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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NHLRC3-BPTF

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NHLRC3-BPTF
	FusionPDB ID: 59074
	FusionGDB2.0 ID: 59074
		Hgene	Tgene
	Gene symbol	NHLRC3	BPTF
	Gene ID	387921	2186
	Gene name	NHL repeat containing 3	bromodomain PHD finger transcription factor
	Synonyms	-	FAC1\|FALZ\|NEDDFL\|NURF301
	Cytomap	13q13.3	17q24.2
	Type of gene	protein-coding	protein-coding
	Description	NHL repeat-containing protein 3	nucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling f
	Modification date	20200313	20200313
	UniProtAcc	Q5JS37	Q12830
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000379599, ENST00000379600, ENST00000470258,	ENST00000577770, ENST00000306378, ENST00000321892, ENST00000335221, ENST00000424123,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 3 X 4=96	23 X 23 X 6=3174
	# samples	7	26
	** MAII score	log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/3174*10)=-3.60971859980673 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NHLRC3 [Title/Abstract] AND BPTF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NHLRC3(39613848)-BPTF(65941525), # samples:1
Anticipated loss of major functional domain due to fusion event.	NHLRC3-BPTF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NHLRC3-BPTF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NHLRC3-BPTF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NHLRC3-BPTF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BPTF	GO:0000122	negative regulation of transcription by RNA polymerase II	10727212
Tgene	BPTF	GO:0006338	chromatin remodeling	14609955

Fusion gene breakpoints across NHLRC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BPTF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A4MH-01A	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000379600	NHLRC3	chr13	39613848	+	ENST00000335221	BPTF	chr17	65941525	+	4431	707	145	2340	731
ENST00000379600	NHLRC3	chr13	39613848	+	ENST00000321892	BPTF	chr17	65941525	+	4860	707	145	2769	874
ENST00000379600	NHLRC3	chr13	39613848	+	ENST00000306378	BPTF	chr17	65941525	+	3635	707	145	2769	874
ENST00000379600	NHLRC3	chr13	39613848	+	ENST00000424123	BPTF	chr17	65941525	+	2341	707	145	2340	732
ENST00000379599	NHLRC3	chr13	39613848	+	ENST00000335221	BPTF	chr17	65941525	+	4358	634	72	2267	731
ENST00000379599	NHLRC3	chr13	39613848	+	ENST00000321892	BPTF	chr17	65941525	+	4787	634	72	2696	874
ENST00000379599	NHLRC3	chr13	39613848	+	ENST00000306378	BPTF	chr17	65941525	+	3562	634	72	2696	874
ENST00000379599	NHLRC3	chr13	39613848	+	ENST00000424123	BPTF	chr17	65941525	+	2268	634	72	2267	731

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000379600	ENST00000335221	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.00052179	0.9994783
ENST00000379600	ENST00000321892	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.000407136	0.99959284
ENST00000379600	ENST00000306378	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.001042102	0.9989579
ENST00000379600	ENST00000424123	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.003025794	0.99697423
ENST00000379599	ENST00000335221	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.000528516	0.9994715
ENST00000379599	ENST00000321892	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.000422253	0.9995777
ENST00000379599	ENST00000306378	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.001107791	0.99889225
ENST00000379599	ENST00000424123	NHLRC3	chr13	39613848	+	BPTF	chr17	65941525	+	0.003223958	0.99677604

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59074_59074_1_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379599_BPTF_chr17_65941525_ENST00000306378_length(amino acids)=874AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSS
GQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAAS
VQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEE
KQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPA
PPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWY
HGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQ

--------------------------------------------------------------

>59074_59074_2_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379599_BPTF_chr17_65941525_ENST00000321892_length(amino acids)=874AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSS
GQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAAS
VQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEE
KQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPA
PPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWY
HGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQ

--------------------------------------------------------------

>59074_59074_3_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379599_BPTF_chr17_65941525_ENST00000335221_length(amino acids)=731AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVVMKHNAVIE
HLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQI
EVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMI
STTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQA
HKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASR

--------------------------------------------------------------

>59074_59074_4_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379599_BPTF_chr17_65941525_ENST00000424123_length(amino acids)=731AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVVMKHNAVIE
HLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQI
EVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMI
STTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQA
HKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASR

--------------------------------------------------------------

>59074_59074_5_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379600_BPTF_chr17_65941525_ENST00000306378_length(amino acids)=874AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSS
GQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAAS
VQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEE
KQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPA
PPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWY
HGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQ

--------------------------------------------------------------

>59074_59074_6_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379600_BPTF_chr17_65941525_ENST00000321892_length(amino acids)=874AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSS
GQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAAS
VQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEE
KQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPA
PPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWY
HGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQ

--------------------------------------------------------------

>59074_59074_7_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379600_BPTF_chr17_65941525_ENST00000335221_length(amino acids)=731AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVVMKHNAVIE
HLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQI
EVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMI
STTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQA
HKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASR

--------------------------------------------------------------

>59074_59074_8_NHLRC3-BPTF_NHLRC3_chr13_39613848_ENST00000379600_BPTF_chr17_65941525_ENST00000424123_length(amino acids)=732AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPT
HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVVMKHNAVIE
HLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQI
EVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMI
STTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQA
HKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:39613848/chr17:65941525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NHLRC3 Q5JS37	BPTF Q12830
	FUNCTION: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379599

47_93

128.33333333333334

281.0

Repeat

Note=NHL 1

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379600

47_93

128.33333333333334

348.0

Repeat

Note=NHL 1

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

2706_2732

2233.3333333333335

2921.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

2706_2732

2359.3333333333335

3047.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

2706_2732

2359.3333333333335

2904.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

2338_2361

2233.3333333333335

2921.0

Compositional bias

Note=Thr-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

2795_2817

2233.3333333333335

2921.0

Compositional bias

Note=Pro-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

2848_2853

2233.3333333333335

2921.0

Compositional bias

Note=Poly-Lys

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

2795_2817

2359.3333333333335

3047.0

Compositional bias

Note=Pro-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

2848_2853

2359.3333333333335

3047.0

Compositional bias

Note=Poly-Lys

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

2795_2817

2359.3333333333335

2904.0

Compositional bias

Note=Pro-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

2848_2853

2359.3333333333335

2904.0

Compositional bias

Note=Poly-Lys

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

2944_3014

2233.3333333333335

2921.0

Domain

Bromo

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

2944_3014

2359.3333333333335

3047.0

Domain

Bromo

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

2944_3014

2359.3333333333335

2904.0

Domain

Bromo

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

2867_2918

2233.3333333333335

2921.0

Zinc finger

PHD-type 2

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

2867_2918

2359.3333333333335

3047.0

Zinc finger

PHD-type 2

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

2867_2918

2359.3333333333335

2904.0

Zinc finger

PHD-type 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379599

150_196

128.33333333333334

281.0

Repeat

Note=NHL 2

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379599

200_243

128.33333333333334

281.0

Repeat

Note=NHL 3

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379599

294_338

128.33333333333334

281.0

Repeat

Note=NHL 4

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379600

150_196

128.33333333333334

348.0

Repeat

Note=NHL 2

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379600

200_243

128.33333333333334

348.0

Repeat

Note=NHL 3

Hgene

NHLRC3

chr13:39613848

chr17:65941525

ENST00000379600

294_338

128.33333333333334

348.0

Repeat

Note=NHL 4

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

2022_2050

2233.3333333333335

2921.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

574_604

2233.3333333333335

2921.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

978_1007

2233.3333333333335

2921.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

2022_2050

2359.3333333333335

3047.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

574_604

2359.3333333333335

3047.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

978_1007

2359.3333333333335

3047.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

2022_2050

2359.3333333333335

2904.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

574_604

2359.3333333333335

2904.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

978_1007

2359.3333333333335

2904.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

143_180

2233.3333333333335

2921.0

Compositional bias

Note=Glu-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

149_185

2233.3333333333335

2921.0

Compositional bias

Note=Asp-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

1709_1803

2233.3333333333335

2921.0

Compositional bias

Note=Thr-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

143_180

2359.3333333333335

3047.0

Compositional bias

Note=Glu-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

149_185

2359.3333333333335

3047.0

Compositional bias

Note=Asp-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

1709_1803

2359.3333333333335

3047.0

Compositional bias

Note=Thr-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

2338_2361

2359.3333333333335

3047.0

Compositional bias

Note=Thr-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

143_180

2359.3333333333335

2904.0

Compositional bias

Note=Glu-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

149_185

2359.3333333333335

2904.0

Compositional bias

Note=Asp-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

1709_1803

2359.3333333333335

2904.0

Compositional bias

Note=Thr-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

2338_2361

2359.3333333333335

2904.0

Compositional bias

Note=Thr-rich

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

240_300

2233.3333333333335

2921.0

Domain

DDT

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

240_300

2359.3333333333335

3047.0

Domain

DDT

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

240_300

2359.3333333333335

2904.0

Domain

DDT

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000306378

390_437

2233.3333333333335

2921.0

Zinc finger

PHD-type 1

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000321892

390_437

2359.3333333333335

3047.0

Zinc finger

PHD-type 1

Tgene

BPTF

chr13:39613848

chr17:65941525

ENST00000335221

390_437

2359.3333333333335

2904.0

Zinc finger

PHD-type 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NHLRC3
BPTF

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	BPTF	chr13:39613848	chr17:65941525	ENST00000306378		19	28	640_749	2233.3333333333335	2921.0	KEAP1
Tgene	BPTF	chr13:39613848	chr17:65941525	ENST00000321892		21	30	640_749	2359.3333333333335	3047.0	KEAP1
Tgene	BPTF	chr13:39613848	chr17:65941525	ENST00000335221		21	30	640_749	2359.3333333333335	2904.0	KEAP1
Tgene	BPTF	chr13:39613848	chr17:65941525	ENST00000306378		19	28	839_921	2233.3333333333335	2921.0	MAZ
Tgene	BPTF	chr13:39613848	chr17:65941525	ENST00000321892		21	30	839_921	2359.3333333333335	3047.0	MAZ
Tgene	BPTF	chr13:39613848	chr17:65941525	ENST00000335221		21	30	839_921	2359.3333333333335	2904.0	MAZ

Top

Related Drugs to NHLRC3-BPTF

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NHLRC3-BPTF

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source