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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NEGR1-DCN

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NEGR1-DCN
FusionPDB ID: 58475
FusionGDB2.0 ID: 58475
HgeneTgene
Gene symbol

NEGR1

DCN

Gene ID

257194

1634

Gene nameneuronal growth regulator 1decorin
SynonymsDMML2433|IGLON4|KILON|NtraCSCD|DSPG2|PG40|PGII|PGS2|SLRR1B
Cytomap

1p31.1

12q21.33

Type of geneprotein-codingprotein-coding
Descriptionneuronal growth regulator 1IgLON family member 4a kindred of IgLONneurotractindecorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1B
Modification date2020031320200313
UniProtAcc

Q7Z3B1

P07585

Ensembl transtripts involved in fusion geneENST idsENST00000306821, ENST00000357731, 
ENST00000434200, ENST00000467479, 
ENST00000228329, ENST00000303320, 
ENST00000393155, ENST00000420120, 
ENST00000425043, ENST00000441303, 
ENST00000456569, ENST00000546370, 
ENST00000546745, ENST00000547568, 
ENST00000548768, ENST00000550099, 
ENST00000551354, ENST00000552962, 
ENST00000052754, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 11 X 7=123212 X 9 X 6=648
# samples 1612
** MAII scorelog2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NEGR1 [Title/Abstract] AND DCN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NEGR1(72241854)-DCN(91558494), # samples:1
Anticipated loss of major functional domain due to fusion event.NEGR1-DCN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NEGR1-DCN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NEGR1-DCN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NEGR1-DCN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NEGR1-DCN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NEGR1-DCN seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NEGR1-DCN seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDCN

GO:0010508

positive regulation of autophagy

23798385

TgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

TgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

TgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

TgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

TgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check buttonFusion gene breakpoints across NEGR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-A7-A0D9-11ANEGR1chr1

72241854

-DCNchr12

91558494

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000357731NEGR1chr172241854-ENST00000052754DCNchr1291558494-24547752401643467
ENST00000434200NEGR1chr172241854-ENST00000052754DCNchr1291558494-220852901397465

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357731ENST00000052754NEGR1chr172241854-DCNchr1291558494-0.0004823610.9995177
ENST00000434200ENST00000052754NEGR1chr172241854-DCNchr1291558494-0.0003543220.9996457

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58475_58475_1_NEGR1-DCN_NEGR1_chr1_72241854_ENST00000357731_DCN_chr12_91558494_ENST00000052754_length(amino acids)=467AA_BP=178
MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPR
VSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSGL
DKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEI
TKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGL
SFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPS

--------------------------------------------------------------

>58475_58475_2_NEGR1-DCN_NEGR1_chr1_72241854_ENST00000434200_DCN_chr12_91558494_ENST00000052754_length(amino acids)=465AA_BP=176
MMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVS
ISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSGLDK
VPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITK
VRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSF
NSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTF

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:72241854/chr12:91558494)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEGR1

Q7Z3B1

DCN

P07585

FUNCTION: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). {ECO:0000250}.FUNCTION: May affect the rate of fibrils formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEGR1chr1:72241854chr12:91558494ENST00000357731-3738_134178.33333333333334355.0DomainNote=Ig-like C2-type 1
TgeneDCNchr1:72241854chr12:91558494ENST000002283290654_670251.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000004201200554_670.0251.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000004250430454_670.0213.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000004565690254_670.076.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000005475680554_670213.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418118_14170.33333333333333360.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418142_16270.33333333333333360.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418163_18670.33333333333333360.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418187_21270.33333333333333360.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418213_23370.33333333333333360.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418234_25770.33333333333333360.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418258_28170.33333333333333360.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418282_30470.33333333333333360.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418305_33470.33333333333333360.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000005275418335_35970.33333333333333360.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000000527541873_9370.33333333333333360.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000000527541894_11770.33333333333333360.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906118_1410251.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906142_1620251.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906163_1860251.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906187_2120251.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906213_2330251.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906234_2570251.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906258_2810251.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906282_3040251.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906305_3340251.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000022832906335_3590251.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000002283290673_930251.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000002283290694_1170251.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014118_14170.33333333333333173.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014142_16270.33333333333333173.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014163_18670.33333333333333173.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014187_21270.33333333333333173.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014213_23370.33333333333333173.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014234_25770.33333333333333173.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014258_28170.33333333333333173.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014282_30470.33333333333333173.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014305_33470.33333333333333173.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000030332014335_35970.33333333333333173.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000003033201473_9370.33333333333333173.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000003033201494_11770.33333333333333173.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518118_14170.33333333333333360.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518142_16270.33333333333333360.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518163_18670.33333333333333360.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518187_21270.33333333333333360.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518213_23370.33333333333333360.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518234_25770.33333333333333360.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518258_28170.33333333333333360.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518282_30470.33333333333333360.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518305_33470.33333333333333360.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000039315518335_35970.33333333333333360.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000003931551873_9370.33333333333333360.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000003931551894_11770.33333333333333360.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005118_1410.0251.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005142_1620.0251.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005163_1860.0251.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005187_2120.0251.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005213_2330.0251.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005234_2570.0251.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005258_2810.0251.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005282_3040.0251.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005305_3340.0251.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000042012005335_3590.0251.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000004201200573_930.0251.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000004201200594_1170.0251.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304118_1410.0213.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304142_1620.0213.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304163_1860.0213.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304187_2120.0213.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304213_2330.0213.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304234_2570.0213.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304258_2810.0213.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304282_3040.0213.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304305_3340.0213.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000042504304335_3590.0213.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000004250430473_930.0213.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000004250430494_1170.0213.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303118_14170.33333333333333173.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303142_16270.33333333333333173.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303163_18670.33333333333333173.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303187_21270.33333333333333173.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303213_23370.33333333333333173.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303234_25770.33333333333333173.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303258_28170.33333333333333173.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303282_30470.33333333333333173.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303305_33470.33333333333333173.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000044130303335_35970.33333333333333173.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000004413030373_9370.33333333333333173.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000004413030394_11770.33333333333333173.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902118_1410.076.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902142_1620.076.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902163_1860.076.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902187_2120.076.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902213_2330.076.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902234_2570.076.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902258_2810.076.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902282_3040.076.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902305_3340.076.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000045656902335_3590.076.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000004565690273_930.076.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000004565690294_1170.076.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805118_1410213.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805142_1620213.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805163_1860213.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805187_2120213.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805213_2330213.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805234_2570213.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805258_2810213.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805282_3040213.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805305_3340213.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000054756805335_3590213.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000005475680573_930213.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000005475680594_1170213.0RepeatNote=LRR 2
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229118_14170.33333333333333360.0RepeatNote=LRR 3
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229142_16270.33333333333333360.0RepeatNote=LRR 4
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229163_18670.33333333333333360.0RepeatNote=LRR 5
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229187_21270.33333333333333360.0RepeatNote=LRR 6
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229213_23370.33333333333333360.0RepeatNote=LRR 7
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229234_25770.33333333333333360.0RepeatNote=LRR 8
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229258_28170.33333333333333360.0RepeatNote=LRR 9
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229282_30470.33333333333333360.0RepeatNote=LRR 10
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229305_33470.33333333333333360.0RepeatNote=LRR 11
TgeneDCNchr1:72241854chr12:91558494ENST0000055296229335_35970.33333333333333360.0RepeatNote=LRR 12
TgeneDCNchr1:72241854chr12:91558494ENST000005529622973_9370.33333333333333360.0RepeatNote=LRR 1
TgeneDCNchr1:72241854chr12:91558494ENST000005529622994_11770.33333333333333360.0RepeatNote=LRR 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEGR1chr1:72241854chr12:91558494ENST00000357731-37139_221178.33333333333334355.0DomainNote=Ig-like C2-type 2
HgeneNEGR1chr1:72241854chr12:91558494ENST00000357731-37225_313178.33333333333334355.0DomainNote=Ig-like C2-type 3
TgeneDCNchr1:72241854chr12:91558494ENST000000527541854_6770.33333333333333360.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000003033201454_6770.33333333333333173.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000003931551854_6770.33333333333333360.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000004413030354_6770.33333333333333173.0Compositional biasNote=Cys-rich
TgeneDCNchr1:72241854chr12:91558494ENST000005529622954_6770.33333333333333360.0Compositional biasNote=Cys-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NEGR1
DCN


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NEGR1-DCN


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NEGR1-DCN


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource