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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NIN-PDGFRB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NIN-PDGFRB
FusionPDB ID: 59161
FusionGDB2.0 ID: 59161
HgeneTgene
Gene symbol

NIN

PDGFRB

Gene ID

51199

5159

Gene namenineinplatelet derived growth factor receptor beta
SynonymsSCKL7CD140B|IBGC4|IMF1|JTK12|KOGS|PDGFR|PDGFR-1|PDGFR1|PENTT
Cytomap

14q22.1

5q32

Type of geneprotein-codingprotein-coding
Descriptionnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal proteinplatelet-derived growth factor receptor betaActivated tyrosine kinase PDGFRBCD140 antigen-like family member BNDEL1-PDGFRBPDGF-R-betaPDGFR-betabeta-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 1platelet-deriv
Modification date2020032820200329
UniProtAcc

Q9Y2I6

P09619

Ensembl transtripts involved in fusion geneENST idsENST00000389868, ENST00000245441, 
ENST00000530997, ENST00000324330, 
ENST00000382041, ENST00000382043, 
ENST00000453196, ENST00000486200, 
ENST00000261799, ENST00000523456, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 18 X 9=259228 X 26 X 6=4368
# samples 2015
** MAII scorelog2(20/2592*10)=-3.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/4368*10)=-4.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NIN [Title/Abstract] AND PDGFRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NIN(51206102)-PDGFRB(149503812), # samples:1
NIN(51192671)-PDGFRB(149505140), # samples:1
NIN(51190639)-PDGFRB(149505576), # samples:1
Anticipated loss of major functional domain due to fusion event.NIN-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NIN-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NIN-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NIN-PDGFRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDGFRB

GO:0007165

signal transduction

10821867

TgenePDGFRB

GO:0010863

positive regulation of phospholipase C activity

1653029

TgenePDGFRB

GO:0018108

peptidyl-tyrosine phosphorylation

1653029|2536956|2850496

TgenePDGFRB

GO:0030335

positive regulation of cell migration

17470632

TgenePDGFRB

GO:0032516

positive regulation of phosphoprotein phosphatase activity

7691811

TgenePDGFRB

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

TgenePDGFRB

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

1314164

TgenePDGFRB

GO:0046777

protein autophosphorylation

1314164|2536956|2850496

TgenePDGFRB

GO:0048008

platelet-derived growth factor receptor signaling pathway

1314164|2536956

TgenePDGFRB

GO:0060326

cell chemotaxis

2554309|17991872


check buttonFusion gene breakpoints across NIN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDGFRB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4chronic myeloid leukemiaAY764156NINchr14

51206102

PDGFRBchr5

149503812
ChimerKB3..NINchr14

51192670

-PDGFRBchr5

149505140

-
ChimerKB3..NINchr14

51192671

-PDGFRBchr5

149505140

-
ChiTaRS5.0N/AAY764156NINchr14

51192671

-PDGFRBchr5

149505140

-
ChiTaRS5.0N/AAY764157NINchr14

51190639

-PDGFRBchr5

149505576

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000245441NINchr1451192670-ENST00000261799PDGFRBchr5149505140-9956638313180292632
ENST00000530997NINchr1451192670-ENST00000261799PDGFRBchr5149505140-97656192078382612
ENST00000245441NINchr1451192671-ENST00000261799PDGFRBchr5149505140-9956638313180292632
ENST00000530997NINchr1451192671-ENST00000261799PDGFRBchr5149505140-97656192078382612
ENST00000245441NINchr1451192671-ENST00000261799PDGFRBchr5149505140-9956638313180292632
ENST00000530997NINchr1451192671-ENST00000261799PDGFRBchr5149505140-97656192078382612

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000245441ENST00000261799NINchr1451192671-PDGFRBchr5149505140-0.0037990150.996201
ENST00000530997ENST00000261799NINchr1451192671-PDGFRBchr5149505140-0.0033420590.99665797

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59161_59161_1_NIN-PDGFRB_NIN_chr14_51192670_ENST00000245441_PDGFRB_chr5_149505140_ENST00000261799_length(amino acids)=2632AA_BP=2083
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT
ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERI
AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD
PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV
IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE
KKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE
KHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETL
KREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE
RLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLL
EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDD
EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER
IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQG
KIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQ
ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVE
LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN
SQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH
RCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL
QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAEL
THSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM
QHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV
KRLLQEKVNQLKEQKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVK
MLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGL
PLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGM
EFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPY
PELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPG
FHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEP

--------------------------------------------------------------

>59161_59161_2_NIN-PDGFRB_NIN_chr14_51192670_ENST00000530997_PDGFRB_chr5_149505140_ENST00000261799_length(amino acids)=2612AA_BP=2063
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDC
SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRR
TSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAM
ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKI
EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQGKIEKLQESVVQRCDCCLWEA
SLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI
TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE
KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK
HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQKPRYEI
RWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKI
MSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMS
KDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLI
CEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMA
QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQP
NEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDS

--------------------------------------------------------------

>59161_59161_3_NIN-PDGFRB_NIN_chr14_51192671_ENST00000245441_PDGFRB_chr5_149505140_ENST00000261799_length(amino acids)=2632AA_BP=2083
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEA
LILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT
ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERI
AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD
PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV
IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE
KKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE
KHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETL
KREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLE
RLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLL
EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDD
EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER
IPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQG
KIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQ
ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVE
LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN
SQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH
RCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL
QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAEL
THSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM
QHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV
KRLLQEKVNQLKEQKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVK
MLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGL
PLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGM
EFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPY
PELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPG
FHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEP

--------------------------------------------------------------

>59161_59161_4_NIN-PDGFRB_NIN_chr14_51192671_ENST00000530997_PDGFRB_chr5_149505140_ENST00000261799_length(amino acids)=2612AA_BP=2063
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDC
SLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSM
QSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRR
TSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAM
ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKI
EESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQGKIEKLQESVVQRCDCCLWEA
SLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI
TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE
KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQK
HLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQKPRYEI
RWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKI
MSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMS
KDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLI
CEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMA
QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQP
NEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:51206102/chr5:149503812)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIN

Q9Y2I6

PDGFRB

P09619

FUNCTION: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311068_10992064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311181_13412064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311441_18162064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311854_18852064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311922_20672064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031357_5702064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031625_10272064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291068_10992064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291181_13412064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291441_18162064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291854_18852064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291922_20672064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829357_5702064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829625_10272064.02134.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031182_2172064.02134.0DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031219_2522064.02134.0DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031317_3522064.02134.0DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000245441-303142_772064.02134.0DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30318_432064.02134.0DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829182_2172064.02134.0DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829219_2522064.02134.0DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829317_3522064.02134.0DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000530997-282942_772064.02134.0DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28298_432064.02134.0DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031245_2522064.02134.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031300_3042064.02134.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031420_4232064.02134.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829245_2522064.02134.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829300_3042064.02134.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829420_4232064.02134.0Nucleotide bindingGTP
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023600_962558.01107.0DomainProtein kinase
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023606_614558.01107.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301068_109902091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301181_134102091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301441_181602091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301854_188502091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301922_206702091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130357_57002091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130625_102702091.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281068_109901378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281181_134101378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281441_181601378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281854_188501378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281922_206701378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128357_57001378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128625_102701378.0Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130182_21702091.0DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130219_25202091.0DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130317_35202091.0DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000382041-13042_7702091.0DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1308_4302091.0DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128182_21701378.0DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128219_25201378.0DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128317_35201378.0DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000382043-12842_7701378.0DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1288_4301378.0DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130245_25202091.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130300_30402091.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130420_42302091.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128245_25201378.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128300_30401378.0Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128420_42301378.0Nucleotide bindingGTP
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023129_210558.01107.0DomainNote=Ig-like C2-type 2
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023214_309558.01107.0DomainNote=Ig-like C2-type 3
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023331_403558.01107.0DomainNote=Ig-like C2-type 4
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799102333_120558.01107.0DomainNote=Ig-like C2-type 1
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023416_524558.01107.0DomainNote=Ig-like C2-type 5
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799102333_532558.01107.0Topological domainExtracellular
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023554_1106558.01107.0Topological domainCytoplasmic
TgenePDGFRBchr14:51192671chr5:149505140ENST000002617991023533_553558.01107.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1157) >>>1157.pdbFusion protein BP residue: 2063
CIF file (1157) >>>1157.cif		NINchr1451192670-PDGFRBchr5149505140-
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQ
QTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVR
GGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQ
RSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDG
HLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNG
KSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENEL
LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM
ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL
TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQ
VDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA
QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE
KKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAW
TEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR
EKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ
QREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE
REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCET
ADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL
SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP
GLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDD
EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKL
LYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEV
TETFLSLEKSYDEVKIENEGLNVLVLRLQGKIEKLQESVVQRCDCCLWEA
SLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL
LEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQAT
IAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGS
QEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN
SQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQ
SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQ
KISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSW
EHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ
LLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP
TEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQ
VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQ
LLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV
KRLLQEKVNQLKEQKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWE
LPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSE
KQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH
RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMS
KDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINE
SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICD
FGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLW
EIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEK
FEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPG
FHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSL
ASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGC
2612
3D view using mol* of 1157 (AA BP:2063)
PDB file (1167) >>>1167.pdbFusion protein BP residue: 2083
CIF file (1167) >>>1167.cif		NINchr1451192670-PDGFRBchr5149505140-
MPAVRALRRDRQKVSTVGYGMDEVEQDQHEARLKELFDSFDTTGTGSLGQ
EELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLS
NEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLD
EEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHN
LDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRT
TTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALD
FSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVV
REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERI
AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQE
ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEV
EANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELE
DKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ
GQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKAR
LTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCE
SALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETL
KREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQ
SLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQER
QEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLS
MLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQN
RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGF
SELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSV
LKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENN
KELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQG
KIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI
LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD
VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI
TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQIS
ELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSAL
EEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKL
AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL
QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLH
NQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQL
ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN
SLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQE
QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQKPRYEIRWKVIESVSS
DGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH
SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKG
GPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGL
PLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAP
YDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVH
RDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPES
IFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMA
QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVD
EEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIP
LPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEP
2632
3D view using mol* of 1167 (AA BP:2083)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NIN_pLDDT.png
all structure
all structure
PDGFRB_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NIN_PDGFRB_1157_pLDDT.png (AA BP:2063)
all structure
NIN_PDGFRB_1167_pLDDT.png (AA BP:2083)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NINNIN, PRKACA, AURKA, GSK3B, AMOT, ELAVL1, LATS2, CEP170, CCDC68, TMOD1, CASQ2, C17orf59, CEP63, MED4, HERC2, OFD1, CEP128, CNTRL, ACTR1A, ANLN, AP3D1, CEP131, BAIAP2, CAMK2D, CC2D1A, CCDC138, CCNB1, CCNB2, CENPE, CEP164, CEP350, CKAP2, CLASP1, CLASP2, CSPP1, DBT, DCTN1, DCTN2, DHX35, DIAPH3, DYNC1H1, DYNC1I2, DYNC1LI1, DYNC1LI2, ECH1, EIF4ENIF1, ERC1, FAM83B, FGFR1OP, GPATCH1, HAUS1, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, HECTD1, HMMR, IQCB1, KIAA1671, KIF14, LUZP1, MAP7D3, MGA, NCKAP5L, NEDD1, NME7, PALLD, PCM1, PLK1, RASSF8, RLTPR, SAMD4B, SDCCAG3, SPC24, SVIL, TJP1, TNRC6B, TP53, TP53BP2, TTC28, TTF2, TTK, TXLNA, UNC45A, UPF1, WDR83, ACTR2, AHCY, ARPC3, CEP192, CSNK1A1, HMGN3, ISOC1, PIBF1, PMPCB, RAB2A, SSX2IP, TCHP, YWHAH, POC5, KIAA1244, NHP2L1, BAX, MYH13, DOT1L, Cep131, Wdr61, Fus, CDC14A, SYCE3, TCP10L, ZNF331, COG5, EGLN3, RBM10, GTSE1, YWHAE, KLC1, KIAA1429, DYNC1I1, APRT, DSG2, EIF6, ERLIN1, FLOT2, GANAB, GCAT, GNAI3, GSK3A, HUS1, LIPA, MCU, MEN1, MIA3, MRPL41, MSTO1, PCID2, PKP4, PRIM1, PUS1, RAB3B, RFC5, RPL35, SENP1, SLC25A15, STXBP3, TIMM44, TMEM165, TUBA1C, ATP6V1H, ANXA2, IQGAP1, ESYT2, ATP1A1, NUP93, NUP205, SLC25A4, CEP55, WDR3, MYO1D, DNAJB6, LMNB1, PLOD1, AGRN, RPL7, KRT5, NOMO2, GFPT1, ARHGEF2, PRDX4, ACOT9, MCM3, TAF2, LONP1, PFKM, DHX40, FLOT1, MTPAP, PPM1F, RBM14, TUBB6, ARCN1, DNAJA3, LTBP4, TUBB4A, AASS, XIAP, TSFM, ETFA, GTPBP1, GCLM, BICD1, ACTR10, C1orf198, C2CD3, C5orf42, CCDC14, CCDC22, CCDC57, CCDC66, CCDC77, CCDC85C, CCHCR1, CENPJ, CEP135, CEP152, CEP162, CEP170B, CEP250, CEP290, CEP295, CEP85L, CEP95, CGNL1, CIAPIN1, DCTN3, DCTN4, EIF4E2, FAM184A, FAM83G, FOPNL, GRN, ICK, IFFO2, KIF7, KIZ, LATS1, LCA5, LRRCC1, C17orf104, MZT2B, NDE1, ODF2, PDZRN3, PLEKHG1, PPP1R13B, PPP2R3A, PROSER3, PXN, RNF135, RPGRIP1L, SASS6, SCLT1, SPATA2, STIL, TBC1D5, TBKBP1, TEX9, TTC30A, TTLL5, TUBGCP2, TXLNG, WRAP73, YTHDF2, ALMS1, PCNT, SIPA1L3, CYLD, ANKRD26, TBC1D31, FAM83H, USP54, SPAG5, IFT81, LIMD1, CAMSAP1, BACH2, SIPA1L2, CKAP5, INA, GIGYF2, TANC1, CEP97, CTTN, CAMSAP3, HAUS2, ARHGAP21, CAPZB, CAMSAP2, VCPIP1, TTC26, XRN1, EIF4G2, SMG7, RINT1, APC, IFT74, TNRC6A, MIB1, ANKHD1-EIF4EBP3, TBK1, SIPA1L1, NDC80, BRCA2, IFT46, PRKACB, EXOC4, KRT8, L3MBTL2, TRIO, KNSTRN, DPYSL2, PSMC2, KRT19, BICD2, KIAA1217, ZNF598, CAPZA1, nsp13, C14orf166, AUNIP, HIST1H1A, CIT, KIF23, TRIM33, nsp13ab, ORF6, DNAJB5, KDM1A, KRT18, MLLT4, SEPT10, SYNE3, VPS33A, VPS33B, CEP170P1, C15orf59, PIP, ARSE, CCDC96, NUP62, KXD1, WHAMMP3, SNRPC, MBD3L2, PTP4A3, KRT38, SGCA, SERINC2, RNF185, MRPL38, SKA3, APLNR, CCDC51, SNW1, PRPF6, UTP14A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NINall structure
PDGFRBall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NIN-PDGFRB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NIN-PDGFRB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNINC3553870SECKEL SYNDROME 72GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePDGFRBC3554321BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 46CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePDGFRBC0393590Fahr's syndrome (disorder)3GENOMICS_ENGLAND;ORPHANET
TgenePDGFRBC4225270Kosaki overgrowth syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePDGFRBC4551572MYOFIBROMATOSIS, INFANTILE, 13GENOMICS_ENGLAND;UNIPROT
TgenePDGFRBC0013421Dystonia2GENOMICS_ENGLAND
TgenePDGFRBC0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
TgenePDGFRBC0023893Liver Cirrhosis, Experimental2CTD_human
TgenePDGFRBC0036341Schizophrenia2PSYGENET
TgenePDGFRBC0432284Infantile myofibromatosis2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgenePDGFRBC0004782Basal Ganglia Diseases1CTD_human
TgenePDGFRBC0006663Calcinosis1CTD_human
TgenePDGFRBC0015371Extrapyramidal Disorders1CTD_human
TgenePDGFRBC0036337Schizoaffective Disorder1PSYGENET
TgenePDGFRBC0206648Myofibromatosis1GENOMICS_ENGLAND
TgenePDGFRBC0263628Tumoral calcinosis1CTD_human
TgenePDGFRBC0521174Microcalcification1CTD_human
TgenePDGFRBC0750951Lenticulostriate Disorders1CTD_human
TgenePDGFRBC1333046Myeloproliferative Neoplasm, Unclassifiable1ORPHANET
TgenePDGFRBC1866182Penttinen-Aula syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePDGFRBC3472621Myeloid neoplasm with beta-type platelet-derived growth factor receptor gene rearrangement1ORPHANET
TgenePDGFRBC3714756Intellectual Disability1GENOMICS_ENGLAND