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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NSD1-FAT2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NSD1-FAT2
FusionPDB ID: 60418
FusionGDB2.0 ID: 60418
HgeneTgene
Gene symbol

NSD1

FAT2

Gene ID

64324

2196

Gene namenuclear receptor binding SET domain protein 1FAT atypical cadherin 2
SynonymsARA267|KMT3B|SOTOS|SOTOS1|STOCDHF8|CDHR9|HFAT2|MEGF1|SCA45
Cytomap

5q35.3

5q33.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-asprotocadherin Fat 2FAT tumor suppressor homolog 2cadherin family member 8cadherin-related family member 9multiple EGF-like domains protein 1multiple epidermal growth factor-like domains 1multiple epidermal growth factor-like domains protein 1protoc
Modification date2020032120200313
UniProtAcc.

Q9NYQ8

Ensembl transtripts involved in fusion geneENST idsENST00000347982, ENST00000354179, 
ENST00000361032, ENST00000439151, 
ENST00000511258, 		ENST00000261800, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 14 X 17=54742 X 2 X 2=8
# samples 372
** MAII scorelog2(37/5474*10)=-3.88699825884864
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: NSD1 [Title/Abstract] AND FAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NSD1(176675325)-FAT2(150892167), # samples:2
Anticipated loss of major functional domain due to fusion event.NSD1-FAT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-FAT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-FAT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-FAT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567

TgeneFAT2

GO:0010631

epithelial cell migration

29053796

TgeneFAT2

GO:0031589

cell-substrate adhesion

29053796


check buttonFusion gene breakpoints across NSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A20T-01ANSD1chr5

176675325

-FAT2chr5

150892167

-
ChimerDB4BLCATCGA-BT-A20T-01ANSD1chr5

176675325

+FAT2chr5

150892167

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354179NSD1chr5176675325+ENST00000261800FAT2chr5150892167-7052399416055801806
ENST00000439151NSD1chr5176675325+ENST00000261800FAT2chr5150892167-774446864562722075
ENST00000347982NSD1chr5176675325+ENST00000261800FAT2chr5150892167-6993393510155211806
ENST00000361032NSD1chr5176675325+ENST00000261800FAT2chr5150892167-73904332059181972

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354179ENST00000261800NSD1chr5176675325+FAT2chr5150892167-0.0005268570.99947315
ENST00000439151ENST00000261800NSD1chr5176675325+FAT2chr5150892167-0.0004519580.999548
ENST00000347982ENST00000261800NSD1chr5176675325+FAT2chr5150892167-0.0004933820.9995066
ENST00000361032ENST00000261800NSD1chr5176675325+FAT2chr5150892167-0.0004549540.99954504

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60418_60418_1_NSD1-FAT2_NSD1_chr5_176675325_ENST00000347982_FAT2_chr5_150892167_ENST00000261800_length(amino acids)=1806AA_BP=1277
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRR
PYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKL
DSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFIS
GDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDE
EKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSA
EPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEE
CSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHI
PIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSG
ELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLR
GGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTK
PRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQ
AELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREA
PFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAG
HLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASK
KMQGERGGGAALKENVCQLASGVPQLEYHCLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLL
GGLILLHSSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHC
EQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRC
KSHKPVAMEDPDLLARSVGVDTQAMPAIELNPLSASSCNNLNQPEPSKASVPNELVTFGPNSKQRPVVCSVPPRLPPAAVPSHSDNEPVI
KRTWSSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGLYGGFPFPLEMENKRAPLPPRYSNQNLEDLMP
SRPPSPRERLVAPCLNEYTAISYYHSQFRQGGGGPCLADGGYKGVGMRLSRAGPSYAVCEVEGAPLAGQGQPRVPPNYEGSDMVESDYGS

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>60418_60418_2_NSD1-FAT2_NSD1_chr5_176675325_ENST00000354179_FAT2_chr5_150892167_ENST00000261800_length(amino acids)=1806AA_BP=1277
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRR
PYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKL
DSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFIS
GDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDE
EKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSA
EPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEE
CSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHI
PIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSG
ELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLR
GGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTK
PRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQ
AELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREA
PFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAG
HLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASK
KMQGERGGGAALKENVCQLASGVPQLEYHCLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLL
GGLILLHSSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHC
EQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRC
KSHKPVAMEDPDLLARSVGVDTQAMPAIELNPLSASSCNNLNQPEPSKASVPNELVTFGPNSKQRPVVCSVPPRLPPAAVPSHSDNEPVI
KRTWSSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGLYGGFPFPLEMENKRAPLPPRYSNQNLEDLMP
SRPPSPRERLVAPCLNEYTAISYYHSQFRQGGGGPCLADGGYKGVGMRLSRAGPSYAVCEVEGAPLAGQGQPRVPPNYEGSDMVESDYGS

--------------------------------------------------------------

>60418_60418_3_NSD1-FAT2_NSD1_chr5_176675325_ENST00000361032_FAT2_chr5_150892167_ENST00000261800_length(amino acids)=1972AA_BP=1443
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTND
PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSR
IANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSD
DGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDL
KASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSP
LASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMM
LKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKR
DLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQI
MGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENS
ECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKR
LRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGG
GHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSY
SKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKE
NVCQLASGVPQLEYHCLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLHSSSNVSQ
GFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLE
GGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRCKSHKPVAMEDPDLL
ARSVGVDTQAMPAIELNPLSASSCNNLNQPEPSKASVPNELVTFGPNSKQRPVVCSVPPRLPPAAVPSHSDNEPVIKRTWSSEEMVYPGG
AMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGLYGGFPFPLEMENKRAPLPPRYSNQNLEDLMPSRPPSPRERLVAPC

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>60418_60418_4_NSD1-FAT2_NSD1_chr5_176675325_ENST00000439151_FAT2_chr5_150892167_ENST00000261800_length(amino acids)=2075AA_BP=1546
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRP
YRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLD
SEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISG
DISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEE
KRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAE
PGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEEC
SLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIP
IEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGE
LSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRG
GAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKP
RKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQA
ELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAP
FLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGH
LENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKK
MQGERGGGAALKENVCQLASGVPQLEYHCLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLG
GLILLHSSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCE
QGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRCK
SHKPVAMEDPDLLARSVGVDTQAMPAIELNPLSASSCNNLNQPEPSKASVPNELVTFGPNSKQRPVVCSVPPRLPPAAVPSHSDNEPVIK
RTWSSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGLYGGFPFPLEMENKRAPLPPRYSNQNLEDLMPS
RPPSPRERLVAPCLNEYTAISYYHSQFRQGGGGPCLADGGYKGVGMRLSRAGPSYAVCEVEGAPLAGQGQPRVPPNYEGSDMVESDYGSC

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176675325/chr5:150892167)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAT2

Q9NYQ8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). {ECO:0000250|UniProtKB:O88277, ECO:0000269|PubMed:18534823}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+1224323_3881278.02428.0DomainPWWP 1
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+1224323_3881278.02428.0DomainPWWP 1
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+820323_3881444.02594.0DomainPWWP 1
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+1123323_3881547.02697.0DomainPWWP 1
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233947_39843821.04350.0DomainEGF-like 1
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233986_40223821.04350.0DomainEGF-like 2
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018234070_43493821.04350.0Topological domainCytoplasmic
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018234049_40693821.04350.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12242207_24211278.02428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12242207_24211278.02428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8202207_24211444.02594.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11232207_24211547.02697.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241756_18181278.02428.0DomainPWWP 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241890_19401278.02428.0DomainAWS
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241942_20591278.02428.0DomainSET
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12242066_20821278.02428.0DomainPost-SET
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241756_18181278.02428.0DomainPWWP 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241890_19401278.02428.0DomainAWS
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241942_20591278.02428.0DomainSET
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12242066_20821278.02428.0DomainPost-SET
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201756_18181444.02594.0DomainPWWP 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201890_19401444.02594.0DomainAWS
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201942_20591444.02594.0DomainSET
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8202066_20821444.02594.0DomainPost-SET
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231756_18181547.02697.0DomainPWWP 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231890_19401547.02697.0DomainAWS
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231942_20591547.02697.0DomainSET
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11232066_20821547.02697.0DomainPost-SET
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241952_19541278.02428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241994_19971278.02428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12242020_20211278.02428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12242060_20661278.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241952_19541278.02428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241994_19971278.02428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12242020_20211278.02428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12242060_20661278.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201952_19541444.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201994_19971444.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8202020_20211444.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8202060_20661444.02594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231952_19541547.02697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231994_19971547.02697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11232020_20211547.02697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11232060_20661547.02697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241543_15891278.02428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241590_16461278.02428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12241707_17511278.02428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176675325chr5:150892167ENST00000347982+12242118_21651278.02428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241543_15891278.02428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241590_16461278.02428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12241707_17511278.02428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176675325chr5:150892167ENST00000354179+12242118_21651278.02428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201543_15891444.02594.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201590_16461444.02594.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8201707_17511444.02594.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176675325chr5:150892167ENST00000361032+8202118_21651444.02594.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231543_15891547.02697.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231590_16461547.02697.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11231707_17511547.02697.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176675325chr5:150892167ENST00000439151+11232118_21651547.02697.0Zinc fingerPHD-type 4%3B atypical
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233297_33023821.04350.0Compositional biasNote=Poly-Ser
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231033_11373821.04350.0DomainCadherin 9
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231138_12423821.04350.0DomainCadherin 10
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231243_13463821.04350.0DomainCadherin 11
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231350_14483821.04350.0DomainCadherin 12
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231449_15553821.04350.0DomainCadherin 13
TgeneFAT2chr5:176675325chr5:150892167ENST000002618001823149_2563821.04350.0DomainCadherin 2
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231556_16603821.04350.0DomainCadherin 14
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231661_17583821.04350.0DomainCadherin 15
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231759_18723821.04350.0DomainCadherin 16
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018231969_20703821.04350.0DomainCadherin 17
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232071_21713821.04350.0DomainCadherin 18
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232172_22723821.04350.0DomainCadherin 19
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232273_23793821.04350.0DomainCadherin 20
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232380_24813821.04350.0DomainCadherin 21
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232482_25853821.04350.0DomainCadherin 22
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232586_26913821.04350.0DomainCadherin 23
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232692_27973821.04350.0DomainCadherin 24
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232798_29063821.04350.0DomainCadherin 25
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018232907_30113821.04350.0DomainCadherin 26
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233012_31133821.04350.0DomainCadherin 27
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233114_32183821.04350.0DomainCadherin 28
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233219_33213821.04350.0DomainCadherin 29
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233322_34263821.04350.0DomainCadherin 30
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233427_35313821.04350.0DomainCadherin 31
TgeneFAT2chr5:176675325chr5:150892167ENST00000261800182334_1483821.04350.0DomainCadherin 1
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233532_36423821.04350.0DomainCadherin 32
TgeneFAT2chr5:176675325chr5:150892167ENST000002618001823363_4583821.04350.0DomainCadherin 3
TgeneFAT2chr5:176675325chr5:150892167ENST0000026180018233773_39443821.04350.0DomainLaminin G-like
TgeneFAT2chr5:176675325chr5:150892167ENST000002618001823459_5643821.04350.0DomainCadherin 4
TgeneFAT2chr5:176675325chr5:150892167ENST000002618001823565_6693821.04350.0DomainCadherin 5
TgeneFAT2chr5:176675325chr5:150892167ENST000002618001823716_8203821.04350.0DomainCadherin 6
TgeneFAT2chr5:176675325chr5:150892167ENST000002618001823821_9253821.04350.0DomainCadherin 7
TgeneFAT2chr5:176675325chr5:150892167ENST000002618001823926_10323821.04350.0DomainCadherin 8
TgeneFAT2chr5:176675325chr5:150892167ENST00000261800182319_40483821.04350.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NSD1
FAT2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NSD1-FAT2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NSD1-FAT2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource