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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NTRK3-ETV6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NTRK3-ETV6
FusionPDB ID: 60707
FusionGDB2.0 ID: 60707
HgeneTgene
Gene symbol

NTRK3

ETV6

Gene ID

4916

2120

Gene nameneurotrophic receptor tyrosine kinase 3ETS variant transcription factor 6
SynonymsGP145-TrkC|TRKC|gp145(trkC)TEL|TEL/ABL|THC5
Cytomap

15q25.3

12p13.2

Type of geneprotein-codingprotein-coding
DescriptionNT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor Ctranscription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)
Modification date2020031320200313
UniProtAcc

Q16288

P41212

Ensembl transtripts involved in fusion geneENST idsENST00000317501, ENST00000355254, 
ENST00000357724, ENST00000360948, 
ENST00000394480, ENST00000540489, 
ENST00000542733, ENST00000557856, 
ENST00000558676, ENST00000558306, 
ENST00000544715, ENST00000396373, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 15 X 5=90021 X 24 X 6=3024
# samples 1719
** MAII scorelog2(17/900*10)=-2.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/3024*10)=-3.99238681589013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NTRK3 [Title/Abstract] AND ETV6 [Title/Abstract] AND fusion [Title/Abstract]

A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma (pmid: 9462753)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ETV6(12006495)-NTRK3(88576276), # samples:23
NTRK3(88669502)-ETV6(12022358), # samples:3
Anticipated loss of major functional domain due to fusion event.ETV6-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ETV6-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNTRK3

GO:0000187

activation of MAPK activity

23027130

HgeneNTRK3

GO:0001933

negative regulation of protein phosphorylation

23027130

HgeneNTRK3

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

23027130

HgeneNTRK3

GO:0008284

positive regulation of cell proliferation

23027130

HgeneNTRK3

GO:0010628

positive regulation of gene expression

23027130

HgeneNTRK3

GO:0030335

positive regulation of cell migration

23027130

HgeneNTRK3

GO:0032148

activation of protein kinase B activity

23027130

HgeneNTRK3

GO:0033138

positive regulation of peptidyl-serine phosphorylation

23027130

HgeneNTRK3

GO:0050927

positive regulation of positive chemotaxis

23027130

HgeneNTRK3

GO:0090630

activation of GTPase activity

23027130

HgeneNTRK3

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027130

TgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502


check buttonFusion gene breakpoints across NTRK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETV6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-DJ-A3UV-01ANTRK3chr15

88669502

-ETV6chr12

12037379

+
ChimerDB4THCATCGA-E8-A438-01ANTRK3chr15

88669502

-ETV6chr12

12022358

+
ChimerKB3..NTRK3chr15

88576276

-ETV6chr12

12006495

+
ChimerKB3..NTRK3chr15

88679697

-ETV6chr12

12022357

+
ChiTaRS5.0N/AAF125809NTRK3chr15

88576088

-ETV6chr12

12037379

+
ChiTaRS5.0N/AGM682734NTRK3chr15

88483987

+ETV6chr12

12022903

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394480NTRK3chr1588679697-ENST00000396373ETV6chr1212022357+6339108710471982311
ENST00000557856NTRK3chr1588669502-ENST00000396373ETV6chr1212037379+61021396241745573
ENST00000558676NTRK3chr1588669502-ENST00000396373ETV6chr1212037379+61041398261747573
ENST00000540489NTRK3chr1588669502-ENST00000396373ETV6chr1212037379+6108140261751581
ENST00000557856NTRK3chr1588669502-ENST00000396373ETV6chr1212022358+66481396242291755
ENST00000558676NTRK3chr1588669502-ENST00000396373ETV6chr1212022358+66501398262293755
ENST00000540489NTRK3chr1588669502-ENST00000396373ETV6chr1212022358+6654140262297763
ENST00000557856NTRK3chr1588576088-ENST00000396373ETV6chr1212037379+62911585241934636
ENST00000558676NTRK3chr1588576088-ENST00000396373ETV6chr1212037379+62931587261936636
ENST00000540489NTRK3chr1588576088-ENST00000396373ETV6chr1212037379+6297159161940644

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000557856ENST00000396373NTRK3chr1588669502-ETV6chr1212037379+0.0015604760.9984395
ENST00000558676ENST00000396373NTRK3chr1588669502-ETV6chr1212037379+0.001562250.9984377
ENST00000540489ENST00000396373NTRK3chr1588669502-ETV6chr1212037379+0.0016899360.9983101
ENST00000557856ENST00000396373NTRK3chr1588669502-ETV6chr1212022358+0.002238380.9977616
ENST00000558676ENST00000396373NTRK3chr1588669502-ETV6chr1212022358+0.0022366450.9977634
ENST00000540489ENST00000396373NTRK3chr1588669502-ETV6chr1212022358+0.0017988220.99820113
ENST00000557856ENST00000396373NTRK3chr1588576088-ETV6chr1212037379+0.0015129130.9984871
ENST00000558676ENST00000396373NTRK3chr1588576088-ETV6chr1212037379+0.0015140240.998486
ENST00000540489ENST00000396373NTRK3chr1588576088-ETV6chr1212037379+0.0016806870.9983193

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60707_60707_1_NTRK3-ETV6_NTRK3_chr15_88576088_ENST00000540489_ETV6_chr12_12037379_ENST00000396373_length(amino acids)=644AA_BP=529
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF
VMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYCRLLWDYVYQL
LSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLE

--------------------------------------------------------------

>60707_60707_2_NTRK3-ETV6_NTRK3_chr15_88576088_ENST00000557856_ETV6_chr12_12037379_ENST00000396373_length(amino acids)=636AA_BP=521
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR
RSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYCRLLWDYVYQLLSDSRYEN
FIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQI

--------------------------------------------------------------

>60707_60707_3_NTRK3-ETV6_NTRK3_chr15_88576088_ENST00000558676_ETV6_chr12_12037379_ENST00000396373_length(amino acids)=636AA_BP=521
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR
RSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYCRLLWDYVYQLLSDSRYEN
FIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQI

--------------------------------------------------------------

>60707_60707_4_NTRK3-ETV6_NTRK3_chr15_88669502_ENST00000540489_ETV6_chr12_12022358_ENST00000396373_length(amino acids)=763AA_BP=465
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF
VMINKYGRRSKFGMKDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNH
QESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIM
VSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRK

--------------------------------------------------------------

>60707_60707_5_NTRK3-ETV6_NTRK3_chr15_88669502_ENST00000540489_ETV6_chr12_12037379_ENST00000396373_length(amino acids)=581AA_BP=465
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF
VMINKYGRRSKFGMKDCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEP

--------------------------------------------------------------

>60707_60707_6_NTRK3-ETV6_NTRK3_chr15_88669502_ENST00000557856_ETV6_chr12_12022358_ENST00000396373_length(amino acids)=755AA_BP=457
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR
RSKFGMKDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSV
SPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEE
HAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLF

--------------------------------------------------------------

>60707_60707_7_NTRK3-ETV6_NTRK3_chr15_88669502_ENST00000557856_ETV6_chr12_12037379_ENST00000396373_length(amino acids)=573AA_BP=457
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR
RSKFGMKDCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRF

--------------------------------------------------------------

>60707_60707_8_NTRK3-ETV6_NTRK3_chr15_88669502_ENST00000558676_ETV6_chr12_12022358_ENST00000396373_length(amino acids)=755AA_BP=457
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR
RSKFGMKDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSV
SPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEE
HAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLF

--------------------------------------------------------------

>60707_60707_9_NTRK3-ETV6_NTRK3_chr15_88669502_ENST00000558676_ETV6_chr12_12037379_ENST00000396373_length(amino acids)=573AA_BP=457
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS
LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL
VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR
RSKFGMKDCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRF

--------------------------------------------------------------

>60707_60707_10_NTRK3-ETV6_NTRK3_chr15_88679697_ENST00000394480_ETV6_chr12_12022357_ENST00000396373_length(amino acids)=311AA_BP=11
MDSHWAAVHQHSPDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQE
SYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVS
VSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:12006495/chr12:88576276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NTRK3

Q16288

ETV6

P41212

FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315160_209528.3333333333334613.0DomainNote=LRRCT
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315210_300528.3333333333334613.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315309_382528.3333333333334613.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318160_209528.3333333333334826.0DomainNote=LRRCT
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319160_209528.3333333333334840.0DomainNote=LRRCT
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319210_300528.3333333333334840.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319309_382528.3333333333334840.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419160_209528.3333333333334826.0DomainNote=LRRCT
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214160_209528.3333333333334613.0DomainNote=LRRCT
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214210_300528.3333333333334613.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214309_382528.3333333333334613.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215160_209465.3333333333333613.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215210_300465.3333333333333613.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215309_382465.3333333333333613.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218160_209465.3333333333333826.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218210_300465.3333333333333826.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218309_382465.3333333333333826.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219160_209465.3333333333333840.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219210_300465.3333333333333840.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219309_382465.3333333333333840.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319160_209465.3333333333333826.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319210_300465.3333333333333826.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319309_382465.3333333333333826.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114160_209465.3333333333333613.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114210_300465.3333333333333613.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114309_382465.3333333333333613.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215160_209465.3333333333333613.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215210_300465.3333333333333613.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215309_382465.3333333333333613.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218160_209465.3333333333333826.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218210_300465.3333333333333826.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218309_382465.3333333333333826.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219160_209465.3333333333333840.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219210_300465.3333333333333840.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219309_382465.3333333333333840.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319160_209465.3333333333333826.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319210_300465.3333333333333826.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319309_382465.3333333333333826.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114160_209465.3333333333333613.0DomainNote=LRRCT
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114210_300465.3333333333333613.0DomainNote=Ig-like C2-type 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114309_382465.3333333333333613.0DomainNote=Ig-like C2-type 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315104_125528.3333333333334613.0RepeatNote=LRR 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315128_149528.3333333333334613.0RepeatNote=LRR 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318104_125528.3333333333334826.0RepeatNote=LRR 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318128_149528.3333333333334826.0RepeatNote=LRR 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319104_125528.3333333333334840.0RepeatNote=LRR 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319128_149528.3333333333334840.0RepeatNote=LRR 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419104_125528.3333333333334826.0RepeatNote=LRR 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419128_149528.3333333333334826.0RepeatNote=LRR 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214104_125528.3333333333334613.0RepeatNote=LRR 1
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214128_149528.3333333333334613.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215104_125465.3333333333333613.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215128_149465.3333333333333613.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218104_125465.3333333333333826.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218128_149465.3333333333333826.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219104_125465.3333333333333840.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219128_149465.3333333333333840.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319104_125465.3333333333333826.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319128_149465.3333333333333826.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114104_125465.3333333333333613.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114128_149465.3333333333333613.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215104_125465.3333333333333613.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215128_149465.3333333333333613.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218104_125465.3333333333333826.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218128_149465.3333333333333826.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219104_125465.3333333333333840.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219128_149465.3333333333333840.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319104_125465.3333333333333826.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319128_149465.3333333333333826.0RepeatNote=LRR 2
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114104_125465.3333333333333613.0RepeatNote=LRR 1
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114128_149465.3333333333333613.0RepeatNote=LRR 2
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-131532_429528.3333333333334613.0Topological domainExtracellular
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-131832_429528.3333333333334826.0Topological domainExtracellular
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-131932_429528.3333333333334840.0Topological domainExtracellular
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-141932_429528.3333333333334826.0Topological domainExtracellular
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-121432_429528.3333333333334613.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-121532_429465.3333333333333613.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-121832_429465.3333333333333826.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-121932_429465.3333333333333840.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-131932_429465.3333333333333826.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-111432_429465.3333333333333613.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-121532_429465.3333333333333613.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-121832_429465.3333333333333826.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-121932_429465.3333333333333840.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-131932_429465.3333333333333826.0Topological domainExtracellular
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-111432_429465.3333333333333613.0Topological domainExtracellular
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315430_453528.3333333333334613.0TransmembraneHelical
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318430_453528.3333333333334826.0TransmembraneHelical
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319430_453528.3333333333334840.0TransmembraneHelical
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419430_453528.3333333333334826.0TransmembraneHelical
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214430_453528.3333333333334613.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215430_453465.3333333333333613.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218430_453465.3333333333333826.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219430_453465.3333333333333840.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319430_453465.3333333333333826.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114430_453465.3333333333333613.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215430_453465.3333333333333613.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218430_453465.3333333333333826.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219430_453465.3333333333333840.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319430_453465.3333333333333826.0TransmembraneHelical
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114430_453465.3333333333333613.0TransmembraneHelical
TgeneETV6chr15:88576088chr12:12037379ENST0000039637348339_420336.3333333333333453.0DNA bindingETS
TgeneETV6chr15:88669502chr12:12022358ENST0000039637338339_420154.33333333333334453.0DNA bindingETS
TgeneETV6chr15:88669502chr12:12037379ENST0000039637348339_420336.3333333333333453.0DNA bindingETS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315538_839528.3333333333334613.0DomainProtein kinase
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318538_839528.3333333333334826.0DomainProtein kinase
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319538_839528.3333333333334840.0DomainProtein kinase
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419538_839528.3333333333334826.0DomainProtein kinase
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214538_839528.3333333333334613.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215538_839465.3333333333333613.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218538_839465.3333333333333826.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219538_839465.3333333333333840.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319538_839465.3333333333333826.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114538_839465.3333333333333613.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215538_839465.3333333333333613.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218538_839465.3333333333333826.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219538_839465.3333333333333840.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319538_839465.3333333333333826.0DomainProtein kinase
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114538_839465.3333333333333613.0DomainProtein kinase
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315544_552528.3333333333334613.0Nucleotide bindingATP
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318544_552528.3333333333334826.0Nucleotide bindingATP
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319544_552528.3333333333334840.0Nucleotide bindingATP
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419544_552528.3333333333334826.0Nucleotide bindingATP
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214544_552528.3333333333334613.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215544_552465.3333333333333613.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218544_552465.3333333333333826.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219544_552465.3333333333333840.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319544_552465.3333333333333826.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114544_552465.3333333333333613.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215544_552465.3333333333333613.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218544_552465.3333333333333826.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219544_552465.3333333333333840.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319544_552465.3333333333333826.0Nucleotide bindingATP
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114544_552465.3333333333333613.0Nucleotide bindingATP
HgeneNTRK3chr15:88576088chr12:12037379ENST00000317501-1315454_839528.3333333333334613.0Topological domainCytoplasmic
HgeneNTRK3chr15:88576088chr12:12037379ENST00000355254-1318454_839528.3333333333334826.0Topological domainCytoplasmic
HgeneNTRK3chr15:88576088chr12:12037379ENST00000360948-1319454_839528.3333333333334840.0Topological domainCytoplasmic
HgeneNTRK3chr15:88576088chr12:12037379ENST00000394480-1419454_839528.3333333333334826.0Topological domainCytoplasmic
HgeneNTRK3chr15:88576088chr12:12037379ENST00000540489-1214454_839528.3333333333334613.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12022358ENST00000317501-1215454_839465.3333333333333613.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12022358ENST00000355254-1218454_839465.3333333333333826.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12022358ENST00000360948-1219454_839465.3333333333333840.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12022358ENST00000394480-1319454_839465.3333333333333826.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12022358ENST00000540489-1114454_839465.3333333333333613.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12037379ENST00000317501-1215454_839465.3333333333333613.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12037379ENST00000355254-1218454_839465.3333333333333826.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12037379ENST00000360948-1219454_839465.3333333333333840.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12037379ENST00000394480-1319454_839465.3333333333333826.0Topological domainCytoplasmic
HgeneNTRK3chr15:88669502chr12:12037379ENST00000540489-1114454_839465.3333333333333613.0Topological domainCytoplasmic
TgeneETV6chr15:88576088chr12:12037379ENST000003963734840_124336.3333333333333453.0DomainPNT
TgeneETV6chr15:88669502chr12:12022358ENST000003963733840_124154.33333333333334453.0DomainPNT
TgeneETV6chr15:88669502chr12:12037379ENST000003963734840_124336.3333333333333453.0DomainPNT


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (71) >>>71.pdbFusion protein BP residue: 11
CIF file (71) >>>71.cif		NTRK3chr1588679697-ETV6chr1212022357+
MDSHWAAVHQHSPDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHR
PSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPME
NNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSR
LSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLL
WDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTY
EKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQE
311
3D view using mol* of 71 (AA BP:11)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NTRK3_pLDDT.png
all structure
all structure
ETV6_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NTRK3_ETV6_71_PAE.png (AA BP:11)
all structure
NTRK3_ETV6_71_pLDDT.png (AA BP:11)
all structure
NTRK3_ETV6_71_pLDDT_and_active_sites.png (AA BP:11)
all structure
NTRK3_ETV6_71_violinplot.png (AA BP:11)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
NTRK3_ETV6_71.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
710.744410.63658.9960.5440.7090.9670.5141.20.4280.427Chain A: 245,246,247,248,252,300,301,304,305,308

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2, EGLN3, NKX2-1, TRAF2, AXIN1, ESR2, LMNA, TP53BP1, BRCA1, MDC1, KIAA1429, WWP2, ESR1, BRD4, NFE2L2, MAD2L1, B4GALT2, KLHL9, KLHL13, SUMO2, ARHGAP32, SEC16A, XPOT, PIAS2, CEP152, NUP214, NUP62, NUP98, SEC13, RBM11, ECH1, ZNF146, TRIP6, CEP85, NUP54, TAB3, ALMS1, CEP192, PPIL4, RQCD1, SDCCAG3, NUP88, TBL1Y, KIAA1671, C2orf44, GRPEL1, TNRC6C, MID1IP1, CYLD, ZMYM2, LIMD1, SPATA2, TNRC6B, TIMM13, FLOT1, LGALS3BP, FLOT2, HNRNPUL1,
NTRK3NTF3, FRS2, SHC1, PLCG1, SQSTM1, PTPN1, APP, HSP90AA1, IRAK3, TNK2, NTRK1, SH3BP4, PTPRS, MYADM, C1GALT1, GNB2, C6orf120, MTOR, LGALS1, PTCD2, TMEM11, PAG1, EFR3A, TBC1D24, GNB4, TMEM192, INTS7, DENND4A, FAM171A2, KIAA0391, EPHA2, ATP7B, CXCR4, ACAD10, HRAS, EHD4, RPTOR, HEATR6, SLC39A11, NDFIP1, ERBB2, NELFB, HEY1, WDR13, KPNA4, NSD1, DOK6, SORT1, Ngfr, DDX58, UBE3C, LINGO1, NEU3, ACAD9,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NTRK3all structure
ETV6all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NTRK3-ETV6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
NTRK3ETV6Rkinhibitors(Eg,Larotrec-Tinib, Loxo Oncology)PubMed32748441

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Related Diseases to NTRK3-ETV6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
NTRK3ETV6Ongenitalinfantile Fibrosarcoma (Cifs) PubMed32748441
NTRK3ETV6Mammary Analog Secretory Carcinoma Of Salivary GlandMyCancerGenome
NTRK3ETV6FibrosarcomaMyCancerGenome
NTRK3ETV6Colon AdenocarcinomaMyCancerGenome
NTRK3ETV6Pancreatic AdenocarcinomaMyCancerGenome
NTRK3ETV6Thyroid Gland Papillary CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNTRK3C0036341Schizophrenia3PSYGENET
HgeneNTRK3C0041696Unipolar Depression2PSYGENET
HgeneNTRK3C1269683Major Depressive Disorder2PSYGENET
HgeneNTRK3C1332965Congenital Mesoblastic Nephroma2ORPHANET
HgeneNTRK3C0014175Endometriosis1CTD_human
HgeneNTRK3C0017638Glioma1CTD_human
HgeneNTRK3C0019569Hirschsprung Disease1GENOMICS_ENGLAND
HgeneNTRK3C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneNTRK3C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneNTRK3C0038220Status Epilepticus1CTD_human
HgeneNTRK3C0238463Papillary thyroid carcinoma1ORPHANET
HgeneNTRK3C0259783mixed gliomas1CTD_human
HgeneNTRK3C0269102Endometrioma1CTD_human
HgeneNTRK3C0270823Petit mal status1CTD_human
HgeneNTRK3C0311335Grand Mal Status Epilepticus1CTD_human
HgeneNTRK3C0393734Complex Partial Status Epilepticus1CTD_human
HgeneNTRK3C0525045Mood Disorders1PSYGENET
HgeneNTRK3C0555198Malignant Glioma1CTD_human
HgeneNTRK3C0751522Status Epilepticus, Subclinical1CTD_human
HgeneNTRK3C0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneNTRK3C0751524Simple Partial Status Epilepticus1CTD_human
HgeneNTRK3C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneETV6C4015537THROMBOCYTOPENIA 54CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
TgeneETV6C0040034Thrombocytopenia3CTD_human;GENOMICS_ENGLAND
TgeneETV6C0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
TgeneETV6C1332965Congenital Mesoblastic Nephroma2ORPHANET
TgeneETV6C0006413Burkitt Lymphoma1ORPHANET
TgeneETV6C0013146Drug abuse1CTD_human
TgeneETV6C0013170Drug habituation1CTD_human
TgeneETV6C0013222Drug Use Disorders1CTD_human
TgeneETV6C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneETV6C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneETV6C0023467Leukemia, Myelocytic, Acute1CGI;CTD_human;GENOMICS_ENGLAND
TgeneETV6C0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneETV6C0038580Substance Dependence1CTD_human
TgeneETV6C0038586Substance Use Disorders1CTD_human
TgeneETV6C0087031Juvenile-Onset Still Disease1CTD_human
TgeneETV6C0236969Substance-Related Disorders1CTD_human
TgeneETV6C0238463Papillary thyroid carcinoma1ORPHANET
TgeneETV6C0376544Hematopoietic Neoplasms1CTD_human
TgeneETV6C0376545Hematologic Neoplasms1CTD_human
TgeneETV6C0740858Substance abuse problem1CTD_human
TgeneETV6C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
TgeneETV6C1510472Drug Dependence1CTD_human
TgeneETV6C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1ORPHANET
TgeneETV6C1838656Macrocytosis, Familial1CTD_human
TgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneETV6C3495559Juvenile arthritis1CTD_human
TgeneETV6C3714758Juvenile psoriatic arthritis1CTD_human
TgeneETV6C4316881Prescription Drug Abuse1CTD_human
TgeneETV6C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneETV6C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human