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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NFIB-STRN

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NFIB-STRN
FusionPDB ID: 58897
FusionGDB2.0 ID: 58897
HgeneTgene
Gene symbol

NFIB

STRN

Gene ID

4781

6801

Gene namenuclear factor I Bstriatin
SynonymsCTF|HMGIC/NFIB|MACID|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3PPP2R6A|SG2NA|STRN1
Cytomap

9p23-p22.3

2p22.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/Bstriatinprotein phosphatase 2 regulatory subunit B'''alphastriatin, calmodulin binding protein
Modification date2020031320200313
UniProtAcc

O00712

O43815

Ensembl transtripts involved in fusion geneENST idsENST00000380921, ENST00000380953, 
ENST00000380959, ENST00000397575, 
ENST00000397579, ENST00000397581, 
ENST00000380924, ENST00000380934, 
ENST00000543693, 		ENST00000263918, 
ENST00000379213, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 16 X 8=20483 X 2 X 1=6
# samples 184
** MAII scorelog2(18/2048*10)=-3.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/6*10)=2.73696559416621
Context (manual curation of fusion genes in FusionPDB)

PubMed: NFIB [Title/Abstract] AND STRN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NFIB(14313481)-STRN(37152351), # samples:3
Anticipated loss of major functional domain due to fusion event.NFIB-STRN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFIB-STRN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFIB-STRN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFIB-STRN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIB

GO:0045893

positive regulation of transcription, DNA-templated

30388402

HgeneNFIB

GO:0045944

positive regulation of transcription by RNA polymerase II

9099724|19540848


check buttonFusion gene breakpoints across NFIB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SB-01ANFIBchr9

14313481

-STRNchr2

37152351

-
ChimerDB4BRCATCGA-A1-A0SBNFIBchr9

14313480

-STRNchr2

37152351

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380959NFIBchr914313481-ENST00000263918STRNchr237152351-84295044742612712
ENST00000380959NFIBchr914313481-ENST00000379213STRNchr237152351-36295044742501675
ENST00000380953NFIBchr914313481-ENST00000263918STRNchr237152351-81111861562294712
ENST00000380953NFIBchr914313481-ENST00000379213STRNchr237152351-33111861562183675
ENST00000397575NFIBchr914313481-ENST00000263918STRNchr237152351-85135885582696712
ENST00000397575NFIBchr914313481-ENST00000379213STRNchr237152351-37135885582585675
ENST00000397581NFIBchr914313481-ENST00000263918STRNchr237152351-8963103810083146712
ENST00000397581NFIBchr914313481-ENST00000379213STRNchr237152351-4163103810083035675
ENST00000397579NFIBchr914313481-ENST00000263918STRNchr237152351-9026110110713209712
ENST00000397579NFIBchr914313481-ENST00000379213STRNchr237152351-4226110110713098675
ENST00000380921NFIBchr914313481-ENST00000263918STRNchr237152351-84014764462584712
ENST00000380921NFIBchr914313481-ENST00000379213STRNchr237152351-36014764462473675
ENST00000380959NFIBchr914313480-ENST00000263918STRNchr237152351-84295044742612712
ENST00000380959NFIBchr914313480-ENST00000379213STRNchr237152351-36295044742501675
ENST00000380953NFIBchr914313480-ENST00000263918STRNchr237152351-81111861562294712
ENST00000380953NFIBchr914313480-ENST00000379213STRNchr237152351-33111861562183675
ENST00000397575NFIBchr914313480-ENST00000263918STRNchr237152351-85135885582696712
ENST00000397575NFIBchr914313480-ENST00000379213STRNchr237152351-37135885582585675
ENST00000397581NFIBchr914313480-ENST00000263918STRNchr237152351-8963103810083146712
ENST00000397581NFIBchr914313480-ENST00000379213STRNchr237152351-4163103810083035675
ENST00000397579NFIBchr914313480-ENST00000263918STRNchr237152351-9026110110713209712
ENST00000397579NFIBchr914313480-ENST00000379213STRNchr237152351-4226110110713098675
ENST00000380921NFIBchr914313480-ENST00000263918STRNchr237152351-84014764462584712
ENST00000380921NFIBchr914313480-ENST00000379213STRNchr237152351-36014764462473675

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380959ENST00000263918NFIBchr914313481-STRNchr237152351-6.25E-050.99993753
ENST00000380959ENST00000379213NFIBchr914313481-STRNchr237152351-0.000425290.9995747
ENST00000380953ENST00000263918NFIBchr914313481-STRNchr237152351-5.72E-050.9999428
ENST00000380953ENST00000379213NFIBchr914313481-STRNchr237152351-0.0003636470.9996363
ENST00000397575ENST00000263918NFIBchr914313481-STRNchr237152351-6.21E-050.9999379
ENST00000397575ENST00000379213NFIBchr914313481-STRNchr237152351-0.000427910.9995721
ENST00000397581ENST00000263918NFIBchr914313481-STRNchr237152351-6.53E-050.9999347
ENST00000397581ENST00000379213NFIBchr914313481-STRNchr237152351-0.0005287270.99947125
ENST00000397579ENST00000263918NFIBchr914313481-STRNchr237152351-6.66E-050.9999335
ENST00000397579ENST00000379213NFIBchr914313481-STRNchr237152351-0.000523780.99947625
ENST00000380921ENST00000263918NFIBchr914313481-STRNchr237152351-6.23E-050.9999378
ENST00000380921ENST00000379213NFIBchr914313481-STRNchr237152351-0.0004071480.99959284
ENST00000380959ENST00000263918NFIBchr914313480-STRNchr237152351-6.25E-050.99993753
ENST00000380959ENST00000379213NFIBchr914313480-STRNchr237152351-0.000425290.9995747
ENST00000380953ENST00000263918NFIBchr914313480-STRNchr237152351-5.72E-050.9999428
ENST00000380953ENST00000379213NFIBchr914313480-STRNchr237152351-0.0003636470.9996363
ENST00000397575ENST00000263918NFIBchr914313480-STRNchr237152351-6.21E-050.9999379
ENST00000397575ENST00000379213NFIBchr914313480-STRNchr237152351-0.000427910.9995721
ENST00000397581ENST00000263918NFIBchr914313480-STRNchr237152351-6.53E-050.9999347
ENST00000397581ENST00000379213NFIBchr914313480-STRNchr237152351-0.0005287270.99947125
ENST00000397579ENST00000263918NFIBchr914313480-STRNchr237152351-6.66E-050.9999335
ENST00000397579ENST00000379213NFIBchr914313480-STRNchr237152351-0.000523780.99947625
ENST00000380921ENST00000263918NFIBchr914313480-STRNchr237152351-6.23E-050.9999378
ENST00000380921ENST00000379213NFIBchr914313480-STRNchr237152351-0.0004071480.99959284

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58897_58897_1_NFIB-STRN_NFIB_chr9_14313480_ENST00000380921_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_2_NFIB-STRN_NFIB_chr9_14313480_ENST00000380921_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_3_NFIB-STRN_NFIB_chr9_14313480_ENST00000380953_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_4_NFIB-STRN_NFIB_chr9_14313480_ENST00000380953_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_5_NFIB-STRN_NFIB_chr9_14313480_ENST00000380959_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_6_NFIB-STRN_NFIB_chr9_14313480_ENST00000380959_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_7_NFIB-STRN_NFIB_chr9_14313480_ENST00000397575_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_8_NFIB-STRN_NFIB_chr9_14313480_ENST00000397575_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_9_NFIB-STRN_NFIB_chr9_14313480_ENST00000397579_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_10_NFIB-STRN_NFIB_chr9_14313480_ENST00000397579_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_11_NFIB-STRN_NFIB_chr9_14313480_ENST00000397581_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_12_NFIB-STRN_NFIB_chr9_14313480_ENST00000397581_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_13_NFIB-STRN_NFIB_chr9_14313481_ENST00000380921_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_14_NFIB-STRN_NFIB_chr9_14313481_ENST00000380921_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_15_NFIB-STRN_NFIB_chr9_14313481_ENST00000380953_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_16_NFIB-STRN_NFIB_chr9_14313481_ENST00000380953_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_17_NFIB-STRN_NFIB_chr9_14313481_ENST00000380959_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_18_NFIB-STRN_NFIB_chr9_14313481_ENST00000380959_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_19_NFIB-STRN_NFIB_chr9_14313481_ENST00000397575_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_20_NFIB-STRN_NFIB_chr9_14313481_ENST00000397575_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_21_NFIB-STRN_NFIB_chr9_14313481_ENST00000397579_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

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>58897_58897_22_NFIB-STRN_NFIB_chr9_14313481_ENST00000397579_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

--------------------------------------------------------------

>58897_58897_23_NFIB-STRN_NFIB_chr9_14313481_ENST00000397581_STRN_chr2_37152351_ENST00000263918_length(amino acids)=712AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKK
ERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAG
LTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP
VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVF
NDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKL

--------------------------------------------------------------

>58897_58897_24_NFIB-STRN_NFIB_chr9_14313481_ENST00000397581_STRN_chr2_37152351_ENST00000379213_length(amino acids)=675AA_BP=8
MMYSPICLTQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQG
RQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDED
EDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVG
SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDG
IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS
YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME
TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:14313481/chr2:37152351)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIB

O00712

STRN

O43815

FUNCTION: Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. {ECO:0000269|PubMed:30388402}.FUNCTION: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTRNchr9:14313480chr2:37152351ENST00000263918018149_16678.0781.0RegionCalmodulin-binding
TgeneSTRNchr9:14313480chr2:37152351ENST00000379213118149_16666.0732.0RegionCalmodulin-binding
TgeneSTRNchr9:14313481chr2:37152351ENST00000263918018149_16678.0781.0RegionCalmodulin-binding
TgeneSTRNchr9:14313481chr2:37152351ENST00000379213118149_16666.0732.0RegionCalmodulin-binding
TgeneSTRNchr9:14313480chr2:37152351ENST00000263918018461_50078.0781.0RepeatNote=WD 1
TgeneSTRNchr9:14313480chr2:37152351ENST00000263918018514_55378.0781.0RepeatNote=WD 2
TgeneSTRNchr9:14313480chr2:37152351ENST00000263918018567_60678.0781.0RepeatNote=WD 3
TgeneSTRNchr9:14313480chr2:37152351ENST00000263918018662_70178.0781.0RepeatNote=WD 4
TgeneSTRNchr9:14313480chr2:37152351ENST00000263918018704_74378.0781.0RepeatNote=WD 5
TgeneSTRNchr9:14313480chr2:37152351ENST00000263918018750_77978.0781.0RepeatNote=WD 6
TgeneSTRNchr9:14313480chr2:37152351ENST00000379213118461_50066.0732.0RepeatNote=WD 1
TgeneSTRNchr9:14313480chr2:37152351ENST00000379213118514_55366.0732.0RepeatNote=WD 2
TgeneSTRNchr9:14313480chr2:37152351ENST00000379213118567_60666.0732.0RepeatNote=WD 3
TgeneSTRNchr9:14313480chr2:37152351ENST00000379213118662_70166.0732.0RepeatNote=WD 4
TgeneSTRNchr9:14313480chr2:37152351ENST00000379213118704_74366.0732.0RepeatNote=WD 5
TgeneSTRNchr9:14313480chr2:37152351ENST00000379213118750_77966.0732.0RepeatNote=WD 6
TgeneSTRNchr9:14313481chr2:37152351ENST00000263918018461_50078.0781.0RepeatNote=WD 1
TgeneSTRNchr9:14313481chr2:37152351ENST00000263918018514_55378.0781.0RepeatNote=WD 2
TgeneSTRNchr9:14313481chr2:37152351ENST00000263918018567_60678.0781.0RepeatNote=WD 3
TgeneSTRNchr9:14313481chr2:37152351ENST00000263918018662_70178.0781.0RepeatNote=WD 4
TgeneSTRNchr9:14313481chr2:37152351ENST00000263918018704_74378.0781.0RepeatNote=WD 5
TgeneSTRNchr9:14313481chr2:37152351ENST00000263918018750_77978.0781.0RepeatNote=WD 6
TgeneSTRNchr9:14313481chr2:37152351ENST00000379213118461_50066.0732.0RepeatNote=WD 1
TgeneSTRNchr9:14313481chr2:37152351ENST00000379213118514_55366.0732.0RepeatNote=WD 2
TgeneSTRNchr9:14313481chr2:37152351ENST00000379213118567_60666.0732.0RepeatNote=WD 3
TgeneSTRNchr9:14313481chr2:37152351ENST00000379213118662_70166.0732.0RepeatNote=WD 4
TgeneSTRNchr9:14313481chr2:37152351ENST00000379213118704_74366.0732.0RepeatNote=WD 5
TgeneSTRNchr9:14313481chr2:37152351ENST00000379213118750_77966.0732.0RepeatNote=WD 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFIBchr9:14313480chr2:37152351ENST00000380953-1111_19510.0495.0DNA bindingCTF/NF-I
HgeneNFIBchr9:14313480chr2:37152351ENST00000380959-191_19510.0421.0DNA bindingCTF/NF-I
HgeneNFIBchr9:14313481chr2:37152351ENST00000380953-1111_19510.0495.0DNA bindingCTF/NF-I
HgeneNFIBchr9:14313481chr2:37152351ENST00000380959-191_19510.0421.0DNA bindingCTF/NF-I
HgeneNFIBchr9:14313480chr2:37152351ENST00000380953-111397_40510.0495.0Motif9aaTAD
HgeneNFIBchr9:14313480chr2:37152351ENST00000380959-19397_40510.0421.0Motif9aaTAD
HgeneNFIBchr9:14313481chr2:37152351ENST00000380953-111397_40510.0495.0Motif9aaTAD
HgeneNFIBchr9:14313481chr2:37152351ENST00000380959-19397_40510.0421.0Motif9aaTAD
TgeneSTRNchr9:14313480chr2:37152351ENST0000026391801853_12078.0781.0Coiled coilOntology_term=ECO:0000255
TgeneSTRNchr9:14313480chr2:37152351ENST0000037921311853_12066.0732.0Coiled coilOntology_term=ECO:0000255
TgeneSTRNchr9:14313481chr2:37152351ENST0000026391801853_12078.0781.0Coiled coilOntology_term=ECO:0000255
TgeneSTRNchr9:14313481chr2:37152351ENST0000037921311853_12066.0732.0Coiled coilOntology_term=ECO:0000255
TgeneSTRNchr9:14313480chr2:37152351ENST0000026391801855_6378.0781.0RegionCaveolin-binding
TgeneSTRNchr9:14313480chr2:37152351ENST0000037921311855_6366.0732.0RegionCaveolin-binding
TgeneSTRNchr9:14313481chr2:37152351ENST0000026391801855_6378.0781.0RegionCaveolin-binding
TgeneSTRNchr9:14313481chr2:37152351ENST0000037921311855_6366.0732.0RegionCaveolin-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
STRNSTK24, MCC, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2CA, PPP2R1A, STK26, SIKE1, STK25, STRN3, PPP2R1B, STRN4, STRIP2, SLMAP, CCT2, CCT8, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, CCT6B, TRAF3IP3, PPP2CB, ZRANB1, Dynll1, ELAVL1, LNX1, APC, TJP1, DDX1, DYNC1H1, CPSF6, EIF2S1, SF3B5, BRCA1, ECT2, PAXIP1, STK3, STK4, TFIP11, RINT1, PCOLCE2, LYPD3, NR1H3, PPP2R2C, RASSF3, PGAM5, NTRK1, HSPB1, DYNLL1, MAP4K4, EEF1E1, BAG2, SLC43A3, AHNAK, Ppp2ca, Ppp2r1a, Strn3, Arrb2, Strip1, PRDM14, TNFRSF1A, NHSL2, PSMC5, PLP1, ZNF550, SNX24, LRRCC1, ZNF331, PRPF19, SPINK2, EXOC1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, GIPC1, ESR2, USP15, GOLGA2, KIAA1429, ATG16L1, HOOK3, EP300, ESR1, RMDN3, CUL4A, TULP3, GOLGA1, TMOD1, MINK1, TNIK, SMAD4, DYNLL2, PMF1, RABEP2, ENDOD1, FLII, KIAA1522, GOLGA8G, ISCA2, GOLGA6A, FILIP1, SSUH2, PCM1, CAMK2B, MAP1S,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NFIBall structure
STRNall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NFIB-STRN


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NFIB-STRN


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFIBC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneNFIBC0221355Macrocephaly1GENOMICS_ENGLAND
HgeneNFIBC0557874Global developmental delay1GENOMICS_ENGLAND
HgeneNFIBC3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneNFIBC4748993MACROCEPHALY, ACQUIRED, WITH IMPAIRED INTELLECTUAL DEVELOPMENT1GENOMICS_ENGLAND;UNIPROT