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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NFASC-PPP1R12B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NFASC-PPP1R12B
FusionPDB ID: 58747
FusionGDB2.0 ID: 58747
HgeneTgene
Gene symbol

NFASC

PPP1R12B

Gene ID

23114

4660

Gene nameneurofascinprotein phosphatase 1 regulatory subunit 12B
SynonymsNEDCPMD|NF|NRCAMLMYPT2|PP1bp55
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionneurofascinneurofascin homologneurofascin isoform 140protein phosphatase 1 regulatory subunit 12Bmyosin phosphatase target subunit 2myosin phosphatase-targeting subunit 2protein phosphatase 1, regulatory (inhibitor) subunit 12B
Modification date2020031320200313
UniProtAcc

O94856

.
Ensembl transtripts involved in fusion geneENST idsENST00000495396, ENST00000338515, 
ENST00000338586, ENST00000339876, 
ENST00000360049, ENST00000367169, 
ENST00000367170, ENST00000367171, 
ENST00000367172, ENST00000401399, 
ENST00000404076, ENST00000404907, 
ENST00000513543, ENST00000539706, 
ENST00000403080, 		ENST00000336894, 
ENST00000608999, ENST00000290419, 
ENST00000367270, ENST00000391959, 
ENST00000356764, ENST00000480184, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 10 X 4=64014 X 15 X 6=1260
# samples 2116
** MAII scorelog2(21/640*10)=-1.60768257722124
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NFASC [Title/Abstract] AND PPP1R12B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NFASC(204957934)-PPP1R12B(202531906), # samples:3
Anticipated loss of major functional domain due to fusion event.NFASC-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFASC-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFASC-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFASC-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFASC-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NFASC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP1R12B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-6688-01ANFASCchr1

204957934

-PPP1R12Bchr1

202531906

+
ChimerDB4LGGTCGA-FG-6688-01ANFASCchr1

204957934

+PPP1R12Bchr1

202531906

+
ChimerDB4LGGTCGA-FG-6688NFASCchr1

204957934

+PPP1R12Bchr1

202531906

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338515NFASCchr1204957934+ENST00000608999PPP1R12Bchr1202531906+160083420738611284
ENST00000367171NFASCchr1204957934+ENST00000608999PPP1R12Bchr1202531906+158253237736781223
ENST00000367169NFASCchr1204957934+ENST00000608999PPP1R12Bchr1202531906+156873099735401177
ENST00000367170NFASCchr1204957934+ENST00000608999PPP1R12Bchr1202531906+160083420738611284
ENST00000367172NFASCchr1204957934+ENST00000608999PPP1R12Bchr1202531906+160083420738611284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338515ENST00000608999NFASCchr1204957934+PPP1R12Bchr1202531906+0.0003313650.9996686
ENST00000367171ENST00000608999NFASCchr1204957934+PPP1R12Bchr1202531906+0.0004374340.99956256
ENST00000367169ENST00000608999NFASCchr1204957934+PPP1R12Bchr1202531906+0.0003092530.9996908
ENST00000367170ENST00000608999NFASCchr1204957934+PPP1R12Bchr1202531906+0.0003313650.9996686
ENST00000367172ENST00000608999NFASCchr1204957934+PPP1R12Bchr1202531906+0.0003313650.9996686

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58747_58747_1_NFASC-PPP1R12B_NFASC_chr1_204957934_ENST00000338515_PPP1R12B_chr1_202531906_ENST00000608999_length(amino acids)=1284AA_BP=1137
MVSALMRRLAARGAAGDAGEVAAPAADSSDSAQGRSPSPWRLIDLCAIWDAGVYLPSAAWNRASSGVARKRLNEAEKLSAVQEAQLKRLE
VTRPRVLGSREQGQVPRMARQPPPPWVHAAFLLCLLSLGGAIEIPMDPNPQHRLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSF
HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCN
PPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTA
SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRML
SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQ
ATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI
AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPV
YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQ
ASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFN
GTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEGRLESGGSNPTTSDSYGDRASARARREAREARLA
TLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTE

--------------------------------------------------------------

>58747_58747_2_NFASC-PPP1R12B_NFASC_chr1_204957934_ENST00000367169_PPP1R12B_chr1_202531906_ENST00000608999_length(amino acids)=1177AA_BP=1030
MVSALMRRLAARGAAGDAGEVAAPAADSSDSAQGRSPSPWRLIDLCAIWDAGVYLPSAAWNRASSGVARKRLNEAEKLSAVQEAQLKRLE
VTRPRVLGSREQGQVPRMARQPPPPWVHAAFLLCLLSLGGAIEIPMDPNPQHRLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSF
HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCN
PPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTA
SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRML
SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQ
ATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI
AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPV
YVPYEIRVQAENDFGKGPEPESVIGYSGEDLPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT
KFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEGRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKL
YESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIR

--------------------------------------------------------------

>58747_58747_3_NFASC-PPP1R12B_NFASC_chr1_204957934_ENST00000367170_PPP1R12B_chr1_202531906_ENST00000608999_length(amino acids)=1284AA_BP=1137
MVSALMRRLAARGAAGDAGEVAAPAADSSDSAQGRSPSPWRLIDLCAIWDAGVYLPSAAWNRASSGVARKRLNEAEKLSAVQEAQLKRLE
VTRPRVLGSREQGQVPRMARQPPPPWVHAAFLLCLLSLGGAIEIPMDPNPQHRLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSF
HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCN
PPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTA
SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRML
SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQ
ATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI
AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPV
YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQ
ASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFN
GTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEGRLESGGSNPTTSDSYGDRASARARREAREARLA
TLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTE

--------------------------------------------------------------

>58747_58747_4_NFASC-PPP1R12B_NFASC_chr1_204957934_ENST00000367171_PPP1R12B_chr1_202531906_ENST00000608999_length(amino acids)=1223AA_BP=1076
MVSALMRRLAARGAAGDAGEVAAPAADSSDSAQGRSPSPWRLIDLCAIWDAGVYLPSAAWNRASSGVARKRLNEAEKLSAVQEAQLKRLE
VTRPRVLGSREQGQVPRMARQPPPPWVHAAFLLCLLSLGGAIEIPMDLSIETTVTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSF
HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCN
PPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTA
SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRML
SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRP
DRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSE
RYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFG
KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRL
FPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVACRCMAAAPGVKGPRLES
GGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRS

--------------------------------------------------------------

>58747_58747_5_NFASC-PPP1R12B_NFASC_chr1_204957934_ENST00000367172_PPP1R12B_chr1_202531906_ENST00000608999_length(amino acids)=1284AA_BP=1137
MVSALMRRLAARGAAGDAGEVAAPAADSSDSAQGRSPSPWRLIDLCAIWDAGVYLPSAAWNRASSGVARKRLNEAEKLSAVQEAQLKRLE
VTRPRVLGSREQGQVPRMARQPPPPWVHAAFLLCLLSLGGAIEIPMDPNPQHRLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSF
HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCN
PPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTA
SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRML
SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQ
ATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI
AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPV
YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQ
ASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFN
GTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEGRLESGGSNPTTSDSYGDRASARARREAREARLA
TLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:204957934/chr1:202531906)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFASC

O94856

.
FUNCTION: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330143_230922.33333333333341241.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330244_332922.33333333333341241.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330337_424922.33333333333341241.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+233041_137922.33333333333341241.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330429_517922.33333333333341241.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330521_603922.33333333333341241.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330630_725922.33333333333341241.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330730_823922.33333333333341241.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427143_2301025.33333333333331170.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427244_3321025.33333333333331170.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427337_4241025.33333333333331170.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+242741_1371025.33333333333331170.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427429_5171025.33333333333331170.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427521_6031025.33333333333331170.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427630_7251025.33333333333331170.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427730_8231025.33333333333331170.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427828_9301025.33333333333331170.0DomainFibronectin type-III 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229143_230922.33333333333341241.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229244_332922.33333333333341241.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229337_424922.33333333333341241.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+222941_137922.33333333333341241.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229429_517922.33333333333341241.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229521_603922.33333333333341241.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229630_725922.33333333333341241.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229730_823922.33333333333341241.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327143_2301008.33333333333341158.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327244_3321008.33333333333341158.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327337_4241008.33333333333341158.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+232741_1371008.33333333333341158.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327429_5171008.33333333333341158.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327521_6031008.33333333333341158.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327630_7251008.33333333333341158.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327730_8231008.33333333333341158.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327828_9301008.33333333333341158.0DomainFibronectin type-III 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226143_2301025.33333333333331175.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226244_3321025.33333333333331175.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226337_4241025.33333333333331175.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+222641_1371025.33333333333331175.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226429_5171025.33333333333331175.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226521_6031025.33333333333331175.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226630_7251025.33333333333331175.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226730_8231025.33333333333331175.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226828_9301025.33333333333331175.0DomainFibronectin type-III 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225143_2301025.33333333333331170.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225244_3321025.33333333333331170.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225337_4241025.33333333333331170.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+222541_1371025.33333333333331170.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225429_5171025.33333333333331170.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225521_6031025.33333333333331170.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225630_7251025.33333333333331170.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225730_8231025.33333333333331170.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225828_9301025.33333333333331170.0DomainFibronectin type-III 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428143_2301025.33333333333331175.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428244_3321025.33333333333331175.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428337_4241025.33333333333331175.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+242841_1371025.33333333333331175.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428429_5171025.33333333333331175.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428521_6031025.33333333333331175.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428630_7251025.33333333333331175.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428730_8231025.33333333333331175.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428828_9301025.33333333333331175.0DomainFibronectin type-III 3
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000035676409336_3790387.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000367270613336_37961.6666666666666642805.3333333333335Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000391959612336_37961.666666666666664209.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000480184010336_3790516.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000035676409123_1520387.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000035676409216_2450387.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000035676409249_2780387.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:204957934chr1:202531906ENST000003567640957_860387.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:204957934chr1:202531906ENST000003567640990_1190387.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000367270613123_15261.6666666666666642805.3333333333335RepeatNote=ANK 3
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000367270613216_24561.6666666666666642805.3333333333335RepeatNote=ANK 4
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000367270613249_27861.6666666666666642805.3333333333335RepeatNote=ANK 5
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000036727061390_11961.6666666666666642805.3333333333335RepeatNote=ANK 2
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000391959612123_15261.666666666666664209.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000391959612216_24561.666666666666664209.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000391959612249_27861.666666666666664209.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000039195961290_11961.666666666666664209.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000480184010123_1520516.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000480184010216_2450516.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:204957934chr1:202531906ENST00000480184010249_2780516.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000048018401057_860516.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000048018401090_1190516.0RepeatNote=ANK 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+23301031_1108922.33333333333341241.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+24271031_11081025.33333333333331170.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+22291031_1108922.33333333333341241.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+1161031_11080620.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+23271031_11081008.33333333333341158.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+22261031_11081025.33333333333331175.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+22251031_11081025.33333333333331170.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+24281031_11081025.33333333333331175.0Compositional biasNote=Thr-rich
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+23301114_1206922.33333333333341241.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330828_930922.33333333333341241.0DomainFibronectin type-III 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+2330934_1030922.33333333333341241.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+24271114_12061025.33333333333331170.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+2427934_10301025.33333333333331170.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+22291114_1206922.33333333333341241.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229828_930922.33333333333341241.0DomainFibronectin type-III 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+2229934_1030922.33333333333341241.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+1161114_12060620.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116143_2300620.0DomainNote=Ig-like C2-type 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116244_3320620.0DomainNote=Ig-like C2-type 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116337_4240620.0DomainNote=Ig-like C2-type 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+11641_1370620.0DomainNote=Ig-like C2-type 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116429_5170620.0DomainNote=Ig-like C2-type 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116521_6030620.0DomainNote=Ig-like C2-type 6
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116630_7250620.0DomainFibronectin type-III 1
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116730_8230620.0DomainFibronectin type-III 2
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116828_9300620.0DomainFibronectin type-III 3
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+116934_10300620.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+23271114_12061008.33333333333341158.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+2327934_10301008.33333333333341158.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+22261114_12061025.33333333333331175.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+2226934_10301025.33333333333331175.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+22251114_12061025.33333333333331170.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+2225934_10301025.33333333333331170.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+24281114_12061025.33333333333331175.0DomainFibronectin type-III 5
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+2428934_10301025.33333333333331175.0DomainFibronectin type-III 4
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+23301239_1347922.33333333333341241.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+233025_1217922.33333333333341241.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+24271239_13471025.33333333333331170.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+242725_12171025.33333333333331170.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+22291239_1347922.33333333333341241.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+222925_1217922.33333333333341241.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+1161239_13470620.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+11625_12170620.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+23271239_13471008.33333333333341158.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+232725_12171008.33333333333341158.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+22261239_13471025.33333333333331175.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+222625_12171025.33333333333331175.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+22251239_13471025.33333333333331170.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+222525_12171025.33333333333331170.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+24281239_13471025.33333333333331175.0Topological domainCytoplasmic
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+242825_12171025.33333333333331175.0Topological domainExtracellular
HgeneNFASCchr1:204957934chr1:202531906ENST00000339876+23301218_1238922.33333333333341241.0TransmembraneHelical
HgeneNFASCchr1:204957934chr1:202531906ENST00000360049+24271218_12381025.33333333333331170.0TransmembraneHelical
HgeneNFASCchr1:204957934chr1:202531906ENST00000401399+22291218_1238922.33333333333341241.0TransmembraneHelical
HgeneNFASCchr1:204957934chr1:202531906ENST00000403080+1161218_12380620.0TransmembraneHelical
HgeneNFASCchr1:204957934chr1:202531906ENST00000404076+23271218_12381008.33333333333341158.0TransmembraneHelical
HgeneNFASCchr1:204957934chr1:202531906ENST00000404907+22261218_12381025.33333333333331175.0TransmembraneHelical
HgeneNFASCchr1:204957934chr1:202531906ENST00000513543+22251218_12381025.33333333333331170.0TransmembraneHelical
HgeneNFASCchr1:204957934chr1:202531906ENST00000539706+24281218_12381025.33333333333331175.0TransmembraneHelical
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000036727061357_8661.6666666666666642805.3333333333335RepeatNote=ANK 1
TgenePPP1R12Bchr1:204957934chr1:202531906ENST0000039195961257_8661.666666666666664209.0RepeatNote=ANK 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NFASC_pLDDT.png
all structure
all structure
PPP1R12B_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NFASC
PPP1R12B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NFASC-PPP1R12B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NFASC-PPP1R12B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource