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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NFATC2-ATP9A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NFATC2-ATP9A
FusionPDB ID: 58787
FusionGDB2.0 ID: 58787
HgeneTgene
Gene symbol

NFATC2

ATP9A

Gene ID

4773

10079

Gene namenuclear factor of activated T cells 2ATPase phospholipid transporting 9A (putative)
SynonymsNFAT1|NFATPATPIIA
Cytomap

20q13.2

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor of activated T-cells, cytoplasmic 2NF-ATc2NFAT pre-existing subunitNFAT transcription complex, preexisting componentT cell transcription factor NFAT1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2nuclear factprobable phospholipid-transporting ATPase IIAATPase type IV, phospholipid-transporting (P-type),(putative)ATPase, class II, type 9Aphospholipid-transporting ATPase IIA
Modification date2020032920200313
UniProtAcc

Q8NCF5

O75110

Ensembl transtripts involved in fusion geneENST idsENST00000371564, ENST00000396009, 
ENST00000414705, ENST00000609507, 
ENST00000609943, ENST00000610033, 
ENST00000477492, ENST00000311637, 
ENST00000338821, ENST00000402822, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 5=40518 X 17 X 7=2142
# samples 818
** MAII scorelog2(8/405*10)=-2.33985000288462
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2142*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NFATC2 [Title/Abstract] AND ATP9A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP9A(50344281)-NFATC2(50078782), # samples:1
NFATC2(50071085)-ATP9A(50292747), # samples:1
Anticipated loss of major functional domain due to fusion event.NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NFATC2-ATP9A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFATC2

GO:0016477

cell migration

21871017

HgeneNFATC2

GO:0045893

positive regulation of transcription, DNA-templated

15790681

HgeneNFATC2

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

23853098


check buttonFusion gene breakpoints across NFATC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP9A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01ANFATC2chr20

50071085

-ATP9Achr20

50292747

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371564NFATC2chr2050071085-ENST00000311637ATP9Achr2050292747-9111206921144131400
ENST00000371564NFATC2chr2050071085-ENST00000338821ATP9Achr2050292747-9111206921144131400
ENST00000371564NFATC2chr2050071085-ENST00000402822ATP9Achr2050292747-4762206921144131400
ENST00000396009NFATC2chr2050071085-ENST00000311637ATP9Achr2050292747-9111206921144131400
ENST00000396009NFATC2chr2050071085-ENST00000338821ATP9Achr2050292747-9111206921144131400
ENST00000396009NFATC2chr2050071085-ENST00000402822ATP9Achr2050292747-4762206921144131400
ENST00000609943NFATC2chr2050071085-ENST00000311637ATP9Achr2050292747-9033199120243351377
ENST00000609943NFATC2chr2050071085-ENST00000338821ATP9Achr2050292747-9033199120243351377
ENST00000609943NFATC2chr2050071085-ENST00000402822ATP9Achr2050292747-4684199120243351377
ENST00000414705NFATC2chr2050071085-ENST00000311637ATP9Achr2050292747-88311789041331377
ENST00000414705NFATC2chr2050071085-ENST00000338821ATP9Achr2050292747-88311789041331377
ENST00000414705NFATC2chr2050071085-ENST00000402822ATP9Achr2050292747-44821789041331377

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371564ENST00000311637NFATC2chr2050071085-ATP9Achr2050292747-0.000454920.99954504
ENST00000371564ENST00000338821NFATC2chr2050071085-ATP9Achr2050292747-0.000454920.99954504
ENST00000371564ENST00000402822NFATC2chr2050071085-ATP9Achr2050292747-0.0031359940.9968641
ENST00000396009ENST00000311637NFATC2chr2050071085-ATP9Achr2050292747-0.000454920.99954504
ENST00000396009ENST00000338821NFATC2chr2050071085-ATP9Achr2050292747-0.000454920.99954504
ENST00000396009ENST00000402822NFATC2chr2050071085-ATP9Achr2050292747-0.0031359940.9968641
ENST00000609943ENST00000311637NFATC2chr2050071085-ATP9Achr2050292747-0.0004563580.9995436
ENST00000609943ENST00000338821NFATC2chr2050071085-ATP9Achr2050292747-0.0004563580.9995436
ENST00000609943ENST00000402822NFATC2chr2050071085-ATP9Achr2050292747-0.0030697260.9969303
ENST00000414705ENST00000311637NFATC2chr2050071085-ATP9Achr2050292747-0.0003454210.99965453
ENST00000414705ENST00000338821NFATC2chr2050071085-ATP9Achr2050292747-0.0003454210.99965453
ENST00000414705ENST00000402822NFATC2chr2050071085-ATP9Achr2050292747-0.0024248760.9975751

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58787_58787_1_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000371564_ATP9A_chr20_50292747_ENST00000311637_length(amino acids)=1400AA_BP=619
MRAMNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG
EPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS
FISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGA
SPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQ
GERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG
YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGR
KNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTG
RELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSK
IPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVH
EAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYE
SKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIE
SLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCAL
VISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFS
ITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYP
ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVF

--------------------------------------------------------------

>58787_58787_2_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000371564_ATP9A_chr20_50292747_ENST00000338821_length(amino acids)=1400AA_BP=619
MRAMNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG
EPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS
FISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGA
SPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQ
GERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG
YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGR
KNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTG
RELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSK
IPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVH
EAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYE
SKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIE
SLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCAL
VISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFS
ITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYP
ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVF

--------------------------------------------------------------

>58787_58787_3_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000371564_ATP9A_chr20_50292747_ENST00000402822_length(amino acids)=1400AA_BP=619
MRAMNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG
EPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS
FISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGA
SPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQ
GERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG
YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGR
KNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTG
RELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSK
IPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVH
EAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYE
SKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIE
SLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCAL
VISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFS
ITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYP
ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVF

--------------------------------------------------------------

>58787_58787_4_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000396009_ATP9A_chr20_50292747_ENST00000311637_length(amino acids)=1400AA_BP=619
MRAMNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG
EPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS
FISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGA
SPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQ
GERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG
YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGR
KNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTG
RELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSK
IPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVH
EAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYE
SKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIE
SLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCAL
VISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFS
ITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYP
ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVF

--------------------------------------------------------------

>58787_58787_5_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000396009_ATP9A_chr20_50292747_ENST00000338821_length(amino acids)=1400AA_BP=619
MRAMNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG
EPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS
FISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGA
SPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQ
GERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG
YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGR
KNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTG
RELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSK
IPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVH
EAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYE
SKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIE
SLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCAL
VISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFS
ITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYP
ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVF

--------------------------------------------------------------

>58787_58787_6_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000396009_ATP9A_chr20_50292747_ENST00000402822_length(amino acids)=1400AA_BP=619
MRAMNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG
EPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS
FISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGA
SPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQ
GERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHG
YMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGR
KNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTG
RELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSK
IPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVH
EAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYE
SKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIE
SLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCAL
VISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFS
ITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYP
ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVF

--------------------------------------------------------------

>58787_58787_7_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000414705_ATP9A_chr20_50292747_ENST00000311637_length(amino acids)=1377AA_BP=596
MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS
PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS
PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP
HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL
QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEV
NCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLT
DKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTD
QAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGA
DVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVR
PTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELAC
QCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSA
ALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLI
SIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVIT

--------------------------------------------------------------

>58787_58787_8_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000414705_ATP9A_chr20_50292747_ENST00000338821_length(amino acids)=1377AA_BP=596
MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS
PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS
PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP
HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL
QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEV
NCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLT
DKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTD
QAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGA
DVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVR
PTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELAC
QCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSA
ALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLI
SIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVIT

--------------------------------------------------------------

>58787_58787_9_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000414705_ATP9A_chr20_50292747_ENST00000402822_length(amino acids)=1377AA_BP=596
MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS
PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS
PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP
HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL
QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEV
NCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLT
DKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTD
QAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGA
DVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVR
PTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELAC
QCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSA
ALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLI
SIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVIT

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>58787_58787_10_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000609943_ATP9A_chr20_50292747_ENST00000311637_length(amino acids)=1377AA_BP=596
MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS
PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS
PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP
HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL
QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEV
NCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLT
DKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTD
QAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGA
DVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVR
PTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELAC
QCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSA
ALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLI
SIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVIT

--------------------------------------------------------------

>58787_58787_11_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000609943_ATP9A_chr20_50292747_ENST00000338821_length(amino acids)=1377AA_BP=596
MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS
PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS
PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP
HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL
QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEV
NCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLT
DKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTD
QAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGA
DVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVR
PTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELAC
QCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSA
ALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLI
SIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVIT

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>58787_58787_12_NFATC2-ATP9A_NFATC2_chr20_50071085_ENST00000609943_ATP9A_chr20_50292747_ENST00000402822_length(amino acids)=1377AA_BP=596
MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS
PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS
PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP
HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL
QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEV
NCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLT
DKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTD
QAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGA
DVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVR
PTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELAC
QCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSA
ALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLI
SIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVIT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:50344281/chr20:50078782)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFATC2

Q8NCF5

ATP9A

O75110

FUNCTION: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.FUNCTION: Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling and endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). {ECO:0000269|PubMed:27733620, ECO:0000269|PubMed:30213940, ECO:0000269|PubMed:30947313}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611421_428616.33333333333341989.6666666666667DNA binding.
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610421_428616.3333333333334926.0DNA binding.
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611421_428596.3333333333334639.3333333333334DNA binding.
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611392_574616.33333333333341989.6666666666667DomainRHD
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610392_574616.3333333333334926.0DomainRHD
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611392_574596.3333333333334639.3333333333334DomainRHD
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611251_253616.33333333333341989.6666666666667MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-61126_34616.33333333333341989.6666666666667MotifNote=9aaTAD
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610251_253616.3333333333334926.0MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-61026_34616.3333333333334926.0MotifNote=9aaTAD
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611251_253596.3333333333334639.3333333333334MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-61126_34596.3333333333334639.3333333333334MotifNote=9aaTAD
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611111_116616.33333333333341989.6666666666667RegionCalcineurin-binding
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611119_199616.33333333333341989.6666666666667RegionNote=Trans-activation domain A (TAD-A)
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611161_175616.33333333333341989.6666666666667RegionRequired for cytoplasmic retention of the phosphorylated form
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611184_286616.33333333333341989.6666666666667RegionNote=3 X approximate SP repeats
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610111_116616.3333333333334926.0RegionCalcineurin-binding
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610119_199616.3333333333334926.0RegionNote=Trans-activation domain A (TAD-A)
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610161_175616.3333333333334926.0RegionRequired for cytoplasmic retention of the phosphorylated form
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610184_286616.3333333333334926.0RegionNote=3 X approximate SP repeats
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611111_116596.3333333333334639.3333333333334RegionCalcineurin-binding
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611119_199596.3333333333334639.3333333333334RegionNote=Trans-activation domain A (TAD-A)
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611161_175596.3333333333334639.3333333333334RegionRequired for cytoplasmic retention of the phosphorylated form
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611184_286596.3333333333334639.3333333333334RegionNote=3 X approximate SP repeats
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611184_200616.33333333333341989.6666666666667RepeatNote=1
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611213_229616.33333333333341989.6666666666667RepeatNote=2
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611272_286616.33333333333341989.6666666666667RepeatNote=3%3B approximate
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610184_200616.3333333333334926.0RepeatNote=1
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610213_229616.3333333333334926.0RepeatNote=2
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610272_286616.3333333333334926.0RepeatNote=3%3B approximate
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611184_200596.3333333333334639.3333333333334RepeatNote=1
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611213_229596.3333333333334639.3333333333334RepeatNote=2
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611272_286596.3333333333334639.3333333333334RepeatNote=3%3B approximate
TgeneATP9Achr20:50071085chr20:50292747ENST000003388218281000_1006266.33333333333331048.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST000003388218281031_1047266.33333333333331048.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828326_332266.33333333333331048.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828355_841266.33333333333331048.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828863_874266.33333333333331048.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828894_923266.33333333333331048.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828943_949266.33333333333331048.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828973_978266.33333333333331048.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST000004028223231000_1006145.33333333333334927.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST000004028223231031_1047145.33333333333334927.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323326_332145.33333333333334927.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323355_841145.33333333333334927.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323863_874145.33333333333334927.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323894_923145.33333333333334927.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323943_949145.33333333333334927.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323973_978145.33333333333334927.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST000003388218281007_1030266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828304_325266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828333_354266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828842_862266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828875_893266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828924_942266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828950_972266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828979_999266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST000004028223231007_1030145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323304_325145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323333_354145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323842_862145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323875_893145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323924_942145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323950_972145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323979_999145.33333333333334927.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611664_666616.33333333333341989.6666666666667MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000371564-611904_913616.33333333333341989.6666666666667MotifNote=Nuclear export signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610664_666616.3333333333334926.0MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000396009-610904_913616.3333333333334926.0MotifNote=Nuclear export signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611664_666596.3333333333334639.3333333333334MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50071085chr20:50292747ENST00000414705-611904_913596.3333333333334639.3333333333334MotifNote=Nuclear export signal
TgeneATP9Achr20:50071085chr20:50292747ENST00000338821828120_303266.33333333333331048.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST000003388218282_69266.33333333333331048.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST0000033882182892_96266.33333333333331048.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST00000402822323120_303145.33333333333334927.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST000004028223232_69145.33333333333334927.0Topological domainCytoplasmic
TgeneATP9Achr20:50071085chr20:50292747ENST0000040282232392_96145.33333333333334927.0Topological domainExtracellular
TgeneATP9Achr20:50071085chr20:50292747ENST0000033882182870_91266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST0000033882182897_119266.33333333333331048.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST0000040282232370_91145.33333333333334927.0TransmembraneHelical
TgeneATP9Achr20:50071085chr20:50292747ENST0000040282232397_119145.33333333333334927.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NFATC2NFATC2, EP300, CREBBP, MED31, VIM, PRKCZ, PIN1, MEF2D, IRF4, FOXP3, MAPK9, MAPK8, SUV39H1, TUBA1A, KPNB1, TAF9, HNRNPA1, TFAP4, IRF2BP2, JUN, LRRK2, IQGAP1, CSE1L, TNPO1, PPP2R1A, USP22, GNB2, HCVgp1, CREB1, IKZF1, RPTOR, FOS, CHEK1, SCAI, IKZF2, GSK3B, RUNX1, SATB1, WDR48, NFATC1, ZNF384, ATF7, ZNF131, MAFK, XRCC5, PRKDC, CSNK1D, JUNB, NFYC, PLK1, LIG3, XRCC1, HSPA1A, HLTF, BTAF1, YWHAB, CHAF1B, LEF1, IRF2BP1, JUND, TFAM, MAFG, SSBP1, RANBP9, CHAMP1, RPA1, WDR26, ZNF148, FOXK1, ZNF217, DEK, RPA3, POLG, CACYBP, RPA2, NFYB, PARP1, ETV6, XRCC6, KIF4A, RFC4, RFC3, EGR1, CAD, RFC5, CTBP1, RFC2, BCL11B, YWHAG, KIF2C, RNGTT, PRDM15, ALDH18A1, MTHFD2, YWHAE, MRPL39, TUFM, IFI16, TP53BP1, ERAL1, SSRP1, TRRAP, YWHAQ, HIRA, ERCC3, UBE2S, SUPT6H, ARID1A, HSPA9, POGZ, UHRF1, SUCLA2, HSPA5, DPF2, YWHAZ, GATAD2A, LRRC47, ZMYM2, DNAJA1, IDH3A, SDHA, CBX5, CABIN1, VAPA, CBX3, MRE11A, SMARCA5, EEF2, RB1, MCRS1, EMD, GTF2H2C, GTF2H2, GTF2H2C_2, SUPT5H, RCOR1, VAPB, MRPL17, UQCRC2, TCF12, BEND3, SMARCA4, KDM1A, SMARCD2, AIFM1, MCM2, H2AFY, HSPA8, POLDIP2, RAD50, SMARCC1, POLR1C, TIMM50, MTA2, HADHA, TLK2, TLK1, RBBP4, GATAD2B, RANBP2, CEBPE, ADNP, SMARCE1, CNP, CBX1, SMARCC2, ZNF24, CHD4, SMARCD1, MBD3, NUDC, ACTL6A, MTA1, IDH3B, CSTF1, RPL23, PPP1CA, HSPH1, PMPCB, GTF3C5, TCP1, GTF3C4, DCAF7, HDAC1, NKX2-1, KIAA1429, ESR1, EGFR, CIC, SOCS3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NFATC2all structure
ATP9A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NFATC2-ATP9A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NFATC2-ATP9A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFATC2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneNFATC2C0020542Pulmonary Hypertension1CTD_human
HgeneNFATC2C0027765nervous system disorder1CTD_human