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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NECAP1-ANK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NECAP1-ANK1
FusionPDB ID: 58366
FusionGDB2.0 ID: 58366
HgeneTgene
Gene symbol

NECAP1

ANK1

Gene ID

25977

286

Gene nameNECAP endocytosis associated 1ankyrin 1
SynonymsEIEE21ANK|SPH1|SPH2
Cytomap

12p13.31

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionadaptin ear-binding coat-associated protein 1ankyrin-1ANK-1ankyrin 1, erythrocyticankyrin-Rerythrocyte ankyrin
Modification date2020032020200313
UniProtAcc

Q8NC96

P16157

Ensembl transtripts involved in fusion geneENST idsENST00000339754, ENST00000314214, 
ENST00000457297, ENST00000521407, 
ENST00000522231, ENST00000522543, 
ENST00000265709, ENST00000289734, 
ENST00000347528, ENST00000352337, 
ENST00000379758, ENST00000396942, 
ENST00000396945, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 8 X 4=25615 X 9 X 9=1215
# samples 918
** MAII scorelog2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1215*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NECAP1 [Title/Abstract] AND ANK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NECAP1(8242895)-ANK1(41529944), # samples:1
Anticipated loss of major functional domain due to fusion event.NECAP1-ANK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NECAP1-ANK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NECAP1-ANK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NECAP1-ANK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANK1

GO:0006888

ER to Golgi vesicle-mediated transport

18768923


check buttonFusion gene breakpoints across NECAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A20W-01ANECAP1chr12

8242895

-ANK1chr8

41529944

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339754NECAP1chr128242895-ENST00000347528ANK1chr841529944-350937922432755170
ENST00000339754NECAP1chr128242895-ENST00000289734ANK1chr841529944-356937922432755170
ENST00000339754NECAP1chr128242895-ENST00000379758ANK1chr841529944-336237922432755170
ENST00000339754NECAP1chr128242895-ENST00000396942ANK1chr841529944-363837922432755170
ENST00000339754NECAP1chr128242895-ENST00000396945ANK1chr841529944-327837922432755170
ENST00000339754NECAP1chr128242895-ENST00000352337ANK1chr841529944-349737922432755170
ENST00000339754NECAP1chr128242895-ENST00000265709ANK1chr841529944-13303791075515186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339754ENST00000347528NECAP1chr128242895-ANK1chr841529944-0.036494070.9635059
ENST00000339754ENST00000289734NECAP1chr128242895-ANK1chr841529944-0.030259510.96974045
ENST00000339754ENST00000379758NECAP1chr128242895-ANK1chr841529944-0.0280515220.97194844
ENST00000339754ENST00000396942NECAP1chr128242895-ANK1chr841529944-0.0341623540.96583766
ENST00000339754ENST00000396945NECAP1chr128242895-ANK1chr841529944-0.0536029970.94639695
ENST00000339754ENST00000352337NECAP1chr128242895-ANK1chr841529944-0.036913050.96308696
ENST00000339754ENST00000265709NECAP1chr128242895-ANK1chr841529944-0.0185047240.9814953

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58366_58366_1_NECAP1-ANK1_NECAP1_chr12_8242895_ENST00000339754_ANK1_chr8_41529944_ENST00000265709_length(amino acids)=186AA_BP=39
MVLVPWNECGPCVTSSCQEPCAASCRYETIEPSASQSCSLLGDNVALLIRELLLCHLLPWNILKLIPLLVLLGGIGAGQVYLSNHLANDP
GSPHGFLTDEVGKKYPVRSQNNLKKKPQNQNPSPATKSPHSLLRSQALLRLFSIPLSPRFLLLLCPGSDRSAVIARGRIEAWRSCVYSQS

--------------------------------------------------------------

>58366_58366_2_NECAP1-ANK1_NECAP1_chr12_8242895_ENST00000339754_ANK1_chr8_41529944_ENST00000289734_length(amino acids)=170AA_BP=
MLLLPLEGRAGRGSSSSGPEFPRGCVGGAAGRARTAAVSARGHPGPASRAQRRPPPSSPIPGATAGGPHSAAGTDSVTAQGSWAQGSPLP

--------------------------------------------------------------

>58366_58366_3_NECAP1-ANK1_NECAP1_chr12_8242895_ENST00000339754_ANK1_chr8_41529944_ENST00000347528_length(amino acids)=170AA_BP=
MLLLPLEGRAGRGSSSSGPEFPRGCVGGAAGRARTAAVSARGHPGPASRAQRRPPPSSPIPGATAGGPHSAAGTDSVTAQGSWAQGSPLP

--------------------------------------------------------------

>58366_58366_4_NECAP1-ANK1_NECAP1_chr12_8242895_ENST00000339754_ANK1_chr8_41529944_ENST00000352337_length(amino acids)=170AA_BP=
MLLLPLEGRAGRGSSSSGPEFPRGCVGGAAGRARTAAVSARGHPGPASRAQRRPPPSSPIPGATAGGPHSAAGTDSVTAQGSWAQGSPLP

--------------------------------------------------------------

>58366_58366_5_NECAP1-ANK1_NECAP1_chr12_8242895_ENST00000339754_ANK1_chr8_41529944_ENST00000379758_length(amino acids)=170AA_BP=
MLLLPLEGRAGRGSSSSGPEFPRGCVGGAAGRARTAAVSARGHPGPASRAQRRPPPSSPIPGATAGGPHSAAGTDSVTAQGSWAQGSPLP

--------------------------------------------------------------

>58366_58366_6_NECAP1-ANK1_NECAP1_chr12_8242895_ENST00000339754_ANK1_chr8_41529944_ENST00000396942_length(amino acids)=170AA_BP=
MLLLPLEGRAGRGSSSSGPEFPRGCVGGAAGRARTAAVSARGHPGPASRAQRRPPPSSPIPGATAGGPHSAAGTDSVTAQGSWAQGSPLP

--------------------------------------------------------------

>58366_58366_7_NECAP1-ANK1_NECAP1_chr12_8242895_ENST00000339754_ANK1_chr8_41529944_ENST00000396945_length(amino acids)=170AA_BP=
MLLLPLEGRAGRGSSSSGPEFPRGCVGGAAGRARTAAVSARGHPGPASRAQRRPPPSSPIPGATAGGPHSAAGTDSVTAQGSWAQGSPLP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:8242895/chr8:41529944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NECAP1

Q8NC96

ANK1

P16157

FUNCTION: Involved in endocytosis. {ECO:0000250}.FUNCTION: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANK1chr12:8242895chr8:41529944ENST000002657090431070_121601898.0DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST000002657090431403_148701898.0DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043913_106801898.0DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST000002897340431070_121602699.6666666666665DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST000002897340431403_148702699.6666666666665DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043913_106802699.6666666666665DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST00000314214051070_12160159.66666666666666DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST00000314214051403_14870159.66666666666666DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405913_10680159.66666666666666DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST000003475280421070_121601882.0DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST000003475280421403_148701882.0DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042913_106801882.0DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST000003523370421070_121602675.6666666666665DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST000003523370421403_148702675.6666666666665DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042913_106802675.6666666666665DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST000003797580411070_121601835.0DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST000003797580411403_148701835.0DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041913_106801835.0DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST000003969420431070_121602722.6666666666665DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST000003969420431403_148702722.6666666666665DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043913_106802722.6666666666665DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST000003969450401070_121601807.0DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST000003969450401403_148701807.0DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040913_106801807.0DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST00000457297031070_12160110.0DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST00000457297031403_14870110.0DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703913_10680110.0DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST00000522543041070_12160157.0DomainZU5 2
TgeneANK1chr12:8242895chr8:41529944ENST00000522543041403_14870157.0DomainDeath
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304913_10680157.0DomainZU5 1
TgeneANK1chr12:8242895chr8:41529944ENST000002657090431234_136201898.0RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST000002657090431383_188101898.0RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST000002657090431_82701898.0RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST000002897340431234_136202699.6666666666665RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST000002897340431383_188102699.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST000002897340431_82702699.6666666666665RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST00000314214051234_13620159.66666666666666RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST00000314214051383_18810159.66666666666666RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST00000314214051_8270159.66666666666666RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST000003475280421234_136201882.0RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST000003475280421383_188101882.0RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST000003475280421_82701882.0RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST000003523370421234_136202675.6666666666665RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST000003523370421383_188102675.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST000003523370421_82702675.6666666666665RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST000003797580411234_136201835.0RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST000003797580411383_188101835.0RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST000003797580411_82701835.0RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST000003969420431234_136202722.6666666666665RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST000003969420431383_188102722.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST000003969420431_82702722.6666666666665RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST000003969450401234_136201807.0RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST000003969450401383_188101807.0RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST000003969450401_82701807.0RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST00000457297031234_13620110.0RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST00000457297031383_18810110.0RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST00000457297031_8270110.0RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST00000522543041234_13620157.0RegionUPA domain
TgeneANK1chr12:8242895chr8:41529944ENST00000522543041383_18810157.0RegionNote=55 kDa regulatory domain
TgeneANK1chr12:8242895chr8:41529944ENST00000522543041_8270157.0RegionNote=89 kDa domain
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043110_13901898.0RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043143_17201898.0RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043174_20101898.0RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043205_23401898.0RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043238_26701898.0RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043271_30001898.0RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043304_33301898.0RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043337_36601898.0RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043370_39901898.0RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043403_43201898.0RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043436_46501898.0RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST0000026570904344_7301898.0RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043469_49801898.0RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043502_53101898.0RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043535_56401898.0RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043568_59701898.0RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043601_63001898.0RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043634_66301898.0RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043667_69601898.0RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043700_72901898.0RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043733_76201898.0RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST00000265709043766_79501898.0RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST0000026570904377_10601898.0RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043110_13902699.6666666666665RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043143_17202699.6666666666665RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043174_20102699.6666666666665RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043205_23402699.6666666666665RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043238_26702699.6666666666665RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043271_30002699.6666666666665RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043304_33302699.6666666666665RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043337_36602699.6666666666665RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043370_39902699.6666666666665RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043403_43202699.6666666666665RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043436_46502699.6666666666665RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST0000028973404344_7302699.6666666666665RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043469_49802699.6666666666665RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043502_53102699.6666666666665RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043535_56402699.6666666666665RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043568_59702699.6666666666665RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043601_63002699.6666666666665RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043634_66302699.6666666666665RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043667_69602699.6666666666665RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043700_72902699.6666666666665RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043733_76202699.6666666666665RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST00000289734043766_79502699.6666666666665RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST0000028973404377_10602699.6666666666665RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405110_1390159.66666666666666RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405143_1720159.66666666666666RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405174_2010159.66666666666666RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405205_2340159.66666666666666RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405238_2670159.66666666666666RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405271_3000159.66666666666666RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405304_3330159.66666666666666RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405337_3660159.66666666666666RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405370_3990159.66666666666666RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405403_4320159.66666666666666RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405436_4650159.66666666666666RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST000003142140544_730159.66666666666666RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405469_4980159.66666666666666RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405502_5310159.66666666666666RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405535_5640159.66666666666666RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405568_5970159.66666666666666RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405601_6300159.66666666666666RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405634_6630159.66666666666666RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405667_6960159.66666666666666RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405700_7290159.66666666666666RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405733_7620159.66666666666666RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST0000031421405766_7950159.66666666666666RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST000003142140577_1060159.66666666666666RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042110_13901882.0RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042143_17201882.0RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042174_20101882.0RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042205_23401882.0RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042238_26701882.0RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042271_30001882.0RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042304_33301882.0RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042337_36601882.0RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042370_39901882.0RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042403_43201882.0RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042436_46501882.0RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST0000034752804244_7301882.0RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042469_49801882.0RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042502_53101882.0RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042535_56401882.0RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042568_59701882.0RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042601_63001882.0RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042634_66301882.0RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042667_69601882.0RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042700_72901882.0RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042733_76201882.0RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST00000347528042766_79501882.0RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST0000034752804277_10601882.0RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042110_13902675.6666666666665RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042143_17202675.6666666666665RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042174_20102675.6666666666665RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042205_23402675.6666666666665RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042238_26702675.6666666666665RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042271_30002675.6666666666665RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042304_33302675.6666666666665RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042337_36602675.6666666666665RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042370_39902675.6666666666665RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042403_43202675.6666666666665RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042436_46502675.6666666666665RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST0000035233704244_7302675.6666666666665RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042469_49802675.6666666666665RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042502_53102675.6666666666665RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042535_56402675.6666666666665RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042568_59702675.6666666666665RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042601_63002675.6666666666665RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042634_66302675.6666666666665RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042667_69602675.6666666666665RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042700_72902675.6666666666665RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042733_76202675.6666666666665RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST00000352337042766_79502675.6666666666665RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST0000035233704277_10602675.6666666666665RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041110_13901835.0RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041143_17201835.0RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041174_20101835.0RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041205_23401835.0RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041238_26701835.0RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041271_30001835.0RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041304_33301835.0RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041337_36601835.0RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041370_39901835.0RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041403_43201835.0RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041436_46501835.0RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST0000037975804144_7301835.0RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041469_49801835.0RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041502_53101835.0RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041535_56401835.0RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041568_59701835.0RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041601_63001835.0RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041634_66301835.0RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041667_69601835.0RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041700_72901835.0RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041733_76201835.0RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST00000379758041766_79501835.0RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST0000037975804177_10601835.0RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043110_13902722.6666666666665RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043143_17202722.6666666666665RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043174_20102722.6666666666665RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043205_23402722.6666666666665RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043238_26702722.6666666666665RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043271_30002722.6666666666665RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043304_33302722.6666666666665RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043337_36602722.6666666666665RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043370_39902722.6666666666665RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043403_43202722.6666666666665RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043436_46502722.6666666666665RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST0000039694204344_7302722.6666666666665RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043469_49802722.6666666666665RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043502_53102722.6666666666665RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043535_56402722.6666666666665RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043568_59702722.6666666666665RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043601_63002722.6666666666665RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043634_66302722.6666666666665RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043667_69602722.6666666666665RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043700_72902722.6666666666665RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043733_76202722.6666666666665RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST00000396942043766_79502722.6666666666665RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST0000039694204377_10602722.6666666666665RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040110_13901807.0RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040143_17201807.0RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040174_20101807.0RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040205_23401807.0RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040238_26701807.0RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040271_30001807.0RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040304_33301807.0RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040337_36601807.0RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040370_39901807.0RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040403_43201807.0RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040436_46501807.0RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST0000039694504044_7301807.0RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040469_49801807.0RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040502_53101807.0RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040535_56401807.0RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040568_59701807.0RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040601_63001807.0RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040634_66301807.0RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040667_69601807.0RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040700_72901807.0RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040733_76201807.0RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST00000396945040766_79501807.0RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST0000039694504077_10601807.0RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703110_1390110.0RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703143_1720110.0RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703174_2010110.0RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703205_2340110.0RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703238_2670110.0RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703271_3000110.0RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703304_3330110.0RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703337_3660110.0RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703370_3990110.0RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703403_4320110.0RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703436_4650110.0RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST000004572970344_730110.0RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703469_4980110.0RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703502_5310110.0RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703535_5640110.0RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703568_5970110.0RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703601_6300110.0RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703634_6630110.0RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703667_6960110.0RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703700_7290110.0RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703733_7620110.0RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST0000045729703766_7950110.0RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST000004572970377_1060110.0RepeatNote=ANK 2
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304110_1390157.0RepeatNote=ANK 3
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304143_1720157.0RepeatNote=ANK 4
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304174_2010157.0RepeatNote=ANK 5
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304205_2340157.0RepeatNote=ANK 6
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304238_2670157.0RepeatNote=ANK 7
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304271_3000157.0RepeatNote=ANK 8
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304304_3330157.0RepeatNote=ANK 9
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304337_3660157.0RepeatNote=ANK 10
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304370_3990157.0RepeatNote=ANK 11
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304403_4320157.0RepeatNote=ANK 12
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304436_4650157.0RepeatNote=ANK 13
TgeneANK1chr12:8242895chr8:41529944ENST000005225430444_730157.0RepeatNote=ANK 1
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304469_4980157.0RepeatNote=ANK 14
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304502_5310157.0RepeatNote=ANK 15
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304535_5640157.0RepeatNote=ANK 16
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304568_5970157.0RepeatNote=ANK 17
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304601_6300157.0RepeatNote=ANK 18
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304634_6630157.0RepeatNote=ANK 19
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304667_6960157.0RepeatNote=ANK 20
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304700_7290157.0RepeatNote=ANK 21
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304733_7620157.0RepeatNote=ANK 22
TgeneANK1chr12:8242895chr8:41529944ENST0000052254304766_7950157.0RepeatNote=ANK 23
TgeneANK1chr12:8242895chr8:41529944ENST000005225430477_1060157.0RepeatNote=ANK 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNECAP1chr12:8242895chr8:41529944ENST00000339754-38252_255100.33333333333333276.0MotifNote=WXXF motif 1
HgeneNECAP1chr12:8242895chr8:41529944ENST00000339754-38272_275100.33333333333333276.0MotifNote=WXXF motif 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NECAP1
ANK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NECAP1-ANK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NECAP1-ANK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource