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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NEDD4L-TLN2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NEDD4L-TLN2
	FusionPDB ID: 58433
	FusionGDB2.0 ID: 58433
		Hgene	Tgene
	Gene symbol	NEDD4L	TLN2
	Gene ID	23327	83660
	Gene name	NEDD4 like E3 ubiquitin protein ligase	talin 2
	Synonyms	NEDD4-2\|NEDD4.2\|PVNH7\|RSP5\|hNEDD4-2	ILWEQ
	Cytomap	18q21.31	15q22.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5	talin-2
	Modification date	20200329	20200313
	UniProtAcc	Q96PU5	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000256830, ENST00000356462, ENST00000382850, ENST00000400345, ENST00000589054, ENST00000256832, ENST00000357895, ENST00000431212, ENST00000435432, ENST00000456173, ENST00000456986, ENST00000586263, ENST00000588516,	ENST00000472902, ENST00000559908, ENST00000306829, ENST00000561311,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	28 X 18 X 11=5544	9 X 12 X 6=648
	# samples	35	12
	** MAII score	log2(35/5544*10)=-3.98550043030488 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/648*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NEDD4L [Title/Abstract] AND TLN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NEDD4L(55711940)-TLN2(63063163), # samples:3
Anticipated loss of major functional domain due to fusion event.	NEDD4L-TLN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-TLN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-TLN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-TLN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NEDD4L	GO:0003254	regulation of membrane depolarization	15217910
Hgene	NEDD4L	GO:0006511	ubiquitin-dependent protein catabolic process	21463633
Hgene	NEDD4L	GO:0010038	response to metal ion	11244092
Hgene	NEDD4L	GO:0016567	protein ubiquitination	15217910\|25631046
Hgene	NEDD4L	GO:0034765	regulation of ion transmembrane transport	17289006
Hgene	NEDD4L	GO:0042391	regulation of membrane potential	17289006
Hgene	NEDD4L	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21463633
Hgene	NEDD4L	GO:0060306	regulation of membrane repolarization	21463633
Hgene	NEDD4L	GO:0070936	protein K48-linked ubiquitination	21463633
Hgene	NEDD4L	GO:1901016	regulation of potassium ion transmembrane transporter activity	17289006
Hgene	NEDD4L	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	21463633
Hgene	NEDD4L	GO:1901380	negative regulation of potassium ion transmembrane transport	21463633
Hgene	NEDD4L	GO:1902306	negative regulation of sodium ion transmembrane transport	15217910
Hgene	NEDD4L	GO:1903861	positive regulation of dendrite extension	23999003
Hgene	NEDD4L	GO:2000009	negative regulation of protein localization to cell surface	21463633
Hgene	NEDD4L	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	15217910

Fusion gene breakpoints across NEDD4L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TLN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A06P-01A	NEDD4L	chr18	55711940	-	TLN2	chr15	63063163	+
ChimerDB4	BRCA	TCGA-A8-A06P-01A	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+
ChimerDB4	BRCA	TCGA-A8-A06P	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356462	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063163	+	6796	342	210	2774	854
ENST00000356462	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063163	+	6796	342	210	2774	854
ENST00000400345	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063163	+	6785	331	199	2763	854
ENST00000400345	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063163	+	6785	331	199	2763	854
ENST00000589054	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063163	+	6779	325	193	2757	854
ENST00000589054	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063163	+	6779	325	193	2757	854
ENST00000382850	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063163	+	6615	161	29	2593	854
ENST00000382850	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063163	+	6615	161	29	2593	854
ENST00000256830	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063163	+	6502	48	0	2480	826
ENST00000256830	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063163	+	6502	48	0	2480	826
ENST00000356462	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063162	+	6796	342	210	2774	854
ENST00000356462	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063162	+	6796	342	210	2774	854
ENST00000400345	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063162	+	6785	331	199	2763	854
ENST00000400345	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063162	+	6785	331	199	2763	854
ENST00000589054	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063162	+	6779	325	193	2757	854
ENST00000589054	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063162	+	6779	325	193	2757	854
ENST00000382850	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063162	+	6615	161	29	2593	854
ENST00000382850	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063162	+	6615	161	29	2593	854
ENST00000256830	NEDD4L	chr18	55711940	+	ENST00000561311	TLN2	chr15	63063162	+	6502	48	0	2480	826
ENST00000256830	NEDD4L	chr18	55711940	+	ENST00000306829	TLN2	chr15	63063162	+	6502	48	0	2480	826

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356462	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001124087	0.9988759
ENST00000356462	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001124087	0.9988759
ENST00000400345	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001103404	0.9988966
ENST00000400345	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001103404	0.9988966
ENST00000589054	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001104051	0.9988959
ENST00000589054	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001104051	0.9988959
ENST00000382850	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001096825	0.99890316
ENST00000382850	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001096825	0.99890316
ENST00000256830	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001022	0.998978
ENST00000256830	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063163	+	0.001022	0.998978
ENST00000356462	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001124087	0.9988759
ENST00000356462	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001124087	0.9988759
ENST00000400345	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001103404	0.9988966
ENST00000400345	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001103404	0.9988966
ENST00000589054	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001104051	0.9988959
ENST00000589054	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001104051	0.9988959
ENST00000382850	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001096825	0.99890316
ENST00000382850	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001096825	0.99890316
ENST00000256830	ENST00000561311	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001022	0.998978
ENST00000256830	ENST00000306829	NEDD4L	chr18	55711940	+	TLN2	chr15	63063162	+	0.001022	0.998978

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58433_58433_1_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000256830_TLN2_chr15_63063162_ENST00000306829_length(amino acids)=826AA_BP=16
MATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEAAQLMKE
AVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGH
LAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQACITAATAV
SGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPE
TQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDV
PEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVL
VILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQI
LEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAAST
AQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIR

--------------------------------------------------------------

>58433_58433_2_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000256830_TLN2_chr15_63063162_ENST00000561311_length(amino acids)=826AA_BP=16
MATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEAAQLMKE
AVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGH
LAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQACITAATAV
SGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPE
TQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDV
PEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVL
VILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQI
LEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAAST
AQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIR

--------------------------------------------------------------

>58433_58433_3_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000256830_TLN2_chr15_63063163_ENST00000306829_length(amino acids)=826AA_BP=16
MATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEAAQLMKE
AVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGH
LAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQACITAATAV
SGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPE
TQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDV
PEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVL
VILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQI
LEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAAST
AQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIR

--------------------------------------------------------------

>58433_58433_4_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000256830_TLN2_chr15_63063163_ENST00000561311_length(amino acids)=826AA_BP=16
MATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEAAQLMKE
AVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGH
LAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQACITAATAV
SGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPE
TQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDV
PEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVL
VILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQI
LEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISSAKQVAAST
AQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIR

--------------------------------------------------------------

>58433_58433_5_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000356462_TLN2_chr15_63063162_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_6_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000356462_TLN2_chr15_63063162_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_7_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000356462_TLN2_chr15_63063163_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_8_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000356462_TLN2_chr15_63063163_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_9_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000382850_TLN2_chr15_63063162_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_10_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000382850_TLN2_chr15_63063162_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_11_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000382850_TLN2_chr15_63063163_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_12_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000382850_TLN2_chr15_63063163_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_13_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000400345_TLN2_chr15_63063162_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_14_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000400345_TLN2_chr15_63063162_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_15_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000400345_TLN2_chr15_63063163_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_16_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000400345_TLN2_chr15_63063163_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_17_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000589054_TLN2_chr15_63063162_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_18_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000589054_TLN2_chr15_63063162_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_19_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000589054_TLN2_chr15_63063163_ENST00000306829_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

>58433_58433_20_NEDD4L-TLN2_NEDD4L_chr18_55711940_ENST00000589054_TLN2_chr15_63063163_ENST00000561311_length(amino acids)=854AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQML
YAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVT
AQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAV
TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQA
AQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVED
EATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPD
VSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIE
AAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSL
CEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGI

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:55711940/chr15:63063163)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NEDD4L Q96PU5	.
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250\|UniProtKB:Q8CFI0, ECO:0000269\|PubMed:12911626, ECO:0000269\|PubMed:15040001, ECO:0000269\|PubMed:15217910, ECO:0000269\|PubMed:15489223, ECO:0000269\|PubMed:15496141, ECO:0000269\|PubMed:15576372, ECO:0000269\|PubMed:19144635, ECO:0000269\|PubMed:23999003, ECO:0000269\|PubMed:25631046, ECO:0000269\|PubMed:26363003, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27694961}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TLN2

chr18:55711940

chr15:63063162

ENST00000306829

2294_2533

1732.0

2543.0

Domain

I/LWEQ

Tgene

TLN2

chr18:55711940

chr15:63063162

ENST00000561311

2294_2533

1732.0

2543.0

Domain

I/LWEQ

Tgene

TLN2

chr18:55711940

chr15:63063163

ENST00000306829

2294_2533

1732.0

2543.0

Domain

I/LWEQ

Tgene

TLN2

chr18:55711940

chr15:63063163

ENST00000561311

2294_2533

1732.0

2543.0

Domain

I/LWEQ

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000256830

193_226

16.0

872.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000256830

385_418

16.0

872.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000256830

497_530

16.0

872.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000256830

4_126

16.0

872.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000256830

548_581

16.0

872.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000256830

640_974

16.0

872.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000356462

193_226

16.0

912.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000356462

385_418

16.0

912.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000356462

497_530

16.0

912.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000356462

4_126

16.0

912.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000356462

548_581

16.0

912.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000356462

640_974

16.0

912.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000357895

193_226

968.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000357895

385_418

968.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000357895

497_530

968.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000357895

4_126

968.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000357895

548_581

968.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000357895

640_974

968.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000382850

193_226

16.0

956.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000382850

385_418

16.0

956.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000382850

497_530

16.0

956.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000382850

4_126

16.0

956.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000382850

548_581

16.0

956.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000382850

640_974

16.0

956.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000400345

193_226

16.0

976.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000400345

385_418

16.0

976.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000400345

497_530

16.0

976.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000400345

4_126

16.0

976.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000400345

548_581

16.0

976.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000400345

640_974

16.0

976.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000431212

193_226

855.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000431212

385_418

855.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000431212

497_530

855.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000431212

4_126

855.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000431212

548_581

855.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000431212

640_974

855.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000435432

193_226

835.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000435432

385_418

835.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000435432

497_530

835.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000435432

4_126

835.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000435432

548_581

835.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000435432

640_974

835.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456173

193_226

835.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456173

385_418

835.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456173

497_530

835.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456173

4_126

835.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456173

548_581

835.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456173

640_974

835.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456986

193_226

855.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456986

385_418

855.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456986

497_530

855.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456986

4_126

855.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456986

548_581

855.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000456986

640_974

855.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000586263

193_226

948.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000586263

385_418

948.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000586263

497_530

948.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000586263

4_126

948.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000586263

548_581

948.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063162

ENST00000586263

640_974

948.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000256830

193_226

16.0

872.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000256830

385_418

16.0

872.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000256830

497_530

16.0

872.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000256830

4_126

16.0

872.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000256830

548_581

16.0

872.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000256830

640_974

16.0

872.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000356462

193_226

16.0

912.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000356462

385_418

16.0

912.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000356462

497_530

16.0

912.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000356462

4_126

16.0

912.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000356462

548_581

16.0

912.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000356462

640_974

16.0

912.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000357895

193_226

968.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000357895

385_418

968.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000357895

497_530

968.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000357895

4_126

968.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000357895

548_581

968.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000357895

640_974

968.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000382850

193_226

16.0

956.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000382850

385_418

16.0

956.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000382850

497_530

16.0

956.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000382850

4_126

16.0

956.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000382850

548_581

16.0

956.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000382850

640_974

16.0

956.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000400345

193_226

16.0

976.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000400345

385_418

16.0

976.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000400345

497_530

16.0

976.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000400345

4_126

16.0

976.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000400345

548_581

16.0

976.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000400345

640_974

16.0

976.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000431212

193_226

855.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000431212

385_418

855.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000431212

497_530

855.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000431212

4_126

855.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000431212

548_581

855.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000431212

640_974

855.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000435432

193_226

835.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000435432

385_418

835.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000435432

497_530

835.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000435432

4_126

835.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000435432

548_581

835.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000435432

640_974

835.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456173

193_226

835.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456173

385_418

835.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456173

497_530

835.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456173

4_126

835.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456173

548_581

835.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456173

640_974

835.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456986

193_226

855.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456986

385_418

855.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456986

497_530

855.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456986

4_126

855.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456986

548_581

855.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000456986

640_974

855.0

Domain

HECT

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000586263

193_226

948.0

Domain

WW 1

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000586263

385_418

948.0

Domain

WW 2

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000586263

497_530

948.0

Domain

WW 3

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000586263

4_126

948.0

Domain

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000586263

548_581

948.0

Domain

WW 4

Hgene

NEDD4L

chr18:55711940

chr15:63063163

ENST00000586263

640_974

948.0

Domain

HECT

Tgene

TLN2

chr18:55711940

chr15:63063162

ENST00000306829

861_1193

1732.0

2543.0

Compositional bias

Note=Ala-rich

Tgene

TLN2

chr18:55711940

chr15:63063162

ENST00000561311

861_1193

1732.0

2543.0

Compositional bias

Note=Ala-rich

Tgene

TLN2

chr18:55711940

chr15:63063163

ENST00000306829

861_1193

1732.0

2543.0

Compositional bias

Note=Ala-rich

Tgene

TLN2

chr18:55711940

chr15:63063163

ENST00000561311

861_1193

1732.0

2543.0

Compositional bias

Note=Ala-rich

Tgene

TLN2

chr18:55711940

chr15:63063162

ENST00000306829

88_406

1732.0

2543.0

Domain

FERM

Tgene

TLN2

chr18:55711940

chr15:63063162

ENST00000561311

88_406

1732.0

2543.0

Domain

FERM

Tgene

TLN2

chr18:55711940

chr15:63063163

ENST00000306829

88_406

1732.0

2543.0

Domain

FERM

Tgene

TLN2

chr18:55711940

chr15:63063163

ENST00000561311

88_406

1732.0

2543.0

Domain

FERM

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NEDD4L
TLN2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	TLN2	chr18:55711940	chr15:63063162	ENST00000306829		37	56	312_406	1732.0	2543.0	PIP5K1C
Tgene	TLN2	chr18:55711940	chr15:63063162	ENST00000561311		39	58	312_406	1732.0	2543.0	PIP5K1C
Tgene	TLN2	chr18:55711940	chr15:63063163	ENST00000306829		37	56	312_406	1732.0	2543.0	PIP5K1C
Tgene	TLN2	chr18:55711940	chr15:63063163	ENST00000561311		39	58	312_406	1732.0	2543.0	PIP5K1C

Top

Related Drugs to NEDD4L-TLN2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NEDD4L-TLN2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source