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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ARHGAP32-PRDM10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARHGAP32-PRDM10
FusionPDB ID: 6077
FusionGDB2.0 ID: 6077
HgeneTgene
Gene symbol

ARHGAP32

PRDM10

Gene ID

9743

56980

Gene nameRho GTPase activating protein 32PR/SET domain 10
SynonymsGC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAPPFM7|TRIS
Cytomap

11q24.3

11q24.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaPR domain zinc finger protein 10PR domain 10PR domain containing 10PR domain-containing protein 10PR-domain family member 7PRDM zinc finger transcription factortristanin
Modification date2020032720200328
UniProtAcc

A7KAX9

.
Ensembl transtripts involved in fusion geneENST idsENST00000310343, ENST00000524655, 
ENST00000392657, ENST00000527272, 
ENST00000304538, ENST00000360871, 
ENST00000423662, ENST00000526082, 
ENST00000528746, ENST00000358825, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 5=4504 X 4 X 3=48
# samples 114
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ARHGAP32 [Title/Abstract] AND PRDM10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARHGAP32(128963516)-PRDM10(129782120), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRDM10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8SK-01BARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
ChimerDB4PRADTCGA-YL-A8SKARHGAP32chr11

128963516

-PRDM10chr11

129782120

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310343ARHGAP32chr11128963516-ENST00000358825PRDM10chr11129782120-372648901118372
ENST00000524655ARHGAP32chr11128963516-ENST00000358825PRDM10chr11129782120-352829124920298

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310343ENST00000358825ARHGAP32chr11128963516-PRDM10chr11129782120-0.0001515190.9998485
ENST00000524655ENST00000358825ARHGAP32chr11128963516-PRDM10chr11129782120-0.0002392170.9997608

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6077_6077_1_ARHGAP32-PRDM10_ARHGAP32_chr11_128963516_ENST00000310343_PRDM10_chr11_129782120_ENST00000358825_length(amino acids)=372AA_BP=162
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQATSPHQSQQSTVDVGQL
HDPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAWNSFRGY
SSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTN

--------------------------------------------------------------

>6077_6077_2_ARHGAP32-PRDM10_ARHGAP32_chr11_128963516_ENST00000524655_PRDM10_chr11_129782120_ENST00000358825_length(amino acids)=298AA_BP=88
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQA
TSPHQSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSS
VQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:128963516/chr11:129782120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP32

A7KAX9

.
FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRDM10chr11:128963516chr11:129782120ENST000003045380161131_113401024.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016866_91601024.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016918_103101024.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST0000035882517221131_1134951.01161.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST0000036087116211131_1134947.01157.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST0000042366213181131_1134865.01062.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318866_916865.01062.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318918_1031865.01062.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST0000052608213181131_1134865.01075.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318866_916865.01075.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318918_1031865.01075.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016208_32601024.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016355_37701024.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016530_55201024.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016560_58201024.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016588_61001024.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016616_63901024.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016644_66601024.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016672_69501024.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016727_75001024.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016772_79501024.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016834_85701024.0Zinc fingerC2H2-type 10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221031_1036163.02088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221305_1310163.02088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522131_245163.02088.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522259_321163.02088.0DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522372_567163.02088.0DomainRho-GAP
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113259_32101739.0DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113372_56701739.0DomainRho-GAP
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112259_32101739.0DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112372_56701739.0DomainRho-GAP
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722866_916951.01161.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722918_1031951.01161.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621866_916947.01157.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621918_1031947.01157.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722208_326951.01161.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621208_326947.01157.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318208_326865.01062.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318208_326865.01075.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722355_377951.01161.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722530_552951.01161.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722560_582951.01161.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722588_610951.01161.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722616_639951.01161.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722644_666951.01161.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722672_695951.01161.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722727_750951.01161.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722772_795951.01161.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722834_857951.01161.0Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621355_377947.01157.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621530_552947.01157.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621560_582947.01157.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621588_610947.01157.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621616_639947.01157.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621644_666947.01157.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621672_695947.01157.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621727_750947.01157.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621772_795947.01157.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621834_857947.01157.0Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318355_377865.01062.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318530_552865.01062.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318560_582865.01062.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318588_610865.01062.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318616_639865.01062.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318644_666865.01062.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318672_695865.01062.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318727_750865.01062.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318772_795865.01062.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318834_857865.01062.0Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318355_377865.01075.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318530_552865.01075.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318560_582865.01075.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318588_610865.01075.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318616_639865.01075.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318644_666865.01075.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318672_695865.01075.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318727_750865.01075.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318772_795865.01075.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318834_857865.01075.0Zinc fingerC2H2-type 10


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>732_ARHGAP32_128963516_PRDM10_129782120_ranked_0.pdbARHGAP32128963516128963516ENST00000358825PRDM10chr11129782120-
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQATSPHQSQQSTVDVGQL
HDPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAWNSFRGY
SSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTN
372


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ARHGAP32_pLDDT.png
all structure
all structure
PRDM10_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ARHGAP32SFN, GRIN2B, RHOA, CDC42, GAB2, GAB1, RAC1, CRK, NCK1, BCAR1, FYN, NTRK1, CRKL, SHC2, SHC3, SRC, PLCG1, PIK3R1, GRB2, ARRB1, NPHP1, ATXN1, FZR1, SMURF1, AES, MDFI, NCK2, DZIP3, ABI2, LZTS2, NXF1, EGFR, SHC1, ZWINT, HNRNPD, SORT1, SYNCRIP, SGTB, Cct4, Mad2l1bp, CDH1, PTPRK, ASB3, TRIM25, EGLN3, ESR2, KRAS, KIAA1429, BICD1, LHX2, OBSL1, CUL7, GOLGA2, ARHGAP24, CPEB4, RC3H1, ZFP36, CEP85, KIAA0355, CIT, GPHN, SEC61B, CBS, CHN1, PRDX4, SEC16A, M, NR3C1, ARF6, C11orf52, CAV1, CEP135, CTNNA1, CTNNB1, CXADR, FLOT1, GJA1, KRT19, LCK, LYN, MLLT4, OCLN, PARD3, PRPH, RAB35, RHOB, SQSTM1, STIL, SYNE3, ZYX, VPS33A, YWHAB, CCL3, YWHAG, YWHAQ, YWHAH, TRIM52, VBP1, PFDN1, LOXL4, PFDN2, PFDN4, CLEC11A, CRYBB3, B4GALT2, KLHL14, SULT1C4, HDHD1, CAMK2A, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ARHGAP32all structure
PRDM10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221685_2087163.02088.0FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131685_208701739.0FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121685_208701739.0FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221391_1711163.02088.0GAB2
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131391_171101739.0GAB2
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121391_171101739.0GAB2


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Related Drugs to ARHGAP32-PRDM10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ARHGAP32-PRDM10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP32C0036341Schizophrenia1PSYGENET