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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NOLC1-IYD

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NOLC1-IYD
	FusionPDB ID: 59580
	FusionGDB2.0 ID: 59580
		Hgene	Tgene
	Gene symbol	NOLC1	IYD
	Gene ID	9221	389434
	Gene name	nucleolar and coiled-body phosphoprotein 1	iodotyrosine deiodinase
	Synonyms	NOPP130\|NOPP140\|NS5ATP13\|P130\|Srp40	C6orf71\|DEHAL1\|IYD-1\|TDH4
	Cytomap	10q24.32	6q25.1
	Type of gene	protein-coding	protein-coding
	Description	nucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphp	iodotyrosine deiodinase 1iodotyrosine dehalogenase 1
	Modification date	20200313	20200313
	UniProtAcc	Q14978	Q6PHW0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000477977, ENST00000405356, ENST00000488254, ENST00000603742, ENST00000605788,	ENST00000229447, ENST00000344419, ENST00000392255, ENST00000392256, ENST00000425615, ENST00000500320,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 7 X 2=98	4 X 4 X 4=64
	# samples	7	5
	** MAII score	log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NOLC1 [Title/Abstract] AND IYD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NOLC1(103920547)-IYD(150713589), # samples:1
Anticipated loss of major functional domain due to fusion event.	NOLC1-IYD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NOLC1-IYD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	IYD	GO:0006570	tyrosine metabolic process	25395621
Tgene	IYD	GO:0042403	thyroid hormone metabolic process	25395621
Tgene	IYD	GO:0055114	oxidation-reduction process	25395621

Fusion gene breakpoints across NOLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IYD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BG949184	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000605788	NOLC1	chr10	103920547	-	ENST00000229447	IYD	chr6	150713589	-	8531	1637	187	1644	485
ENST00000605788	NOLC1	chr10	103920547	-	ENST00000344419	IYD	chr6	150713589	-	9760	1637	187	1644	485
ENST00000605788	NOLC1	chr10	103920547	-	ENST00000392256	IYD	chr6	150713589	-	1961	1637	187	1644	485
ENST00000605788	NOLC1	chr10	103920547	-	ENST00000392255	IYD	chr6	150713589	-	2303	1637	187	1644	485
ENST00000605788	NOLC1	chr10	103920547	-	ENST00000500320	IYD	chr6	150713589	-	3281	1637	187	1644	485
ENST00000605788	NOLC1	chr10	103920547	-	ENST00000425615	IYD	chr6	150713589	-	1984	1637	187	1644	485
ENST00000405356	NOLC1	chr10	103920547	-	ENST00000229447	IYD	chr6	150713589	-	8561	1667	187	1674	495
ENST00000405356	NOLC1	chr10	103920547	-	ENST00000344419	IYD	chr6	150713589	-	9790	1667	187	1674	495
ENST00000405356	NOLC1	chr10	103920547	-	ENST00000392256	IYD	chr6	150713589	-	1991	1667	187	1674	495
ENST00000405356	NOLC1	chr10	103920547	-	ENST00000392255	IYD	chr6	150713589	-	2333	1667	187	1674	495
ENST00000405356	NOLC1	chr10	103920547	-	ENST00000500320	IYD	chr6	150713589	-	3311	1667	187	1674	495
ENST00000405356	NOLC1	chr10	103920547	-	ENST00000425615	IYD	chr6	150713589	-	2014	1667	187	1674	495
ENST00000603742	NOLC1	chr10	103920547	-	ENST00000229447	IYD	chr6	150713589	-	8154	1260	197	1267	356
ENST00000603742	NOLC1	chr10	103920547	-	ENST00000344419	IYD	chr6	150713589	-	9383	1260	197	1267	356
ENST00000603742	NOLC1	chr10	103920547	-	ENST00000392256	IYD	chr6	150713589	-	1584	1260	197	1267	356
ENST00000603742	NOLC1	chr10	103920547	-	ENST00000392255	IYD	chr6	150713589	-	1926	1260	197	1267	356
ENST00000603742	NOLC1	chr10	103920547	-	ENST00000500320	IYD	chr6	150713589	-	2904	1260	197	1267	356
ENST00000603742	NOLC1	chr10	103920547	-	ENST00000425615	IYD	chr6	150713589	-	1607	1260	197	1267	356
ENST00000488254	NOLC1	chr10	103920547	-	ENST00000229447	IYD	chr6	150713589	-	8306	1412	7	1419	470
ENST00000488254	NOLC1	chr10	103920547	-	ENST00000344419	IYD	chr6	150713589	-	9535	1412	7	1419	470
ENST00000488254	NOLC1	chr10	103920547	-	ENST00000392256	IYD	chr6	150713589	-	1736	1412	7	1419	470
ENST00000488254	NOLC1	chr10	103920547	-	ENST00000392255	IYD	chr6	150713589	-	2078	1412	7	1419	470
ENST00000488254	NOLC1	chr10	103920547	-	ENST00000500320	IYD	chr6	150713589	-	3056	1412	7	1419	470
ENST00000488254	NOLC1	chr10	103920547	-	ENST00000425615	IYD	chr6	150713589	-	1759	1412	7	1419	470

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000605788	ENST00000229447	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.000352961	0.999647
ENST00000605788	ENST00000344419	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.000281596	0.99971837
ENST00000605788	ENST00000392256	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.00772983	0.9922701
ENST00000605788	ENST00000392255	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.006962955	0.99303705
ENST00000605788	ENST00000500320	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.001639776	0.9983602
ENST00000605788	ENST00000425615	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.007646341	0.9923537
ENST00000405356	ENST00000229447	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.000460694	0.9995394
ENST00000405356	ENST00000344419	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.000367754	0.99963224
ENST00000405356	ENST00000392256	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.009762534	0.99023753
ENST00000405356	ENST00000392255	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.008409672	0.9915903
ENST00000405356	ENST00000500320	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.002028073	0.99797195
ENST00000405356	ENST00000425615	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.009753907	0.99024606
ENST00000603742	ENST00000229447	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.000431638	0.9995684
ENST00000603742	ENST00000344419	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.00026725	0.9997328
ENST00000603742	ENST00000392256	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.002062822	0.9979372
ENST00000603742	ENST00000392255	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.002415633	0.99758434
ENST00000603742	ENST00000500320	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.001052707	0.9989473
ENST00000603742	ENST00000425615	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.002173416	0.9978265
ENST00000488254	ENST00000229447	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.000497147	0.9995029
ENST00000488254	ENST00000344419	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.000393325	0.99960667
ENST00000488254	ENST00000392256	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.01424855	0.98575145
ENST00000488254	ENST00000392255	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.012692777	0.9873072
ENST00000488254	ENST00000500320	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.002780187	0.9972198
ENST00000488254	ENST00000425615	NOLC1	chr10	103920547	-	IYD	chr6	150713589	-	0.013956321	0.9860437

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59580_59580_1_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000405356_IYD_chr6_150713589_ENST00000229447_length(amino acids)=495AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKVWTITSVRAETVP
KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE
EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG

--------------------------------------------------------------

>59580_59580_2_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000405356_IYD_chr6_150713589_ENST00000344419_length(amino acids)=495AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKVWTITSVRAETVP
KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE
EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG

--------------------------------------------------------------

>59580_59580_3_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000405356_IYD_chr6_150713589_ENST00000392255_length(amino acids)=495AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKVWTITSVRAETVP
KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE
EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG

--------------------------------------------------------------

>59580_59580_4_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000405356_IYD_chr6_150713589_ENST00000392256_length(amino acids)=495AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKVWTITSVRAETVP
KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE
EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG

--------------------------------------------------------------

>59580_59580_5_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000405356_IYD_chr6_150713589_ENST00000425615_length(amino acids)=495AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKVWTITSVRAETVP
KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE
EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG

--------------------------------------------------------------

>59580_59580_6_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000405356_IYD_chr6_150713589_ENST00000500320_length(amino acids)=495AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKVWTITSVRAETVP
KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE
EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG

--------------------------------------------------------------

>59580_59580_7_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000488254_IYD_chr6_150713589_ENST00000229447_length(amino acids)=470AA_BP=
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLNRSAKVPERKLQANGPVAKKAKKKASSSDSED
SSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP
PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED
SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA
ESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN

--------------------------------------------------------------

>59580_59580_8_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000488254_IYD_chr6_150713589_ENST00000344419_length(amino acids)=470AA_BP=
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLNRSAKVPERKLQANGPVAKKAKKKASSSDSED
SSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP
PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED
SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA
ESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN

--------------------------------------------------------------

>59580_59580_9_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000488254_IYD_chr6_150713589_ENST00000392255_length(amino acids)=470AA_BP=
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLNRSAKVPERKLQANGPVAKKAKKKASSSDSED
SSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP
PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED
SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA
ESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN

--------------------------------------------------------------

>59580_59580_10_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000488254_IYD_chr6_150713589_ENST00000392256_length(amino acids)=470AA_BP=
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLNRSAKVPERKLQANGPVAKKAKKKASSSDSED
SSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP
PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED
SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA
ESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN

--------------------------------------------------------------

>59580_59580_11_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000488254_IYD_chr6_150713589_ENST00000425615_length(amino acids)=470AA_BP=
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLNRSAKVPERKLQANGPVAKKAKKKASSSDSED
SSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP
PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED
SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA
ESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN

--------------------------------------------------------------

>59580_59580_12_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000488254_IYD_chr6_150713589_ENST00000500320_length(amino acids)=470AA_BP=
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLNRSAKVPERKLQANGPVAKKAKKKASSSDSED
SSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP
PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED
SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA
ESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN

--------------------------------------------------------------

>59580_59580_13_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000603742_IYD_chr6_150713589_ENST00000229447_length(amino acids)=356AA_BP=
MPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA
RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP
PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQK

--------------------------------------------------------------

>59580_59580_14_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000603742_IYD_chr6_150713589_ENST00000344419_length(amino acids)=356AA_BP=
MPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA
RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP
PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQK

--------------------------------------------------------------

>59580_59580_15_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000603742_IYD_chr6_150713589_ENST00000392255_length(amino acids)=356AA_BP=
MPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA
RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP
PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQK

--------------------------------------------------------------

>59580_59580_16_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000603742_IYD_chr6_150713589_ENST00000392256_length(amino acids)=356AA_BP=
MPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA
RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP
PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQK

--------------------------------------------------------------

>59580_59580_17_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000603742_IYD_chr6_150713589_ENST00000425615_length(amino acids)=356AA_BP=
MPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA
RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP
PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQK

--------------------------------------------------------------

>59580_59580_18_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000603742_IYD_chr6_150713589_ENST00000500320_length(amino acids)=356AA_BP=
MPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA
RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP
PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQK

--------------------------------------------------------------

>59580_59580_19_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000605788_IYD_chr6_150713589_ENST00000229447_length(amino acids)=485AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV
KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV
VSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN

--------------------------------------------------------------

>59580_59580_20_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000605788_IYD_chr6_150713589_ENST00000344419_length(amino acids)=485AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV
KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV
VSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN

--------------------------------------------------------------

>59580_59580_21_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000605788_IYD_chr6_150713589_ENST00000392255_length(amino acids)=485AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV
KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV
VSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN

--------------------------------------------------------------

>59580_59580_22_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000605788_IYD_chr6_150713589_ENST00000392256_length(amino acids)=485AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV
KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV
VSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN

--------------------------------------------------------------

>59580_59580_23_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000605788_IYD_chr6_150713589_ENST00000425615_length(amino acids)=485AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV
KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV
VSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN

--------------------------------------------------------------

>59580_59580_24_NOLC1-IYD_NOLC1_chr10_103920547_ENST00000605788_IYD_chr6_150713589_ENST00000500320_length(amino acids)=485AA_BP=
MSRAASTTVVTRIAWRMADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPV
AKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKA
KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV
KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV
VSKATTKPPPAKKAAESSSDSSEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:103920547/chr6:150713589)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NOLC1 Q14978	IYD Q6PHW0
FUNCTION: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269\|PubMed:10567578, ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:9016786}.	FUNCTION: Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:25395621, PubMed:18434651). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways (PubMed:18434651). Acts more efficiently on monoiodotyrosine than on diiodotyrosine (PubMed:15289438). {ECO:0000269\|PubMed:15289438, ECO:0000269\|PubMed:18434651, ECO:0000269\|PubMed:25395621}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000229447

100_104

294.0

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000229447

128_129

294.0

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000229447

237_239

294.0

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000344419

100_104

290.0

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000344419

128_129

290.0

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000344419

237_239

290.0

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000392256

100_104

180.66666666666666

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000392256

128_129

180.66666666666666

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000392256

237_239

180.66666666666666

Nucleotide binding

FMN

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000229447

236_289

294.0

Topological domain

Cytoplasmic

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000229447

24_214

294.0

Topological domain

Extracellular

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000344419

236_289

290.0

Topological domain

Cytoplasmic

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000344419

24_214

290.0

Topological domain

Extracellular

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000392256

236_289

180.66666666666666

Topological domain

Cytoplasmic

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000392256

24_214

180.66666666666666

Topological domain

Extracellular

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000229447

215_235

294.0

Transmembrane

Helical

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000344419

215_235

290.0

Transmembrane

Helical

Tgene

IYD

chr10:103920547

chr6:150713589

ENST00000392256

215_235

180.66666666666666

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

10_42

710.0

Domain

LisH

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

10_42

701.0

Domain

LisH

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

10_42

700.0

Domain

LisH

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

384_587

710.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

601_617

710.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

68_82

710.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

384_587

701.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

601_617

701.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

68_82

701.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

384_587

700.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

601_617

700.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

68_82

700.0

Motif

Nuclear localization signal

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

84_566

710.0

Region

Note=11 X 12 AA approximate repeats of an acidic serine cluster

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

84_566

701.0

Region

Note=11 X 12 AA approximate repeats of an acidic serine cluster

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

84_566

700.0

Region

Note=11 X 12 AA approximate repeats of an acidic serine cluster

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

125_136

710.0

Repeat

Note=Acidic serine cluster 2

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

167_178

710.0

Repeat

Note=Acidic serine cluster 3

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

221_232

710.0

Repeat

Note=Acidic serine cluster 4

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

264_275

710.0

Repeat

Note=Acidic serine cluster 5

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

325_336

710.0

Repeat

Note=Acidic serine cluster 6

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

363_375

710.0

Repeat

Note=Acidic serine cluster 7

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

425_436

710.0

Repeat

Note=Acidic serine cluster 8

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

470_481

710.0

Repeat

Note=Acidic serine cluster 9

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

519_529

710.0

Repeat

Note=Acidic serine cluster 10

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

555_566

710.0

Repeat

Note=Acidic serine cluster 11

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000405356

84_95

710.0

Repeat

Note=Acidic serine cluster 1

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

125_136

701.0

Repeat

Note=Acidic serine cluster 2

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

167_178

701.0

Repeat

Note=Acidic serine cluster 3

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

221_232

701.0

Repeat

Note=Acidic serine cluster 4

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

264_275

701.0

Repeat

Note=Acidic serine cluster 5

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

325_336

701.0

Repeat

Note=Acidic serine cluster 6

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

363_375

701.0

Repeat

Note=Acidic serine cluster 7

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

425_436

701.0

Repeat

Note=Acidic serine cluster 8

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

470_481

701.0

Repeat

Note=Acidic serine cluster 9

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

519_529

701.0

Repeat

Note=Acidic serine cluster 10

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

555_566

701.0

Repeat

Note=Acidic serine cluster 11

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000488254

84_95

701.0

Repeat

Note=Acidic serine cluster 1

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

125_136

700.0

Repeat

Note=Acidic serine cluster 2

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

167_178

700.0

Repeat

Note=Acidic serine cluster 3

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

221_232

700.0

Repeat

Note=Acidic serine cluster 4

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

264_275

700.0

Repeat

Note=Acidic serine cluster 5

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

325_336

700.0

Repeat

Note=Acidic serine cluster 6

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

363_375

700.0

Repeat

Note=Acidic serine cluster 7

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

425_436

700.0

Repeat

Note=Acidic serine cluster 8

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

470_481

700.0

Repeat

Note=Acidic serine cluster 9

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

519_529

700.0

Repeat

Note=Acidic serine cluster 10

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

555_566

700.0

Repeat

Note=Acidic serine cluster 11

Hgene

NOLC1

chr10:103920547

chr6:150713589

ENST00000605788

84_95

700.0

Repeat

Note=Acidic serine cluster 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NOLC1
IYD

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NOLC1	chr10:103920547	chr6:150713589	ENST00000405356	-	1	13	204_382	0	710.0	RPA194
Hgene	NOLC1	chr10:103920547	chr6:150713589	ENST00000488254	-	1	13	204_382	0	701.0	RPA194
Hgene	NOLC1	chr10:103920547	chr6:150713589	ENST00000605788	-	1	13	204_382	0	700.0	RPA194

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Related Drugs to NOLC1-IYD

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NOLC1-IYD

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source