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Fusion Protein:NEDD4L-MORC3 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: NEDD4L-MORC3 | FusionPDB ID: 58423 | FusionGDB2.0 ID: 58423 | Hgene | Tgene | Gene symbol | NEDD4L | MORC3 | Gene ID | 23327 | 23515 |
| Gene name | NEDD4 like E3 ubiquitin protein ligase | MORC family CW-type zinc finger 3 | |
| Synonyms | NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2 | NXP2|ZCW5|ZCWCC3 | |
| Cytomap | 18q21.31 | 21q22.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5 | MORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3 | |
| Modification date | 20200329 | 20200320 | |
| UniProtAcc | Q96PU5 | Q14149 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000588516, ENST00000256830, ENST00000356462, ENST00000357895, ENST00000382850, ENST00000400345, ENST00000586263, ENST00000256832, ENST00000435432, ENST00000456986, ENST00000431212, ENST00000456173, ENST00000589054, | ENST00000400485, ENST00000487909, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 28 X 18 X 11=5544 | 8 X 11 X 4=352 |
| # samples | 35 | 11 | |
| ** MAII score | log2(35/5544*10)=-3.98550043030488 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/352*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: NEDD4L [Title/Abstract] AND MORC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NEDD4L(55833093)-MORC3(37728918), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | NEDD4L-MORC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-MORC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-MORC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-MORC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEDD4L | GO:0003254 | regulation of membrane depolarization | 15217910 |
| Hgene | NEDD4L | GO:0006511 | ubiquitin-dependent protein catabolic process | 21463633 |
| Hgene | NEDD4L | GO:0010038 | response to metal ion | 11244092 |
| Hgene | NEDD4L | GO:0016567 | protein ubiquitination | 15217910|25631046 |
| Hgene | NEDD4L | GO:0034765 | regulation of ion transmembrane transport | 17289006 |
| Hgene | NEDD4L | GO:0042391 | regulation of membrane potential | 17289006 |
| Hgene | NEDD4L | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 21463633 |
| Hgene | NEDD4L | GO:0060306 | regulation of membrane repolarization | 21463633 |
| Hgene | NEDD4L | GO:0070936 | protein K48-linked ubiquitination | 21463633 |
| Hgene | NEDD4L | GO:1901016 | regulation of potassium ion transmembrane transporter activity | 17289006 |
| Hgene | NEDD4L | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity | 21463633 |
| Hgene | NEDD4L | GO:1901380 | negative regulation of potassium ion transmembrane transport | 21463633 |
| Hgene | NEDD4L | GO:1902306 | negative regulation of sodium ion transmembrane transport | 15217910 |
| Hgene | NEDD4L | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Hgene | NEDD4L | GO:2000009 | negative regulation of protein localization to cell surface | 21463633 |
| Hgene | NEDD4L | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 15217910 |
| Tgene | MORC3 | GO:0006468 | protein phosphorylation | 17332504 |
| Tgene | MORC3 | GO:0007569 | cell aging | 17332504 |
| Tgene | MORC3 | GO:0018105 | peptidyl-serine phosphorylation | 17332504 |
| Tgene | MORC3 | GO:0048147 | negative regulation of fibroblast proliferation | 17332504 |
| Tgene | MORC3 | GO:0050821 | protein stabilization | 17332504 |
| Tgene | MORC3 | GO:0051457 | maintenance of protein location in nucleus | 17332504 |
| Fusion gene breakpoints across NEDD4L (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MORC3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-KK-A8IL-01A | NEDD4L | chr18 | 55833093 | - | MORC3 | chr21 | 37728918 | + |
| ChimerDB4 | PRAD | TCGA-KK-A8IL-01A | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + |
| ChimerDB4 | PRAD | TCGA-KK-A8IL | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728917 | + |
| ChimerDB4 | PRAD | TCGA-KK-A8IL | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000356462 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728918 | + | 3483 | 416 | 210 | 2132 | 640 |
| ENST00000400345 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728918 | + | 3472 | 405 | 199 | 2121 | 640 |
| ENST00000382850 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728918 | + | 3302 | 235 | 29 | 1951 | 640 |
| ENST00000256830 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728918 | + | 3189 | 122 | 0 | 1838 | 612 |
| ENST00000357895 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728918 | + | 3368 | 301 | 203 | 2017 | 604 |
| ENST00000586263 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728918 | + | 3364 | 297 | 199 | 2013 | 604 |
| ENST00000356462 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728917 | + | 3483 | 416 | 210 | 2132 | 640 |
| ENST00000400345 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728917 | + | 3472 | 405 | 199 | 2121 | 640 |
| ENST00000382850 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728917 | + | 3302 | 235 | 29 | 1951 | 640 |
| ENST00000256830 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728917 | + | 3189 | 122 | 0 | 1838 | 612 |
| ENST00000357895 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728917 | + | 3368 | 301 | 203 | 2017 | 604 |
| ENST00000586263 | NEDD4L | chr18 | 55833093 | + | ENST00000400485 | MORC3 | chr21 | 37728917 | + | 3364 | 297 | 199 | 2013 | 604 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000356462 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + | 0.000767894 | 0.99923205 |
| ENST00000400345 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + | 0.000776616 | 0.99922335 |
| ENST00000382850 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + | 0.000828745 | 0.99917126 |
| ENST00000256830 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + | 0.000775924 | 0.99922407 |
| ENST00000357895 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + | 0.000182505 | 0.99981755 |
| ENST00000586263 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728918 | + | 0.000183584 | 0.9998165 |
| ENST00000356462 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728917 | + | 0.000767894 | 0.99923205 |
| ENST00000400345 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728917 | + | 0.000776616 | 0.99922335 |
| ENST00000382850 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728917 | + | 0.000828745 | 0.99917126 |
| ENST00000256830 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728917 | + | 0.000775924 | 0.99922407 |
| ENST00000357895 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728917 | + | 0.000182505 | 0.99981755 |
| ENST00000586263 | ENST00000400485 | NEDD4L | chr18 | 55833093 | + | MORC3 | chr21 | 37728917 | + | 0.000183584 | 0.9998165 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >58423_58423_1_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000256830_MORC3_chr21_37728917_ENST00000400485_length(amino acids)=612AA_BP=40 MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACL KWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKES VPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMK SEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDK SADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQAL EEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQ -------------------------------------------------------------- >58423_58423_2_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000256830_MORC3_chr21_37728918_ENST00000400485_length(amino acids)=612AA_BP=40 MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACL KWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKES VPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMK SEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDK SADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQAL EEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQ -------------------------------------------------------------- >58423_58423_3_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000356462_MORC3_chr21_37728917_ENST00000400485_length(amino acids)=640AA_BP=68 MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKK NTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQP EMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYK GDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEI DVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE TDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVEL LEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQV -------------------------------------------------------------- >58423_58423_4_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000356462_MORC3_chr21_37728918_ENST00000400485_length(amino acids)=640AA_BP=68 MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKK NTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQP EMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYK GDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEI DVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE TDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVEL LEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQV -------------------------------------------------------------- >58423_58423_5_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000357895_MORC3_chr21_37728917_ENST00000400485_length(amino acids)=604AA_BP=32 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDG MDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSE GTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQ GGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQ LQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKK QCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTS -------------------------------------------------------------- >58423_58423_6_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000357895_MORC3_chr21_37728918_ENST00000400485_length(amino acids)=604AA_BP=32 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDG MDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSE GTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQ GGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQ LQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKK QCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTS -------------------------------------------------------------- >58423_58423_7_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000382850_MORC3_chr21_37728917_ENST00000400485_length(amino acids)=640AA_BP=68 MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKK NTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQP EMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYK GDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEI DVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE TDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVEL LEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQV -------------------------------------------------------------- >58423_58423_8_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000382850_MORC3_chr21_37728918_ENST00000400485_length(amino acids)=640AA_BP=68 MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKK NTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQP EMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYK GDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEI DVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE TDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVEL LEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQV -------------------------------------------------------------- >58423_58423_9_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000400345_MORC3_chr21_37728917_ENST00000400485_length(amino acids)=640AA_BP=68 MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKK NTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQP EMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYK GDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEI DVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE TDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVEL LEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQV -------------------------------------------------------------- >58423_58423_10_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000400345_MORC3_chr21_37728918_ENST00000400485_length(amino acids)=640AA_BP=68 MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKK NTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQP EMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYK GDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEI DVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE TDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVEL LEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQV -------------------------------------------------------------- >58423_58423_11_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000586263_MORC3_chr21_37728917_ENST00000400485_length(amino acids)=604AA_BP=32 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDG MDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSE GTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQ GGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQ LQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKK QCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTS -------------------------------------------------------------- >58423_58423_12_NEDD4L-MORC3_NEDD4L_chr18_55833093_ENST00000586263_MORC3_chr21_37728918_ENST00000400485_length(amino acids)=604AA_BP=32 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDG MDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSE GTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQ GGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQ LQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKK QCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:55833093/chr21:37728918) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEDD4L | MORC3 |
| FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961}. | FUNCTION: Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26202233, ECO:0000269|PubMed:26933034}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MORC3 | chr18:55833093 | chr21:37728917 | ENST00000400485 | 8 | 17 | 686_877 | 367.6666666666667 | 940.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MORC3 | chr18:55833093 | chr21:37728918 | ENST00000400485 | 8 | 17 | 686_877 | 367.6666666666667 | 940.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MORC3 | chr18:55833093 | chr21:37728917 | ENST00000400485 | 8 | 17 | 500_591 | 367.6666666666667 | 940.0 | Region | RNA binding | |
| Tgene | MORC3 | chr18:55833093 | chr21:37728918 | ENST00000400485 | 8 | 17 | 500_591 | 367.6666666666667 | 940.0 | Region | RNA binding | |
| Tgene | MORC3 | chr18:55833093 | chr21:37728917 | ENST00000400485 | 8 | 17 | 404_454 | 367.6666666666667 | 940.0 | Zinc finger | CW-type | |
| Tgene | MORC3 | chr18:55833093 | chr21:37728918 | ENST00000400485 | 8 | 17 | 404_454 | 367.6666666666667 | 940.0 | Zinc finger | CW-type |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000256830 | + | 2 | 28 | 193_226 | 40.666666666666664 | 872.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000256830 | + | 2 | 28 | 385_418 | 40.666666666666664 | 872.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000256830 | + | 2 | 28 | 497_530 | 40.666666666666664 | 872.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000256830 | + | 2 | 28 | 4_126 | 40.666666666666664 | 872.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000256830 | + | 2 | 28 | 548_581 | 40.666666666666664 | 872.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000256830 | + | 2 | 28 | 640_974 | 40.666666666666664 | 872.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000356462 | + | 2 | 29 | 193_226 | 40.666666666666664 | 912.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000356462 | + | 2 | 29 | 385_418 | 40.666666666666664 | 912.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000356462 | + | 2 | 29 | 497_530 | 40.666666666666664 | 912.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000356462 | + | 2 | 29 | 4_126 | 40.666666666666664 | 912.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000356462 | + | 2 | 29 | 548_581 | 40.666666666666664 | 912.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000356462 | + | 2 | 29 | 640_974 | 40.666666666666664 | 912.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000357895 | + | 2 | 31 | 193_226 | 32.666666666666664 | 968.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000357895 | + | 2 | 31 | 385_418 | 32.666666666666664 | 968.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000357895 | + | 2 | 31 | 497_530 | 32.666666666666664 | 968.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000357895 | + | 2 | 31 | 4_126 | 32.666666666666664 | 968.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000357895 | + | 2 | 31 | 548_581 | 32.666666666666664 | 968.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000357895 | + | 2 | 31 | 640_974 | 32.666666666666664 | 968.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000382850 | + | 2 | 30 | 193_226 | 40.666666666666664 | 956.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000382850 | + | 2 | 30 | 385_418 | 40.666666666666664 | 956.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000382850 | + | 2 | 30 | 497_530 | 40.666666666666664 | 956.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000382850 | + | 2 | 30 | 4_126 | 40.666666666666664 | 956.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000382850 | + | 2 | 30 | 548_581 | 40.666666666666664 | 956.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000382850 | + | 2 | 30 | 640_974 | 40.666666666666664 | 956.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000400345 | + | 2 | 31 | 193_226 | 40.666666666666664 | 976.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000400345 | + | 2 | 31 | 385_418 | 40.666666666666664 | 976.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000400345 | + | 2 | 31 | 497_530 | 40.666666666666664 | 976.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000400345 | + | 2 | 31 | 4_126 | 40.666666666666664 | 976.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000400345 | + | 2 | 31 | 548_581 | 40.666666666666664 | 976.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000400345 | + | 2 | 31 | 640_974 | 40.666666666666664 | 976.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000431212 | + | 1 | 30 | 193_226 | 0 | 855.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000431212 | + | 1 | 30 | 385_418 | 0 | 855.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000431212 | + | 1 | 30 | 497_530 | 0 | 855.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000431212 | + | 1 | 30 | 4_126 | 0 | 855.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000431212 | + | 1 | 30 | 548_581 | 0 | 855.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000431212 | + | 1 | 30 | 640_974 | 0 | 855.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000435432 | + | 2 | 31 | 193_226 | 0 | 835.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000435432 | + | 2 | 31 | 385_418 | 0 | 835.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000435432 | + | 2 | 31 | 497_530 | 0 | 835.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000435432 | + | 2 | 31 | 4_126 | 0 | 835.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000435432 | + | 2 | 31 | 548_581 | 0 | 835.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000435432 | + | 2 | 31 | 640_974 | 0 | 835.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456173 | + | 1 | 29 | 193_226 | 0 | 835.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456173 | + | 1 | 29 | 385_418 | 0 | 835.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456173 | + | 1 | 29 | 497_530 | 0 | 835.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456173 | + | 1 | 29 | 4_126 | 0 | 835.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456173 | + | 1 | 29 | 548_581 | 0 | 835.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456173 | + | 1 | 29 | 640_974 | 0 | 835.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456986 | + | 2 | 31 | 193_226 | 0 | 855.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456986 | + | 2 | 31 | 385_418 | 0 | 855.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456986 | + | 2 | 31 | 497_530 | 0 | 855.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456986 | + | 2 | 31 | 4_126 | 0 | 855.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456986 | + | 2 | 31 | 548_581 | 0 | 855.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000456986 | + | 2 | 31 | 640_974 | 0 | 855.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000586263 | + | 2 | 30 | 193_226 | 32.666666666666664 | 948.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000586263 | + | 2 | 30 | 385_418 | 32.666666666666664 | 948.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000586263 | + | 2 | 30 | 497_530 | 32.666666666666664 | 948.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000586263 | + | 2 | 30 | 4_126 | 32.666666666666664 | 948.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000586263 | + | 2 | 30 | 548_581 | 32.666666666666664 | 948.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728917 | ENST00000586263 | + | 2 | 30 | 640_974 | 32.666666666666664 | 948.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000256830 | + | 2 | 28 | 193_226 | 40.666666666666664 | 872.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000256830 | + | 2 | 28 | 385_418 | 40.666666666666664 | 872.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000256830 | + | 2 | 28 | 497_530 | 40.666666666666664 | 872.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000256830 | + | 2 | 28 | 4_126 | 40.666666666666664 | 872.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000256830 | + | 2 | 28 | 548_581 | 40.666666666666664 | 872.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000256830 | + | 2 | 28 | 640_974 | 40.666666666666664 | 872.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000356462 | + | 2 | 29 | 193_226 | 40.666666666666664 | 912.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000356462 | + | 2 | 29 | 385_418 | 40.666666666666664 | 912.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000356462 | + | 2 | 29 | 497_530 | 40.666666666666664 | 912.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000356462 | + | 2 | 29 | 4_126 | 40.666666666666664 | 912.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000356462 | + | 2 | 29 | 548_581 | 40.666666666666664 | 912.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000356462 | + | 2 | 29 | 640_974 | 40.666666666666664 | 912.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000357895 | + | 2 | 31 | 193_226 | 32.666666666666664 | 968.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000357895 | + | 2 | 31 | 385_418 | 32.666666666666664 | 968.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000357895 | + | 2 | 31 | 497_530 | 32.666666666666664 | 968.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000357895 | + | 2 | 31 | 4_126 | 32.666666666666664 | 968.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000357895 | + | 2 | 31 | 548_581 | 32.666666666666664 | 968.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000357895 | + | 2 | 31 | 640_974 | 32.666666666666664 | 968.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000382850 | + | 2 | 30 | 193_226 | 40.666666666666664 | 956.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000382850 | + | 2 | 30 | 385_418 | 40.666666666666664 | 956.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000382850 | + | 2 | 30 | 497_530 | 40.666666666666664 | 956.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000382850 | + | 2 | 30 | 4_126 | 40.666666666666664 | 956.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000382850 | + | 2 | 30 | 548_581 | 40.666666666666664 | 956.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000382850 | + | 2 | 30 | 640_974 | 40.666666666666664 | 956.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000400345 | + | 2 | 31 | 193_226 | 40.666666666666664 | 976.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000400345 | + | 2 | 31 | 385_418 | 40.666666666666664 | 976.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000400345 | + | 2 | 31 | 497_530 | 40.666666666666664 | 976.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000400345 | + | 2 | 31 | 4_126 | 40.666666666666664 | 976.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000400345 | + | 2 | 31 | 548_581 | 40.666666666666664 | 976.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000400345 | + | 2 | 31 | 640_974 | 40.666666666666664 | 976.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000431212 | + | 1 | 30 | 193_226 | 0 | 855.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000431212 | + | 1 | 30 | 385_418 | 0 | 855.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000431212 | + | 1 | 30 | 497_530 | 0 | 855.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000431212 | + | 1 | 30 | 4_126 | 0 | 855.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000431212 | + | 1 | 30 | 548_581 | 0 | 855.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000431212 | + | 1 | 30 | 640_974 | 0 | 855.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000435432 | + | 2 | 31 | 193_226 | 0 | 835.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000435432 | + | 2 | 31 | 385_418 | 0 | 835.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000435432 | + | 2 | 31 | 497_530 | 0 | 835.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000435432 | + | 2 | 31 | 4_126 | 0 | 835.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000435432 | + | 2 | 31 | 548_581 | 0 | 835.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000435432 | + | 2 | 31 | 640_974 | 0 | 835.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456173 | + | 1 | 29 | 193_226 | 0 | 835.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456173 | + | 1 | 29 | 385_418 | 0 | 835.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456173 | + | 1 | 29 | 497_530 | 0 | 835.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456173 | + | 1 | 29 | 4_126 | 0 | 835.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456173 | + | 1 | 29 | 548_581 | 0 | 835.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456173 | + | 1 | 29 | 640_974 | 0 | 835.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456986 | + | 2 | 31 | 193_226 | 0 | 855.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456986 | + | 2 | 31 | 385_418 | 0 | 855.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456986 | + | 2 | 31 | 497_530 | 0 | 855.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456986 | + | 2 | 31 | 4_126 | 0 | 855.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456986 | + | 2 | 31 | 548_581 | 0 | 855.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000456986 | + | 2 | 31 | 640_974 | 0 | 855.0 | Domain | HECT |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000586263 | + | 2 | 30 | 193_226 | 32.666666666666664 | 948.0 | Domain | WW 1 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000586263 | + | 2 | 30 | 385_418 | 32.666666666666664 | 948.0 | Domain | WW 2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000586263 | + | 2 | 30 | 497_530 | 32.666666666666664 | 948.0 | Domain | WW 3 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000586263 | + | 2 | 30 | 4_126 | 32.666666666666664 | 948.0 | Domain | C2 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000586263 | + | 2 | 30 | 548_581 | 32.666666666666664 | 948.0 | Domain | WW 4 |
| Hgene | NEDD4L | chr18:55833093 | chr21:37728918 | ENST00000586263 | + | 2 | 30 | 640_974 | 32.666666666666664 | 948.0 | Domain | HECT |
| Tgene | MORC3 | chr18:55833093 | chr21:37728917 | ENST00000400485 | 8 | 17 | 326_353 | 367.6666666666667 | 940.0 | Region | Nuclear matrix binding | |
| Tgene | MORC3 | chr18:55833093 | chr21:37728918 | ENST00000400485 | 8 | 17 | 326_353 | 367.6666666666667 | 940.0 | Region | Nuclear matrix binding |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1342_NEDD4L_55833093_MORC3_37728918_1342_NEDD4L_55833093_MORC3_37728918_ranked_0.pdb | NEDD4L | 55833093 | 55833093 | ENST00000400485 | MORC3 | chr21 | 37728918 | + | MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKK NTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQP EMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYK GDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEI DVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE TDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVEL LEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQV | 640 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
NEDD4L_pLDDT.png  |
MORC3_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| NEDD4L | |
| MORC3 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to NEDD4L-MORC3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to NEDD4L-MORC3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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