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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NEK9-EPC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NEK9-EPC1
	FusionPDB ID: 58546
	FusionGDB2.0 ID: 58546
		Hgene	Tgene
	Gene symbol	NEK9	EPC1
	Gene ID	91754	80314
	Gene name	NIMA related kinase 9	enhancer of polycomb homolog 1
	Synonyms	APUG\|LCCS10\|NC\|NERCC\|NERCC1	Epl1
	Cytomap	14q24.3	10p11.22
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase Nek9NIMA (never in mitosis gene a)- related kinase 9nercc1 kinasenimA-related protein kinase 9	enhancer of polycomb homolog 1
	Modification date	20200320	20200313
	UniProtAcc	Q8TD19	Q9H2F5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000238616, ENST00000555763,	ENST00000480402, ENST00000263062, ENST00000319778, ENST00000375110,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 8 X 3=96	9 X 10 X 3=270
	# samples	8	10
	** MAII score	log2(8/96*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NEK9 [Title/Abstract] AND EPC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NEK9(75562074)-EPC1(32562209), # samples:1 NEK9(75562075)-EPC1(32562209), # samples:1
Anticipated loss of major functional domain due to fusion event.	NEK9-EPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEK9-EPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEK9-EPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NEK9-EPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EPC1	GO:0000122	negative regulation of transcription by RNA polymerase II	10976108
Tgene	EPC1	GO:0043967	histone H4 acetylation	14966270
Tgene	EPC1	GO:0043968	histone H2A acetylation	14966270
Tgene	EPC1	GO:0045814	negative regulation of gene expression, epigenetic	10976108
Tgene	EPC1	GO:0045892	negative regulation of transcription, DNA-templated	10976108
Tgene	EPC1	GO:0045944	positive regulation of transcription by RNA polymerase II	10976108

Fusion gene breakpoints across NEK9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EPC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8364-01A	NEK9	chr14	75562075	-	EPC1	chr10	32562209	-
ChimerDB4	STAD	TCGA-BR-8364	NEK9	chr14	75562074	-	EPC1	chr10	32562209	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000238616	NEK9	chr14	75562074	-	ENST00000375110	EPC1	chr10	32562209	-	4402	2392	159	3089	976
ENST00000238616	NEK9	chr14	75562074	-	ENST00000319778	EPC1	chr10	32562209	-	4402	2392	159	3089	976
ENST00000238616	NEK9	chr14	75562074	-	ENST00000263062	EPC1	chr10	32562209	-	3291	2392	159	3158	999
ENST00000238616	NEK9	chr14	75562075	-	ENST00000375110	EPC1	chr10	32562209	-	4402	2392	159	3089	976
ENST00000238616	NEK9	chr14	75562075	-	ENST00000319778	EPC1	chr10	32562209	-	4402	2392	159	3089	976
ENST00000238616	NEK9	chr14	75562075	-	ENST00000263062	EPC1	chr10	32562209	-	3291	2392	159	3158	999

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000238616	ENST00000375110	NEK9	chr14	75562074	-	EPC1	chr10	32562209	-	0.000312361	0.9996877
ENST00000238616	ENST00000319778	NEK9	chr14	75562074	-	EPC1	chr10	32562209	-	0.000312361	0.9996877
ENST00000238616	ENST00000263062	NEK9	chr14	75562074	-	EPC1	chr10	32562209	-	0.001495084	0.998505
ENST00000238616	ENST00000375110	NEK9	chr14	75562075	-	EPC1	chr10	32562209	-	0.000312361	0.9996877
ENST00000238616	ENST00000319778	NEK9	chr14	75562075	-	EPC1	chr10	32562209	-	0.000312361	0.9996877
ENST00000238616	ENST00000263062	NEK9	chr14	75562075	-	EPC1	chr10	32562209	-	0.001495084	0.998505

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58546_58546_1_NEK9-EPC1_NEK9_chr14_75562074_ENST00000238616_EPC1_chr10_32562209_ENST00000263062_length(amino acids)=999AA_BP=744
MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE
KERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAM
EVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF
GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG
VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
ILIVEKVLNSKTIRSNSSGLSIGTAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFV
SKTLDSASAQFAASALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSH
QVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIA

--------------------------------------------------------------

>58546_58546_2_NEK9-EPC1_NEK9_chr14_75562074_ENST00000238616_EPC1_chr10_32562209_ENST00000319778_length(amino acids)=976AA_BP=744
MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE
KERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAM
EVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF
GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG
VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
ILIVEKVLNSKTIRSNSSGLSIGTAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQGFVSKTLDSASAQFAASALVTSEQLM
GFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVP

--------------------------------------------------------------

>58546_58546_3_NEK9-EPC1_NEK9_chr14_75562074_ENST00000238616_EPC1_chr10_32562209_ENST00000375110_length(amino acids)=976AA_BP=744
MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE
KERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAM
EVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF
GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG
VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
ILIVEKVLNSKTIRSNSSGLSIGTAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQGFVSKTLDSASAQFAASALVTSEQLM
GFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVP

--------------------------------------------------------------

>58546_58546_4_NEK9-EPC1_NEK9_chr14_75562075_ENST00000238616_EPC1_chr10_32562209_ENST00000263062_length(amino acids)=999AA_BP=744
MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE
KERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAM
EVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF
GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG
VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
ILIVEKVLNSKTIRSNSSGLSIGTAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFV
SKTLDSASAQFAASALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSH
QVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIA

--------------------------------------------------------------

>58546_58546_5_NEK9-EPC1_NEK9_chr14_75562075_ENST00000238616_EPC1_chr10_32562209_ENST00000319778_length(amino acids)=976AA_BP=744
MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE
KERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAM
EVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF
GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG
VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
ILIVEKVLNSKTIRSNSSGLSIGTAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQGFVSKTLDSASAQFAASALVTSEQLM
GFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVP

--------------------------------------------------------------

>58546_58546_6_NEK9-EPC1_NEK9_chr14_75562075_ENST00000238616_EPC1_chr10_32562209_ENST00000375110_length(amino acids)=976AA_BP=744
MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE
KERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAM
EVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF
GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG
VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
ILIVEKVLNSKTIRSNSSGLSIGTAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQGFVSKTLDSASAQFAASALVTSEQLM
GFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:75562074/chr10:32562209)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NEK9 Q8TD19	EPC1 Q9H2F5
FUNCTION: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. {ECO:0000269\|PubMed:12840024, ECO:0000269\|PubMed:14660563, ECO:0000269\|PubMed:19941817}.	FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. {ECO:0000269\|PubMed:14966270}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

52_308

744.3333333333334

980.0

Domain

Protein kinase

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

52_308

744.3333333333334

980.0

Domain

Protein kinase

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

58_66

744.3333333333334

980.0

Nucleotide binding

ATP

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

58_66

744.3333333333334

980.0

Nucleotide binding

ATP

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

388_444

744.3333333333334

980.0

Repeat

Note=RCC1 1

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

445_498

744.3333333333334

980.0

Repeat

Note=RCC1 2

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

499_550

744.3333333333334

980.0

Repeat

Note=RCC1 3

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

551_615

744.3333333333334

980.0

Repeat

Note=RCC1 4

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

616_668

744.3333333333334

980.0

Repeat

Note=RCC1 5

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

669_726

744.3333333333334

980.0

Repeat

Note=RCC1 6

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

388_444

744.3333333333334

980.0

Repeat

Note=RCC1 1

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

445_498

744.3333333333334

980.0

Repeat

Note=RCC1 2

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

499_550

744.3333333333334

980.0

Repeat

Note=RCC1 3

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

551_615

744.3333333333334

980.0

Repeat

Note=RCC1 4

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

616_668

744.3333333333334

980.0

Repeat

Note=RCC1 5

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

669_726

744.3333333333334

980.0

Repeat

Note=RCC1 6

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

892_939

744.3333333333334

980.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

892_939

744.3333333333334

980.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

752_760

744.3333333333334

980.0

Compositional bias

Note=Poly-Gly

Hgene

NEK9

chr14:75562074

chr10:32562209

ENST00000238616

765_888

744.3333333333334

980.0

Compositional bias

Note=Pro/Ser/Thr-rich

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

752_760

744.3333333333334

980.0

Compositional bias

Note=Poly-Gly

Hgene

NEK9

chr14:75562075

chr10:32562209

ENST00000238616

765_888

744.3333333333334

980.0

Compositional bias

Note=Pro/Ser/Thr-rich

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NEK9
EPC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NEK9	chr14:75562074	chr10:32562209	ENST00000238616	-	18	22	732_891	744.3333333333334	980.0	NEK6
Hgene	NEK9	chr14:75562075	chr10:32562209	ENST00000238616	-	18	22	732_891	744.3333333333334	980.0	NEK6

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Related Drugs to NEK9-EPC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NEK9-EPC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source