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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NPEPPS-MLLT10

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NPEPPS-MLLT10
	FusionPDB ID: 59886
	FusionGDB2.0 ID: 59886
		Hgene	Tgene
	Gene symbol	NPEPPS	MLLT10
	Gene ID	9520	8028
	Gene name	aminopeptidase puromycin sensitive	MLLT10 histone lysine methyltransferase DOT1L cofactor
	Synonyms	AAP-S\|MP100\|PSA	AF10
	Cytomap	17q21.32	10p12.31
	Type of gene	protein-coding	protein-coding
	Description	puromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100	protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot
	Modification date	20200313	20200313
	UniProtAcc	P55786	P55197
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000322157, ENST00000530173, ENST00000544660, ENST00000525037,	ENST00000495130, ENST00000377091, ENST00000377100, ENST00000307729, ENST00000377059, ENST00000377072, ENST00000446906,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 9 X 9=1458	17 X 30 X 5=2550
	# samples	19	30
	** MAII score	log2(19/1458*10)=-2.93991939599599 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/2550*10)=-3.08746284125034 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NPEPPS [Title/Abstract] AND MLLT10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NPEPPS(45608921)-MLLT10(21875222), # samples:1
Anticipated loss of major functional domain due to fusion event.	NPEPPS-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NPEPPS-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NPEPPS-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NPEPPS-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NPEPPS	GO:0071456	cellular response to hypoxia	21056661
Tgene	MLLT10	GO:0045944	positive regulation of transcription by RNA polymerase II	17868029

Fusion gene breakpoints across NPEPPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MLLT10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-29-1770	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000530173	NPEPPS	chr17	45608921	+	ENST00000446906	MLLT10	chr10	21875222	+	4758	273	30	3068	1012
ENST00000530173	NPEPPS	chr17	45608921	+	ENST00000377072	MLLT10	chr10	21875222	+	4811	273	30	3116	1028
ENST00000530173	NPEPPS	chr17	45608921	+	ENST00000307729	MLLT10	chr10	21875222	+	4887	273	30	3239	1069
ENST00000530173	NPEPPS	chr17	45608921	+	ENST00000377059	MLLT10	chr10	21875222	+	4758	273	30	3068	1012
ENST00000322157	NPEPPS	chr17	45608921	+	ENST00000446906	MLLT10	chr10	21875222	+	4977	492	66	3287	1073
ENST00000322157	NPEPPS	chr17	45608921	+	ENST00000377072	MLLT10	chr10	21875222	+	5030	492	66	3335	1089
ENST00000322157	NPEPPS	chr17	45608921	+	ENST00000307729	MLLT10	chr10	21875222	+	5106	492	66	3458	1130
ENST00000322157	NPEPPS	chr17	45608921	+	ENST00000377059	MLLT10	chr10	21875222	+	4977	492	66	3287	1073
ENST00000544660	NPEPPS	chr17	45608921	+	ENST00000446906	MLLT10	chr10	21875222	+	4714	229	13	3024	1003
ENST00000544660	NPEPPS	chr17	45608921	+	ENST00000377072	MLLT10	chr10	21875222	+	4767	229	13	3072	1019
ENST00000544660	NPEPPS	chr17	45608921	+	ENST00000307729	MLLT10	chr10	21875222	+	4843	229	13	3195	1060
ENST00000544660	NPEPPS	chr17	45608921	+	ENST00000377059	MLLT10	chr10	21875222	+	4714	229	13	3024	1003

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000530173	ENST00000446906	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000418871	0.99958116
ENST00000530173	ENST00000377072	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000177329	0.9998227
ENST00000530173	ENST00000307729	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000437639	0.9995623
ENST00000530173	ENST00000377059	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000418871	0.99958116
ENST00000322157	ENST00000446906	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000464181	0.9995358
ENST00000322157	ENST00000377072	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000318888	0.9996811
ENST00000322157	ENST00000307729	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.00071701	0.999283
ENST00000322157	ENST00000377059	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000464181	0.9995358
ENST00000544660	ENST00000446906	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000173784	0.99982625
ENST00000544660	ENST00000377072	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000186772	0.99981326
ENST00000544660	ENST00000307729	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000436041	0.999564
ENST00000544660	ENST00000377059	NPEPPS	chr17	45608921	+	MLLT10	chr10	21875222	+	0.000173784	0.99982625

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59886_59886_1_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000322157_MLLT10_chr10_21875222_ENST00000307729_length(amino acids)=1130AA_BP=142
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVS
TMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGS
NRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVS
AHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYS
HSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGP
GRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGI
YNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQS
ENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLH
QLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSG
QSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQ
NPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQ

--------------------------------------------------------------

>59886_59886_2_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000322157_MLLT10_chr10_21875222_ENST00000377059_length(amino acids)=1073AA_BP=142
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVS
TMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGS
NRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVS
AHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYS
HSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGP
GRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGI
YNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQS
ENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLH
QLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSG
QSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQ

--------------------------------------------------------------

>59886_59886_3_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000322157_MLLT10_chr10_21875222_ENST00000377072_length(amino acids)=1089AA_BP=142
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVS
TMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGS
NRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVS
AHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYS
HSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGP
GRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNDR
GDSSTLTKQELKFIGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHM
YGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLL
EQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFL
PDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGI
VGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPVHRHPHFTQLPPTHFSP

--------------------------------------------------------------

>59886_59886_4_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000322157_MLLT10_chr10_21875222_ENST00000446906_length(amino acids)=1073AA_BP=142
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVS
TMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGS
NRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVS
AHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYS
HSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGP
GRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGI
YNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQS
ENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLH
QLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSG
QSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQ

--------------------------------------------------------------

>59886_59886_5_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000530173_MLLT10_chr10_21875222_ENST00000307729_length(amino acids)=1069AA_BP=81
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKD
GALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCE
EEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTS
TSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGS
VKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAG
YKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVG
SEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANT
LSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQL
LERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSL
NSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGII
GALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPEQHQ

--------------------------------------------------------------

>59886_59886_6_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000530173_MLLT10_chr10_21875222_ENST00000377059_length(amino acids)=1012AA_BP=81
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKD
GALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCE
EEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTS
TSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGS
VKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAG
YKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVG
SEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANT
LSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQL
LERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSL
NSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGII
GALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPVHRH

--------------------------------------------------------------

>59886_59886_7_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000530173_MLLT10_chr10_21875222_ENST00000377072_length(amino acids)=1028AA_BP=81
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKD
GALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCE
EEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTS
TSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGS
VKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAG
YKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVG
SEISMQYRHDGACPTTTFSELLNAIHNDRGDSSTLTKQELKFIGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPS
AVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGN
SSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSH
QIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQ
PVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQ

--------------------------------------------------------------

>59886_59886_8_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000530173_MLLT10_chr10_21875222_ENST00000446906_length(amino acids)=1012AA_BP=81
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKD
GALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCE
EEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTS
TSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGS
VKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAG
YKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVG
SEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANT
LSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQL
LERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSL
NSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGII
GALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPVHRH

--------------------------------------------------------------

>59886_59886_9_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000544660_MLLT10_chr10_21875222_ENST00000307729_length(amino acids)=1060AA_BP=72
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNG
GWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNV
QYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGS
LKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSV
QSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGI
EEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRH
DGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQA
PSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQ
QFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIG
NSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLA
INGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPEQHQAFLYQLMQH

--------------------------------------------------------------

>59886_59886_10_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000544660_MLLT10_chr10_21875222_ENST00000377059_length(amino acids)=1003AA_BP=72
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNG
GWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNV
QYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGS
LKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSV
QSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGI
EEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRH
DGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQA
PSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQ
QFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIG
NSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLA
INGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPVHRHPHFTQLPPT

--------------------------------------------------------------

>59886_59886_11_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000544660_MLLT10_chr10_21875222_ENST00000377072_length(amino acids)=1019AA_BP=72
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNG
GWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNV
QYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGS
LKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSV
QSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGI
EEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRH
DGACPTTTFSELLNAIHNDRGDSSTLTKQELKFIGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAV
ATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPV
AASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQT
APTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAV
SAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQ

--------------------------------------------------------------

>59886_59886_12_NPEPPS-MLLT10_NPEPPS_chr17_45608921_ENST00000544660_MLLT10_chr10_21875222_ENST00000446906_length(amino acids)=1003AA_BP=72
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQRCELCPHKDGALKRTDNG
GWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNV
QYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGS
LKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSV
QSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGI
EEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRH
DGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQA
PSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQ
QFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIG
NSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLA
INGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPVHRHPHFTQLPPT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:45608921/chr10:21875222)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NPEPPS P55786	MLLT10 P55197
FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269\|PubMed:10978616, ECO:0000269\|PubMed:11062501, ECO:0000269\|PubMed:17154549, ECO:0000269\|PubMed:17318184, ECO:0000269\|PubMed:19917696}.	FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269\|PubMed:17868029, ECO:0000269\|PubMed:26439302}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

229_240

80.0

1069.0

Compositional bias

Note=Glu/Lys-rich

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

229_240

80.0

1476.0

Compositional bias

Note=Glu/Lys-rich

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

229_240

127.0

Compositional bias

Note=Glu/Lys-rich

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

229_240

180.0

Compositional bias

Note=Glu/Lys-rich

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

311_674

80.0

1069.0

Region

Note=DNA-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

703_784

80.0

1069.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

750_778

80.0

1069.0

Region

Note=Leucine-zipper

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

80_287

80.0

1069.0

Region

Note=Self-association

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

311_674

80.0

1476.0

Region

Note=DNA-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

703_784

80.0

1476.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

750_778

80.0

1476.0

Region

Note=Leucine-zipper

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

80_287

80.0

1476.0

Region

Note=Self-association

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

311_674

127.0

Region

Note=DNA-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

703_784

127.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

750_778

127.0

Region

Note=Leucine-zipper

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

80_287

127.0

Region

Note=Self-association

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

311_674

180.0

Region

Note=DNA-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

703_784

180.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

750_778

180.0

Region

Note=Leucine-zipper

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

80_287

180.0

Region

Note=Self-association

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

135_198

80.0

1069.0

Zinc finger

PHD-type 2

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

79_112

80.0

1069.0

Zinc finger

C2HC pre-PHD-type

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

135_198

80.0

1476.0

Zinc finger

PHD-type 2

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

79_112

80.0

1476.0

Zinc finger

C2HC pre-PHD-type

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

135_198

127.0

Zinc finger

PHD-type 2

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

22_74

127.0

Zinc finger

PHD-type 1

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377091

79_112

127.0

Zinc finger

C2HC pre-PHD-type

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

135_198

180.0

Zinc finger

PHD-type 2

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

22_74

180.0

Zinc finger

PHD-type 1

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377100

79_112

180.0

Zinc finger

C2HC pre-PHD-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NPEPPS

chr17:45608921

chr10:21875222

ENST00000322157

726_730

85.0

920.0

Motif

Nuclear localization signal

Hgene

NPEPPS

chr17:45608921

chr10:21875222

ENST00000322157

316_320

85.0

920.0

Region

Substrate binding

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000307729

22_74

80.0

1069.0

Zinc finger

PHD-type 1

Tgene

MLLT10

chr17:45608921

chr10:21875222

ENST00000377072

22_74

80.0

1476.0

Zinc finger

PHD-type 1

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NPEPPS
MLLT10

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to NPEPPS-MLLT10

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NPEPPS-MLLT10

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	MLLT10	C0007134	Renal Cell Carcinoma	1	CTD_human
Tgene	MLLT10	C0025202	melanoma	1	CTD_human
Tgene	MLLT10	C0025286	Meningioma	1	CTD_human
Tgene	MLLT10	C0205834	Meningiomas, Multiple	1	CTD_human
Tgene	MLLT10	C0259785	Malignant Meningioma	1	CTD_human
Tgene	MLLT10	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
Tgene	MLLT10	C0281784	Benign Meningioma	1	CTD_human
Tgene	MLLT10	C0334605	Meningothelial meningioma	1	CTD_human
Tgene	MLLT10	C0334606	Fibrous Meningioma	1	CTD_human
Tgene	MLLT10	C0334607	Psammomatous Meningioma	1	CTD_human
Tgene	MLLT10	C0334608	Angiomatous Meningioma	1	CTD_human
Tgene	MLLT10	C0334609	Hemangioblastic Meningioma	1	CTD_human
Tgene	MLLT10	C0334610	Hemangiopericytic Meningioma	1	CTD_human
Tgene	MLLT10	C0334611	Transitional Meningioma	1	CTD_human
Tgene	MLLT10	C0347515	Spinal Meningioma	1	CTD_human
Tgene	MLLT10	C0349604	Intracranial Meningioma	1	CTD_human
Tgene	MLLT10	C0431121	Clear Cell Meningioma	1	CTD_human
Tgene	MLLT10	C0457190	Xanthomatous Meningioma	1	CTD_human
Tgene	MLLT10	C0751303	Cerebral Convexity Meningioma	1	CTD_human
Tgene	MLLT10	C0751304	Parasagittal Meningioma	1	CTD_human
Tgene	MLLT10	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
Tgene	MLLT10	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
Tgene	MLLT10	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
Tgene	MLLT10	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human
Tgene	MLLT10	C1334261	Intraorbital Meningioma	1	CTD_human
Tgene	MLLT10	C1334271	Intraventricular Meningioma	1	CTD_human
Tgene	MLLT10	C1335107	Olfactory Groove Meningioma	1	CTD_human
Tgene	MLLT10	C1384406	Secretory meningioma	1	CTD_human
Tgene	MLLT10	C1384408	Microcystic meningioma	1	CTD_human
Tgene	MLLT10	C1527197	Angioblastic Meningioma	1	CTD_human
Tgene	MLLT10	C1565950	Posterior Fossa Meningioma	1	CTD_human
Tgene	MLLT10	C1565951	Sphenoid Wing Meningioma	1	CTD_human
Tgene	MLLT10	C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	ORPHANET
Tgene	MLLT10	C3163622	Papillary Meningioma	1	CTD_human