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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NLRC5-ILF2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NLRC5-ILF2
FusionPDB ID: 59373
FusionGDB2.0 ID: 59373
HgeneTgene
Gene symbol

NLRC5

ILF2

Gene ID

84166

3608

Gene nameNLR family CARD domain containing 5interleukin enhancer binding factor 2
SynonymsCLR16.1|NOD27|NOD4NF45|PRO3063
Cytomap

16q13

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotein NLRC5NOD-like receptor C5caterpiller protein 16.1nucleotide-binding oligomerization domain protein 4nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5nucleotide-binding oligomerization domains 27interleukin enhancer-binding factor 2interleukin enhancer binding factor 2, 45kDinterleukin enhancer binding factor 2, 45kDanuclear factor of activated T-cells, 45-kDa
Modification date2020031320200313
UniProtAcc

Q86WI3

Q12905

Ensembl transtripts involved in fusion geneENST idsENST00000262510, ENST00000308149, 
ENST00000436936, ENST00000539144, 
ENST00000543141, 		ENST00000368681, 
ENST00000480213, ENST00000361891, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 10 X 6=4808 X 8 X 3=192
# samples 108
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NLRC5 [Title/Abstract] AND ILF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NLRC5(57054919)-ILF2(153636950), # samples:1
Anticipated loss of major functional domain due to fusion event.NLRC5-ILF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NLRC5-ILF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NLRC5-ILF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NLRC5-ILF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NLRC5-ILF2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NLRC5-ILF2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNLRC5

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20434986

HgeneNLRC5

GO:0043549

regulation of kinase activity

20434986

HgeneNLRC5

GO:0045345

positive regulation of MHC class I biosynthetic process

20639463

HgeneNLRC5

GO:0045944

positive regulation of transcription by RNA polymerase II

20639463

HgeneNLRC5

GO:0060335

positive regulation of interferon-gamma-mediated signaling pathway

20061403

HgeneNLRC5

GO:0060339

negative regulation of type I interferon-mediated signaling pathway

20434986

HgeneNLRC5

GO:0060340

positive regulation of type I interferon-mediated signaling pathway

20061403

TgeneILF2

GO:0006351

transcription, DNA-templated

11739746

TgeneILF2

GO:0045893

positive regulation of transcription, DNA-templated

11739746


check buttonFusion gene breakpoints across NLRC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ILF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A2G7NLRC5chr16

57054919

+ILF2chr1

153636950

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262510NLRC5chr1657054919+ENST00000361891ILF2chr1153636950-14765202251115296
ENST00000436936NLRC5chr1657054919+ENST00000361891ILF2chr1153636950-14765202251115296
ENST00000308149NLRC5chr1657054919+ENST00000361891ILF2chr1153636950-14765202251115296
ENST00000539144NLRC5chr1657054919+ENST00000361891ILF2chr1153636950-12512950890296

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262510ENST00000361891NLRC5chr1657054919+ILF2chr1153636950-0.0056857730.99431425
ENST00000436936ENST00000361891NLRC5chr1657054919+ILF2chr1153636950-0.0056857730.99431425
ENST00000308149ENST00000361891NLRC5chr1657054919+ILF2chr1153636950-0.0056857730.99431425
ENST00000539144ENST00000361891NLRC5chr1657054919+ILF2chr1153636950-0.0038243570.99617565

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59373_59373_1_NLRC5-ILF2_NLRC5_chr16_57054919_ENST00000262510_ILF2_chr1_153636950_ENST00000361891_length(amino acids)=296AA_BP=98
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL
LSTFGYDDVDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQI
LAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEK

--------------------------------------------------------------

>59373_59373_2_NLRC5-ILF2_NLRC5_chr16_57054919_ENST00000308149_ILF2_chr1_153636950_ENST00000361891_length(amino acids)=296AA_BP=98
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL
LSTFGYDDVDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQI
LAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEK

--------------------------------------------------------------

>59373_59373_3_NLRC5-ILF2_NLRC5_chr16_57054919_ENST00000436936_ILF2_chr1_153636950_ENST00000361891_length(amino acids)=296AA_BP=98
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL
LSTFGYDDVDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQI
LAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEK

--------------------------------------------------------------

>59373_59373_4_NLRC5-ILF2_NLRC5_chr16_57054919_ENST00000539144_ILF2_chr1_153636950_ENST00000361891_length(amino acids)=296AA_BP=98
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL
LSTFGYDDVDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQI
LAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:57054919/chr1:153636950)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NLRC5

Q86WI3

ILF2

Q12905

FUNCTION: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269|PubMed:20061403, ECO:0000269|PubMed:20434986}.FUNCTION: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:9442054}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneILF2chr16:57054919chr1:153636950ENST00000361891714366_372192.33333333333334391.0Compositional biasNote=Poly-Glu
TgeneILF2chr16:57054919chr1:153636950ENST00000361891714381_384192.33333333333334391.0Compositional biasNote=Poly-Glu

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349222_53998.333333333333331867.0DomainNACHT
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348222_53998.333333333333331838.0DomainNACHT
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349222_53998.333333333333331294.6666666666667DomainNACHT
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146222_53998.333333333333331838.0DomainNACHT
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349228_23598.333333333333331867.0Nucleotide bindingATP
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348228_23598.333333333333331838.0Nucleotide bindingATP
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349228_23598.333333333333331294.6666666666667Nucleotide bindingATP
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146228_23598.333333333333331838.0Nucleotide bindingATP
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491004_102698.333333333333331867.0RepeatNote=LRR 9
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491031_105898.333333333333331867.0RepeatNote=LRR 10
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491138_116198.333333333333331867.0RepeatNote=LRR 11
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491162_118498.333333333333331867.0RepeatNote=LRR 12
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491242_126598.333333333333331867.0RepeatNote=LRR 13
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491272_129498.333333333333331867.0RepeatNote=LRR 14
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491462_148898.333333333333331867.0RepeatNote=LRR 15
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491493_151698.333333333333331867.0RepeatNote=LRR 16
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491521_154498.333333333333331867.0RepeatNote=LRR 17
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491554_157798.333333333333331867.0RepeatNote=LRR 18
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491578_160098.333333333333331867.0RepeatNote=LRR 19
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491605_162898.333333333333331867.0RepeatNote=LRR 20
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491633_165698.333333333333331867.0RepeatNote=LRR 21
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491661_168498.333333333333331867.0RepeatNote=LRR 22
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491687_171498.333333333333331867.0RepeatNote=LRR 23
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491715_173998.333333333333331867.0RepeatNote=LRR 24
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491741_176298.333333333333331867.0RepeatNote=LRR 25
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+3491795_181898.333333333333331867.0RepeatNote=LRR 26
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349599_62298.333333333333331867.0RepeatNote=LRR 1
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349713_73798.333333333333331867.0RepeatNote=LRR 2
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349741_76598.333333333333331867.0RepeatNote=LRR 3
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349769_79298.333333333333331867.0RepeatNote=LRR 4
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349869_89298.333333333333331867.0RepeatNote=LRR 5
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349897_92198.333333333333331867.0RepeatNote=LRR 6
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349930_95398.333333333333331867.0RepeatNote=LRR 7
HgeneNLRC5chr16:57054919chr1:153636950ENST00000262510+349976_100098.333333333333331867.0RepeatNote=LRR 8
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481004_102698.333333333333331838.0RepeatNote=LRR 9
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481031_105898.333333333333331838.0RepeatNote=LRR 10
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481138_116198.333333333333331838.0RepeatNote=LRR 11
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481162_118498.333333333333331838.0RepeatNote=LRR 12
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481242_126598.333333333333331838.0RepeatNote=LRR 13
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481272_129498.333333333333331838.0RepeatNote=LRR 14
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481462_148898.333333333333331838.0RepeatNote=LRR 15
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481493_151698.333333333333331838.0RepeatNote=LRR 16
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481521_154498.333333333333331838.0RepeatNote=LRR 17
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481554_157798.333333333333331838.0RepeatNote=LRR 18
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481578_160098.333333333333331838.0RepeatNote=LRR 19
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481605_162898.333333333333331838.0RepeatNote=LRR 20
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481633_165698.333333333333331838.0RepeatNote=LRR 21
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481661_168498.333333333333331838.0RepeatNote=LRR 22
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481687_171498.333333333333331838.0RepeatNote=LRR 23
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481715_173998.333333333333331838.0RepeatNote=LRR 24
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481741_176298.333333333333331838.0RepeatNote=LRR 25
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+3481795_181898.333333333333331838.0RepeatNote=LRR 26
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348599_62298.333333333333331838.0RepeatNote=LRR 1
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348713_73798.333333333333331838.0RepeatNote=LRR 2
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348741_76598.333333333333331838.0RepeatNote=LRR 3
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348769_79298.333333333333331838.0RepeatNote=LRR 4
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348869_89298.333333333333331838.0RepeatNote=LRR 5
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348897_92198.333333333333331838.0RepeatNote=LRR 6
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348930_95398.333333333333331838.0RepeatNote=LRR 7
HgeneNLRC5chr16:57054919chr1:153636950ENST00000308149+348976_100098.333333333333331838.0RepeatNote=LRR 8
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491004_102698.333333333333331294.6666666666667RepeatNote=LRR 9
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491031_105898.333333333333331294.6666666666667RepeatNote=LRR 10
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491138_116198.333333333333331294.6666666666667RepeatNote=LRR 11
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491162_118498.333333333333331294.6666666666667RepeatNote=LRR 12
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491242_126598.333333333333331294.6666666666667RepeatNote=LRR 13
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491272_129498.333333333333331294.6666666666667RepeatNote=LRR 14
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491462_148898.333333333333331294.6666666666667RepeatNote=LRR 15
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491493_151698.333333333333331294.6666666666667RepeatNote=LRR 16
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491521_154498.333333333333331294.6666666666667RepeatNote=LRR 17
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491554_157798.333333333333331294.6666666666667RepeatNote=LRR 18
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491578_160098.333333333333331294.6666666666667RepeatNote=LRR 19
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491605_162898.333333333333331294.6666666666667RepeatNote=LRR 20
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491633_165698.333333333333331294.6666666666667RepeatNote=LRR 21
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491661_168498.333333333333331294.6666666666667RepeatNote=LRR 22
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491687_171498.333333333333331294.6666666666667RepeatNote=LRR 23
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491715_173998.333333333333331294.6666666666667RepeatNote=LRR 24
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491741_176298.333333333333331294.6666666666667RepeatNote=LRR 25
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+3491795_181898.333333333333331294.6666666666667RepeatNote=LRR 26
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349599_62298.333333333333331294.6666666666667RepeatNote=LRR 1
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349713_73798.333333333333331294.6666666666667RepeatNote=LRR 2
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349741_76598.333333333333331294.6666666666667RepeatNote=LRR 3
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349769_79298.333333333333331294.6666666666667RepeatNote=LRR 4
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349869_89298.333333333333331294.6666666666667RepeatNote=LRR 5
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349897_92198.333333333333331294.6666666666667RepeatNote=LRR 6
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349930_95398.333333333333331294.6666666666667RepeatNote=LRR 7
HgeneNLRC5chr16:57054919chr1:153636950ENST00000436936+349976_100098.333333333333331294.6666666666667RepeatNote=LRR 8
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461004_102698.333333333333331838.0RepeatNote=LRR 9
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461031_105898.333333333333331838.0RepeatNote=LRR 10
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461138_116198.333333333333331838.0RepeatNote=LRR 11
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461162_118498.333333333333331838.0RepeatNote=LRR 12
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461242_126598.333333333333331838.0RepeatNote=LRR 13
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461272_129498.333333333333331838.0RepeatNote=LRR 14
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461462_148898.333333333333331838.0RepeatNote=LRR 15
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461493_151698.333333333333331838.0RepeatNote=LRR 16
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461521_154498.333333333333331838.0RepeatNote=LRR 17
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461554_157798.333333333333331838.0RepeatNote=LRR 18
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461578_160098.333333333333331838.0RepeatNote=LRR 19
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461605_162898.333333333333331838.0RepeatNote=LRR 20
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461633_165698.333333333333331838.0RepeatNote=LRR 21
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461661_168498.333333333333331838.0RepeatNote=LRR 22
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461687_171498.333333333333331838.0RepeatNote=LRR 23
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461715_173998.333333333333331838.0RepeatNote=LRR 24
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461741_176298.333333333333331838.0RepeatNote=LRR 25
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+1461795_181898.333333333333331838.0RepeatNote=LRR 26
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146599_62298.333333333333331838.0RepeatNote=LRR 1
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146713_73798.333333333333331838.0RepeatNote=LRR 2
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146741_76598.333333333333331838.0RepeatNote=LRR 3
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146769_79298.333333333333331838.0RepeatNote=LRR 4
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146869_89298.333333333333331838.0RepeatNote=LRR 5
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146897_92198.333333333333331838.0RepeatNote=LRR 6
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146930_95398.333333333333331838.0RepeatNote=LRR 7
HgeneNLRC5chr16:57054919chr1:153636950ENST00000539144+146976_100098.333333333333331838.0RepeatNote=LRR 8
TgeneILF2chr16:57054919chr1:153636950ENST0000036189171424_371192.33333333333334391.0DomainDZF


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NLRC5
ILF2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NLRC5-ILF2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NLRC5-ILF2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource