UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:NEDD4-ADAMTSL3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NEDD4-ADAMTSL3
FusionPDB ID: 58405
FusionGDB2.0 ID: 58405
HgeneTgene
Gene symbol

NEDD4

ADAMTSL3

Gene ID

4734

57188

Gene nameNEDD4 E3 ubiquitin protein ligaseADAMTS like 3
SynonymsNEDD4-1|RPF1ADAMTSL-3
Cytomap

15q21.3

15q25.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase NEDD4HECT-type E3 ubiquitin transferase NEDD4cell proliferation-inducing gene 53 proteinneural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligasereceptor-potentiating factor 1ADAMTS-like protein 3a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3punctin-2
Modification date2020031320200320
UniProtAcc

Q96PU5

P82987

Ensembl transtripts involved in fusion geneENST idsENST00000435532, ENST00000338963, 
ENST00000506154, ENST00000508075, 
ENST00000508342, 
ENST00000567716, 
ENST00000286744, ENST00000567476, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 3=10813 X 14 X 6=1092
# samples 614
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/1092*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NEDD4 [Title/Abstract] AND ADAMTSL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NEDD4(56243574)-ADAMTSL3(84373141), # samples:1
Anticipated loss of major functional domain due to fusion event.NEDD4-ADAMTSL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NEDD4-ADAMTSL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NEDD4-ADAMTSL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NEDD4-ADAMTSL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEDD4

GO:0006511

ubiquitin-dependent protein catabolic process

20086093|26263374

HgeneNEDD4

GO:0006622

protein targeting to lysosome

17116753

HgeneNEDD4

GO:0007041

lysosomal transport

18544533

HgeneNEDD4

GO:0010766

negative regulation of sodium ion transport

10642508

HgeneNEDD4

GO:0016567

protein ubiquitination

17996703|18305167|25631046|26280536

HgeneNEDD4

GO:0031623

receptor internalization

18544533

HgeneNEDD4

GO:0032801

receptor catabolic process

18544533

HgeneNEDD4

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneNEDD4

GO:0042391

regulation of membrane potential

17289006

HgeneNEDD4

GO:0042921

glucocorticoid receptor signaling pathway

8649367

HgeneNEDD4

GO:0045732

positive regulation of protein catabolic process

14973438

HgeneNEDD4

GO:0046824

positive regulation of nucleocytoplasmic transport

17218261

HgeneNEDD4

GO:0050847

progesterone receptor signaling pathway

8649367

HgeneNEDD4

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

HgeneNEDD4

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

10642508


check buttonFusion gene breakpoints across NEDD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAMTSL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A03P-01ANEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000435532NEDD4chr1556243574-ENST00000286744ADAMTSL3chr1584373141+74714281754341805
ENST00000435532NEDD4chr1556243574-ENST00000567476ADAMTSL3chr1584373141+70104281754071796

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435532ENST00000286744NEDD4chr1556243574-ADAMTSL3chr1584373141+0.0002979290.99970204
ENST00000435532ENST00000567476NEDD4chr1556243574-ADAMTSL3chr1584373141+0.0008706670.99912935

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58405_58405_1_NEDD4-ADAMTSL3_NEDD4_chr15_56243574_ENST00000435532_ADAMTSL3_chr15_84373141_ENST00000286744_length(amino acids)=1805AA_BP=135
MPGAASARSPREALLSLRERLLLFLQLFPASSRFSSSSSTVACPGRGRARPVCWKRSEMATCAVEVFGLLEDEENSRIVRVRVIAGIGLA
KKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSR
NTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYND
PAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREEN
VIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFY
QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNP
WTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGC
NPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE
EECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ
ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC
RQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQ
MPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGS
LKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFL
RALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRGIQEETP
PAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWTKDGTLLQP
SVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGV
PQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSND
PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSR
QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGA
CDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQ

--------------------------------------------------------------

>58405_58405_2_NEDD4-ADAMTSL3_NEDD4_chr15_56243574_ENST00000435532_ADAMTSL3_chr15_84373141_ENST00000567476_length(amino acids)=1796AA_BP=135
MPGAASARSPREALLSLRERLLLFLQLFPASSRFSSSSSTVACPGRGRARPVCWKRSEMATCAVEVFGLLEDEENSRIVRVRVIAGIGLA
KKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSR
NTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYND
PAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREEN
VIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFY
QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNP
WTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGC
NPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE
EECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ
ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC
RQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQ
MPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGS
LKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFL
RALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRGIQEETP
PAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWTKDGTLLQP
SVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGV
PQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSND
PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSR
QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:56243574/chr15:84373141)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEDD4

Q96PU5

ADAMTSL3

P82987

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301185_127923.01692.0DomainNote=Ig-like C2-type 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301296_137823.01692.0DomainNote=Ig-like C2-type 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301424_148223.01692.0DomainTSP type-1 8
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301483_154523.01692.0DomainTSP type-1 9
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301597_164423.01692.0DomainTSP type-1 10
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301655_169123.01692.0DomainPLAC
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130418_46823.01692.0DomainTSP type-1 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130478_53523.01692.0DomainTSP type-1 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130564_62623.01692.0DomainTSP type-1 4
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130703_76023.01692.0DomainTSP type-1 5
TgeneADAMTSL3chr15:56243574chr15:84373141ENST0000028674413075_12423.01692.0DomainTSP type-1 1
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130763_81823.01692.0DomainTSP type-1 6
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130819_88123.01692.0DomainTSP type-1 7
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130896_99223.01692.0DomainNote=Ig-like C2-type 1
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301185_127923.01683.0DomainNote=Ig-like C2-type 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301296_137823.01683.0DomainNote=Ig-like C2-type 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301424_148223.01683.0DomainTSP type-1 8
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301483_154523.01683.0DomainTSP type-1 9
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301597_164423.01683.0DomainTSP type-1 10
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301655_169123.01683.0DomainPLAC
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130418_46823.01683.0DomainTSP type-1 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130478_53523.01683.0DomainTSP type-1 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130564_62623.01683.0DomainTSP type-1 4
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130703_76023.01683.0DomainTSP type-1 5
TgeneADAMTSL3chr15:56243574chr15:84373141ENST0000056747613075_12423.01683.0DomainTSP type-1 1
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130763_81823.01683.0DomainTSP type-1 6
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130819_88123.01683.0DomainTSP type-1 7
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130896_99223.01683.0DomainNote=Ig-like C2-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-12268_21501248.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-42968_21579.0901.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-12568_21501304.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-12568_21501320.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122610_64301248.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122767_80001248.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122840_87301248.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122892_92501248.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122984_131801248.0DomainHECT
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429610_64379.0901.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429767_80079.0901.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429840_87379.0901.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429892_92579.0901.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429984_131879.0901.0DomainHECT
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125610_64301304.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125767_80001304.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125840_87301304.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125892_92501304.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125984_131801304.0DomainHECT
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125610_64301320.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125767_80001320.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125840_87301320.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125892_92501320.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125984_131801320.0DomainHECT


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NEDD4
ADAMTSL3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to NEDD4-ADAMTSL3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to NEDD4-ADAMTSL3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource