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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NSD1-DPEP2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NSD1-DPEP2
FusionPDB ID: 60416
FusionGDB2.0 ID: 60416
HgeneTgene
Gene symbol

NSD1

DPEP2

Gene ID

64324

64174

Gene namenuclear receptor binding SET domain protein 1dipeptidase 2
SynonymsARA267|KMT3B|SOTOS|SOTOS1|STOMBD2
Cytomap

5q35.3

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-asdipeptidase 2
Modification date2020032120200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000347982, ENST00000354179, 
ENST00000439151, ENST00000361032, 
ENST00000511258, 		ENST00000393847, 
ENST00000412757, ENST00000572888, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 14 X 17=54742 X 4 X 2=16
# samples 372
** MAII scorelog2(37/5474*10)=-3.88699825884864
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/16*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NSD1 [Title/Abstract] AND DPEP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NSD1(176619020)-DPEP2(68023301), # samples:3
Anticipated loss of major functional domain due to fusion event.NSD1-DPEP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-DPEP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-DPEP2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NSD1-DPEP2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NSD1-DPEP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NSD1-DPEP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NSD1-DPEP2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567


check buttonFusion gene breakpoints across NSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPEP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A7UH-01ANSD1chr5

176619020

-DPEP2chr16

68023301

-
ChimerDB4CESCTCGA-C5-A7UH-01ANSD1chr5

176619020

+DPEP2chr16

68023301

-
ChimerDB4CESCTCGA-C5-A7UH-01ANSD1chr5

176619020

+DPEP2chr16

68024900

-
ChimerDB4CESCTCGA-C5-A7UH-01ANSD1chr5

176619020

+DPEP2chr16

68027160

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354179NSD1chr5176619020+ENST00000393847DPEP2chr1668023301-995416160882240
ENST00000354179NSD1chr5176619020+ENST00000412757DPEP2chr1668023301-992416160882240
ENST00000354179NSD1chr5176619020+ENST00000572888DPEP2chr1668023301-883416160882241
ENST00000439151NSD1chr5176619020+ENST00000393847DPEP2chr1668023301-16871108451574509
ENST00000439151NSD1chr5176619020+ENST00000412757DPEP2chr1668023301-16841108451574509
ENST00000439151NSD1chr5176619020+ENST00000572888DPEP2chr1668023301-15751108451574509
ENST00000347982NSD1chr5176619020+ENST00000393847DPEP2chr1668023301-936357101823240
ENST00000347982NSD1chr5176619020+ENST00000412757DPEP2chr1668023301-933357101823240
ENST00000347982NSD1chr5176619020+ENST00000572888DPEP2chr1668023301-824357101823241

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354179ENST00000393847NSD1chr5176619020+DPEP2chr1668023301-0.0394372270.96056277
ENST00000354179ENST00000412757NSD1chr5176619020+DPEP2chr1668023301-0.037943710.9620562
ENST00000354179ENST00000572888NSD1chr5176619020+DPEP2chr1668023301-0.0347691850.9652308
ENST00000439151ENST00000393847NSD1chr5176619020+DPEP2chr1668023301-0.0013350930.99866486
ENST00000439151ENST00000412757NSD1chr5176619020+DPEP2chr1668023301-0.0013221550.9986778
ENST00000439151ENST00000572888NSD1chr5176619020+DPEP2chr1668023301-0.0014874080.99851257
ENST00000347982ENST00000393847NSD1chr5176619020+DPEP2chr1668023301-0.0373016670.9626984
ENST00000347982ENST00000412757NSD1chr5176619020+DPEP2chr1668023301-0.035577270.96442276
ENST00000347982ENST00000572888NSD1chr5176619020+DPEP2chr1668023301-0.0336390250.96636105

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60416_60416_1_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000347982_DPEP2_chr16_68023301_ENST00000393847_length(amino acids)=240AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDH
IKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSC

--------------------------------------------------------------

>60416_60416_2_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000347982_DPEP2_chr16_68023301_ENST00000412757_length(amino acids)=240AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDH
IKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSC

--------------------------------------------------------------

>60416_60416_3_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000347982_DPEP2_chr16_68023301_ENST00000572888_length(amino acids)=241AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDH
IKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSC

--------------------------------------------------------------

>60416_60416_4_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000354179_DPEP2_chr16_68023301_ENST00000393847_length(amino acids)=240AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDH
IKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSC

--------------------------------------------------------------

>60416_60416_5_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000354179_DPEP2_chr16_68023301_ENST00000412757_length(amino acids)=240AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDH
IKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSC

--------------------------------------------------------------

>60416_60416_6_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000354179_DPEP2_chr16_68023301_ENST00000572888_length(amino acids)=241AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDH
IKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSC

--------------------------------------------------------------

>60416_60416_7_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000439151_DPEP2_chr16_68023301_ENST00000393847_length(amino acids)=509AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDHI
KAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCH

--------------------------------------------------------------

>60416_60416_8_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000439151_DPEP2_chr16_68023301_ENST00000412757_length(amino acids)=509AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDHI
KAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCH

--------------------------------------------------------------

>60416_60416_9_NSD1-DPEP2_NSD1_chr5_176619020_ENST00000439151_DPEP2_chr16_68023301_ENST00000572888_length(amino acids)=509AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDHFDHI
KAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCH

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176619020/chr16:68023301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4242207_242185.333333333333332428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4242207_242185.333333333333332428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1202207_24210.02594.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3232207_2421354.33333333333332697.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241756_181885.333333333333332428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241890_194085.333333333333332428.0DomainAWS
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241942_205985.333333333333332428.0DomainSET
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4242066_208285.333333333333332428.0DomainPost-SET
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+424323_38885.333333333333332428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241756_181885.333333333333332428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241890_194085.333333333333332428.0DomainAWS
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241942_205985.333333333333332428.0DomainSET
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4242066_208285.333333333333332428.0DomainPost-SET
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+424323_38885.333333333333332428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201756_18180.02594.0DomainPWWP 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201890_19400.02594.0DomainAWS
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201942_20590.02594.0DomainSET
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1202066_20820.02594.0DomainPost-SET
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+120323_3880.02594.0DomainPWWP 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231756_1818354.33333333333332697.0DomainPWWP 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231890_1940354.33333333333332697.0DomainAWS
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231942_2059354.33333333333332697.0DomainSET
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3232066_2082354.33333333333332697.0DomainPost-SET
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+323323_388354.33333333333332697.0DomainPWWP 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241952_195485.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241994_199785.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4242020_202185.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4242060_206685.333333333333332428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241952_195485.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241994_199785.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4242020_202185.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4242060_206685.333333333333332428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201952_19540.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201994_19970.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1202020_20210.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1202060_20660.02594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231952_1954354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231994_1997354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3232020_2021354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3232060_2066354.33333333333332697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241543_158985.333333333333332428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241590_164685.333333333333332428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4241707_175185.333333333333332428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr16:68023301ENST00000347982+4242118_216585.333333333333332428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241543_158985.333333333333332428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241590_164685.333333333333332428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4241707_175185.333333333333332428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr16:68023301ENST00000354179+4242118_216585.333333333333332428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201543_15890.02594.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201590_16460.02594.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1201707_17510.02594.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr16:68023301ENST00000361032+1202118_21650.02594.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231543_1589354.33333333333332697.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231590_1646354.33333333333332697.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3231707_1751354.33333333333332697.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr16:68023301ENST00000439151+3232118_2165354.33333333333332697.0Zinc fingerPHD-type 4%3B atypical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NSD1
DPEP2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NSD1-DPEP2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NSD1-DPEP2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource