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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NFIX-CALR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NFIX-CALR
FusionPDB ID: 58938
FusionGDB2.0 ID: 58938
HgeneTgene
Gene symbol

NFIX

CALR

Gene ID

4784

811

Gene namenuclear factor I Xcalreticulin
SynonymsCTF|MRSHSS|NF-I/X|NF1-X|NF1A|SOTOS2CRT|HEL-S-99n|RO|SSA|cC1qR
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 X-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/XcalreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60
Modification date2020032920200329
UniProtAcc

Q14938

Q96L12

Ensembl transtripts involved in fusion geneENST idsENST00000397661, ENST00000585575, 
ENST00000587260, ENST00000587760, 
ENST00000588228, ENST00000592199, 
ENST00000358552, ENST00000360105, 
ENST00000588680, 		ENST00000316448, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 14 X 16=604824 X 30 X 7=5040
# samples 4238
** MAII scorelog2(42/6048*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(38/5040*10)=-3.72935241005633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NFIX [Title/Abstract] AND CALR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NFIX(13136366)-CALR(13050866), # samples:1
NFIX(13136366)-CALR(13049947), # samples:1
NFIX(13192669)-CALR(13054350), # samples:1
NFIX(13189549)-CALR(13055026), # samples:1
NFIX(13136366)-CALR(13049948), # samples:1
NFIX(13136366)-CALR(13050242), # samples:1
NFIX(13192669)-CALR(13054351), # samples:1
Anticipated loss of major functional domain due to fusion event.NFIX-CALR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFIX-CALR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFIX-CALR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFIX-CALR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIX

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

HgeneNFIX

GO:0045944

positive regulation of transcription by RNA polymerase II

19706729

TgeneCALR

GO:0000122

negative regulation of transcription by RNA polymerase II

8107809

TgeneCALR

GO:0006611

protein export from nucleus

11149926

TgeneCALR

GO:0017148

negative regulation of translation

14726956

TgeneCALR

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

8107809

TgeneCALR

GO:0034504

protein localization to nucleus

15998798

TgeneCALR

GO:0045665

negative regulation of neuron differentiation

8107809

TgeneCALR

GO:0045892

negative regulation of transcription, DNA-templated

8107809

TgeneCALR

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

8107809


check buttonFusion gene breakpoints across NFIX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CALR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0G0-01ANFIXchr19

13189549

+CALRchr19

13055026

+
ChimerDB4OVTCGA-13-0887-01ANFIXchr19

13136366

+CALRchr19

13049948

+
ChimerDB4OVTCGA-13-0887-01ANFIXchr19

13136366

+CALRchr19

13050242

+
ChimerDB4OVTCGA-13-0887NFIXchr19

13136366

+CALRchr19

13049947

+
ChimerDB4OVTCGA-25-2396NFIXchr19

13136366

+CALRchr19

13050866

+
ChimerDB4OVTCGA-36-1577-01ANFIXchr19

13192669

+CALRchr19

13054351

+
ChimerDB4OVTCGA-36-1577NFIXchr19

13192669

+CALRchr19

13054350

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397661NFIXchr1913192669+ENST00000316448CALRchr1913054350+235414841731777534
ENST00000592199NFIXchr1913192669+ENST00000316448CALRchr1913054350+2124125401547515
ENST00000587760NFIXchr1913192669+ENST00000316448CALRchr1913054350+21411271141564516
ENST00000585575NFIXchr1913192669+ENST00000316448CALRchr1913054350+2100123001523507
ENST00000360105NFIXchr1913192669+ENST00000316448CALRchr1913054350+20751205651498477
ENST00000588228NFIXchr1913192669+ENST00000316448CALRchr1913054350+22011331531624523
ENST00000587260NFIXchr1913192669+ENST00000316448CALRchr1913054350+21791309581602514
ENST00000358552NFIXchr1913192669+ENST00000316448CALRchr1913054350+1998112801421473
ENST00000397661NFIXchr1913192669+ENST00000316448CALRchr1913054351+235414841731777534
ENST00000592199NFIXchr1913192669+ENST00000316448CALRchr1913054351+2124125401547515
ENST00000587760NFIXchr1913192669+ENST00000316448CALRchr1913054351+21411271141564516
ENST00000585575NFIXchr1913192669+ENST00000316448CALRchr1913054351+2100123001523507
ENST00000360105NFIXchr1913192669+ENST00000316448CALRchr1913054351+20751205651498477
ENST00000588228NFIXchr1913192669+ENST00000316448CALRchr1913054351+22011331531624523
ENST00000587260NFIXchr1913192669+ENST00000316448CALRchr1913054351+21791309581602514
ENST00000358552NFIXchr1913192669+ENST00000316448CALRchr1913054351+1998112801421473

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397661ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.007245210.99275476
ENST00000592199ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.0051532510.9948467
ENST00000587760ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.0033118340.9966882
ENST00000585575ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.0031152250.99688476
ENST00000360105ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.0048454650.9951545
ENST00000588228ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.0057719360.994228
ENST00000587260ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.0059296970.99407023
ENST00000358552ENST00000316448NFIXchr1913192669+CALRchr1913054350+0.0035570340.996443
ENST00000397661ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.007245210.99275476
ENST00000592199ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.0051532510.9948467
ENST00000587760ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.0033118340.9966882
ENST00000585575ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.0031152250.99688476
ENST00000360105ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.0048454650.9951545
ENST00000588228ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.0057719360.994228
ENST00000587260ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.0059296970.99407023
ENST00000358552ENST00000316448NFIXchr1913192669+CALRchr1913054351+0.0035570340.996443

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58938_58938_1_NFIX-CALR_NFIX_chr19_13192669_ENST00000358552_CALR_chr19_13054350_ENST00000316448_length(amino acids)=473AA_BP=375
MLPACRLQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDF
VLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAY
FVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPS
TSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKE
FVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDED

--------------------------------------------------------------

>58938_58938_2_NFIX-CALR_NFIX_chr19_13192669_ENST00000358552_CALR_chr19_13054351_ENST00000316448_length(amino acids)=473AA_BP=375
MLPACRLQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDF
VLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAY
FVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPS
TSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKE
FVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDED

--------------------------------------------------------------

>58938_58938_3_NFIX-CALR_NFIX_chr19_13192669_ENST00000360105_CALR_chr19_13054350_ENST00000316448_length(amino acids)=477AA_BP=379
MGATEPGGDTSSDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEF
REDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDL
YLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSIT
SPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQD
SLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDED

--------------------------------------------------------------

>58938_58938_4_NFIX-CALR_NFIX_chr19_13192669_ENST00000360105_CALR_chr19_13054351_ENST00000316448_length(amino acids)=477AA_BP=379
MGATEPGGDTSSDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEF
REDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDL
YLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSIT
SPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQD
SLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDED

--------------------------------------------------------------

>58938_58938_5_NFIX-CALR_NFIX_chr19_13192669_ENST00000397661_CALR_chr19_13054350_ENST00000316448_length(amino acids)=534AA_BP=436
MPGLPSPRPAAALPPGRPAMYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKW
ASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGL
CVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESP
SYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSS
PRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLIT

--------------------------------------------------------------

>58938_58938_6_NFIX-CALR_NFIX_chr19_13192669_ENST00000397661_CALR_chr19_13054351_ENST00000316448_length(amino acids)=534AA_BP=436
MPGLPSPRPAAALPPGRPAMYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKW
ASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGL
CVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESP
SYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSS
PRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLIT

--------------------------------------------------------------

>58938_58938_7_NFIX-CALR_NFIX_chr19_13192669_ENST00000585575_CALR_chr19_13054350_ENST00000316448_length(amino acids)=507AA_BP=409
MDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGK
KPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPES
GQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRP
KSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASA
LHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK

--------------------------------------------------------------

>58938_58938_8_NFIX-CALR_NFIX_chr19_13192669_ENST00000585575_CALR_chr19_13054351_ENST00000316448_length(amino acids)=507AA_BP=409
MDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGK
KPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPES
GQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRP
KSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASA
LHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK

--------------------------------------------------------------

>58938_58938_9_NFIX-CALR_NFIX_chr19_13192669_ENST00000587260_CALR_chr19_13054350_ENST00000316448_length(amino acids)=514AA_BP=416
MLPACRLQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDF
VLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAY
FVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPS
TSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGS
PRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAA

--------------------------------------------------------------

>58938_58938_10_NFIX-CALR_NFIX_chr19_13192669_ENST00000587260_CALR_chr19_13054351_ENST00000316448_length(amino acids)=514AA_BP=416
MLPACRLQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDF
VLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAY
FVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPS
TSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGS
PRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAA

--------------------------------------------------------------

>58938_58938_11_NFIX-CALR_NFIX_chr19_13192669_ENST00000587760_CALR_chr19_13054350_ENST00000316448_length(amino acids)=516AA_BP=418
MGFAGCFRSMDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFRE
DFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYL
AYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSP
PSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRP
GSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTK

--------------------------------------------------------------

>58938_58938_12_NFIX-CALR_NFIX_chr19_13192669_ENST00000587760_CALR_chr19_13054351_ENST00000316448_length(amino acids)=516AA_BP=418
MGFAGCFRSMDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFRE
DFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYL
AYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSP
PSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRP
GSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTK

--------------------------------------------------------------

>58938_58938_13_NFIX-CALR_NFIX_chr19_13192669_ENST00000588228_CALR_chr19_13054350_ENST00000316448_length(amino acids)=523AA_BP=425
MEMSWARQSLAGIPAACDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKD
IRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTI
KELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLG
RRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLP
VLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGN

--------------------------------------------------------------

>58938_58938_14_NFIX-CALR_NFIX_chr19_13192669_ENST00000588228_CALR_chr19_13054351_ENST00000316448_length(amino acids)=523AA_BP=425
MEMSWARQSLAGIPAACDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKD
IRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTI
KELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLG
RRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLP
VLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGN

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>58938_58938_15_NFIX-CALR_NFIX_chr19_13192669_ENST00000592199_CALR_chr19_13054350_ENST00000316448_length(amino acids)=515AA_BP=417
MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFRED
FVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLA
YFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPP
STSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPG
SPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKA

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>58938_58938_16_NFIX-CALR_NFIX_chr19_13192669_ENST00000592199_CALR_chr19_13054351_ENST00000316448_length(amino acids)=515AA_BP=417
MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFRED
FVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLA
YFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPP
STSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPG
SPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKA

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:13136366/chr19:13050866)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIX

Q14938

CALR

Q96L12

FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.FUNCTION: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. {ECO:0000250, ECO:0000269|PubMed:21590275}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFIXchr19:13192669chr19:13054350ENST00000397661+8101_194418.0878.6666666666666DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054350ENST00000585575+8111_194410.0495.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054350ENST00000587260+791_194417.0281.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054350ENST00000587760+8101_194410.0460.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054350ENST00000592199+8111_194418.0503.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054351ENST00000397661+8101_194418.0878.6666666666666DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054351ENST00000585575+8111_194410.0495.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054351ENST00000587260+791_194417.0281.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054351ENST00000587760+8101_194410.0460.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054351ENST00000592199+8111_194418.0503.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13192669chr19:13054350ENST00000397661+810398_406418.0878.6666666666666Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054350ENST00000585575+811398_406410.0495.0Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054350ENST00000587260+79398_406417.0281.6666666666667Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054350ENST00000587760+810398_406410.0460.6666666666667Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054350ENST00000592199+811398_406418.0503.0Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054351ENST00000397661+810398_406418.0878.6666666666666Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054351ENST00000585575+811398_406410.0495.0Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054351ENST00000587260+79398_406417.0281.6666666666667Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054351ENST00000587760+810398_406410.0460.6666666666667Motif9aaTAD
HgeneNFIXchr19:13192669chr19:13054351ENST00000592199+811398_406418.0503.0Motif9aaTAD
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809351_40830.333333333333332418.0Compositional biasNote=Asp/Glu/Lys-rich
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809351_40830.333333333333332418.0Compositional biasNote=Asp/Glu/Lys-rich
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819351_40864.33333333333333418.0Compositional biasNote=Asp/Glu/Lys-rich
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829351_408132.33333333333334418.0Compositional biasNote=Asp/Glu/Lys-rich
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869351_408320.0418.0Compositional biasNote=Asp/Glu/Lys-rich
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869351_408320.0418.0Compositional biasNote=Asp/Glu/Lys-rich
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809414_41730.333333333333332418.0MotifNote=Prevents secretion from ER
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809414_41730.333333333333332418.0MotifNote=Prevents secretion from ER
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819414_41764.33333333333333418.0MotifNote=Prevents secretion from ER
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829414_417132.33333333333334418.0MotifNote=Prevents secretion from ER
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869414_417320.0418.0MotifNote=Prevents secretion from ER
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869414_417320.0418.0MotifNote=Prevents secretion from ER
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809191_25530.333333333333332418.0RegionNote=4 X approximate repeats
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809198_30830.333333333333332418.0RegionNote=P-domain
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809259_29730.333333333333332418.0RegionNote=3 X approximate repeats
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809309_41730.333333333333332418.0RegionNote=C-domain
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809191_25530.333333333333332418.0RegionNote=4 X approximate repeats
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809198_30830.333333333333332418.0RegionNote=P-domain
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809259_29730.333333333333332418.0RegionNote=3 X approximate repeats
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809309_41730.333333333333332418.0RegionNote=C-domain
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819191_25564.33333333333333418.0RegionNote=4 X approximate repeats
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819198_30864.33333333333333418.0RegionNote=P-domain
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819259_29764.33333333333333418.0RegionNote=3 X approximate repeats
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819309_41764.33333333333333418.0RegionNote=C-domain
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829191_255132.33333333333334418.0RegionNote=4 X approximate repeats
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829198_308132.33333333333334418.0RegionNote=P-domain
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829259_297132.33333333333334418.0RegionNote=3 X approximate repeats
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829309_417132.33333333333334418.0RegionNote=C-domain
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809191_20230.333333333333332418.0RepeatNote=1-1
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809210_22130.333333333333332418.0RepeatNote=1-2
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809227_23830.333333333333332418.0RepeatNote=1-3
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809244_25530.333333333333332418.0RepeatNote=1-4
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809259_26930.333333333333332418.0RepeatNote=2-1
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809273_28330.333333333333332418.0RepeatNote=2-2
TgeneCALRchr19:13136366chr19:13049947ENST0000031644809287_29730.333333333333332418.0RepeatNote=2-3
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809191_20230.333333333333332418.0RepeatNote=1-1
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809210_22130.333333333333332418.0RepeatNote=1-2
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809227_23830.333333333333332418.0RepeatNote=1-3
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809244_25530.333333333333332418.0RepeatNote=1-4
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809259_26930.333333333333332418.0RepeatNote=2-1
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809273_28330.333333333333332418.0RepeatNote=2-2
TgeneCALRchr19:13136366chr19:13049948ENST0000031644809287_29730.333333333333332418.0RepeatNote=2-3
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819191_20264.33333333333333418.0RepeatNote=1-1
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819210_22164.33333333333333418.0RepeatNote=1-2
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819227_23864.33333333333333418.0RepeatNote=1-3
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819244_25564.33333333333333418.0RepeatNote=1-4
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819259_26964.33333333333333418.0RepeatNote=2-1
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819273_28364.33333333333333418.0RepeatNote=2-2
TgeneCALRchr19:13136366chr19:13050242ENST0000031644819287_29764.33333333333333418.0RepeatNote=2-3
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829191_202132.33333333333334418.0RepeatNote=1-1
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829210_221132.33333333333334418.0RepeatNote=1-2
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829227_238132.33333333333334418.0RepeatNote=1-3
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829244_255132.33333333333334418.0RepeatNote=1-4
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829259_269132.33333333333334418.0RepeatNote=2-1
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829273_283132.33333333333334418.0RepeatNote=2-2
TgeneCALRchr19:13136366chr19:13050866ENST0000031644829287_297132.33333333333334418.0RepeatNote=2-3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFIXchr19:13136366chr19:13049947ENST00000397661+2101_194186.33333333333334878.6666666666666DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049947ENST00000585575+2111_194178.33333333333334495.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049947ENST00000587260+191_194185.33333333333334281.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049947ENST00000587760+2101_194178.33333333333334460.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049947ENST00000592199+2111_194186.33333333333334503.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049948ENST00000397661+2101_194186.33333333333334878.6666666666666DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049948ENST00000585575+2111_194178.33333333333334495.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049948ENST00000587260+191_194185.33333333333334281.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049948ENST00000587760+2101_194178.33333333333334460.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049948ENST00000592199+2111_194186.33333333333334503.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050242ENST00000397661+2101_194186.33333333333334878.6666666666666DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050242ENST00000585575+2111_194178.33333333333334495.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050242ENST00000587260+191_194185.33333333333334281.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050242ENST00000587760+2101_194178.33333333333334460.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050242ENST00000592199+2111_194186.33333333333334503.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050866ENST00000397661+2101_194186.33333333333334878.6666666666666DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050866ENST00000585575+2111_194178.33333333333334495.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050866ENST00000587260+191_194185.33333333333334281.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050866ENST00000587760+2101_194178.33333333333334460.6666666666667DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13050866ENST00000592199+2111_194186.33333333333334503.0DNA bindingCTF/NF-I
HgeneNFIXchr19:13136366chr19:13049947ENST00000397661+210398_406186.33333333333334878.6666666666666Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049947ENST00000585575+211398_406178.33333333333334495.0Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049947ENST00000587260+19398_406185.33333333333334281.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049947ENST00000587760+210398_406178.33333333333334460.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049947ENST00000592199+211398_406186.33333333333334503.0Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049948ENST00000397661+210398_406186.33333333333334878.6666666666666Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049948ENST00000585575+211398_406178.33333333333334495.0Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049948ENST00000587260+19398_406185.33333333333334281.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049948ENST00000587760+210398_406178.33333333333334460.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13049948ENST00000592199+211398_406186.33333333333334503.0Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050242ENST00000397661+210398_406186.33333333333334878.6666666666666Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050242ENST00000585575+211398_406178.33333333333334495.0Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050242ENST00000587260+19398_406185.33333333333334281.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050242ENST00000587760+210398_406178.33333333333334460.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050242ENST00000592199+211398_406186.33333333333334503.0Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050866ENST00000397661+210398_406186.33333333333334878.6666666666666Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050866ENST00000585575+211398_406178.33333333333334495.0Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050866ENST00000587260+19398_406185.33333333333334281.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050866ENST00000587760+210398_406178.33333333333334460.6666666666667Motif9aaTAD
HgeneNFIXchr19:13136366chr19:13050866ENST00000592199+211398_406186.33333333333334503.0Motif9aaTAD
TgeneCALRchr19:13136366chr19:13049947ENST000003164480918_19730.333333333333332418.0RegionNote=N-domain
TgeneCALRchr19:13136366chr19:13049948ENST000003164480918_19730.333333333333332418.0RegionNote=N-domain
TgeneCALRchr19:13136366chr19:13050242ENST000003164481918_19764.33333333333333418.0RegionNote=N-domain
TgeneCALRchr19:13136366chr19:13050866ENST000003164482918_197132.33333333333334418.0RegionNote=N-domain
TgeneCALRchr19:13192669chr19:13054350ENST000003164486918_197320.0418.0RegionNote=N-domain
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869191_255320.0418.0RegionNote=4 X approximate repeats
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869198_308320.0418.0RegionNote=P-domain
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869259_297320.0418.0RegionNote=3 X approximate repeats
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869309_417320.0418.0RegionNote=C-domain
TgeneCALRchr19:13192669chr19:13054351ENST000003164486918_197320.0418.0RegionNote=N-domain
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869191_255320.0418.0RegionNote=4 X approximate repeats
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869198_308320.0418.0RegionNote=P-domain
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869259_297320.0418.0RegionNote=3 X approximate repeats
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869309_417320.0418.0RegionNote=C-domain
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869191_202320.0418.0RepeatNote=1-1
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869210_221320.0418.0RepeatNote=1-2
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869227_238320.0418.0RepeatNote=1-3
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869244_255320.0418.0RepeatNote=1-4
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869259_269320.0418.0RepeatNote=2-1
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869273_283320.0418.0RepeatNote=2-2
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869287_297320.0418.0RepeatNote=2-3
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869191_202320.0418.0RepeatNote=1-1
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869210_221320.0418.0RepeatNote=1-2
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869227_238320.0418.0RepeatNote=1-3
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869244_255320.0418.0RepeatNote=1-4
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869259_269320.0418.0RepeatNote=2-1
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869273_283320.0418.0RepeatNote=2-2
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869287_297320.0418.0RepeatNote=2-3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NFIX
CALR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCALRchr19:13192669chr19:13054350ENST0000031644869237_270320.0418.0PPIB
TgeneCALRchr19:13192669chr19:13054351ENST0000031644869237_270320.0418.0PPIB


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Related Drugs to NFIX-CALR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NFIX-CALR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource