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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NOTCH2-PDE4DIP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NOTCH2-PDE4DIP
FusionPDB ID: 59764
FusionGDB2.0 ID: 59764
HgeneTgene
Gene symbol

NOTCH2

PDE4DIP

Gene ID

4853

9659

Gene namenotch receptor 2phosphodiesterase 4D interacting protein
SynonymsAGS2|HJCYS|hN2CMYA2|MMGL
Cytomap

1p12

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 2Notch homolog 2notch 2myomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8
Modification date2020032920200313
UniProtAcc

P0DPK3

.
Ensembl transtripts involved in fusion geneENST idsENST00000256646, ENST00000602566, 
ENST00000493703, 		ENST00000313431, 
ENST00000369345, ENST00000369347, 
ENST00000369348, ENST00000369349, 
ENST00000369351, ENST00000369354, 
ENST00000369356, ENST00000369359, 
ENST00000478649, ENST00000479408, 
ENST00000493130, ENST00000524974, 
ENST00000529945, ENST00000530740, 
ENST00000313382, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 22 X 14=800812 X 9 X 8=864
# samples 3513
** MAII scorelog2(35/8008*10)=-4.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NOTCH2 [Title/Abstract] AND PDE4DIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NOTCH2(120466260)-PDE4DIP(144994701), # samples:1
NOTCH2(120572529)-PDE4DIP(145021167), # samples:1
Anticipated loss of major functional domain due to fusion event.NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH2

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH2

GO:0007219

Notch signaling pathway

11306509|25985737

HgeneNOTCH2

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH2

GO:0010838

positive regulation of keratinocyte proliferation

18469519

HgeneNOTCH2

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH2

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH2

GO:2000249

regulation of actin cytoskeleton reorganization

18469519

TgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across NOTCH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE4DIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-NJ-A4YF-01ANOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
ChimerDB4PRADTCGA-EJ-5527NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256646NOTCH2chr1120572529-ENST00000313382PDE4DIPchr1145021167-81123751670772353

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256646ENST00000313382NOTCH2chr1120572529-PDE4DIPchr1145021167-0.0070547210.99294525

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59764_59764_1_NOTCH2-PDE4DIP_NOTCH2_chr1_120572529_ENST00000256646_PDE4DIP_chr1_145021167_ENST00000313382_length(amino acids)=2353AA_BP=120
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQ
TQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQF
EERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQS
LAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC
AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV
VRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ
EFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL
RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLL
SDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIP
SRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI
KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDR
TLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPP
SPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGE
LDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCG
RSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKV
IQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKL
AEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTK
DHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSH
SDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGT
IELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGR
GSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLH
FREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ
GNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDT
SPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHA
LEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:120466260/chr1:144994701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOTCH2

P0DPK3

.
FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955). {ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461002_10436.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461096_11246.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461212_12406.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461346_13856.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461431_14556.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046162_2056.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461736_17606.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461840_20776.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820462273_23126.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046238_3186.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046350_6846.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000031338204641_1326.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046743_9366.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191002_104301133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191096_112401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191212_124001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191346_138501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191431_145501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019162_20501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191736_176001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191840_207701133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310192273_231201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019238_31801133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019350_68401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000031343101941_13201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019743_93601133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041002_10430174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041096_11240174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041212_12400174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041346_13850174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041431_14550174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704162_2050174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041736_17600174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041840_20770174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347042273_23120174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704238_3180174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704350_6840174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693470441_1320174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704743_9360174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071002_104377.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071096_112477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071212_124077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071346_138577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071431_145577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807162_20577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071736_176077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071840_207777.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348072273_231277.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807238_31877.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807350_68477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807743_93677.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231002_10430970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231096_11240970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231212_12400970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231346_13850970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231431_14550970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023162_2050970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231736_17600970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231840_20770970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490232273_23120970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023238_3180970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023350_6840970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934902341_1320970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023743_9360970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221002_10430989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221096_11240989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221212_12400989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221346_13850989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221431_14550989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022162_2050989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221736_17600989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221840_20770989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510222273_23120989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022238_3180989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022350_6840989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036935102241_1320989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022743_9360989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441002_104302347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441096_112402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441212_124002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441346_138502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441431_145502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044162_20502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441736_176002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441840_207702347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540442273_231202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044238_31802347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044350_68402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036935404441_13202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044743_93602347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441002_104302363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441096_112402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441212_124002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441346_138502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441431_145502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044162_20502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441736_176002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441840_207702363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560442273_231202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044238_31802363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044350_68402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036935604441_13202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044743_93602363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461551_16426.6666666666666672241.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191551_164201133.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041551_16420174.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071551_164277.66666666666667311.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231551_16420970.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221551_16420989.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441551_164202347.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441551_164202363.0DomainOlduvai

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341645_164851.6666666666666642472.0Compositional biasNote=Poly-Ala
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341994_199751.6666666666666642472.0Compositional biasNote=Poly-Leu
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2342426_242951.6666666666666642472.0Compositional biasNote=Poly-Ser
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341025_106151.6666666666666642472.0DomainEGF-like 27%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234105_14351.6666666666666642472.0DomainEGF-like 3
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341063_109951.6666666666666642472.0DomainEGF-like 28
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341101_114751.6666666666666642472.0DomainEGF-like 29
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341149_118551.6666666666666642472.0DomainEGF-like 30%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341187_122351.6666666666666642472.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341225_126251.6666666666666642472.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341264_130251.6666666666666642472.0DomainEGF-like 33
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341304_134351.6666666666666642472.0DomainEGF-like 34
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341374_141251.6666666666666642472.0DomainEGF-like 35
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234144_18051.6666666666666642472.0DomainEGF-like 4
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234182_21951.6666666666666642472.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234221_25851.6666666666666642472.0DomainEGF-like 6
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234260_29651.6666666666666642472.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-23426_6351.6666666666666642472.0DomainEGF-like 1
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234298_33651.6666666666666642472.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234338_37451.6666666666666642472.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234375_41351.6666666666666642472.0DomainEGF-like 10
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234415_45451.6666666666666642472.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234456_49251.6666666666666642472.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234494_53051.6666666666666642472.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234532_56851.6666666666666642472.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234570_60551.6666666666666642472.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234607_64351.6666666666666642472.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234645_68051.6666666666666642472.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-23464_10251.6666666666666642472.0DomainEGF-like 2
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234682_71851.6666666666666642472.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234720_75551.6666666666666642472.0DomainEGF-like 19
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234757_79351.6666666666666642472.0DomainEGF-like 20%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234795_83151.6666666666666642472.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234833_87151.6666666666666642472.0DomainEGF-like 22
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234873_90951.6666666666666642472.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234911_94751.6666666666666642472.0DomainEGF-like 24%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234949_98551.6666666666666642472.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234987_102351.6666666666666642472.0DomainEGF-like 26%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341425_167751.6666666666666642472.0RegionNote=Negative regulatory region (NRR)
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341425_146551.6666666666666642472.0RepeatNote=LNR 1
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341466_150251.6666666666666642472.0RepeatNote=LNR 2
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341503_154451.6666666666666642472.0RepeatNote=LNR 3
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341827_187151.6666666666666642472.0RepeatNote=ANK 1
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341876_190551.6666666666666642472.0RepeatNote=ANK 2
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341909_193951.6666666666666642472.0RepeatNote=ANK 3
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341943_197251.6666666666666642472.0RepeatNote=ANK 4
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341976_200551.6666666666666642472.0RepeatNote=ANK 5
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2342009_203851.6666666666666642472.0RepeatNote=ANK 6
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341699_247151.6666666666666642472.0Topological domainCytoplasmic
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-23426_167751.6666666666666642472.0Topological domainExtracellular
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341678_169851.6666666666666642472.0TransmembraneHelical
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693480741_13277.66666666666667311.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NOTCH2
PDE4DIP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NOTCH2-PDE4DIP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NOTCH2-PDE4DIP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource