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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NTRK2-AFAP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NTRK2-AFAP1
	FusionPDB ID: 60695
	FusionGDB2.0 ID: 60695
		Hgene	Tgene
	Gene symbol	NTRK2	AFAP1
	Gene ID	4915	60312
	Gene name	neurotrophic receptor tyrosine kinase 2	actin filament associated protein 1
	Synonyms	EIEE58\|GP145-TrkB\|OBHD\|TRKB\|trk-B	AFAP\|AFAP-110\|AFAP110
	Cytomap	9q21.33	4p16.1
	Type of gene	protein-coding	protein-coding
	Description	BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B	actin filament-associated protein 1110 kDa actin filament-associated proteinactin filament-associated protein, 110 kDa
	Modification date	20200313	20200313
	UniProtAcc	Q16620	Q8N4X5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000277120, ENST00000304053, ENST00000323115, ENST00000359847, ENST00000376208, ENST00000376213, ENST00000376214, ENST00000395866, ENST00000395882,	ENST00000513842, ENST00000358461, ENST00000360265, ENST00000382543, ENST00000420658,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 8 X 5=320	4 X 4 X 3=48
	# samples	8	4
	** MAII score	log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NTRK2 [Title/Abstract] AND AFAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	AFAP1(7780489)-NTRK2(87356807), # samples:3 NTRK2(87342874)-AFAP1(7776630), # samples:2
Anticipated loss of major functional domain due to fusion event.	AFAP1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AFAP1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NTRK2-AFAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NTRK2-AFAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NTRK2-AFAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NTRK2-AFAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NTRK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AFAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-7680-01A	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-
ChimerDB4	LGG	TCGA-HT-7680	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000376214	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	7696	2097	929	2644	571
ENST00000376214	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	7695	2097	929	2644	571
ENST00000376214	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	7695	2097	929	2644	571
ENST00000376214	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	2786	2097	929	2644	571
ENST00000376213	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	7696	2097	929	2644	571
ENST00000376213	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	7695	2097	929	2644	571
ENST00000376213	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	7695	2097	929	2644	571
ENST00000376213	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	2786	2097	929	2644	571
ENST00000395882	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	7308	1709	541	2256	571
ENST00000395882	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	7307	1709	541	2256	571
ENST00000395882	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	7307	1709	541	2256	571
ENST00000395882	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	2398	1709	541	2256	571
ENST00000304053	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	7241	1642	474	2189	571
ENST00000304053	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	7240	1642	474	2189	571
ENST00000304053	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	7240	1642	474	2189	571
ENST00000304053	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	2331	1642	474	2189	571
ENST00000376208	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	7241	1642	474	2189	571
ENST00000376208	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	7240	1642	474	2189	571
ENST00000376208	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	7240	1642	474	2189	571
ENST00000376208	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	2331	1642	474	2189	571
ENST00000277120	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	7241	1642	474	2189	571
ENST00000277120	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	7240	1642	474	2189	571
ENST00000277120	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	7240	1642	474	2189	571
ENST00000277120	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	2331	1642	474	2189	571
ENST00000323115	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	7111	1512	344	2059	571
ENST00000323115	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	7110	1512	344	2059	571
ENST00000323115	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	7110	1512	344	2059	571
ENST00000323115	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	2201	1512	344	2059	571
ENST00000359847	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	6847	1248	80	1795	571
ENST00000359847	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	6846	1248	80	1795	571
ENST00000359847	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	6846	1248	80	1795	571
ENST00000359847	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	1937	1248	80	1795	571
ENST00000395866	NTRK2	chr9	87342874	+	ENST00000360265	AFAP1	chr4	7776630	-	6631	1032	59	1579	506
ENST00000395866	NTRK2	chr9	87342874	+	ENST00000358461	AFAP1	chr4	7776630	-	6630	1032	59	1579	506
ENST00000395866	NTRK2	chr9	87342874	+	ENST00000420658	AFAP1	chr4	7776630	-	6630	1032	59	1579	506
ENST00000395866	NTRK2	chr9	87342874	+	ENST00000382543	AFAP1	chr4	7776630	-	1721	1032	59	1579	506

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000376214	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000830399	0.9991696
ENST00000376214	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000835682	0.99916434
ENST00000376214	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000835682	0.99916434
ENST00000376214	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.012778091	0.9872219
ENST00000376213	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000830399	0.9991696
ENST00000376213	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000835682	0.99916434
ENST00000376213	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000835682	0.99916434
ENST00000376213	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.012778091	0.9872219
ENST00000395882	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000730255	0.9992698
ENST00000395882	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000734226	0.99926573
ENST00000395882	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000734226	0.99926573
ENST00000395882	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.012743796	0.98725617
ENST00000304053	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000694137	0.99930584
ENST00000304053	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000697048	0.999303
ENST00000304053	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000697048	0.999303
ENST00000304053	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.012139419	0.9878606
ENST00000376208	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000694137	0.99930584
ENST00000376208	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000697048	0.999303
ENST00000376208	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000697048	0.999303
ENST00000376208	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.012139419	0.9878606
ENST00000277120	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000694137	0.99930584
ENST00000277120	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000697048	0.999303
ENST00000277120	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000697048	0.999303
ENST00000277120	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.012139419	0.9878606
ENST00000323115	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000637949	0.99936205
ENST00000323115	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000640995	0.99935895
ENST00000323115	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000640995	0.99935895
ENST00000323115	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.011075696	0.9889243
ENST00000359847	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.00054183	0.99945813
ENST00000359847	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000545209	0.9994548
ENST00000359847	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000545209	0.9994548
ENST00000359847	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.00874349	0.9912565
ENST00000395866	ENST00000360265	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000721901	0.9992781
ENST00000395866	ENST00000358461	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000723517	0.99927646
ENST00000395866	ENST00000420658	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.000723517	0.99927646
ENST00000395866	ENST00000382543	NTRK2	chr9	87342874	+	AFAP1	chr4	7776630	-	0.005989373	0.9940106

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60695_60695_1_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000277120_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_2_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000277120_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_3_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000277120_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_4_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000277120_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_5_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000304053_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_6_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000304053_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_7_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000304053_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_8_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000304053_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_9_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000323115_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_10_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000323115_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_11_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000323115_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_12_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000323115_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_13_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000359847_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_14_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000359847_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_15_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000359847_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_16_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000359847_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_17_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376208_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_18_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376208_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_19_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376208_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_20_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376208_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_21_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376213_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_22_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376213_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_23_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376213_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_24_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376213_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_25_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376214_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_26_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376214_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_27_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376214_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_28_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000376214_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_29_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395866_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=506AA_BP=324
MTKITCFLIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTC
SCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNE
TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICT
KIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNR
LAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHR

--------------------------------------------------------------

>60695_60695_30_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395866_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=506AA_BP=324
MTKITCFLIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTC
SCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNE
TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICT
KIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNR
LAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHR

--------------------------------------------------------------

>60695_60695_31_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395866_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=506AA_BP=324
MTKITCFLIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTC
SCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNE
TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICT
KIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNR
LAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHR

--------------------------------------------------------------

>60695_60695_32_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395866_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=506AA_BP=324
MTKITCFLIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTC
SCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNE
TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICT
KIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNR
LAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHR

--------------------------------------------------------------

>60695_60695_33_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395882_AFAP1_chr4_7776630_ENST00000358461_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_34_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395882_AFAP1_chr4_7776630_ENST00000360265_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_35_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395882_AFAP1_chr4_7776630_ENST00000382543_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

>60695_60695_36_NTRK2-AFAP1_NTRK2_chr9_87342874_ENST00000395882_AFAP1_chr4_7776630_ENST00000420658_length(amino acids)=571AA_BP=389
MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL
NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV
AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG
DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA
ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:7780489/chr4:87356807)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NTRK2 Q16620	AFAP1 Q8N4X5
FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250\|UniProtKB:P15209, ECO:0000269\|PubMed:15494731, ECO:0000269\|PubMed:7574684}.	FUNCTION: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269\|PubMed:17412687}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

148_196

386.3333333333333

839.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

197_282

386.3333333333333

839.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

295_365

386.3333333333333

839.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

32_61

386.3333333333333

839.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

148_196

386.3333333333333

554.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

197_282

386.3333333333333

554.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

295_365

386.3333333333333

554.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

32_61

386.3333333333333

554.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

148_196

386.3333333333333

823.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

197_282

386.3333333333333

823.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

295_365

386.3333333333333

823.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

32_61

386.3333333333333

823.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

148_196

386.3333333333333

478.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

197_282

386.3333333333333

478.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

295_365

386.3333333333333

478.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

32_61

386.3333333333333

478.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

148_196

386.3333333333333

538.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

197_282

386.3333333333333

538.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

295_365

386.3333333333333

538.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

32_61

386.3333333333333

538.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

148_196

386.3333333333333

823.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

197_282

386.3333333333333

823.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

295_365

386.3333333333333

823.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

32_61

386.3333333333333

823.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

148_196

386.3333333333333

839.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

197_282

386.3333333333333

839.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

295_365

386.3333333333333

839.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

32_61

386.3333333333333

839.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

148_196

230.33333333333334

322.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

32_61

230.33333333333334

322.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

148_196

386.3333333333333

478.0

Domain

Note=LRRCT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

197_282

386.3333333333333

478.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

295_365

386.3333333333333

478.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

32_61

386.3333333333333

478.0

Domain

Note=LRRNT

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

116_137

386.3333333333333

839.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

92_113

386.3333333333333

839.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

116_137

386.3333333333333

554.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

92_113

386.3333333333333

554.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

116_137

386.3333333333333

823.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

92_113

386.3333333333333

823.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

116_137

386.3333333333333

478.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

92_113

386.3333333333333

478.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

116_137

386.3333333333333

538.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

92_113

386.3333333333333

538.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

116_137

386.3333333333333

823.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

92_113

386.3333333333333

823.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

116_137

386.3333333333333

839.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

92_113

386.3333333333333

839.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

116_137

230.33333333333334

322.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

92_113

230.33333333333334

322.0

Repeat

Note=LRR 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

116_137

386.3333333333333

478.0

Repeat

Note=LRR 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

92_113

386.3333333333333

478.0

Repeat

Note=LRR 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000358461

557_648

548.3333333333334

731.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000360265

557_648

548.3333333333334

731.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

538_807

386.3333333333333

839.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

538_807

386.3333333333333

554.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

538_807

386.3333333333333

823.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

538_807

386.3333333333333

478.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

538_807

386.3333333333333

538.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

538_807

386.3333333333333

823.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

538_807

386.3333333333333

839.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

197_282

230.33333333333334

322.0

Domain

Note=Ig-like C2-type 1

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

295_365

230.33333333333334

322.0

Domain

Note=Ig-like C2-type 2

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

538_807

230.33333333333334

322.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

538_807

386.3333333333333

478.0

Domain

Protein kinase

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

544_552

386.3333333333333

839.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

544_552

386.3333333333333

554.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

544_552

386.3333333333333

823.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

544_552

386.3333333333333

478.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

544_552

386.3333333333333

538.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

544_552

386.3333333333333

823.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

544_552

386.3333333333333

839.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

544_552

230.33333333333334

322.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

544_552

386.3333333333333

478.0

Nucleotide binding

ATP

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

32_430

386.3333333333333

839.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

455_822

386.3333333333333

839.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

32_430

386.3333333333333

554.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

455_822

386.3333333333333

554.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

32_430

386.3333333333333

823.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

455_822

386.3333333333333

823.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

32_430

386.3333333333333

478.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

455_822

386.3333333333333

478.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

32_430

386.3333333333333

538.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

455_822

386.3333333333333

538.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

32_430

386.3333333333333

823.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

455_822

386.3333333333333

823.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

32_430

386.3333333333333

839.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

455_822

386.3333333333333

839.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

32_430

230.33333333333334

322.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

455_822

230.33333333333334

322.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

32_430

386.3333333333333

478.0

Topological domain

Extracellular

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

455_822

386.3333333333333

478.0

Topological domain

Cytoplasmic

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000277120

431_454

386.3333333333333

839.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000304053

431_454

386.3333333333333

554.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000323115

431_454

386.3333333333333

823.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000359847

431_454

386.3333333333333

478.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376208

431_454

386.3333333333333

538.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376213

431_454

386.3333333333333

823.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000376214

431_454

386.3333333333333

839.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395866

431_454

230.33333333333334

322.0

Transmembrane

Helical

Hgene

NTRK2

chr9:87342874

chr4:7776630

ENST00000395882

431_454

386.3333333333333

478.0

Transmembrane

Helical

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000382543

557_648

632.3333333333334

815.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000420658

557_648

632.3333333333334

815.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000358461

60_106

548.3333333333334

731.0

Compositional bias

Note=Pro-rich

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000360265

60_106

548.3333333333334

731.0

Compositional bias

Note=Pro-rich

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000382543

60_106

632.3333333333334

815.0

Compositional bias

Note=Pro-rich

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000420658

60_106

632.3333333333334

815.0

Compositional bias

Note=Pro-rich

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000358461

153_249

548.3333333333334

731.0

Domain

PH 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000358461

347_441

548.3333333333334

731.0

Domain

PH 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000360265

153_249

548.3333333333334

731.0

Domain

PH 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000360265

347_441

548.3333333333334

731.0

Domain

PH 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000382543

153_249

632.3333333333334

815.0

Domain

PH 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000382543

347_441

632.3333333333334

815.0

Domain

PH 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000420658

153_249

632.3333333333334

815.0

Domain

PH 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000420658

347_441

632.3333333333334

815.0

Domain

PH 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000358461

451_456

548.3333333333334

731.0

Motif

SH2-binding 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000358461

71_74

548.3333333333334

731.0

Motif

SH3-binding

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000358461

94_97

548.3333333333334

731.0

Motif

SH2-binding 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000360265

451_456

548.3333333333334

731.0

Motif

SH2-binding 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000360265

71_74

548.3333333333334

731.0

Motif

SH3-binding

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000360265

94_97

548.3333333333334

731.0

Motif

SH2-binding 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000382543

451_456

632.3333333333334

815.0

Motif

SH2-binding 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000382543

71_74

632.3333333333334

815.0

Motif

SH3-binding

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000382543

94_97

632.3333333333334

815.0

Motif

SH2-binding 1

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000420658

451_456

632.3333333333334

815.0

Motif

SH2-binding 2

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000420658

71_74

632.3333333333334

815.0

Motif

SH3-binding

Tgene

AFAP1

chr9:87342874

chr4:7776630

ENST00000420658

94_97

632.3333333333334

815.0

Motif

SH2-binding 1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1225_NTRK2_87342874_AFAP1_7776630_1225_NTRK2_87342874_AFAP1_7776630_ranked_0.pdb	NTRK2	87342874	87342874	ENST00000382543	AFAP1	chr4	7776630	-	MLGMSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDV EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCL NESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCV AENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG DYTLIAKNEYGKDEKQISAHFMGWPGIDDDAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA ILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA	571

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

NTRK2_pLDDT.png

AFAP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NTRK2
AFAP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000277120	+	9	19	455_466	386.3333333333333	839.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000304053	+	9	15	455_466	386.3333333333333	554.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000323115	+	8	17	455_466	386.3333333333333	823.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000359847	+	8	12	455_466	386.3333333333333	478.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000376208	+	9	14	455_466	386.3333333333333	538.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000376213	+	11	20	455_466	386.3333333333333	823.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000376214	+	11	21	455_466	386.3333333333333	839.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000395866	+	8	12	455_466	230.33333333333334	322.0	MAPK8IP3/JIP3
Hgene	NTRK2	chr9:87342874	chr4:7776630	ENST00000395882	+	9	13	455_466	386.3333333333333	478.0	MAPK8IP3/JIP3
Tgene	AFAP1	chr9:87342874	chr4:7776630	ENST00000382543		12	17	594_637	632.3333333333334	815.0	F-actin
Tgene	AFAP1	chr9:87342874	chr4:7776630	ENST00000420658		13	18	594_637	632.3333333333334	815.0	F-actin

Top

Related Drugs to NTRK2-AFAP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NTRK2-AFAP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	NTRK2	C0011570	Mental Depression	5	PSYGENET
Hgene	NTRK2	C0011581	Depressive disorder	5	PSYGENET
Hgene	NTRK2	C0041696	Unipolar Depression	5	PSYGENET
Hgene	NTRK2	C0525045	Mood Disorders	5	PSYGENET
Hgene	NTRK2	C1269683	Major Depressive Disorder	5	PSYGENET
Hgene	NTRK2	C3151303	Obesity, Hyperphagia, and Developmental Delay	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	NTRK2	C0005586	Bipolar Disorder	3	CTD_human;PSYGENET
Hgene	NTRK2	C4693367	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 58	3	GENOMICS_ENGLAND;UNIPROT
Hgene	NTRK2	C0009171	Cocaine Abuse	2	CTD_human
Hgene	NTRK2	C0036341	Schizophrenia	2	PSYGENET
Hgene	NTRK2	C0038220	Status Epilepticus	2	CTD_human
Hgene	NTRK2	C0236736	Cocaine-Related Disorders	2	CTD_human
Hgene	NTRK2	C0270823	Petit mal status	2	CTD_human
Hgene	NTRK2	C0311335	Grand Mal Status Epilepticus	2	CTD_human
Hgene	NTRK2	C0393734	Complex Partial Status Epilepticus	2	CTD_human
Hgene	NTRK2	C0600427	Cocaine Dependence	2	CTD_human
Hgene	NTRK2	C0751217	Hyperkinesia, Generalized	2	CTD_human
Hgene	NTRK2	C0751522	Status Epilepticus, Subclinical	2	CTD_human
Hgene	NTRK2	C0751523	Non-Convulsive Status Epilepticus	2	CTD_human
Hgene	NTRK2	C0751524	Simple Partial Status Epilepticus	2	CTD_human
Hgene	NTRK2	C3887506	Hyperkinesia	2	CTD_human
Hgene	NTRK2	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	NTRK2	C0004114	Astrocytoma	1	CTD_human
Hgene	NTRK2	C0004352	Autistic Disorder	1	CTD_human
Hgene	NTRK2	C0005587	Depression, Bipolar	1	CTD_human
Hgene	NTRK2	C0008073	Developmental Disabilities	1	CTD_human
Hgene	NTRK2	C0013415	Dysthymic Disorder	1	PSYGENET
Hgene	NTRK2	C0017638	Glioma	1	CTD_human
Hgene	NTRK2	C0020505	Hyperphagia	1	CTD_human
Hgene	NTRK2	C0024713	Manic Disorder	1	CTD_human
Hgene	NTRK2	C0027819	Neuroblastoma	1	CTD_human
Hgene	NTRK2	C0028754	Obesity	1	CTD_human
Hgene	NTRK2	C0036349	Paranoid Schizophrenia	1	PSYGENET
Hgene	NTRK2	C0037769	West Syndrome	1	ORPHANET
Hgene	NTRK2	C0085996	Child Development Deviations	1	CTD_human
Hgene	NTRK2	C0085997	Child Development Disorders, Specific	1	CTD_human
Hgene	NTRK2	C0205768	Subependymal Giant Cell Astrocytoma	1	CTD_human
Hgene	NTRK2	C0259783	mixed gliomas	1	CTD_human
Hgene	NTRK2	C0280783	Juvenile Pilocytic Astrocytoma	1	CTD_human
Hgene	NTRK2	C0280785	Diffuse Astrocytoma	1	CTD_human
Hgene	NTRK2	C0334579	Anaplastic astrocytoma	1	CTD_human
Hgene	NTRK2	C0334580	Protoplasmic astrocytoma	1	CTD_human
Hgene	NTRK2	C0334581	Gemistocytic astrocytoma	1	CTD_human
Hgene	NTRK2	C0334582	Fibrillary Astrocytoma	1	CTD_human
Hgene	NTRK2	C0334583	Pilocytic Astrocytoma	1	CTD_human
Hgene	NTRK2	C0338070	Childhood Cerebral Astrocytoma	1	CTD_human
Hgene	NTRK2	C0338831	Manic	1	CTD_human
Hgene	NTRK2	C0547065	Mixed oligoastrocytoma	1	CTD_human
Hgene	NTRK2	C0555198	Malignant Glioma	1	CTD_human
Hgene	NTRK2	C0678807	prenatal alcohol exposure	1	PSYGENET
Hgene	NTRK2	C0750935	Cerebral Astrocytoma	1	CTD_human
Hgene	NTRK2	C0750936	Intracranial Astrocytoma	1	CTD_human
Hgene	NTRK2	C0752347	Lewy Body Disease	1	CTD_human
Hgene	NTRK2	C1519086	Pilomyxoid astrocytoma	1	ORPHANET
Hgene	NTRK2	C1704230	Grade I Astrocytoma	1	CTD_human
Hgene	NTRK2	C3146244	Alcohol Related Birth Defect	1	PSYGENET