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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NRG1-STMN2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NRG1-STMN2
	FusionPDB ID: 60283
	FusionGDB2.0 ID: 60283
		Hgene	Tgene
	Gene symbol	NRG1	STMN2
	Gene ID	3084	11075
	Gene name	neuregulin 1	stathmin 2
	Synonyms	ARIA\|GGF\|GGF2\|HGL\|HRG\|HRG1\|HRGA\|MST131\|MSTP131\|NDF\|NRG1-IT2\|SMDF	SCG10\|SCGN10
	Cytomap	8p12	8q21.13
	Type of gene	protein-coding	protein-coding
	Description	pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor	stathmin-2neuron-specific growth-associated proteinneuronal growth-associated protein (silencer element)stathmin-like 2superior cervical ganglia, neural specific 10superior cervical ganglion-10 protein
	Modification date	20200320	20200313
	UniProtAcc	Q02297	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000287842, ENST00000287845, ENST00000338921, ENST00000341377, ENST00000356819, ENST00000405005, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000523079, ENST00000520502, ENST00000523681, ENST00000539990,	ENST00000518491, ENST00000220876, ENST00000518111,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 10 X 7=840	4 X 2 X 3=24
	# samples	12	4
	** MAII score	log2(12/840*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NRG1 [Title/Abstract] AND STMN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NRG1(32463201)-STMN2(80549037), # samples:3
Anticipated loss of major functional domain due to fusion event.	NRG1-STMN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NRG1-STMN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NRG1-STMN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NRG1-STMN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NRG1	GO:0003222	ventricular trabecula myocardium morphogenesis	17336907
Hgene	NRG1	GO:0031334	positive regulation of protein complex assembly	10559227
Hgene	NRG1	GO:0038127	ERBB signaling pathway	11389077
Hgene	NRG1	GO:0038129	ERBB3 signaling pathway	27353365
Hgene	NRG1	GO:0045892	negative regulation of transcription, DNA-templated	15073182
Hgene	NRG1	GO:0051048	negative regulation of secretion	10559227
Hgene	NRG1	GO:0060379	cardiac muscle cell myoblast differentiation	17336907
Hgene	NRG1	GO:0060956	endocardial cell differentiation	17336907
Tgene	STMN2	GO:0007026	negative regulation of microtubule depolymerization	18452648
Tgene	STMN2	GO:0010976	positive regulation of neuron projection development	18452648\|21215777
Tgene	STMN2	GO:0010977	negative regulation of neuron projection development	18452648
Tgene	STMN2	GO:0031115	negative regulation of microtubule polymerization	18452648\|21215777
Tgene	STMN2	GO:0031117	positive regulation of microtubule depolymerization	18452648
Tgene	STMN2	GO:1990090	cellular response to nerve growth factor stimulus	21215777

Fusion gene breakpoints across NRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STMN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-FC-A4JI-01A	NRG1	chr8	32463201	-	STMN2	chr8	80549037	+
ChimerDB4	PRAD	TCGA-FC-A4JI-01A	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+
ChimerDB4	PRAD	TCGA-FC-A4JI	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000519301	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2168	346	9	866	285
ENST00000519301	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1082	346	9	890	293
ENST00000520407	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	3097	1275	230	1795	521
ENST00000520407	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	2011	1275	230	1819	529
ENST00000523079	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2739	917	154	1437	427
ENST00000523079	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1653	917	154	1461	435
ENST00000338921	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2739	917	154	1437	427
ENST00000338921	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1653	917	154	1461	435
ENST00000356819	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2739	917	154	1437	427
ENST00000356819	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1653	917	154	1461	435
ENST00000287845	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2739	917	154	1437	427
ENST00000287845	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1653	917	154	1461	435
ENST00000341377	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2739	917	154	1437	427
ENST00000341377	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1653	917	154	1461	435
ENST00000287842	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2682	860	97	1380	427
ENST00000287842	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1596	860	97	1404	435
ENST00000521670	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2330	508	108	1028	306
ENST00000521670	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1244	508	108	1052	314
ENST00000405005	NRG1	chr8	32463201	+	ENST00000220876	STMN2	chr8	80549037	+	2222	400	0	920	306
ENST00000405005	NRG1	chr8	32463201	+	ENST00000518111	STMN2	chr8	80549037	+	1136	400	0	944	314

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000519301	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.001310021	0.99868995
ENST00000519301	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.003812257	0.99618775
ENST00000520407	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.001762203	0.9982377
ENST00000520407	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.008567645	0.9914323
ENST00000523079	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.00152102	0.99847895
ENST00000523079	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.005219879	0.9947802
ENST00000338921	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.00152102	0.99847895
ENST00000338921	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.005219879	0.9947802
ENST00000356819	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.00152102	0.99847895
ENST00000356819	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.005219879	0.9947802
ENST00000287845	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.00152102	0.99847895
ENST00000287845	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.005219879	0.9947802
ENST00000341377	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.00152102	0.99847895
ENST00000341377	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.005219879	0.9947802
ENST00000287842	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.001388943	0.998611
ENST00000287842	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.005309243	0.9946907
ENST00000521670	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.00094464	0.9990553
ENST00000521670	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.003309703	0.9966903
ENST00000405005	ENST00000220876	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.000838247	0.9991617
ENST00000405005	ENST00000518111	NRG1	chr8	32463201	+	STMN2	chr8	80549037	+	0.00308882	0.9969112

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60283_60283_1_NRG1-STMN2_NRG1_chr8_32463201_ENST00000287842_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=427AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_2_NRG1-STMN2_NRG1_chr8_32463201_ENST00000287842_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=435AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_3_NRG1-STMN2_NRG1_chr8_32463201_ENST00000287845_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=427AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_4_NRG1-STMN2_NRG1_chr8_32463201_ENST00000287845_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=435AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_5_NRG1-STMN2_NRG1_chr8_32463201_ENST00000338921_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=427AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_6_NRG1-STMN2_NRG1_chr8_32463201_ENST00000338921_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=435AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_7_NRG1-STMN2_NRG1_chr8_32463201_ENST00000341377_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=427AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_8_NRG1-STMN2_NRG1_chr8_32463201_ENST00000341377_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=435AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_9_NRG1-STMN2_NRG1_chr8_32463201_ENST00000356819_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=427AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_10_NRG1-STMN2_NRG1_chr8_32463201_ENST00000356819_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=435AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_11_NRG1-STMN2_NRG1_chr8_32463201_ENST00000405005_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=306AA_BP=133
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK
KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQA
FELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIK

--------------------------------------------------------------

>60283_60283_12_NRG1-STMN2_NRG1_chr8_32463201_ENST00000405005_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=314AA_BP=133
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK
KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQA
FELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIK

--------------------------------------------------------------

>60283_60283_13_NRG1-STMN2_NRG1_chr8_32463201_ENST00000519301_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=285AA_BP=112
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASP
KKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHA

--------------------------------------------------------------

>60283_60283_14_NRG1-STMN2_NRG1_chr8_32463201_ENST00000519301_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=293AA_BP=112
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASP
KKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKLVKF

--------------------------------------------------------------

>60283_60283_15_NRG1-STMN2_NRG1_chr8_32463201_ENST00000520407_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=521AA_BP=348
MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQ
RRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL
LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVL
RCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSML
SLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAE

--------------------------------------------------------------

>60283_60283_16_NRG1-STMN2_NRG1_chr8_32463201_ENST00000520407_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=529AA_BP=348
MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQ
RRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL
LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVL
RCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSML
SLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAE

--------------------------------------------------------------

>60283_60283_17_NRG1-STMN2_NRG1_chr8_32463201_ENST00000521670_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=306AA_BP=133
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK
KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQA
FELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIK

--------------------------------------------------------------

>60283_60283_18_NRG1-STMN2_NRG1_chr8_32463201_ENST00000521670_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=314AA_BP=133
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK
KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQA
FELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIK

--------------------------------------------------------------

>60283_60283_19_NRG1-STMN2_NRG1_chr8_32463201_ENST00000523079_STMN2_chr8_80549037_ENST00000220876_length(amino acids)=427AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

>60283_60283_20_NRG1-STMN2_NRG1_chr8_32463201_ENST00000523079_STMN2_chr8_80549037_ENST00000518111_length(amino acids)=435AA_BP=254
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSMLSLIC
SCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:32463201/chr8:80549037)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NRG1 Q02297	.
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250\|UniProtKB:P43322, ECO:0000269\|PubMed:10867024, ECO:0000269\|PubMed:1348215, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:7902537}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520407

165_177

348.3333333333333

423.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000287842

37_128

133.33333333333334

638.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000341377

37_128

133.33333333333334

525.3333333333334

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000356819

37_128

133.33333333333334

646.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000405005

37_128

133.33333333333334

641.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520407

178_222

348.3333333333333

423.0

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520407

37_128

348.3333333333333

423.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000521670

37_128

133.33333333333334

477.3333333333333

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000523079

37_128

133.33333333333334

421.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520407

20_242

348.3333333333333

423.0

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520407

243_265

348.3333333333333

423.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000220876

75_179

6.333333333333333

180.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000518111

75_179

6.333333333333333

188.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000220876

38_179

6.333333333333333

180.0

Domain

SLD

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000518111

38_179

6.333333333333333

188.0

Domain

SLD

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000220876

39_96

6.333333333333333

180.0

Region

Regulatory/phosphorylation domain

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000518111

39_96

6.333333333333333

188.0

Region

Regulatory/phosphorylation domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000287842

165_177

133.33333333333334

638.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000341377

165_177

133.33333333333334

525.3333333333334

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000356819

165_177

133.33333333333334

646.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000405005

165_177

133.33333333333334

641.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000519301

165_177

112.33333333333333

591.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520502

165_177

0.0

297.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000521670

165_177

133.33333333333334

477.3333333333333

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000523079

165_177

133.33333333333334

421.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000287842

178_222

133.33333333333334

638.0

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000341377

178_222

133.33333333333334

525.3333333333334

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000356819

178_222

133.33333333333334

646.0

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000405005

178_222

133.33333333333334

641.0

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000519301

178_222

112.33333333333333

591.0

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000519301

37_128

112.33333333333333

591.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520502

178_222

0.0

297.0

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520502

37_128

0.0

297.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000521670

178_222

133.33333333333334

477.3333333333333

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000523079

178_222

133.33333333333334

421.0

Domain

EGF-like

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000287842

20_242

133.33333333333334

638.0

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000287842

266_640

133.33333333333334

638.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000341377

20_242

133.33333333333334

525.3333333333334

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000341377

266_640

133.33333333333334

525.3333333333334

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000356819

20_242

133.33333333333334

646.0

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000356819

266_640

133.33333333333334

646.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000405005

20_242

133.33333333333334

641.0

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000405005

266_640

133.33333333333334

641.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000519301

20_242

112.33333333333333

591.0

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000519301

266_640

112.33333333333333

591.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520407

266_640

348.3333333333333

423.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520502

20_242

0.0

297.0

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520502

266_640

0.0

297.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000521670

20_242

133.33333333333334

477.3333333333333

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000521670

266_640

133.33333333333334

477.3333333333333

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000523079

20_242

133.33333333333334

421.0

Topological domain

Extracellular

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000523079

266_640

133.33333333333334

421.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000287842

243_265

133.33333333333334

638.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000341377

243_265

133.33333333333334

525.3333333333334

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000356819

243_265

133.33333333333334

646.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000405005

243_265

133.33333333333334

641.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000519301

243_265

112.33333333333333

591.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000520502

243_265

0.0

297.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000521670

243_265

133.33333333333334

477.3333333333333

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:32463201

chr8:80549037

ENST00000523079

243_265

133.33333333333334

421.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000220876

1_26

6.333333333333333

180.0

Region

Membrane attachment

Tgene

STMN2

chr8:32463201

chr8:80549037

ENST00000518111

1_26

6.333333333333333

188.0

Region

Membrane attachment

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1136_NRG1_32463201_STMN2_80549037_1136_NRG1_32463201_STMN2_80549037_ranked_0.pdb	NRG1	32463201	32463201	ENST00000518111	STMN2	chr8	80549037	+	MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQ RRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVL RCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNAYKEKMKELSML SLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAE	529

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

NRG1_pLDDT.png

STMN2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NRG1
STMN2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to NRG1-STMN2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NRG1-STMN2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	NRG1	C0036341	Schizophrenia	7	CTD_human
Hgene	NRG1	C0005586	Bipolar Disorder	5	PSYGENET
Hgene	NRG1	C0024809	Marijuana Abuse	3	PSYGENET
Hgene	NRG1	C0011570	Mental Depression	2	PSYGENET
Hgene	NRG1	C0011581	Depressive disorder	2	PSYGENET
Hgene	NRG1	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	NRG1	C0006870	Cannabis Dependence	1	PSYGENET
Hgene	NRG1	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	NRG1	C0011616	Contact Dermatitis	1	CTD_human
Hgene	NRG1	C0018801	Heart failure	1	CTD_human
Hgene	NRG1	C0018802	Congestive heart failure	1	CTD_human
Hgene	NRG1	C0019569	Hirschsprung Disease	1	CTD_human
Hgene	NRG1	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	NRG1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	NRG1	C0024121	Lung Neoplasms	1	CTD_human
Hgene	NRG1	C0026650	Movement Disorders	1	CTD_human
Hgene	NRG1	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	NRG1	C0030193	Pain	1	CTD_human
Hgene	NRG1	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Hgene	NRG1	C0038358	Gastric ulcer	1	CTD_human
Hgene	NRG1	C0085758	Aganglionosis, Colonic	1	CTD_human
Hgene	NRG1	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	NRG1	C0162351	Contact hypersensitivity	1	CTD_human
Hgene	NRG1	C0234230	Pain, Burning	1	CTD_human
Hgene	NRG1	C0234238	Ache	1	CTD_human
Hgene	NRG1	C0234254	Radiating pain	1	CTD_human
Hgene	NRG1	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	NRG1	C0236733	Amphetamine-Related Disorders	1	CTD_human
Hgene	NRG1	C0236804	Amphetamine Addiction	1	CTD_human
Hgene	NRG1	C0236807	Amphetamine Abuse	1	CTD_human
Hgene	NRG1	C0242379	Malignant neoplasm of lung	1	CTD_human
Hgene	NRG1	C0266487	Etat Marbre	1	CTD_human
Hgene	NRG1	C0458257	Pain, Splitting	1	CTD_human
Hgene	NRG1	C0458259	Pain, Crushing	1	CTD_human
Hgene	NRG1	C0678222	Breast Carcinoma	1	CTD_human
Hgene	NRG1	C0751407	Pain, Migratory	1	CTD_human
Hgene	NRG1	C0751408	Suffering, Physical	1	CTD_human
Hgene	NRG1	C0876994	Cardiotoxicity	1	CTD_human
Hgene	NRG1	C1136382	Sclerocystic Ovaries	1	CTD_human
Hgene	NRG1	C1257840	Aganglionosis, Rectosigmoid Colon	1	CTD_human
Hgene	NRG1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	NRG1	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	NRG1	C1959583	Myocardial Failure	1	CTD_human
Hgene	NRG1	C1961112	Heart Decompensation	1	CTD_human
Hgene	NRG1	C3495559	Juvenile arthritis	1	CTD_human
Hgene	NRG1	C3661523	Congenital Intestinal Aganglionosis	1	CTD_human
Hgene	NRG1	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	NRG1	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	NRG1	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Hgene	NRG1	C4704874	Mammary Carcinoma, Human	1	CTD_human