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Fusion Protein:NF1-ATAD5 |
Fusion Protein Summary |
Fusion gene summary |
Fusion partner gene information | Fusion gene name: NF1-ATAD5 | FusionPDB ID: 58672 | FusionGDB2.0 ID: 58672 | Hgene | Tgene | Gene symbol | NF1 | ATAD5 | Gene ID | 4763 | 79915 |
Gene name | neurofibromin 1 | ATPase family AAA domain containing 5 | |
Synonyms | NFNS|VRNF|WSS | C17orf41|ELG1|FRAG1 | |
Cytomap | 17q11.2 | 17q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | neurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1 | ATPase family AAA domain-containing protein 5chromosome fragility associated gene 1chromosome fragility-associated gene 1 proteinenhanced level of genomic instability 1 homolog | |
Modification date | 20200322 | 20200313 | |
UniProtAcc | P21359 | Q96QE3 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000356175, ENST00000358273, ENST00000431387, ENST00000417592, ENST00000444181, ENST00000581113, | ENST00000321990, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 47 X 26 X 21=25662 | 5 X 7 X 5=175 |
# samples | 69 | 8 | |
** MAII score | log2(69/25662*10)=-5.21689344093196 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: NF1 [Title/Abstract] AND ATAD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ATAD5(29159431)-NF1(29483000), # samples:2 NF1(29497015)-ATAD5(29192722), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ATAD5-NF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATAD5-NF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-ATAD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-ATAD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-ATAD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-ATAD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-ATAD5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NF1-ATAD5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. NF1-ATAD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NF1 | GO:0043547 | positive regulation of GTPase activity | 2121371 |
Fusion gene breakpoints across NF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ATAD5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
Fusion gene information from FusionGDB2.0. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-E2-A1LE-01A | NF1 | chr17 | 29497015 | - | ATAD5 | chr17 | 29192722 | + |
ChimerDB4 | BRCA | TCGA-E2-A1LE-01A | NF1 | chr17 | 29497015 | + | ATAD5 | chr17 | 29192722 | + |
ChimerDB4 | STAD | TCGA-BR-4357-01A | NF1 | chr17 | 29422387 | - | ATAD5 | chr17 | 29203392 | + |
ChimerDB4 | STAD | TCGA-CG-4440-01A | NF1 | chr17 | 29533389 | - | ATAD5 | chr17 | 29161166 | + |
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Fusion ORF Analysis |
Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000356175 | NF1 | chr17 | 29497015 | + | ENST00000321990 | ATAD5 | chr17 | 29192722 | + | 4324 | 969 | 254 | 3367 | 1037 |
ENST00000358273 | NF1 | chr17 | 29497015 | + | ENST00000321990 | ATAD5 | chr17 | 29192722 | + | 4324 | 969 | 254 | 3367 | 1037 |
ENST00000431387 | NF1 | chr17 | 29497015 | + | ENST00000321990 | ATAD5 | chr17 | 29192722 | + | 4274 | 919 | 204 | 3317 | 1037 |
ENST00000356175 | NF1 | chr17 | 29533389 | - | ENST00000321990 | ATAD5 | chr17 | 29161166 | + | 8200 | 1775 | 254 | 7243 | 2329 |
ENST00000358273 | NF1 | chr17 | 29533389 | - | ENST00000321990 | ATAD5 | chr17 | 29161166 | + | 8200 | 1775 | 254 | 7243 | 2329 |
ENST00000431387 | NF1 | chr17 | 29533389 | - | ENST00000321990 | ATAD5 | chr17 | 29161166 | + | 8150 | 1725 | 204 | 7193 | 2329 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000356175 | ENST00000321990 | NF1 | chr17 | 29497015 | + | ATAD5 | chr17 | 29192722 | + | 0.000157989 | 0.9998419 |
ENST00000358273 | ENST00000321990 | NF1 | chr17 | 29497015 | + | ATAD5 | chr17 | 29192722 | + | 0.000157989 | 0.9998419 |
ENST00000431387 | ENST00000321990 | NF1 | chr17 | 29497015 | + | ATAD5 | chr17 | 29192722 | + | 0.000151905 | 0.9998481 |
ENST00000356175 | ENST00000321990 | NF1 | chr17 | 29533389 | - | ATAD5 | chr17 | 29161166 | + | 0.000319642 | 0.9996804 |
ENST00000358273 | ENST00000321990 | NF1 | chr17 | 29533389 | - | ATAD5 | chr17 | 29161166 | + | 0.000319642 | 0.9996804 |
ENST00000431387 | ENST00000321990 | NF1 | chr17 | 29533389 | - | ATAD5 | chr17 | 29161166 | + | 0.000304295 | 0.9996958 |
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Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >58672_58672_1_NF1-ATAD5_NF1_chr17_29497015_ENST00000356175_ATAD5_chr17_29192722_ENST00000321990_length(amino acids)=1037AA_BP=238 MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKDSGTEDMLWTEKYQPQTASELIGNELAIKKLH SWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQI LSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLL ENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNAIKTFMATTKRPVILTTSDPTFSLMFDG CFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDN KIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQMRNVDFLYSNLEFILPLPVDTIPETKN FCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKG NNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWTNGKVTSGLCDEFSLESNDGWTSQSSGE LKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEY -------------------------------------------------------------- >58672_58672_2_NF1-ATAD5_NF1_chr17_29497015_ENST00000358273_ATAD5_chr17_29192722_ENST00000321990_length(amino acids)=1037AA_BP=238 MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKDSGTEDMLWTEKYQPQTASELIGNELAIKKLH SWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQI LSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLL ENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNAIKTFMATTKRPVILTTSDPTFSLMFDG CFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDN KIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQMRNVDFLYSNLEFILPLPVDTIPETKN FCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKG NNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWTNGKVTSGLCDEFSLESNDGWTSQSSGE LKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEY -------------------------------------------------------------- >58672_58672_3_NF1-ATAD5_NF1_chr17_29497015_ENST00000431387_ATAD5_chr17_29192722_ENST00000321990_length(amino acids)=1037AA_BP=238 MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKDSGTEDMLWTEKYQPQTASELIGNELAIKKLH SWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQI LSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLL ENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNAIKTFMATTKRPVILTTSDPTFSLMFDG CFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDN KIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQMRNVDFLYSNLEFILPLPVDTIPETKN FCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKG NNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWTNGKVTSGLCDEFSLESNDGWTSQSSGE LKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEY -------------------------------------------------------------- >58672_58672_4_NF1-ATAD5_NF1_chr17_29533389_ENST00000356175_ATAD5_chr17_29161166_ENST00000321990_length(amino acids)=2329AA_BP=507 MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLT ESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFH YVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFA PPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDY SLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKD TKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVL AQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDAL KNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKET TFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTR RSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGG FTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLND VLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVST SFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSN PEFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSK DSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTG VGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKS SGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDA GFLNAIKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIR SGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQL LTEFQMRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDF PDQSISLSSVSSSSNAEESKTGDEESKARDKGNNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRN DFSWTNGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANL -------------------------------------------------------------- >58672_58672_5_NF1-ATAD5_NF1_chr17_29533389_ENST00000358273_ATAD5_chr17_29161166_ENST00000321990_length(amino acids)=2329AA_BP=507 MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLT ESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFH YVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFA PPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDY SLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKD TKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVL AQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDAL KNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKET TFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTR RSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGG FTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLND VLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVST SFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSN PEFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSK DSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTG VGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKS SGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDA GFLNAIKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIR SGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQL LTEFQMRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDF PDQSISLSSVSSSSNAEESKTGDEESKARDKGNNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRN DFSWTNGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANL -------------------------------------------------------------- >58672_58672_6_NF1-ATAD5_NF1_chr17_29533389_ENST00000431387_ATAD5_chr17_29161166_ENST00000321990_length(amino acids)=2329AA_BP=507 MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLT ESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFH YVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFA PPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDY SLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKD TKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVL AQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDAL KNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKET TFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTR RSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGG FTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLND VLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVST SFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSN PEFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSK DSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTG VGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKS SGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDA GFLNAIKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIR SGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQL LTEFQMRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDF PDQSISLSSVSSSSNAEESKTGDEESKARDKGNNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRN DFSWTNGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:29159431/chr17:29483000) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NF1 | ATAD5 |
FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. | FUNCTION: Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. {ECO:0000269|PubMed:15983387}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ATAD5 | chr17:29497015 | chr17:29192722 | ENST00000321990 | 9 | 23 | 1589_1599 | 1045.3333333333333 | 1845.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ATAD5 | chr17:29533389 | chr17:29161166 | ENST00000321990 | 0 | 23 | 1589_1599 | 22.0 | 1845.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ATAD5 | chr17:29497015 | chr17:29192722 | ENST00000321990 | 9 | 23 | 1428_1432 | 1045.3333333333333 | 1845.0 | Motif | Note=LXCXE motif | |
Tgene | ATAD5 | chr17:29533389 | chr17:29161166 | ENST00000321990 | 0 | 23 | 1428_1432 | 22.0 | 1845.0 | Motif | Note=LXCXE motif | |
Tgene | ATAD5 | chr17:29497015 | chr17:29192722 | ENST00000321990 | 9 | 23 | 1132_1139 | 1045.3333333333333 | 1845.0 | Nucleotide binding | ATP | |
Tgene | ATAD5 | chr17:29533389 | chr17:29161166 | ENST00000321990 | 0 | 23 | 1132_1139 | 22.0 | 1845.0 | Nucleotide binding | ATP |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000356175 | + | 5 | 57 | 1352_1355 | 195.33333333333334 | 2819.0 | Compositional bias | Note=Poly-Ser |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000358273 | + | 5 | 58 | 1352_1355 | 195.33333333333334 | 2840.0 | Compositional bias | Note=Poly-Ser |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000431387 | + | 5 | 15 | 1352_1355 | 195.33333333333334 | 594.0 | Compositional bias | Note=Poly-Ser |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000356175 | - | 12 | 57 | 1352_1355 | 464.0 | 2819.0 | Compositional bias | Note=Poly-Ser |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000358273 | - | 12 | 58 | 1352_1355 | 464.0 | 2840.0 | Compositional bias | Note=Poly-Ser |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000431387 | - | 12 | 15 | 1352_1355 | 464.0 | 594.0 | Compositional bias | Note=Poly-Ser |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000356175 | + | 5 | 57 | 1235_1451 | 195.33333333333334 | 2819.0 | Domain | Ras-GAP |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000356175 | + | 5 | 57 | 1580_1738 | 195.33333333333334 | 2819.0 | Domain | CRAL-TRIO |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000358273 | + | 5 | 58 | 1235_1451 | 195.33333333333334 | 2840.0 | Domain | Ras-GAP |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000358273 | + | 5 | 58 | 1580_1738 | 195.33333333333334 | 2840.0 | Domain | CRAL-TRIO |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000431387 | + | 5 | 15 | 1235_1451 | 195.33333333333334 | 594.0 | Domain | Ras-GAP |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000431387 | + | 5 | 15 | 1580_1738 | 195.33333333333334 | 594.0 | Domain | CRAL-TRIO |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000356175 | - | 12 | 57 | 1235_1451 | 464.0 | 2819.0 | Domain | Ras-GAP |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000356175 | - | 12 | 57 | 1580_1738 | 464.0 | 2819.0 | Domain | CRAL-TRIO |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000358273 | - | 12 | 58 | 1235_1451 | 464.0 | 2840.0 | Domain | Ras-GAP |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000358273 | - | 12 | 58 | 1580_1738 | 464.0 | 2840.0 | Domain | CRAL-TRIO |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000431387 | - | 12 | 15 | 1235_1451 | 464.0 | 594.0 | Domain | Ras-GAP |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000431387 | - | 12 | 15 | 1580_1738 | 464.0 | 594.0 | Domain | CRAL-TRIO |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000356175 | + | 5 | 57 | 2555_2571 | 195.33333333333334 | 2819.0 | Motif | Note=Bipartite nuclear localization signal |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000358273 | + | 5 | 58 | 2555_2571 | 195.33333333333334 | 2840.0 | Motif | Note=Bipartite nuclear localization signal |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000431387 | + | 5 | 15 | 2555_2571 | 195.33333333333334 | 594.0 | Motif | Note=Bipartite nuclear localization signal |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000356175 | - | 12 | 57 | 2555_2571 | 464.0 | 2819.0 | Motif | Note=Bipartite nuclear localization signal |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000358273 | - | 12 | 58 | 2555_2571 | 464.0 | 2840.0 | Motif | Note=Bipartite nuclear localization signal |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000431387 | - | 12 | 15 | 2555_2571 | 464.0 | 594.0 | Motif | Note=Bipartite nuclear localization signal |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000356175 | + | 5 | 57 | 1580_1837 | 195.33333333333334 | 2819.0 | Region | Note=Lipid binding |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000358273 | + | 5 | 58 | 1580_1837 | 195.33333333333334 | 2840.0 | Region | Note=Lipid binding |
Hgene | NF1 | chr17:29497015 | chr17:29192722 | ENST00000431387 | + | 5 | 15 | 1580_1837 | 195.33333333333334 | 594.0 | Region | Note=Lipid binding |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000356175 | - | 12 | 57 | 1580_1837 | 464.0 | 2819.0 | Region | Note=Lipid binding |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000358273 | - | 12 | 58 | 1580_1837 | 464.0 | 2840.0 | Region | Note=Lipid binding |
Hgene | NF1 | chr17:29533389 | chr17:29161166 | ENST00000431387 | - | 12 | 15 | 1580_1837 | 464.0 | 594.0 | Region | Note=Lipid binding |
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Fusion Protein-Protein Interaction |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
Gene | PPI interactors |
NF1 | HRAS, SMARCA4, POLR2A, TIRAP, SIRT7, VCP, NSFL1C, CAV1, YWHAB, FAF2, NXF1, CCDC8, HLA-DPA1, EFNB2, CD274, TNFSF13B, CA14, SLAMF1, VSIG4, TGOLN2, HTR6, NOSIP, KRAS, CLK1, CDC5L, APP, YWHAH, PML, TRAF6, PTEN, SDC2, EGFR, CD79B, P4HA3, SCN3B, VSIG1, SIGLECL1, EPHA1, FAM174A, KCTD3, KIF13B, ZBTB21, KSR1, CGN, GIGYF1, LRFN1, RTKN, MAST3, DENND1A, SH3PXD2A, SRGAP2, DENND4C, PPM1H, EIF4E2, SIPA1L1, LIMA1, RALGPS2, MAGI1, CBY1, TESK2, CDC25C, DCLK1, GIGYF2, HDAC4, LPIN3, ZNF638, CAMSAP2, NADK, MAPKAP1, SRSF12, RASAL2, SYDE1, KIAA1804, TIAM1, AGAP1, CDC25B, CDK16, SH3RF3, PHLDB2, PLEKHA7, KIF1C, OSBPL6, FAM110B, USP21, NAV1, TANC2, PTPN13, FAM53C, ANKRD34A, STARD13, PTPN14, GAB2, DENND4A, INPP5E, TOP1, TOP2A, TOP3A, NRAS, ZUFSP, ESR2, LZTR1, SPRED1, MYC, LIMK2, KIAA1429, CTDP1, DYRK1A, F12, AKT1, EPHA2, MAP2K3, RAF1, SOX4, BIRC3, ORF7a, LCK, NOLC1, N, nsp7, KIF14, PRC1, MKI67, FASN, NR3C1, DDRGK1, FLOT1, LYN, PFN1, RHOB, ATG7, EFS, C19orf38, CDHR2, ITFG3, CD80, SEMA4C, DGCR2, EFNA4, PTGES2, LRRC25, EVI2A, EFNB1, TPST2, C3orf18, GYPA, HCST, TACSTD2, OPALIN, IL2RA, CD226, SIRT6, |
Protein-protein interactors based on sequence similarity (STRING) |
Gene | STRING network |
NF1 | |
ATAD5 |
- Retained interactions in fusion protein (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost interactions due to fusion (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to NF1-ATAD5 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to NF1-ATAD5 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NF1 | C0027831 | Neurofibromatosis 1 | 44 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | NF1 | C1708353 | Hereditary Paraganglioma-Pheochromocytoma Syndrome | 10 | CLINGEN |
Hgene | NF1 | C0349639 | Juvenile Myelomonocytic Leukemia | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | NF1 | C2931482 | Neurofibromatosis-Noonan syndrome | 6 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | NF1 | C0553586 | Cafe-au-lait macules with pulmonary stenosis | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | NF1 | C0162678 | Neurofibromatoses | 3 | CGI;CTD_human;GENOMICS_ENGLAND |
Hgene | NF1 | C0004114 | Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
Hgene | NF1 | C0025202 | melanoma | 2 | CGI;CTD_human |
Hgene | NF1 | C0026998 | Acute Myeloid Leukemia, M1 | 2 | CTD_human |
Hgene | NF1 | C0205768 | Subependymal Giant Cell Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0206727 | Nerve Sheath Tumors | 2 | CTD_human |
Hgene | NF1 | C0280783 | Juvenile Pilocytic Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0280785 | Diffuse Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0334579 | Anaplastic astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0334580 | Protoplasmic astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0334581 | Gemistocytic astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0334582 | Fibrillary Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0334583 | Pilocytic Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0338070 | Childhood Cerebral Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0547065 | Mixed oligoastrocytoma | 2 | CTD_human |
Hgene | NF1 | C0750935 | Cerebral Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0750936 | Intracranial Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C0751689 | Peripheral Nerve Sheath Neoplasm | 2 | CTD_human |
Hgene | NF1 | C0751691 | Perineurioma | 2 | CTD_human |
Hgene | NF1 | C1704230 | Grade I Astrocytoma | 2 | CTD_human |
Hgene | NF1 | C1834235 | NEUROFIBROMATOSIS, FAMILIAL SPINAL | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | NF1 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 2 | CTD_human |
Hgene | NF1 | C0001430 | Adenoma | 1 | CTD_human |
Hgene | NF1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | NF1 | C0016057 | Fibrosarcoma | 1 | CTD_human |
Hgene | NF1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | NF1 | C0017638 | Glioma | 1 | CGI;CTD_human |
Hgene | NF1 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
Hgene | NF1 | C0023186 | Learning Disorders | 1 | CTD_human |
Hgene | NF1 | C0023827 | liposarcoma | 1 | CTD_human |
Hgene | NF1 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
Hgene | NF1 | C0026654 | Moyamoya Disease | 1 | GENOMICS_ENGLAND |
Hgene | NF1 | C0027809 | Neurilemmoma | 1 | CTD_human |
Hgene | NF1 | C0027830 | neurofibroma | 1 | CTD_human |
Hgene | NF1 | C0027962 | Melanocytic nevus | 1 | CTD_human |
Hgene | NF1 | C0028326 | Noonan Syndrome | 1 | GENOMICS_ENGLAND |
Hgene | NF1 | C0031511 | Pheochromocytoma | 1 | CTD_human |
Hgene | NF1 | C0035320 | Retinal Neovascularization | 1 | CTD_human |
Hgene | NF1 | C0205646 | Adenoma, Basal Cell | 1 | CTD_human |
Hgene | NF1 | C0205647 | Follicular adenoma | 1 | CTD_human |
Hgene | NF1 | C0205648 | Adenoma, Microcystic | 1 | CTD_human |
Hgene | NF1 | C0205649 | Adenoma, Monomorphic | 1 | CTD_human |
Hgene | NF1 | C0205650 | Papillary adenoma | 1 | CTD_human |
Hgene | NF1 | C0205651 | Adenoma, Trabecular | 1 | CTD_human |
Hgene | NF1 | C0205824 | Liposarcoma, Dedifferentiated | 1 | CTD_human |
Hgene | NF1 | C0205825 | Liposarcoma, Pleomorphic | 1 | CTD_human |
Hgene | NF1 | C0205944 | Sarcoma, Epithelioid | 1 | CTD_human |
Hgene | NF1 | C0205945 | Sarcoma, Spindle Cell | 1 | CTD_human |
Hgene | NF1 | C0259783 | mixed gliomas | 1 | CTD_human |
Hgene | NF1 | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
Hgene | NF1 | C0555198 | Malignant Glioma | 1 | CTD_human |
Hgene | NF1 | C0751262 | Adult Learning Disorders | 1 | CTD_human |
Hgene | NF1 | C0751263 | Learning Disturbance | 1 | CTD_human |
Hgene | NF1 | C0751265 | Learning Disabilities | 1 | CTD_human |
Hgene | NF1 | C0751374 | Schwannomatosis, Plexiform | 1 | CTD_human |
Hgene | NF1 | C0917816 | Mental deficiency | 1 | CTD_human |
Hgene | NF1 | C0917817 | Neurofibromatosis 3 | 1 | CTD_human |
Hgene | NF1 | C1257877 | Pheochromocytoma, Extra-Adrenal | 1 | CTD_human |
Hgene | NF1 | C1261473 | Sarcoma | 1 | CTD_human |
Hgene | NF1 | C1330966 | Developmental Academic Disorder | 1 | CTD_human |
Hgene | NF1 | C1370889 | Liposarcoma, well differentiated | 1 | CTD_human |
Hgene | NF1 | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |
Hgene | NF1 | C3150928 | NF1 Microdeletion Syndrome | 1 | ORPHANET |
Hgene | NF1 | C3714756 | Intellectual Disability | 1 | CTD_human |