578Prostatic Neoplasms7CTD_human
TgeneERGC0376358Malignant neoplasm of prostate7CTD_human
TgeneERGC0023418leukemia1CTD_human
TgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
TgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human