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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NPM1-VIM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NPM1-VIM
FusionPDB ID: 59993
FusionGDB2.0 ID: 59993
HgeneTgene
Gene symbol

NPM1

VIM

Gene ID

4869

7431

Gene namenucleophosmin 1vimentin
SynonymsB23|NPM-
Cytomap

5q35.1

10p13

Type of geneprotein-codingprotein-coding
Descriptionnucleophosminnucleolar protein NO38nucleophosmin (nucleolar phosphoprotein B23, numatrin)nucleophosmin/nucleoplasmin family, member 1testicular tissue protein Li 128vimentinepididymis secretory sperm binding protein
Modification date2020032920200327
UniProtAcc

P06748

VMAC

Ensembl transtripts involved in fusion geneENST idsENST00000296930, ENST00000351986, 
ENST00000393820, ENST00000517671, 
ENST00000485947, ENST00000224237, 
ENST00000544301, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 25 X 6=315042 X 25 X 11=11550
# samples 3241
** MAII scorelog2(32/3150*10)=-3.29920801838728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11550*10)=-4.81612513168534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NPM1 [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NPM1(170815010)-VIM(17278293), # samples:1
Anticipated loss of major functional domain due to fusion event.NPM1-VIM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NPM1-VIM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NPM1-VIM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NPM1-VIM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNPM1

GO:0006281

DNA repair

19188445

HgeneNPM1

GO:0006334

nucleosome assembly

11602260

HgeneNPM1

GO:0006913

nucleocytoplasmic transport

16041368

HgeneNPM1

GO:0008104

protein localization

18420587

HgeneNPM1

GO:0008284

positive regulation of cell proliferation

22528486

HgeneNPM1

GO:0032071

regulation of endodeoxyribonuclease activity

19188445

HgeneNPM1

GO:0034644

cellular response to UV

19160485

HgeneNPM1

GO:0043066

negative regulation of apoptotic process

12882984

HgeneNPM1

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

12882984

HgeneNPM1

GO:0045727

positive regulation of translation

12882984

HgeneNPM1

GO:0045893

positive regulation of transcription, DNA-templated

22528486

HgeneNPM1

GO:0045944

positive regulation of transcription by RNA polymerase II

19160485

HgeneNPM1

GO:0060699

regulation of endoribonuclease activity

19188445

HgeneNPM1

GO:0060735

regulation of eIF2 alpha phosphorylation by dsRNA

12882984

HgeneNPM1

GO:1902751

positive regulation of cell cycle G2/M phase transition

22528486


check buttonFusion gene breakpoints across NPM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-6692-01ANPM1chr5

170815010

+VIMchr10

17278293

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000517671NPM1chr5170815010+ENST00000544301VIMchr1017278293+6351934232092
ENST00000517671NPM1chr5170815010+ENST00000224237VIMchr1017278293+6431934232092
ENST00000296930NPM1chr5170815010+ENST00000544301VIMchr1017278293+80135970486138
ENST00000296930NPM1chr5170815010+ENST00000224237VIMchr1017278293+80935970486138
ENST00000351986NPM1chr5170815010+ENST00000544301VIMchr1017278293+6201784230587
ENST00000351986NPM1chr5170815010+ENST00000224237VIMchr1017278293+6281784230587
ENST00000393820NPM1chr5170815010+ENST00000544301VIMchr1017278293+5981562028387
ENST00000393820NPM1chr5170815010+ENST00000224237VIMchr1017278293+6061562028387

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000517671ENST00000544301NPM1chr5170815010+VIMchr1017278293+0.219709750.78029025
ENST00000517671ENST00000224237NPM1chr5170815010+VIMchr1017278293+0.222492950.77750707
ENST00000296930ENST00000544301NPM1chr5170815010+VIMchr1017278293+0.520275240.4797248
ENST00000296930ENST00000224237NPM1chr5170815010+VIMchr1017278293+0.498240560.50175947
ENST00000351986ENST00000544301NPM1chr5170815010+VIMchr1017278293+0.201462490.79853755
ENST00000351986ENST00000224237NPM1chr5170815010+VIMchr1017278293+0.204753060.7952469
ENST00000393820ENST00000544301NPM1chr5170815010+VIMchr1017278293+0.144889820.8551102
ENST00000393820ENST00000224237NPM1chr5170815010+VIMchr1017278293+0.16085950.8391405

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59993_59993_1_NPM1-VIM_NPM1_chr5_170815010_ENST00000296930_VIM_chr10_17278293_ENST00000224237_length(amino acids)=138AA_BP=96
MKSACAGRLRYGGGRASEHARGGGTWEALARSSGSIYKRGEPASFPWCDSVLRGCSLEQRSFISVRLLSYLSACRHPMEDSMDMDMSPLR

--------------------------------------------------------------

>59993_59993_2_NPM1-VIM_NPM1_chr5_170815010_ENST00000296930_VIM_chr10_17278293_ENST00000544301_length(amino acids)=138AA_BP=96
MKSACAGRLRYGGGRASEHARGGGTWEALARSSGSIYKRGEPASFPWCDSVLRGCSLEQRSFISVRLLSYLSACRHPMEDSMDMDMSPLR

--------------------------------------------------------------

>59993_59993_3_NPM1-VIM_NPM1_chr5_170815010_ENST00000351986_VIM_chr10_17278293_ENST00000224237_length(amino acids)=87AA_BP=45

--------------------------------------------------------------

>59993_59993_4_NPM1-VIM_NPM1_chr5_170815010_ENST00000351986_VIM_chr10_17278293_ENST00000544301_length(amino acids)=87AA_BP=45

--------------------------------------------------------------

>59993_59993_5_NPM1-VIM_NPM1_chr5_170815010_ENST00000393820_VIM_chr10_17278293_ENST00000224237_length(amino acids)=87AA_BP=45

--------------------------------------------------------------

>59993_59993_6_NPM1-VIM_NPM1_chr5_170815010_ENST00000393820_VIM_chr10_17278293_ENST00000544301_length(amino acids)=87AA_BP=45

--------------------------------------------------------------

>59993_59993_7_NPM1-VIM_NPM1_chr5_170815010_ENST00000517671_VIM_chr10_17278293_ENST00000224237_length(amino acids)=92AA_BP=50
MAPKLRKDKDFGDVFSGRTELKNKVPACRHPMEDSMDMDMSPLRPQNYLFETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDD

--------------------------------------------------------------

>59993_59993_8_NPM1-VIM_NPM1_chr5_170815010_ENST00000517671_VIM_chr10_17278293_ENST00000544301_length(amino acids)=92AA_BP=50
MAPKLRKDKDFGDVFSGRTELKNKVPACRHPMEDSMDMDMSPLRPQNYLFETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:170815010/chr10:17278293)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPM1

P06748

VIM

VMAC

FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). {ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}.169

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPM1chr5:170815010chr10:17278293ENST00000296930+1111_919.333333333333332295.0Compositional biasNote=Met-rich
HgeneNPM1chr5:170815010chr10:17278293ENST00000351986+1101_919.333333333333332266.0Compositional biasNote=Met-rich
HgeneNPM1chr5:170815010chr10:17278293ENST00000393820+1101_919.333333333333332260.0Compositional biasNote=Met-rich
HgeneNPM1chr5:170815010chr10:17278293ENST00000517671+2121_919.333333333333332295.0Compositional biasNote=Met-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPM1chr5:170815010chr10:17278293ENST00000296930+111120_13219.333333333333332295.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000296930+111161_18819.333333333333332295.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000351986+110120_13219.333333333333332266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000351986+110161_18819.333333333333332266.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000393820+110120_13219.333333333333332260.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000393820+110161_18819.333333333333332260.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000517671+212120_13219.333333333333332295.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000517671+212161_18819.333333333333332295.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneNPM1chr5:170815010chr10:17278293ENST00000296930+111152_15719.333333333333332295.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000296930+111191_19719.333333333333332295.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000351986+110152_15719.333333333333332266.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000351986+110191_19719.333333333333332266.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000393820+110152_15719.333333333333332260.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000393820+110191_19719.333333333333332260.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000517671+212152_15719.333333333333332295.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000517671+212191_19719.333333333333332295.0MotifNuclear localization signal
HgeneNPM1chr5:170815010chr10:17278293ENST00000296930+111243_29419.333333333333332295.0RegionNote=Required for nucleolar localization
HgeneNPM1chr5:170815010chr10:17278293ENST00000351986+110243_29419.333333333333332266.0RegionNote=Required for nucleolar localization
HgeneNPM1chr5:170815010chr10:17278293ENST00000393820+110243_29419.333333333333332260.0RegionNote=Required for nucleolar localization
HgeneNPM1chr5:170815010chr10:17278293ENST00000517671+212243_29419.333333333333332295.0RegionNote=Required for nucleolar localization
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr5:170815010chr10:17278293ENST000002242376996_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr5:170815010chr10:17278293ENST0000054430171096_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr5:170815010chr10:17278293ENST00000224237692_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr5:170815010chr10:17278293ENST0000022423769408_466424.3333333333333467.0RegionNote=Tail
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr5:170815010chr10:17278293ENST000005443017102_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr5:170815010chr10:17278293ENST00000544301710408_466424.3333333333333467.0RegionNote=Tail


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NPM1TCERG1, LYAR, USF2, HIST3H3, SWAP70, HAND2, NCL, OTUB1, AKT1, CDT1, RRP1B, Rrp1b, GRB2, CENPF, CASKIN1, CDC14A, PIK3R1, NUP98, PPID, GRB7, NCAPG, NUMA1, NSUN2, PADI4, TP53, BARD1, BRCA1, H2AFX, CDKN2A, HMGA2, HMGA1, HCVgp1, YY1, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, EP300, tat, PML, RARA, CTNNBL1, FANCA, FANCC, TFAP2A, HDAC1, HDAC2, SMARCA4, DOT1L, ACACA, HNRNPM, HNRNPU, DDX21, HIST1H1C, SIRT1, YBX1, PC, YBX3, H1FX, HIST1H1A, ESR1, Trp53, Cdkn2a, CDK5RAP3, ZNF668, UBC, RYK, SMN1, CD4, YWHAQ, USP36, CTCF, HDAC5, CDKN1A, NOP56, CENPA, AFF1, DYRK2, TOP1, CDK2, SREK1, SENP3, RB1, PARP1, HJURP, ARRB1, ARRB2, SIRT7, NPM3, NPM1, FBXO25, IRF1, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, MDM2, PA2G4, PPP2R1A, MID1, GZF1, APEX1, COPS2, PLCG1, FBXO6, GAPDH, SIAH1, PTBP1, SRSF1, APP, RPL14, RPS6, RPL24, RPL6, NAP1L1, HNRNPR, RPS4X, PRPF6, LAMP2, SURF4, RPL10L, NAP1L4, ZYX, NUP62, NUP50, RPL5, YWHAE, FMNL1, CPSF6, HNRNPH1, PAPOLG, JUNB, MC4R, HIVEP2, CPSF1, CPSF2, CPSF4, CPSF3, FN1, VCAM1, CSNK2A1, NOS2, UBL4A, ITGA4, CBX2, CBX4, CBX8, PHB, EIF2AK2, XPO1, GZMM, PAN2, CD81, IGSF8, ICAM1, PRKCZ, KIF11, SQSTM1, FLNA, LLGL1, HSP90AA1, TRIM21, TUBA1C, HSP90AB1, PARD6B, CDC37, TUBB3, MRPL46, KCTD2, CLTC, MRPL50, VCP, KCTD5, MRPL12, HSPA5, PTRF, MRPL52, EEF1A1, KCTD17, TAB1, BAG2, ANXA2, EIF5A, PPIL4, MRPL38, STK38, FLNB, LGALS1, C1QBP, COPB1, MRPL37, MRPL49, KEAP1, PRDX4, WDR26, PSMC4, SDPR, SLC25A3, RPS12, EEF1B2, NIPSNAP1, EEF1G, MRPL39, DDX3X, RNH1, OSBPL1A, EIF3H, MRPL54, ENO1, MYCBP, MRPL18, MAP1B, PSMD1, EEF1D, DNAJC13, HSPB1, CFL1, FLNC, PPP1CC, RPLP1, CEP152, SNRPD1, ATP5A1, ARHGAP5, PRKAR1A, MRPL53, GID8, YWHAZ, CCT2, EIF3E, LAMB2, DICER1, CHCHD4, MRPL19, SNRPD2, GRWD1, TPR, PSMD4, PSMC5, PPP2CA, UNC5C, SLC25A5, PTPN14, RPS5, TTC27, BOLA2, EIF4A1, TUFM, S100A10, IMPG1, NUDT21, UTRN, MRPL44, EIF3M, MRPL43, PKM, IMPDH2, TRRAP, CHCHD6, RANBP6, EIF3I, TAB2, MRPL24, DZIP1, IPO5, AGR2, MRPS30, ICT1, PRDX6, TCP1, RCOR1, GRN, TXN, RPLP0, PCBP1, MRPL28, MRPL10, TAF3, EPAS1, CHCHD3, TXNDC12, ELMO2, SRRT, MRPL11, EIF2S1, SNRPF, KTN1, FGD6, UQCRH, RBBP4, DNAJA1, CTTN, USP15, NUDCD1, RPS28, JAK1, PROS1, PYGB, KDR, EEF2, FASN, AKAP11, CSNK2B, DNAJA2, EIF3G, DHX15, MRPS26, HNRNPA0, DOCK4, PRKCI, VASP, COPE, SAMM50, TEX15, PSME3, PPM1G, COPG1, CALU, S100A11, HSPA4, PSMD12, POLR2E, TRIM28, SLAIN2, RPL10, GOLGA2, GOLGA3, PRKCA, IPO9, PARK7, SPIN1, PPA1, BANP, DSTN, GNAI2, HOXA7, ABCC1, RELA, ACY1, TARDBP, PARK2, KPNA1, ARMCX3, LIMCH1, OSBP, TRMT61A, rev, RPA1, RPA2, RPA3, ERG, LGR4, STAU1, ELF4, AURKA, HUWE1, FUS, COX8A, NPM2, MOV10, NXF1, PHF6, CUL7, OBSL1, CCDC8, SIRT6, EBNA1BP2, NOL12, RPL10A, POP4, ZNF22, NSA2, TAF1D, NIFK, RPL26L1, NIP7, RPL4, RPF1, CCDC137, KNOP1, RBM28, RPL7A, POP1, DDX24, FTSJ3, RRS1, RPL3, ZFP62, ZNF512, DDX56, DDX27, GLYR1, MAK16, CEBPZ, RSL1D1, HP1BP3, REXO4, DDX31, MYBBP1A, NOP16, C3orf17, RRP8, GNL2, PAPD5, RSL24D1, SURF6, GTPBP4, KIAA0020, NOP2, NVL, GLTSCR2, URB1, RPL23A, GPATCH4, TEX10, RPS8, NOC3L, BRIX1, DDX54, PWP1, RBM34, NMNAT1, CENPC, SENP5, RPL36AL, PAK1IP1, ZNF800, RPL7L1, RPL37A, RPF2, PELP1, NOC2L, RPP40, RBMX2, CENPV, PPAN-P2RY11, SDAD1, RPP38, RPP25, SPTY2D1, RPP25L, POP7, RPS6KB2, UTP15, NTRK1, EWSR1, CLK1, HIST1H3E, BYSL, CHD1, DDX1, DECR1, EIF1AX, EIF4G2, FBL, FAU, HIST1H1D, HIST1H1B, RPSA, MKI67, MPG, EXOSC10, RPL7, RPL8, RPL9, RPL11, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL27, RPL27A, RPL29, RPL32, RPL37, RPL38, RPS2, RPS3, RPS3A, RPS9, RPS10, RPS11, RPS13, RPS14, RPS15, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS29, SKIV2L, SRP72, XPC, IFRD2, HIST1H2BC, SMARCA5, CGGBP1, EIF3A, EIF3C, PABPC4, USP10, TTC37, JADE3, ABCF2, G3BP1, GNB2L1, EMG1, IGF2BP3, PSIP1, SUPT16H, RPL35, PDCD11, LARP4B, RRP12, LARP1, RPL13A, RPL36, MTHFD1L, AHCTF1, FAM98A, SERBP1, GNL3, SND1, NOB1, RPS27L, DDX47, EIF3L, RTCB, TRMT112, DHX29, MTPAP, NAT10, TSR1, NKRF, MEPCE, BCCIP, PNO1, MRPS22, WDR18, SCAF1, NOL6, DDX50, CCDC86, MUS81, ZNF622, DHX57, H2AFV, LARP4, WBSCR22, Eif3a, Eif3e, Ktn1, Rpl35, Srp72, Rrbp1, GAN, HEMGN, TMUB1, CRY1, DNAJB4, MCM2, GLI1, Mdm2, SP1, U2AF2, RC3H1, EIF2S2, EGFR, WWP2, CD24, ZNF746, DDX51, MAGED2, HNRNPA2B1, HNRNPD, HNRNPA1, RPL23, RPS7, HIST1H2BB, HIST1H2AA, CBX3, CYLD, INO80B, LMNA, YAP1, MTF1, BRD1, HDAC6, FBXW7, CENPW, API5, CTNNB1, MAP2K3, BMP4, CCNT1, DIMT1, MATN2, TRIP4, CUL4B, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, LARP7, RNF31, TNF, FAM188B, SPDL1, HEXIM1, SNAI1, RECQL4, GPC1, REST, ZFP36L2, MYC, CDK9, Prkab1, NEK2, METTL3, METTL14, KIAA1429, RC3H2, PSMA3, ACTC1, ESR2, FAF1, RBX1, BRCA2, DISC1, NR2C2, UBQLN2, MTDH, GADD45A, AGRN, ATXN3, VRK1, VRK3, DYRK1A, SNRNP70, ITFG1, GHET1, ARAF, HMGB1, BIRC3, NFX1, BRD7, N, SOX2, PPIA, CACYBP, RNR1, CMTR1, ARIH2, PLEKHA4, RAD18, PINK1, WHSC1, FANCD2, SAMD12, LINC01554, ZC3H18, CAMK2A, FYN, PTPN12, RPS6KA3, STX7, IL7R, GPC3, RP1, KMT2A, SUZ12, BSX, LEMD1, ZCCHC7, SYNE2, ZBTB9, R3HDM4, ZNF496, PIKFYVE, COL8A1, PMS2, TRDN, PLCZ1, ASPM, TTN, SETD2, BDP1, C4orf47, CFAP54, HIST2H2BC, AIM2, SYT7, LTN1, EPRS, FST, LMOD1, MCAM, RPL34, MYT1, DYNC1I2, KIF22, ZNF181, ATAT1, TRMT10B, RBM44, ANKS3, FILIP1, FAM9A, SUPT20H, THOC2, CENPI, BICD1, CCL13, JPH2, NDST4, SARDH, SLC27A6, LECT2, HMGN4, OPA1, ITGB1, HIVEP1, PNRC1, PDE4DIP, CAPRIN2, C1orf110, MICAL1, STAB2, CEP63, NGRN, CAMSAP3, ARHGEF9, SNIP1, ORF14, ILF3, LRRC31, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, BRD3, SP110, TRIM24, ZMYND8, LRRC59, NMRAL1, SUMO2, Rnf183, BRD4, NUPR1, RBM45, CIC, Apc2, RBM39, FBP1, ASXL1, vpr, RIN3, DNAJC19, DNAJC25, DNAJC2, OGT, DDRGK1, UFL1, CD3EAP, DDX23, HIST1H2BG, ACTG1, ALKBH4, DNAJC10, GLUD2, HIST1H2AE, HIST1H3F, HIST1H4J, HLCS, HSPA1B, MALT1, PEG10, PLD3, UBB, AIP, BCORL1, BID, CSK, LCK, PSMG1, RAB21, RBM11, VDAC1, RPL31, ZNF330, TRIM37, FZR1, WDR5, PAGE4, NUDCD2, NAA40, BGLT3, CCDC140, RPL23AP32, MTG2, NGDN, UTP18, PRPF4B, WDR74, WDR36, DKC1, DDX52, EPB41L5, ZBTB11, H2AFY, CIRH1A, SRSF5, DUSP11, DDX10, TSPYL1, IMP3, RBM19, NOM1, ZC3HAV1, RPP14, UTP14A, WDR12, DNTTIP2, MPHOSPH10, RRP1, WDR3, BUD13, RPLP2, C14orf169, ZNF771, AATF, C1orf35, OASL, NLE1, BMS1, BOP1, STAU2, TAF1C, WDR55, ZNF638, RFC1, FYTTD1, WDR43, C7orf50, SRPK2, LUC7L, FAM111A, PBRM1, NOL10, TAF1A, TBL3, ZNF770, BAZ1B, ESF1, TTF1, LAS1L, RPP30, ZNF16, RRP15, ABT1, SPRTN, ULK1, TRAF6, BTF3, SLFN11, NLRP7, RCHY1, DIDO1, CCNF, FAM129A, ATR, ATM, PSMD9, ZEB1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NPM1all structure
VIM


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NPM1-VIM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NPM1-VIM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNPM1C0026998Acute Myeloid Leukemia, M16CTD_human;ORPHANET
HgeneNPM1C1879321Acute Myeloid Leukemia (AML-M2)6CTD_human;ORPHANET
HgeneNPM1C0023467Leukemia, Myelocytic, Acute5CGI;CTD_human
HgeneNPM1C0023487Acute Promyelocytic Leukemia2CGI;CTD_human;ORPHANET
HgeneNPM1C0024623Malignant neoplasm of stomach1CTD_human
HgeneNPM1C0038356Stomach Neoplasms1CTD_human
HgeneNPM1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneNPM1C0206182Lymphomatoid Papulosis1ORPHANET
HgeneNPM1C0265965Dyskeratosis Congenita1CTD_human;GENOMICS_ENGLAND
HgeneNPM1C1148551X-Linked Dyskeratosis Congenita1CTD_human
HgeneNPM1C1301362Primary Cutaneous Anaplastic Large Cell Lymphoma1ORPHANET
HgeneNPM1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneNPM1C2930974Acute erythroleukemia1CTD_human
HgeneNPM1C2930975Acute erythroleukemia - M6a subtype1CTD_human
HgeneNPM1C2930976Acute myeloid leukemia FAB-M61CTD_human
HgeneNPM1C2930977Acute erythroleukemia - M6b subtype1CTD_human