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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NFAT5-CSMD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NFAT5-CSMD2
FusionPDB ID: 58759
FusionGDB2.0 ID: 58759
HgeneTgene
Gene symbol

NFAT5

CSMD2

Gene ID

10725

114784

Gene namenuclear factor of activated T cells 5CUB and Sushi multiple domains 2
SynonymsNF-AT5|NFATL1|NFATZ|OREBP|TONEBPdJ1007G16.1|dJ1007G16.2|dJ947L8.1
Cytomap

16q22.1

1p35.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor of activated T-cells 5NFAT-like protein 1T-cell transcription factor NFAT5TonE-binding proteinglutamine rich protein H65nuclear factor of activated T-cells 5, tonicity-responsiveosmotic response element-binding proteintonicity-responCUB and sushi domain-containing protein 2CUB and Sushi (SCR repeat) domainCUB and sushi multiple domains protein 2
Modification date2020031320200313
UniProtAcc

O94916

Q7Z408

Ensembl transtripts involved in fusion geneENST idsENST00000354436, ENST00000432919, 
ENST00000567239, ENST00000349945, 
ENST00000393742, ENST00000566899, 
ENST00000338325, ENST00000373377, 
ENST00000373380, ENST00000373388, 
ENST00000489419, ENST00000373381, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 13 X 19=666913 X 12 X 7=1092
# samples 4514
** MAII scorelog2(45/6669*10)=-3.88947354253111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1092*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NFAT5 [Title/Abstract] AND CSMD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NFAT5(69600277)-CSMD2(34015950), # samples:4
Anticipated loss of major functional domain due to fusion event.NFAT5-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFAT5-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFAT5-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFAT5-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFAT5

GO:0045944

positive regulation of transcription by RNA polymerase II

11485737


check buttonFusion gene breakpoints across NFAT5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CSMD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-SX-A71S-01ANFAT5chr16

69600277

-CSMD2chr1

34015950

-
ChimerDB4KIRPTCGA-SX-A71S-01ANFAT5chr16

69600277

+CSMD2chr1

34015950

-
ChimerDB4KIRPTCGA-SX-A71SNFAT5chr16

69600277

+CSMD2chr1

34015950

-
ChimerDB4KIRPTCGA-SX-A71SNFAT5chr16

69602451

+CSMD2chr1

34015950

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000432919NFAT5chr1669600277+ENST00000373381CSMD2chr134015950-604512819863433815
ENST00000354436NFAT5chr1669600277+ENST00000373381CSMD2chr134015950-5155391962543815
ENST00000567239NFAT5chr1669600277+ENST00000373381CSMD2chr134015950-5077313182465815
ENST00000432919NFAT5chr1669602451+ENST00000373381CSMD2chr134015950-609913359863487833
ENST00000567239NFAT5chr1669602451+ENST00000373381CSMD2chr134015950-5131367182519833

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000432919ENST00000373381NFAT5chr1669600277+CSMD2chr134015950-0.0017102170.99828976
ENST00000354436ENST00000373381NFAT5chr1669600277+CSMD2chr134015950-0.0017842690.9982158
ENST00000567239ENST00000373381NFAT5chr1669600277+CSMD2chr134015950-0.0017760750.99822396
ENST00000432919ENST00000373381NFAT5chr1669602451+CSMD2chr134015950-0.0015461380.99845386
ENST00000567239ENST00000373381NFAT5chr1669602451+CSMD2chr134015950-0.0015990210.998401

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58759_58759_1_NFAT5-CSMD2_NFAT5_chr16_69600277_ENST00000354436_CSMD2_chr1_34015950_ENST00000373381_length(amino acids)=815AA_BP=279
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE
SPKSLYSRVVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFD
PGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTG
SDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGS
SVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPS
CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYT
LIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVA
NSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRL
LESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVST

--------------------------------------------------------------

>58759_58759_2_NFAT5-CSMD2_NFAT5_chr16_69600277_ENST00000432919_CSMD2_chr1_34015950_ENST00000373381_length(amino acids)=815AA_BP=279
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE
SPKSLYSRVVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFD
PGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTG
SDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGS
SVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPS
CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYT
LIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVA
NSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRL
LESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVST

--------------------------------------------------------------

>58759_58759_3_NFAT5-CSMD2_NFAT5_chr16_69600277_ENST00000567239_CSMD2_chr1_34015950_ENST00000373381_length(amino acids)=815AA_BP=279
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE
SPKSLYSRVVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFD
PGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTG
SDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGS
SVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPS
CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYT
LIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVA
NSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRL
LESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVST

--------------------------------------------------------------

>58759_58759_4_NFAT5-CSMD2_NFAT5_chr16_69602451_ENST00000432919_CSMD2_chr1_34015950_ENST00000373381_length(amino acids)=833AA_BP=297
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE
SPKSLYSRDSLKLHPSQNFHRAGLLEVVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGV
CGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGY
YATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKP
PPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVG
SPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPE
TPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYE
YQGKKQPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGS
VKGQGFGQFGFQRLDLRLLESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDR

--------------------------------------------------------------

>58759_58759_5_NFAT5-CSMD2_NFAT5_chr16_69602451_ENST00000567239_CSMD2_chr1_34015950_ENST00000373381_length(amino acids)=833AA_BP=297
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE
SPKSLYSRDSLKLHPSQNFHRAGLLEVVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGV
CGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGY
YATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKP
PPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVG
SPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPE
TPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYE
YQGKKQPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGS
VKGQGFGQFGFQRLDLRLLESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:69600277/chr1:34015950)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFAT5

O94916

CSMD2

Q7Z408

FUNCTION: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241037_109601168.0DomainSushi 6
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241098_120601168.0DomainCUB 7
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241209_126901168.0DomainSushi 7
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241271_138001168.0DomainCUB 8
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024137_19801168.0DomainSushi 1
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241383_144301168.0DomainSushi 8
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241445_155301168.0DomainCUB 9
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241556_161701168.0DomainSushi 9
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241619_172701168.0DomainCUB 10
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241733_179401168.0DomainSushi 10
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241796_190401168.0DomainCUB 11
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241907_196601168.0DomainSushi 11
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241968_207601168.0DomainCUB 12
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024202_30601168.0DomainCUB 2
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242121_218001168.0DomainSushi 12
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242182_229301168.0DomainCUB 13
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242292_235301168.0DomainSushi 13
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242355_246601168.0DomainCUB 14
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242466_252801168.0DomainSushi 14
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242529_259001168.0DomainSushi 15
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242591_265501168.0DomainSushi 16
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242656_271301168.0DomainSushi 17
TgeneCSMD2chr16:69600277chr1:34015950ENST0000037338002426_13401168.0DomainCUB 1
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242714_277101168.0DomainSushi 18
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242772_282901168.0DomainSushi 19
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242833_289001168.0DomainSushi 20
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242891_294901168.0DomainSushi 21
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800242950_300901168.0DomainSushi 22
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800243010_306701168.0DomainSushi 23
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800243068_312501168.0DomainSushi 24
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800243129_318701168.0DomainSushi 25
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800243188_324701168.0DomainSushi 26
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024341_40201168.0DomainSushi 2
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024405_51601168.0DomainCUB 3
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024519_57601168.0DomainSushi 3
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024578_68601168.0DomainCUB 4
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024689_75001168.0DomainSushi 4
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024752_86001168.0DomainCUB 5
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024865_92201168.0DomainSushi 5
TgeneCSMD2chr16:69600277chr1:34015950ENST00000373380024924_103401168.0DomainCUB 6
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241037_109601168.0DomainSushi 6
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241098_120601168.0DomainCUB 7
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241209_126901168.0DomainSushi 7
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241271_138001168.0DomainCUB 8
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024137_19801168.0DomainSushi 1
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241383_144301168.0DomainSushi 8
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241445_155301168.0DomainCUB 9
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241556_161701168.0DomainSushi 9
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241619_172701168.0DomainCUB 10
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241733_179401168.0DomainSushi 10
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241796_190401168.0DomainCUB 11
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241907_196601168.0DomainSushi 11
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241968_207601168.0DomainCUB 12
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024202_30601168.0DomainCUB 2
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242121_218001168.0DomainSushi 12
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242182_229301168.0DomainCUB 13
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242292_235301168.0DomainSushi 13
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242355_246601168.0DomainCUB 14
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242466_252801168.0DomainSushi 14
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242529_259001168.0DomainSushi 15
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242591_265501168.0DomainSushi 16
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242656_271301168.0DomainSushi 17
TgeneCSMD2chr16:69602451chr1:34015950ENST0000037338002426_13401168.0DomainCUB 1
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242714_277101168.0DomainSushi 18
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242772_282901168.0DomainSushi 19
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242833_289001168.0DomainSushi 20
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242891_294901168.0DomainSushi 21
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800242950_300901168.0DomainSushi 22
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800243010_306701168.0DomainSushi 23
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800243068_312501168.0DomainSushi 24
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800243129_318701168.0DomainSushi 25
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800243188_324701168.0DomainSushi 26
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024341_40201168.0DomainSushi 2
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024405_51601168.0DomainCUB 3
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024519_57601168.0DomainSushi 3
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024578_68601168.0DomainCUB 4
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024689_75001168.0DomainSushi 4
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024752_86001168.0DomainCUB 5
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024865_92201168.0DomainSushi 5
TgeneCSMD2chr16:69602451chr1:34015950ENST00000373380024924_103401168.0DomainCUB 6
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800241_340801168.0Topological domainExtracellular
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800243430_348701168.0Topological domainCytoplasmic
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800241_340801168.0Topological domainExtracellular
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800243430_348701168.0Topological domainCytoplasmic
TgeneCSMD2chr16:69600277chr1:34015950ENST000003733800243409_342901168.0TransmembraneHelical
TgeneCSMD2chr16:69602451chr1:34015950ENST000003733800243409_342901168.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFAT5chr16:69600277chr1:34015950ENST00000349945+1161248_126603792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000349945+11669_10003792.6666666666665Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr1:34015950ENST00000349945+116739_74303792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000349945+116879_88803792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000349945+116966_97103792.6666666666665Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr1:34015950ENST00000354436+1141248_126624.3333333333333324170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000354436+11469_10024.3333333333333324170.666666666667Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr1:34015950ENST00000354436+114739_74324.3333333333333324170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000354436+114879_88824.3333333333333324170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000354436+114966_97124.3333333333333324170.666666666667Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr1:34015950ENST00000393742+1151248_126604169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000393742+11569_10004169.333333333333Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr1:34015950ENST00000393742+115739_74304169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000393742+115879_88804169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000393742+115966_97104169.333333333333Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr1:34015950ENST00000432919+1151248_126624.3333333333333323886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000432919+11569_10024.3333333333333323886.6666666666665Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr1:34015950ENST00000432919+115739_74324.3333333333333323886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000432919+115879_88824.3333333333333323886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000432919+115966_97124.3333333333333323886.6666666666665Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr1:34015950ENST00000566899+1141248_126601456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000566899+11469_10001456.0Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr1:34015950ENST00000566899+114739_74301456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000566899+114879_88801456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000566899+114966_97101456.0Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr1:34015950ENST00000567239+1151248_126624.3333333333333321938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000567239+11569_10024.3333333333333321938.3333333333333Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr1:34015950ENST00000567239+115739_74324.3333333333333321938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000567239+115879_88824.3333333333333321938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr1:34015950ENST00000567239+115966_97124.3333333333333321938.3333333333333Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69602451chr1:34015950ENST00000349945+2161248_126603792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000349945+21669_10003792.6666666666665Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69602451chr1:34015950ENST00000349945+216739_74303792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000349945+216879_88803792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000349945+216966_97103792.6666666666665Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69602451chr1:34015950ENST00000354436+1141248_126604170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000354436+11469_10004170.666666666667Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69602451chr1:34015950ENST00000354436+114739_74304170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000354436+114879_88804170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000354436+114966_97104170.666666666667Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69602451chr1:34015950ENST00000393742+1151248_126604169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000393742+11569_10004169.333333333333Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69602451chr1:34015950ENST00000393742+115739_74304169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000393742+115879_88804169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000393742+115966_97104169.333333333333Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69602451chr1:34015950ENST00000432919+2151248_126642.3333333333333363886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000432919+21569_10042.3333333333333363886.6666666666665Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69602451chr1:34015950ENST00000432919+215739_74342.3333333333333363886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000432919+215879_88842.3333333333333363886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000432919+215966_97142.3333333333333363886.6666666666665Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69602451chr1:34015950ENST00000566899+1141248_126601456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000566899+11469_10001456.0Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69602451chr1:34015950ENST00000566899+114739_74301456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000566899+114879_88801456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000566899+114966_97101456.0Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69602451chr1:34015950ENST00000567239+2151248_126642.3333333333333361938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000567239+21569_10042.3333333333333361938.3333333333333Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69602451chr1:34015950ENST00000567239+215739_74342.3333333333333361938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000567239+215879_88842.3333333333333361938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69602451chr1:34015950ENST00000567239+215966_97142.3333333333333361938.3333333333333Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr1:34015950ENST00000349945+116293_30003792.6666666666665DNA binding.
HgeneNFAT5chr16:69600277chr1:34015950ENST00000354436+114293_30024.3333333333333324170.666666666667DNA binding.
HgeneNFAT5chr16:69600277chr1:34015950ENST00000393742+115293_30004169.333333333333DNA binding.
HgeneNFAT5chr16:69600277chr1:34015950ENST00000432919+115293_30024.3333333333333323886.6666666666665DNA binding.
HgeneNFAT5chr16:69600277chr1:34015950ENST00000566899+114293_30001456.0DNA binding.
HgeneNFAT5chr16:69600277chr1:34015950ENST00000567239+115293_30024.3333333333333321938.3333333333333DNA binding.
HgeneNFAT5chr16:69602451chr1:34015950ENST00000349945+216293_30003792.6666666666665DNA binding.
HgeneNFAT5chr16:69602451chr1:34015950ENST00000354436+114293_30004170.666666666667DNA binding.
HgeneNFAT5chr16:69602451chr1:34015950ENST00000393742+115293_30004169.333333333333DNA binding.
HgeneNFAT5chr16:69602451chr1:34015950ENST00000432919+215293_30042.3333333333333363886.6666666666665DNA binding.
HgeneNFAT5chr16:69602451chr1:34015950ENST00000566899+114293_30001456.0DNA binding.
HgeneNFAT5chr16:69602451chr1:34015950ENST00000567239+215293_30042.3333333333333361938.3333333333333DNA binding.
HgeneNFAT5chr16:69600277chr1:34015950ENST00000349945+116264_44303792.6666666666665DomainRHD
HgeneNFAT5chr16:69600277chr1:34015950ENST00000354436+114264_44324.3333333333333324170.666666666667DomainRHD
HgeneNFAT5chr16:69600277chr1:34015950ENST00000393742+115264_44304169.333333333333DomainRHD
HgeneNFAT5chr16:69600277chr1:34015950ENST00000432919+115264_44324.3333333333333323886.6666666666665DomainRHD
HgeneNFAT5chr16:69600277chr1:34015950ENST00000566899+114264_44301456.0DomainRHD
HgeneNFAT5chr16:69600277chr1:34015950ENST00000567239+115264_44324.3333333333333321938.3333333333333DomainRHD
HgeneNFAT5chr16:69602451chr1:34015950ENST00000349945+216264_44303792.6666666666665DomainRHD
HgeneNFAT5chr16:69602451chr1:34015950ENST00000354436+114264_44304170.666666666667DomainRHD
HgeneNFAT5chr16:69602451chr1:34015950ENST00000393742+115264_44304169.333333333333DomainRHD
HgeneNFAT5chr16:69602451chr1:34015950ENST00000432919+215264_44342.3333333333333363886.6666666666665DomainRHD
HgeneNFAT5chr16:69602451chr1:34015950ENST00000566899+114264_44301456.0DomainRHD
HgeneNFAT5chr16:69602451chr1:34015950ENST00000567239+215264_44342.3333333333333361938.3333333333333DomainRHD


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1592_NFAT5_69600277_CSMD2_34015950_ranked_0.pdbNFAT56960245169600277ENST00000373381CSMD2chr134015950-
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE
SPKSLYSRVVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFD
PGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTG
SDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGS
SVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPS
CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYT
LIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVA
NSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRL
LESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVST
815


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NFAT5_pLDDT.png
all structure
all structure
CSMD2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NFAT5
CSMD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NFAT5-CSMD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NFAT5-CSMD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource