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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NOVA1-FUS

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NOVA1-FUS
	FusionPDB ID: 59799
	FusionGDB2.0 ID: 59799
		Hgene	Tgene
	Gene symbol	NOVA1	FUS
	Gene ID	4857	2521
	Gene name	NOVA alternative splicing regulator 1	FUS RNA binding protein
	Synonyms	Nova-1	ALS6\|ETM4\|FUS1\|HNRNPP2\|POMP75\|TLS
	Cytomap	14q12	16p11.2
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein Nova-1neuro-oncological ventral antigen 1onconeural ventral antigen 1paraneoplastic Ri antigenventral neuron-specific protein 1	RNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein
	Modification date	20200327	20200329
	UniProtAcc	P51513	P35637
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000344429, ENST00000465357, ENST00000539517, ENST00000547619, ENST00000574031, ENST00000267422, ENST00000551754,	ENST00000474990, ENST00000254108, ENST00000380244, ENST00000568685,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 5 X 5=175	20 X 13 X 10=2600
	# samples	8	22
	** MAII score	log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2600*10)=-3.56293619439116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NOVA1 [Title/Abstract] AND FUS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NOVA1(27064616)-FUS(31199646), # samples:1
Anticipated loss of major functional domain due to fusion event.	NOVA1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NOVA1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NOVA1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NOVA1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FUS	GO:0006355	regulation of transcription, DNA-templated	26124092
Tgene	FUS	GO:0006357	regulation of transcription by RNA polymerase II	25453086
Tgene	FUS	GO:0008380	RNA splicing	26124092
Tgene	FUS	GO:0043484	regulation of RNA splicing	25453086\|27731383
Tgene	FUS	GO:0048255	mRNA stabilization	27378374
Tgene	FUS	GO:0051260	protein homooligomerization	25453086
Tgene	FUS	GO:1905168	positive regulation of double-strand break repair via homologous recombination	10567410

Fusion gene breakpoints across NOVA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FUS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-S9-A7J0	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000465357	NOVA1	chr14	27064616	-	ENST00000254108	FUS	chr16	31199646	+	1480	330	50	1111	353
ENST00000465357	NOVA1	chr14	27064616	-	ENST00000380244	FUS	chr16	31199646	+	1276	330	50	1111	353
ENST00000465357	NOVA1	chr14	27064616	-	ENST00000568685	FUS	chr16	31199646	+	1252	330	50	1114	354
ENST00000539517	NOVA1	chr14	27064616	-	ENST00000254108	FUS	chr16	31199646	+	1748	598	318	1379	353
ENST00000539517	NOVA1	chr14	27064616	-	ENST00000380244	FUS	chr16	31199646	+	1544	598	318	1379	353
ENST00000539517	NOVA1	chr14	27064616	-	ENST00000568685	FUS	chr16	31199646	+	1520	598	318	1382	354
ENST00000344429	NOVA1	chr14	27064616	-	ENST00000254108	FUS	chr16	31199646	+	1434	284	4	1065	353
ENST00000344429	NOVA1	chr14	27064616	-	ENST00000380244	FUS	chr16	31199646	+	1230	284	4	1065	353
ENST00000344429	NOVA1	chr14	27064616	-	ENST00000568685	FUS	chr16	31199646	+	1206	284	4	1068	354
ENST00000547619	NOVA1	chr14	27064616	-	ENST00000254108	FUS	chr16	31199646	+	1489	339	59	1120	353
ENST00000547619	NOVA1	chr14	27064616	-	ENST00000380244	FUS	chr16	31199646	+	1285	339	59	1120	353
ENST00000547619	NOVA1	chr14	27064616	-	ENST00000568685	FUS	chr16	31199646	+	1261	339	59	1123	354
ENST00000574031	NOVA1	chr14	27064616	-	ENST00000254108	FUS	chr16	31199646	+	1454	304	24	1085	353
ENST00000574031	NOVA1	chr14	27064616	-	ENST00000380244	FUS	chr16	31199646	+	1250	304	24	1085	353
ENST00000574031	NOVA1	chr14	27064616	-	ENST00000568685	FUS	chr16	31199646	+	1226	304	24	1088	354

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000465357	ENST00000254108	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001605091	0.9983949
ENST00000465357	ENST00000380244	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001795554	0.99820447
ENST00000465357	ENST00000568685	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001109415	0.9988906
ENST00000539517	ENST00000254108	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.0017664	0.99823356
ENST00000539517	ENST00000380244	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001992889	0.9980071
ENST00000539517	ENST00000568685	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001168823	0.9988312
ENST00000344429	ENST00000254108	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.00158337	0.99841666
ENST00000344429	ENST00000380244	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.00184189	0.99815816
ENST00000344429	ENST00000568685	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001106777	0.9988932
ENST00000547619	ENST00000254108	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001556501	0.99844354
ENST00000547619	ENST00000380244	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001762231	0.9982377
ENST00000547619	ENST00000568685	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001097372	0.99890256
ENST00000574031	ENST00000254108	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001649006	0.998351
ENST00000574031	ENST00000380244	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001847299	0.9981527
ENST00000574031	ENST00000568685	NOVA1	chr14	27064616	-	FUS	chr16	31199646	+	0.001180158	0.99881977

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59799_59799_1_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000344429_FUS_chr16_31199646_ENST00000254108_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_2_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000344429_FUS_chr16_31199646_ENST00000380244_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_3_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000344429_FUS_chr16_31199646_ENST00000568685_length(amino acids)=354AA_BP=210
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAID
WFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN

--------------------------------------------------------------

>59799_59799_4_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000465357_FUS_chr16_31199646_ENST00000254108_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_5_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000465357_FUS_chr16_31199646_ENST00000380244_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_6_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000465357_FUS_chr16_31199646_ENST00000568685_length(amino acids)=354AA_BP=210
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAID
WFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN

--------------------------------------------------------------

>59799_59799_7_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000539517_FUS_chr16_31199646_ENST00000254108_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_8_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000539517_FUS_chr16_31199646_ENST00000380244_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_9_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000539517_FUS_chr16_31199646_ENST00000568685_length(amino acids)=354AA_BP=210
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAID
WFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN

--------------------------------------------------------------

>59799_59799_10_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000547619_FUS_chr16_31199646_ENST00000254108_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_11_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000547619_FUS_chr16_31199646_ENST00000380244_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_12_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000547619_FUS_chr16_31199646_ENST00000568685_length(amino acids)=354AA_BP=210
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAID
WFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN

--------------------------------------------------------------

>59799_59799_13_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000574031_FUS_chr16_31199646_ENST00000254108_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_14_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000574031_FUS_chr16_31199646_ENST00000380244_length(amino acids)=353AA_BP=209
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>59799_59799_15_NOVA1-FUS_NOVA1_chr14_27064616_ENST00000574031_FUS_chr16_31199646_ENST00000568685_length(amino acids)=354AA_BP=210
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKD
FYPGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAID
WFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:27064616/chr16:31199646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NOVA1 P51513	FUS P35637
FUNCTION: May regulate RNA splicing or metabolism in a specific subset of developing neurons.	FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250\|UniProtKB:P56959, ECO:0000269\|PubMed:10567410, ECO:0000269\|PubMed:24204307, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27731383}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000344429

27_43

93.33333333333333

182.0

Motif

Bipartite nuclear localization signal

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000465357

27_43

93.33333333333333

484.0

Motif

Bipartite nuclear localization signal

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000539517

27_43

93.33333333333333

508.0

Motif

Bipartite nuclear localization signal

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000254108

371_526

266.3333333333333

527.0

Compositional bias

Note=Arg/Gly-rich

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000380244

371_526

265.3333333333333

526.0

Compositional bias

Note=Arg/Gly-rich

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000254108

285_371

266.3333333333333

527.0

Domain

RRM

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000380244

285_371

265.3333333333333

526.0

Domain

RRM

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000254108

422_453

266.3333333333333

527.0

Zinc finger

RanBP2-type

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000380244

422_453

265.3333333333333

526.0

Zinc finger

RanBP2-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000344429

273_409

93.33333333333333

182.0

Compositional bias

Note=Ala-rich

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000465357

273_409

93.33333333333333

484.0

Compositional bias

Note=Ala-rich

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000539517

273_409

93.33333333333333

508.0

Compositional bias

Note=Ala-rich

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000344429

171_237

93.33333333333333

182.0

Domain

KH 2

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000344429

421_488

93.33333333333333

182.0

Domain

KH 3

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000344429

49_116

93.33333333333333

182.0

Domain

KH 1

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000465357

171_237

93.33333333333333

484.0

Domain

KH 2

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000465357

421_488

93.33333333333333

484.0

Domain

KH 3

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000465357

49_116

93.33333333333333

484.0

Domain

KH 1

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000539517

171_237

93.33333333333333

508.0

Domain

KH 2

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000539517

421_488

93.33333333333333

508.0

Domain

KH 3

Hgene

NOVA1

chr14:27064616

chr16:31199646

ENST00000539517

49_116

93.33333333333333

508.0

Domain

KH 1

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000254108

166_267

266.3333333333333

527.0

Compositional bias

Note=Gly-rich

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000254108

1_165

266.3333333333333

527.0

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000380244

166_267

265.3333333333333

526.0

Compositional bias

Note=Gly-rich

Tgene

FUS

chr14:27064616

chr16:31199646

ENST00000380244

1_165

265.3333333333333

526.0

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

FUS

EIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, Mapk13, DGCR8, Pds5a, Shoc2, Ccdc15, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, ECM32, NAM8, SBP1, SKO1, VHR1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, rev, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, DBR1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, HSP104, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6, WDR77, PCBP1, PPIE, YAP1, EFTUD2, AAR2, PIH1D1, NKX2-1, CHD3, CHD4, TNF, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, CTDSPL2, AGR2, RECQL4, CDK9, ARID1A, SMARCA4, SMARCD1, DDIT3, SMARCC2, SMARCC1, SS18, SMARCB1, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H2, ATG16L1, LINC00470, AKT1, ACTC1, RBX1, MYC, MAPT, HIV2gp4, HIV2gp3, NR2C2, UBQLN2, HDAC2, ZFYVE21, XRCC6, DYNLT1, HIST1H4A, SNRNP70, SNRPA, SRSF1, SNRPB, SNRPC, SNRPD1, SNRPD3, RNU1-1, FUS, TRIM28, HNRNPA2B1, HNRNPR, PPP1R10, ILF2, DHX9, PABPC1, DDX3X, SRSF7, HNRNPM, HNRNPUL1, PABPC4, SF3B1, LARP1, PBRM1, THRAP3, MOV10, FAM120A, SKIV2L2, TOX, POLR2A, ELAVL1, SF3B2, STRBP, WDR82, HNRNPCL1, CCNT1, RBM14, U2SURP, DDX20, HIST1H1C, NUMA1, CCBL2, ZFR, ACIN1, CDC73, DDX23, SLTM, SRRT, IGF2BP3, ZC3H18, PRRC2A, HNRNPUL2, THOC1, AKAP8, BCLAF1, SRSF3, CHERP, INTS12, PAF1, PNN, PPFIA1, RBM10, SNRNP200, TOE1, TRA2B, HNRNPC, HNRNPA0, PPP1CC, CCAR1, DDX21, HNRNPAB, INTS6, POLR2B, PRPF6, RALY, RBM25, RBM7, SAFB, THOC5, XRN2, EBNA1BP2, HSPA1A, RBM39, STRAP, TRA2A, YBX3, ZCCHC8, GPATCH8, SMN1, SRSF5, CTR9, EIF4A3, GNL3, HNRNPH3, HP1BP3, NCBP1, PRPF19, RBM17, RRP9, THOC2, ZC3HAV1, EXOSC10, GEMIN6, XAB2, HSPB1, PABPN1, CAPRIN1, CCAR2, GEMIN4, INTS4, KHDRBS1, PLRG1, PRMT5, SRSF6, ZNF326, ADAR, ARID2, GEMIN5, PHF10, PURB, SMU1, TOX4, AQR, ITFG1, ARAF, BIRC3, NFX1, VPS15, VPS34, VPS38, VPS8, PEP3, VPS21, CDC48, UBX3, BRE5, UBP3, SOX2, EP300, CMTR1, ARIH2, PLEKHA4, PINK1, PRMT8, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ADAMTS9-AS2, MDM2, OPTN, PRKD1, HVCN1, CELF1, FUBP3, DUX4, DUX4L9, CIT, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, BRD4, NINL, RBM45, UCHL1, Apc2, FBP1, LGALS9, WDR76, EIF3F, CREBBP, vpr, RNF4, OGT, CD274, SPOP, DDRGK1, TP53, DDX39B, HIST1H2BG, USP15, FZR1, WDR5, NUDCD2, CPSF1, NUP43, BTF3, BSG, S, RCHY1, NBR1, BACH2, PDE4B, SIRT6,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NOVA1
FUS

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to NOVA1-FUS

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NOVA1-FUS

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	FUS	C1842675	AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)	5	UNIPROT
Tgene	FUS	C3468114	Juvenile amyotrophic lateral sclerosis	5	ORPHANET
Tgene	FUS	C0002736	Amyotrophic Lateral Sclerosis	2	CTD_human;ORPHANET
Tgene	FUS	C0206634	Liposarcoma, Myxoid	2	CTD_human;ORPHANET
Tgene	FUS	C0393554	Amyotrophic Lateral Sclerosis With Dementia	1	CTD_human
Tgene	FUS	C0497327	Dementia	1	GENOMICS_ENGLAND
Tgene	FUS	C0543859	Amyotrophic Lateral Sclerosis, Guam Form	1	CTD_human
Tgene	FUS	C3539195	TREMOR, HEREDITARY ESSENTIAL, 4	1	CTD_human;UNIPROT
Tgene	FUS	C3888102	Frontotemporal Dementia With Motor Neuron Disease	1	ORPHANET