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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NSD1-ZNF346

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NSD1-ZNF346
FusionPDB ID: 60438
FusionGDB2.0 ID: 60438
HgeneTgene
Gene symbol

NSD1

ZNF346

Gene ID

64324

23567

Gene namenuclear receptor binding SET domain protein 1zinc finger protein 346
SynonymsARA267|KMT3B|SOTOS|SOTOS1|STOJAZ|Zfp346
Cytomap

5q35.3

5q35.2

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-aszinc finger protein 346double-stranded RNA-binding zinc finger protein JAZjust another zinc finger protein
Modification date2020032120200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000347982, ENST00000354179, 
ENST00000361032, ENST00000439151, 
ENST00000511258, 		ENST00000503039, 
ENST00000512315, ENST00000261948, 
ENST00000358149, ENST00000503425, 
ENST00000506693, ENST00000511834, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 14 X 17=54744 X 12 X 8=384
# samples 3718
** MAII scorelog2(37/5474*10)=-3.88699825884864
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/384*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NSD1 [Title/Abstract] AND ZNF346 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NSD1(176563031)-ZNF346(176489059), # samples:2
NSD1(176563031)-ZNF346(176468127), # samples:2
NSD1(176619020)-ZNF346(176489059), # samples:2
NSD1(176696808)-ZNF346(176468127), # samples:2
NSD1(176678854)-ZNF346(176468127), # samples:2
ZNF346(176471534)-NSD1(176631121), # samples:1
Anticipated loss of major functional domain due to fusion event.NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF346-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF346-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567


check buttonFusion gene breakpoints across NSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF346 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5JE-01ANSD1chr5

176563031

+ZNF346chr5

176477752

+
ChimerDB4ACCTCGA-OR-A5JE-01ANSD1chr5

176563031

-ZNF346chr5

176489059

+
ChimerDB4ACCTCGA-OR-A5JE-01ANSD1chr5

176563031

+ZNF346chr5

176489059

+
ChimerDB4BRCATCGA-A7-A26G-01ANSD1chr5

176563031

-ZNF346chr5

176468127

+
ChimerDB4BRCATCGA-A7-A26G-01ANSD1chr5

176563031

+ZNF346chr5

176468127

+
ChimerDB4BRCATCGA-A7-A26GNSD1chr5

176563031

+ZNF346chr5

176468126

+
ChimerDB4BRCATCGA-D8-A140-01ANSD1chr5

176619020

-ZNF346chr5

176489059

+
ChimerDB4BRCATCGA-D8-A140-01ANSD1chr5

176619020

+ZNF346chr5

176489059

+
ChimerDB4BRCATCGA-D8-A140NSD1chr5

176619020

+ZNF346chr5

176489058

+
ChimerDB4CESCTCGA-C5-A3HF-01ANSD1chr5

176619020

-ZNF346chr5

176468127

+
ChimerDB4LUSCTCGA-NC-A5HL-01ANSD1chr5

176696808

-ZNF346chr5

176468127

+
ChimerDB4LUSCTCGA-NC-A5HLNSD1chr5

176696808

+ZNF346chr5

176468127

+
ChimerDB4OVTCGA-23-1111NSD1chr5

176639196

+ZNF346chr5

176468126

+
ChimerDB4OVTCGA-24-0968NSD1chr5

176631293

+ZNF346chr5

176468126

+
ChimerDB4OVTCGA-24-1427-01ANSD1chr5

176678854

-ZNF346chr5

176468127

+
ChimerDB4OVTCGA-24-1427-01ANSD1chr5

176678854

+ZNF346chr5

176468127

+
ChimerDB4OVTCGA-24-1427NSD1chr5

176678854

+ZNF346chr5

176468126

+
ChimerDB4OVTCGA-57-1585NSD1chr5

176560953

+ZNF346chr5

176477751

+
ChimerDB4STADTCGA-FP-8210-01ANSD1chr5

176563031

+ZNF346chr5

176506383

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354179NSD1chr5176619020+ENST00000506693ZNF346chr5176489058+1240416160597145
ENST00000354179NSD1chr5176619020+ENST00000358149ZNF346chr5176489058+1984416160597145
ENST00000354179NSD1chr5176619020+ENST00000512315ZNF346chr5176489058+1773416160597145
ENST00000354179NSD1chr5176619020+ENST00000503425ZNF346chr5176489058+965416160597145
ENST00000354179NSD1chr5176619020+ENST00000261948ZNF346chr5176489058+1973416160597145
ENST00000354179NSD1chr5176619020+ENST00000511834ZNF346chr5176489058+1964416160597145
ENST00000354179NSD1chr5176619020+ENST00000503039ZNF346chr5176489058+2408416160597145
ENST00000439151NSD1chr5176619020+ENST00000506693ZNF346chr5176489058+19321108451289414
ENST00000439151NSD1chr5176619020+ENST00000358149ZNF346chr5176489058+26761108451289414
ENST00000439151NSD1chr5176619020+ENST00000512315ZNF346chr5176489058+24651108451289414
ENST00000439151NSD1chr5176619020+ENST00000503425ZNF346chr5176489058+16571108451289414
ENST00000439151NSD1chr5176619020+ENST00000261948ZNF346chr5176489058+26651108451289414
ENST00000439151NSD1chr5176619020+ENST00000511834ZNF346chr5176489058+26561108451289414
ENST00000439151NSD1chr5176619020+ENST00000503039ZNF346chr5176489058+31001108451289414
ENST00000347982NSD1chr5176619020+ENST00000506693ZNF346chr5176489058+1181357101538145
ENST00000347982NSD1chr5176619020+ENST00000358149ZNF346chr5176489058+1925357101538145
ENST00000347982NSD1chr5176619020+ENST00000512315ZNF346chr5176489058+1714357101538145
ENST00000347982NSD1chr5176619020+ENST00000503425ZNF346chr5176489058+906357101538145
ENST00000347982NSD1chr5176619020+ENST00000261948ZNF346chr5176489058+1914357101538145
ENST00000347982NSD1chr5176619020+ENST00000511834ZNF346chr5176489058+1905357101538145
ENST00000347982NSD1chr5176619020+ENST00000503039ZNF346chr5176489058+2349357101538145
ENST00000354179NSD1chr5176619020+ENST00000506693ZNF346chr5176489059+1240416160597145
ENST00000354179NSD1chr5176619020+ENST00000358149ZNF346chr5176489059+1984416160597145
ENST00000354179NSD1chr5176619020+ENST00000512315ZNF346chr5176489059+1773416160597145
ENST00000354179NSD1chr5176619020+ENST00000503425ZNF346chr5176489059+965416160597145
ENST00000354179NSD1chr5176619020+ENST00000261948ZNF346chr5176489059+1973416160597145
ENST00000354179NSD1chr5176619020+ENST00000511834ZNF346chr5176489059+1964416160597145
ENST00000354179NSD1chr5176619020+ENST00000503039ZNF346chr5176489059+2408416160597145
ENST00000439151NSD1chr5176619020+ENST00000506693ZNF346chr5176489059+19321108451289414
ENST00000439151NSD1chr5176619020+ENST00000358149ZNF346chr5176489059+26761108451289414
ENST00000439151NSD1chr5176619020+ENST00000512315ZNF346chr5176489059+24651108451289414
ENST00000439151NSD1chr5176619020+ENST00000503425ZNF346chr5176489059+16571108451289414
ENST00000439151NSD1chr5176619020+ENST00000261948ZNF346chr5176489059+26651108451289414
ENST00000439151NSD1chr5176619020+ENST00000511834ZNF346chr5176489059+26561108451289414
ENST00000439151NSD1chr5176619020+ENST00000503039ZNF346chr5176489059+31001108451289414
ENST00000347982NSD1chr5176619020+ENST00000506693ZNF346chr5176489059+1181357101538145
ENST00000347982NSD1chr5176619020+ENST00000358149ZNF346chr5176489059+1925357101538145
ENST00000347982NSD1chr5176619020+ENST00000512315ZNF346chr5176489059+1714357101538145
ENST00000347982NSD1chr5176619020+ENST00000503425ZNF346chr5176489059+906357101538145
ENST00000347982NSD1chr5176619020+ENST00000261948ZNF346chr5176489059+1914357101538145
ENST00000347982NSD1chr5176619020+ENST00000511834ZNF346chr5176489059+1905357101538145
ENST00000347982NSD1chr5176619020+ENST00000503039ZNF346chr5176489059+2349357101538145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354179ENST00000506693NSD1chr5176619020+ZNF346chr5176489058+0.035997980.9640021
ENST00000354179ENST00000358149NSD1chr5176619020+ZNF346chr5176489058+0.183609140.8163909
ENST00000354179ENST00000512315NSD1chr5176619020+ZNF346chr5176489058+0.174520120.82547987
ENST00000354179ENST00000503425NSD1chr5176619020+ZNF346chr5176489058+0.0443146820.9556853
ENST00000354179ENST00000261948NSD1chr5176619020+ZNF346chr5176489058+0.192308650.80769134
ENST00000354179ENST00000511834NSD1chr5176619020+ZNF346chr5176489058+0.18880410.81119585
ENST00000354179ENST00000503039NSD1chr5176619020+ZNF346chr5176489058+0.229357320.77064276
ENST00000439151ENST00000506693NSD1chr5176619020+ZNF346chr5176489058+0.0015967150.99840325
ENST00000439151ENST00000358149NSD1chr5176619020+ZNF346chr5176489058+0.0013403410.9986596
ENST00000439151ENST00000512315NSD1chr5176619020+ZNF346chr5176489058+0.0014586130.99854136
ENST00000439151ENST00000503425NSD1chr5176619020+ZNF346chr5176489058+0.001242510.9987575
ENST00000439151ENST00000261948NSD1chr5176619020+ZNF346chr5176489058+0.0013805370.99861944
ENST00000439151ENST00000511834NSD1chr5176619020+ZNF346chr5176489058+0.0013866050.99861336
ENST00000439151ENST00000503039NSD1chr5176619020+ZNF346chr5176489058+0.0012461060.9987539
ENST00000347982ENST00000506693NSD1chr5176619020+ZNF346chr5176489058+0.0345441140.9654559
ENST00000347982ENST00000358149NSD1chr5176619020+ZNF346chr5176489058+0.106897470.89310247
ENST00000347982ENST00000512315NSD1chr5176619020+ZNF346chr5176489058+0.0839947760.9160052
ENST00000347982ENST00000503425NSD1chr5176619020+ZNF346chr5176489058+0.038861870.9611381
ENST00000347982ENST00000261948NSD1chr5176619020+ZNF346chr5176489058+0.1041367950.89586323
ENST00000347982ENST00000511834NSD1chr5176619020+ZNF346chr5176489058+0.102810270.8971897
ENST00000347982ENST00000503039NSD1chr5176619020+ZNF346chr5176489058+0.163872030.836128
ENST00000354179ENST00000506693NSD1chr5176619020+ZNF346chr5176489059+0.035997980.9640021
ENST00000354179ENST00000358149NSD1chr5176619020+ZNF346chr5176489059+0.183609140.8163909
ENST00000354179ENST00000512315NSD1chr5176619020+ZNF346chr5176489059+0.174520120.82547987
ENST00000354179ENST00000503425NSD1chr5176619020+ZNF346chr5176489059+0.0443146820.9556853
ENST00000354179ENST00000261948NSD1chr5176619020+ZNF346chr5176489059+0.192308650.80769134
ENST00000354179ENST00000511834NSD1chr5176619020+ZNF346chr5176489059+0.18880410.81119585
ENST00000354179ENST00000503039NSD1chr5176619020+ZNF346chr5176489059+0.229357320.77064276
ENST00000439151ENST00000506693NSD1chr5176619020+ZNF346chr5176489059+0.0015967150.99840325
ENST00000439151ENST00000358149NSD1chr5176619020+ZNF346chr5176489059+0.0013403410.9986596
ENST00000439151ENST00000512315NSD1chr5176619020+ZNF346chr5176489059+0.0014586130.99854136
ENST00000439151ENST00000503425NSD1chr5176619020+ZNF346chr5176489059+0.001242510.9987575
ENST00000439151ENST00000261948NSD1chr5176619020+ZNF346chr5176489059+0.0013805370.99861944
ENST00000439151ENST00000511834NSD1chr5176619020+ZNF346chr5176489059+0.0013866050.99861336
ENST00000439151ENST00000503039NSD1chr5176619020+ZNF346chr5176489059+0.0012461060.9987539
ENST00000347982ENST00000506693NSD1chr5176619020+ZNF346chr5176489059+0.0345441140.9654559
ENST00000347982ENST00000358149NSD1chr5176619020+ZNF346chr5176489059+0.106897470.89310247
ENST00000347982ENST00000512315NSD1chr5176619020+ZNF346chr5176489059+0.0839947760.9160052
ENST00000347982ENST00000503425NSD1chr5176619020+ZNF346chr5176489059+0.038861870.9611381
ENST00000347982ENST00000261948NSD1chr5176619020+ZNF346chr5176489059+0.1041367950.89586323
ENST00000347982ENST00000511834NSD1chr5176619020+ZNF346chr5176489059+0.102810270.8971897
ENST00000347982ENST00000503039NSD1chr5176619020+ZNF346chr5176489059+0.163872030.836128

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60438_60438_1_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489058_ENST00000261948_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_2_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489058_ENST00000358149_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_3_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489058_ENST00000503039_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_4_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489058_ENST00000503425_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_5_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489058_ENST00000506693_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_6_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489058_ENST00000511834_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_7_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489058_ENST00000512315_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_8_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489059_ENST00000261948_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_9_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489059_ENST00000358149_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_10_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489059_ENST00000503039_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_11_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489059_ENST00000503425_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_12_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489059_ENST00000506693_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_13_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489059_ENST00000511834_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_14_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000347982_ZNF346_chr5_176489059_ENST00000512315_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_15_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489058_ENST00000261948_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_16_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489058_ENST00000358149_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_17_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489058_ENST00000503039_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_18_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489058_ENST00000503425_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_19_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489058_ENST00000506693_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_20_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489058_ENST00000511834_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_21_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489058_ENST00000512315_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_22_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489059_ENST00000261948_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_23_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489059_ENST00000358149_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_24_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489059_ENST00000503039_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_25_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489059_ENST00000503425_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_26_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489059_ENST00000506693_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_27_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489059_ENST00000511834_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_28_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000354179_ZNF346_chr5_176489059_ENST00000512315_length(amino acids)=145AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGY

--------------------------------------------------------------

>60438_60438_29_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489058_ENST00000261948_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_30_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489058_ENST00000358149_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_31_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489058_ENST00000503039_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_32_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489058_ENST00000503425_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

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>60438_60438_33_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489058_ENST00000506693_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

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>60438_60438_34_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489058_ENST00000511834_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_35_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489058_ENST00000512315_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_36_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489059_ENST00000261948_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_37_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489059_ENST00000358149_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_38_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489059_ENST00000503039_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_39_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489059_ENST00000503425_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_40_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489059_ENST00000506693_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_41_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489059_ENST00000511834_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

>60438_60438_42_NSD1-ZNF346_NSD1_chr5_176619020_ENST00000439151_ZNF346_chr5_176489059_ENST00000512315_length(amino acids)=414AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKAGKGYP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176563031/chr5:176489059)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF346chr5:176619020chr5:176489058ENST0000035814947236_270234.33333333333334295.0Zinc fingerNote=Matrin-type 4
TgeneZNF346chr5:176619020chr5:176489059ENST0000035814947236_270234.33333333333334295.0Zinc fingerNote=Matrin-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4242207_242185.333333333333332428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4242207_242185.333333333333332428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1202207_24210.02594.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3232207_2421354.33333333333332697.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4242207_242185.333333333333332428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4242207_242185.333333333333332428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1202207_24210.02594.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3232207_2421354.33333333333332697.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241756_181885.333333333333332428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241890_194085.333333333333332428.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241942_205985.333333333333332428.0DomainSET
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4242066_208285.333333333333332428.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+424323_38885.333333333333332428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241756_181885.333333333333332428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241890_194085.333333333333332428.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241942_205985.333333333333332428.0DomainSET
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4242066_208285.333333333333332428.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+424323_38885.333333333333332428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201756_18180.02594.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201890_19400.02594.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201942_20590.02594.0DomainSET
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1202066_20820.02594.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+120323_3880.02594.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231756_1818354.33333333333332697.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231890_1940354.33333333333332697.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231942_2059354.33333333333332697.0DomainSET
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3232066_2082354.33333333333332697.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+323323_388354.33333333333332697.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241756_181885.333333333333332428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241890_194085.333333333333332428.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241942_205985.333333333333332428.0DomainSET
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4242066_208285.333333333333332428.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+424323_38885.333333333333332428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241756_181885.333333333333332428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241890_194085.333333333333332428.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241942_205985.333333333333332428.0DomainSET
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4242066_208285.333333333333332428.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+424323_38885.333333333333332428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201756_18180.02594.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201890_19400.02594.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201942_20590.02594.0DomainSET
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1202066_20820.02594.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+120323_3880.02594.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231756_1818354.33333333333332697.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231890_1940354.33333333333332697.0DomainAWS
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231942_2059354.33333333333332697.0DomainSET
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3232066_2082354.33333333333332697.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+323323_388354.33333333333332697.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241952_195485.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241994_199785.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4242020_202185.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4242060_206685.333333333333332428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241952_195485.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241994_199785.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4242020_202185.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4242060_206685.333333333333332428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201952_19540.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201994_19970.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1202020_20210.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1202060_20660.02594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231952_1954354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231994_1997354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3232020_2021354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3232060_2066354.33333333333332697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241952_195485.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241994_199785.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4242020_202185.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4242060_206685.333333333333332428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241952_195485.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241994_199785.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4242020_202185.333333333333332428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4242060_206685.333333333333332428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201952_19540.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201994_19970.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1202020_20210.02594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1202060_20660.02594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231952_1954354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231994_1997354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3232020_2021354.33333333333332697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3232060_2066354.33333333333332697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241543_158985.333333333333332428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241590_164685.333333333333332428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4241707_175185.333333333333332428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489058ENST00000347982+4242118_216585.333333333333332428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241543_158985.333333333333332428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241590_164685.333333333333332428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4241707_175185.333333333333332428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489058ENST00000354179+4242118_216585.333333333333332428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201543_15890.02594.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201590_16460.02594.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1201707_17510.02594.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489058ENST00000361032+1202118_21650.02594.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231543_1589354.33333333333332697.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231590_1646354.33333333333332697.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3231707_1751354.33333333333332697.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489058ENST00000439151+3232118_2165354.33333333333332697.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241543_158985.333333333333332428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241590_164685.333333333333332428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4241707_175185.333333333333332428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489059ENST00000347982+4242118_216585.333333333333332428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241543_158985.333333333333332428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241590_164685.333333333333332428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4241707_175185.333333333333332428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489059ENST00000354179+4242118_216585.333333333333332428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201543_15890.02594.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201590_16460.02594.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1201707_17510.02594.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489059ENST00000361032+1202118_21650.02594.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231543_1589354.33333333333332697.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231590_1646354.33333333333332697.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3231707_1751354.33333333333332697.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:176489059ENST00000439151+3232118_2165354.33333333333332697.0Zinc fingerPHD-type 4%3B atypical
TgeneZNF346chr5:176619020chr5:176489058ENST0000026194858131_165259.3333333333333320.0Zinc fingerNote=Matrin-type 2
TgeneZNF346chr5:176619020chr5:176489058ENST0000026194858182_216259.3333333333333320.0Zinc fingerNote=Matrin-type 3
TgeneZNF346chr5:176619020chr5:176489058ENST0000026194858236_270259.3333333333333320.0Zinc fingerNote=Matrin-type 4
TgeneZNF346chr5:176619020chr5:176489058ENST000002619485870_104259.3333333333333320.0Zinc fingerNote=Matrin-type 1
TgeneZNF346chr5:176619020chr5:176489058ENST0000035814947131_165234.33333333333334295.0Zinc fingerNote=Matrin-type 2
TgeneZNF346chr5:176619020chr5:176489058ENST0000035814947182_216234.33333333333334295.0Zinc fingerNote=Matrin-type 3
TgeneZNF346chr5:176619020chr5:176489058ENST000003581494770_104234.33333333333334295.0Zinc fingerNote=Matrin-type 1
TgeneZNF346chr5:176619020chr5:176489058ENST0000050303959131_165259.3333333333333863.0Zinc fingerNote=Matrin-type 2
TgeneZNF346chr5:176619020chr5:176489058ENST0000050303959182_216259.3333333333333863.0Zinc fingerNote=Matrin-type 3
TgeneZNF346chr5:176619020chr5:176489058ENST0000050303959236_270259.3333333333333863.0Zinc fingerNote=Matrin-type 4
TgeneZNF346chr5:176619020chr5:176489058ENST000005030395970_104259.3333333333333863.0Zinc fingerNote=Matrin-type 1
TgeneZNF346chr5:176619020chr5:176489059ENST0000026194858131_165259.3333333333333320.0Zinc fingerNote=Matrin-type 2
TgeneZNF346chr5:176619020chr5:176489059ENST0000026194858182_216259.3333333333333320.0Zinc fingerNote=Matrin-type 3
TgeneZNF346chr5:176619020chr5:176489059ENST0000026194858236_270259.3333333333333320.0Zinc fingerNote=Matrin-type 4
TgeneZNF346chr5:176619020chr5:176489059ENST000002619485870_104259.3333333333333320.0Zinc fingerNote=Matrin-type 1
TgeneZNF346chr5:176619020chr5:176489059ENST0000035814947131_165234.33333333333334295.0Zinc fingerNote=Matrin-type 2
TgeneZNF346chr5:176619020chr5:176489059ENST0000035814947182_216234.33333333333334295.0Zinc fingerNote=Matrin-type 3
TgeneZNF346chr5:176619020chr5:176489059ENST000003581494770_104234.33333333333334295.0Zinc fingerNote=Matrin-type 1
TgeneZNF346chr5:176619020chr5:176489059ENST0000050303959131_165259.3333333333333863.0Zinc fingerNote=Matrin-type 2
TgeneZNF346chr5:176619020chr5:176489059ENST0000050303959182_216259.3333333333333863.0Zinc fingerNote=Matrin-type 3
TgeneZNF346chr5:176619020chr5:176489059ENST0000050303959236_270259.3333333333333863.0Zinc fingerNote=Matrin-type 4
TgeneZNF346chr5:176619020chr5:176489059ENST000005030395970_104259.3333333333333863.0Zinc fingerNote=Matrin-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NSD1
ZNF346


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NSD1-ZNF346


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NSD1-ZNF346


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource