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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NRCAM-ACN9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NRCAM-ACN9
FusionPDB ID: 60221
FusionGDB2.0 ID: 60221
HgeneTgene
Gene symbol

NRCAM

ACN9

Gene ID

4897

57001

Gene nameneuronal cell adhesion moleculesuccinate dehydrogenase complex assembly factor 3
Synonyms-ACN9|DC11|LYRM10|Sdh7
Cytomap

7q31.1

7q21.3

Type of geneprotein-codingprotein-coding
Descriptionneuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravosuccinate dehydrogenase assembly factor 3, mitochondrialACN9 homologSDH assembly factor 3protein ACN9 homolog, mitochondrial
Modification date2020031320200313
UniProtAcc

Q92823

.
Ensembl transtripts involved in fusion geneENST idsENST00000351718, ENST00000379022, 
ENST00000379024, ENST00000379028, 
ENST00000413765, ENST00000425651, 
ENST00000522550, 		ENST00000360382, 
ENST00000479853, ENST00000432641, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 7=6164 X 2 X 4=32
# samples 124
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NRCAM [Title/Abstract] AND ACN9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NRCAM(107830089)-ACN9(96810324), # samples:1
Anticipated loss of major functional domain due to fusion event.NRCAM-ACN9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NRCAM-ACN9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NRCAM-ACN9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NRCAM-ACN9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRCAM

GO:0045162

clustering of voltage-gated sodium channels

14602817


check buttonFusion gene breakpoints across NRCAM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACN9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-3652-01ANRCAMchr7

107830089

-ACN9chr7

96810324

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379028NRCAMchr7107830089-ENST00000432641ACN9chr796810324+325825064712537688
ENST00000413765NRCAMchr7107830089-ENST00000432641ACN9chr796810324+320124494712480669
ENST00000351718NRCAMchr7107830089-ENST00000432641ACN9chr796810324+316724154282446672
ENST00000379024NRCAMchr7107830089-ENST00000432641ACN9chr796810324+314023884102419669
ENST00000379022NRCAMchr7107830089-ENST00000432641ACN9chr796810324+325825064712537688
ENST00000425651NRCAMchr7107830089-ENST00000432641ACN9chr796810324+2787203502066688

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379028ENST00000432641NRCAMchr7107830089-ACN9chr796810324+0.0010850430.99891496
ENST00000413765ENST00000432641NRCAMchr7107830089-ACN9chr796810324+0.00100380.9989962
ENST00000351718ENST00000432641NRCAMchr7107830089-ACN9chr796810324+0.0003459470.99965405
ENST00000379024ENST00000432641NRCAMchr7107830089-ACN9chr796810324+0.0008679150.9991321
ENST00000379022ENST00000432641NRCAMchr7107830089-ACN9chr796810324+0.0012390820.99876094
ENST00000425651ENST00000432641NRCAMchr7107830089-ACN9chr796810324+0.0009805890.9990194

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60221_60221_1_NRCAM-ACN9_NRCAM_chr7_107830089_ENST00000351718_ACN9_chr7_96810324_ENST00000432641_length(amino acids)=672AA_BP=
MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVT
MKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQ
RLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN
ASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITA
PQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI
LTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPT
WIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDV

--------------------------------------------------------------

>60221_60221_2_NRCAM-ACN9_NRCAM_chr7_107830089_ENST00000379022_ACN9_chr7_96810324_ENST00000432641_length(amino acids)=688AA_BP=
MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDQKSTEVMVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDID
KDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFW
MDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF
LTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA
PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL
AEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL
EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAV

--------------------------------------------------------------

>60221_60221_3_NRCAM-ACN9_NRCAM_chr7_107830089_ENST00000379024_ACN9_chr7_96810324_ENST00000432641_length(amino acids)=669AA_BP=
MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDID
KDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFW
MDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLS
LECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT
LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIAN
RPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR
GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNP

--------------------------------------------------------------

>60221_60221_4_NRCAM-ACN9_NRCAM_chr7_107830089_ENST00000379028_ACN9_chr7_96810324_ENST00000432641_length(amino acids)=688AA_BP=
MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDID
KDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFW
MDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF
LTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA
PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL
AEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL
EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAV

--------------------------------------------------------------

>60221_60221_5_NRCAM-ACN9_NRCAM_chr7_107830089_ENST00000413765_ACN9_chr7_96810324_ENST00000432641_length(amino acids)=669AA_BP=
MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDQKSTEVMVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDID
KDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFW
MDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLS
LECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT
LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIAN
RPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR
GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNP

--------------------------------------------------------------

>60221_60221_6_NRCAM-ACN9_NRCAM_chr7_107830089_ENST00000425651_ACN9_chr7_96810324_ENST00000432641_length(amino acids)=688AA_BP=
MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDID
KDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFW
MDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF
LTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA
PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL
AEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL
EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:107830089/chr7:96810324)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRCAM

Q92823

.
FUNCTION: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828141_235662.33333333333341184.0DomainNote=Ig-like 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828267_356662.33333333333341184.0DomainNote=Ig-like 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828361_448662.33333333333341184.0DomainNote=Ig-like 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828454_541662.33333333333341184.0DomainNote=Ig-like 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-182846_134662.33333333333341184.0DomainNote=Ig-like 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828545_632662.33333333333341184.0DomainNote=Ig-like 6
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930141_235659.33333333333341193.0DomainNote=Ig-like 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930267_356659.33333333333341193.0DomainNote=Ig-like 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930361_448659.33333333333341193.0DomainNote=Ig-like 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930454_541659.33333333333341193.0DomainNote=Ig-like 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-193046_134659.33333333333341193.0DomainNote=Ig-like 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930545_632659.33333333333341193.0DomainNote=Ig-like 6
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033141_235678.33333333333341305.0DomainNote=Ig-like 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033267_356678.33333333333341305.0DomainNote=Ig-like 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033361_448678.33333333333341305.0DomainNote=Ig-like 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033454_541678.33333333333341305.0DomainNote=Ig-like 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-203346_134678.33333333333341305.0DomainNote=Ig-like 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033545_632678.33333333333341305.0DomainNote=Ig-like 6
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730141_235678.33333333333341305.0DomainNote=Ig-like 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730267_356678.33333333333341305.0DomainNote=Ig-like 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730361_448678.33333333333341305.0DomainNote=Ig-like 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730454_541678.33333333333341305.0DomainNote=Ig-like 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-173046_134678.33333333333341305.0DomainNote=Ig-like 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730545_632678.33333333333341305.0DomainNote=Ig-like 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-18281064_1156662.33333333333341184.0DomainFibronectin type-III 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828649_744662.33333333333341184.0DomainFibronectin type-III 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828746_843662.33333333333341184.0DomainFibronectin type-III 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828848_950662.33333333333341184.0DomainFibronectin type-III 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-1828954_1051662.33333333333341184.0DomainFibronectin type-III 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-19301064_1156659.33333333333341193.0DomainFibronectin type-III 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930649_744659.33333333333341193.0DomainFibronectin type-III 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930746_843659.33333333333341193.0DomainFibronectin type-III 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930848_950659.33333333333341193.0DomainFibronectin type-III 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-1930954_1051659.33333333333341193.0DomainFibronectin type-III 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-20331064_1156678.33333333333341305.0DomainFibronectin type-III 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033649_744678.33333333333341305.0DomainFibronectin type-III 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033746_843678.33333333333341305.0DomainFibronectin type-III 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033848_950678.33333333333341305.0DomainFibronectin type-III 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-2033954_1051678.33333333333341305.0DomainFibronectin type-III 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-17301064_1156678.33333333333341305.0DomainFibronectin type-III 5
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730649_744678.33333333333341305.0DomainFibronectin type-III 1
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730746_843678.33333333333341305.0DomainFibronectin type-III 2
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730848_950678.33333333333341305.0DomainFibronectin type-III 3
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-1730954_1051678.33333333333341305.0DomainFibronectin type-III 4
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-18281191_1304662.33333333333341184.0Topological domainCytoplasmic
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-182825_1167662.33333333333341184.0Topological domainExtracellular
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-19301191_1304659.33333333333341193.0Topological domainCytoplasmic
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-193025_1167659.33333333333341193.0Topological domainExtracellular
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-20331191_1304678.33333333333341305.0Topological domainCytoplasmic
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-203325_1167678.33333333333341305.0Topological domainExtracellular
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-17301191_1304678.33333333333341305.0Topological domainCytoplasmic
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-173025_1167678.33333333333341305.0Topological domainExtracellular
HgeneNRCAMchr7:107830089chr7:96810324ENST00000351718-18281168_1190662.33333333333341184.0TransmembraneHelical
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379024-19301168_1190659.33333333333341193.0TransmembraneHelical
HgeneNRCAMchr7:107830089chr7:96810324ENST00000379028-20331168_1190678.33333333333341305.0TransmembraneHelical
HgeneNRCAMchr7:107830089chr7:96810324ENST00000425651-17301168_1190678.33333333333341305.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NRCAM
ACN9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NRCAM-ACN9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NRCAM-ACN9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource