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Fusion Protein:NUMA1-YAP1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: NUMA1-YAP1 | FusionPDB ID: 60924 | FusionGDB2.0 ID: 60924 | Hgene | Tgene | Gene symbol | NUMA1 | YAP1 | Gene ID | 4926 | 10413 |
| Gene name | nuclear mitotic apparatus protein 1 | Yes1 associated transcriptional regulator | |
| Synonyms | NMP-22|NUMA | COB1|YAP|YAP2|YAP65|YKI | |
| Cytomap | 11q13.4 | 11q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear mitotic apparatus protein 1SP-H antigencentrophilin stabilizes mitotic spindle in mitotic cellsnuclear matrix protein-22structural nuclear protein | transcriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | Q14980 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000351960, ENST00000358965, ENST00000393695, ENST00000543450, | ENST00000528834, ENST00000282441, ENST00000345877, ENST00000524575, ENST00000526343, ENST00000531439, ENST00000537274, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 36 X 22 X 17=13464 | 20 X 10 X 13=2600 |
| # samples | 43 | 21 | |
| ** MAII score | log2(43/13464*10)=-4.96862661174049 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/2600*10)=-3.63005039024969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: NUMA1 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NUMA1(71746948)-YAP1(102094353), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | NUMA1-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NUMA1-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NUMA1-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NUMA1-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NUMA1-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NUMA1-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NUMA1-YAP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NUMA1-YAP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUMA1 | GO:0000132 | establishment of mitotic spindle orientation | 21816348 |
| Hgene | NUMA1 | GO:0030953 | astral microtubule organization | 12445386 |
| Hgene | NUMA1 | GO:0060236 | regulation of mitotic spindle organization | 26195665 |
| Hgene | NUMA1 | GO:1902365 | positive regulation of protein localization to spindle pole body | 16076287 |
| Tgene | YAP1 | GO:0006974 | cellular response to DNA damage stimulus | 18280240 |
| Tgene | YAP1 | GO:0008283 | cell proliferation | 17974916 |
| Tgene | YAP1 | GO:0032570 | response to progesterone | 16772533 |
| Tgene | YAP1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20368466 |
| Tgene | YAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25796446 |
| Tgene | YAP1 | GO:0050767 | regulation of neurogenesis | 25433207 |
| Tgene | YAP1 | GO:0050847 | progesterone receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0060242 | contact inhibition | 17974916 |
| Tgene | YAP1 | GO:0065003 | protein-containing complex assembly | 20368466 |
| Tgene | YAP1 | GO:0071480 | cellular response to gamma radiation | 18280240 |
| Tgene | YAP1 | GO:0072091 | regulation of stem cell proliferation | 25433207 |
| Fusion gene breakpoints across NUMA1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across YAP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-GN-A4U7-06A | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000351960 | NUMA1 | chr11 | 71746948 | - | ENST00000526343 | YAP1 | chr11 | 102094353 | + | 1349 | 214 | 154 | 696 | 180 |
| ENST00000351960 | NUMA1 | chr11 | 71746948 | - | ENST00000282441 | YAP1 | chr11 | 102094353 | + | 4180 | 214 | 154 | 696 | 180 |
| ENST00000351960 | NUMA1 | chr11 | 71746948 | - | ENST00000537274 | YAP1 | chr11 | 102094353 | + | 4180 | 214 | 154 | 696 | 180 |
| ENST00000351960 | NUMA1 | chr11 | 71746948 | - | ENST00000345877 | YAP1 | chr11 | 102094353 | + | 4180 | 214 | 154 | 696 | 180 |
| ENST00000351960 | NUMA1 | chr11 | 71746948 | - | ENST00000531439 | YAP1 | chr11 | 102094353 | + | 720 | 214 | 154 | 696 | 180 |
| ENST00000351960 | NUMA1 | chr11 | 71746948 | - | ENST00000524575 | YAP1 | chr11 | 102094353 | + | 909 | 214 | 154 | 696 | 180 |
| ENST00000393695 | NUMA1 | chr11 | 71746948 | - | ENST00000526343 | YAP1 | chr11 | 102094353 | + | 1509 | 374 | 314 | 856 | 180 |
| ENST00000393695 | NUMA1 | chr11 | 71746948 | - | ENST00000282441 | YAP1 | chr11 | 102094353 | + | 4340 | 374 | 314 | 856 | 180 |
| ENST00000393695 | NUMA1 | chr11 | 71746948 | - | ENST00000537274 | YAP1 | chr11 | 102094353 | + | 4340 | 374 | 314 | 856 | 180 |
| ENST00000393695 | NUMA1 | chr11 | 71746948 | - | ENST00000345877 | YAP1 | chr11 | 102094353 | + | 4340 | 374 | 314 | 856 | 180 |
| ENST00000393695 | NUMA1 | chr11 | 71746948 | - | ENST00000531439 | YAP1 | chr11 | 102094353 | + | 880 | 374 | 314 | 856 | 180 |
| ENST00000393695 | NUMA1 | chr11 | 71746948 | - | ENST00000524575 | YAP1 | chr11 | 102094353 | + | 1069 | 374 | 314 | 856 | 180 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000351960 | ENST00000526343 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.001992253 | 0.9980077 |
| ENST00000351960 | ENST00000282441 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00251198 | 0.997488 |
| ENST00000351960 | ENST00000537274 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00251198 | 0.997488 |
| ENST00000351960 | ENST00000345877 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00251198 | 0.997488 |
| ENST00000351960 | ENST00000531439 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00375878 | 0.9962412 |
| ENST00000351960 | ENST00000524575 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.002782307 | 0.99721766 |
| ENST00000393695 | ENST00000526343 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00294375 | 0.99705625 |
| ENST00000393695 | ENST00000282441 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00259728 | 0.9974027 |
| ENST00000393695 | ENST00000537274 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00259728 | 0.9974027 |
| ENST00000393695 | ENST00000345877 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.00259728 | 0.9974027 |
| ENST00000393695 | ENST00000531439 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.005058347 | 0.99494165 |
| ENST00000393695 | ENST00000524575 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + | 0.004513742 | 0.9954862 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >60924_60924_1_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000351960_YAP1_chr11_102094353_ENST00000282441_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_2_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000351960_YAP1_chr11_102094353_ENST00000345877_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_3_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000351960_YAP1_chr11_102094353_ENST00000524575_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_4_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000351960_YAP1_chr11_102094353_ENST00000526343_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_5_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000351960_YAP1_chr11_102094353_ENST00000531439_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_6_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000351960_YAP1_chr11_102094353_ENST00000537274_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_7_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000393695_YAP1_chr11_102094353_ENST00000282441_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_8_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000393695_YAP1_chr11_102094353_ENST00000345877_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_9_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000393695_YAP1_chr11_102094353_ENST00000524575_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_10_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000393695_YAP1_chr11_102094353_ENST00000526343_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_11_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000393695_YAP1_chr11_102094353_ENST00000531439_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- >60924_60924_12_NUMA1-YAP1_NUMA1_chr11_71746948_ENST00000393695_YAP1_chr11_102094353_ENST00000537274_length(amino acids)=180AA_BP=20 MSGITKMTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPD DFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71746948/chr11:102094353) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUMA1 | . |
| FUNCTION: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | 3 | 7 | 298_359 | 294.0 | 455.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | 5 | 9 | 298_359 | 166.0 | 327.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | 3 | 7 | 298_359 | 290.0 | 451.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | 5 | 9 | 171_204 | 166.0 | 327.0 | Domain | WW 1 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | 5 | 9 | 230_263 | 166.0 | 327.0 | Domain | WW 2 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | 3 | 7 | 291_504 | 294.0 | 455.0 | Region | Note=Transactivation domain | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | 5 | 9 | 291_504 | 166.0 | 327.0 | Region | Note=Transactivation domain | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | 3 | 7 | 291_504 | 290.0 | 451.0 | Region | Note=Transactivation domain |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 213_1699 | 14.0 | 2102.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 213_1699 | 14.0 | 2116.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1742_1748 | 14.0 | 2102.0 | Motif | Tankyrase-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1984_1989 | 14.0 | 2102.0 | Motif | Nuclear localization signal |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1742_1748 | 14.0 | 2116.0 | Motif | Tankyrase-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1984_1989 | 14.0 | 2116.0 | Motif | Nuclear localization signal |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1699_1876 | 14.0 | 2102.0 | Region | Membrane-binding domain 1 |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1700_2115 | 14.0 | 2102.0 | Region | Note=Tail (Globular) |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1788_1810 | 14.0 | 2102.0 | Region | 4.1-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1882_1985 | 14.0 | 2102.0 | Region | Tubulin-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1892_1926 | 14.0 | 2102.0 | Region | GPSM2-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1981_2060 | 14.0 | 2102.0 | Region | Membrane-binding domain 2 |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1_212 | 14.0 | 2102.0 | Region | Note=Head (Globular) |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1699_1876 | 14.0 | 2116.0 | Region | Membrane-binding domain 1 |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1700_2115 | 14.0 | 2116.0 | Region | Note=Tail (Globular) |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1788_1810 | 14.0 | 2116.0 | Region | 4.1-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1882_1985 | 14.0 | 2116.0 | Region | Tubulin-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1892_1926 | 14.0 | 2116.0 | Region | GPSM2-binding domain |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1981_2060 | 14.0 | 2116.0 | Region | Membrane-binding domain 2 |
| Hgene | NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1_212 | 14.0 | 2116.0 | Region | Note=Head (Globular) |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | 5 | 9 | 298_359 | 344.0 | 505.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | 5 | 9 | 86_100 | 344.0 | 505.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | 3 | 7 | 86_100 | 294.0 | 455.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | 5 | 9 | 86_100 | 166.0 | 327.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | 3 | 7 | 86_100 | 290.0 | 451.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | 4 | 8 | 298_359 | 328.0 | 489.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | 4 | 8 | 86_100 | 328.0 | 489.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | 4 | 8 | 298_359 | 332.0 | 493.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | 4 | 8 | 86_100 | 332.0 | 493.0 | Coiled coil | Ontology_term=ECO:0000269 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | 5 | 9 | 3_49 | 344.0 | 505.0 | Compositional bias | Note=Pro-rich | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | 3 | 7 | 3_49 | 294.0 | 455.0 | Compositional bias | Note=Pro-rich | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | 5 | 9 | 3_49 | 166.0 | 327.0 | Compositional bias | Note=Pro-rich | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | 3 | 7 | 3_49 | 290.0 | 451.0 | Compositional bias | Note=Pro-rich | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | 4 | 8 | 3_49 | 328.0 | 489.0 | Compositional bias | Note=Pro-rich | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | 4 | 8 | 3_49 | 332.0 | 493.0 | Compositional bias | Note=Pro-rich | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | 5 | 9 | 171_204 | 344.0 | 505.0 | Domain | WW 1 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | 5 | 9 | 230_263 | 344.0 | 505.0 | Domain | WW 2 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | 3 | 7 | 171_204 | 294.0 | 455.0 | Domain | WW 1 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | 3 | 7 | 230_263 | 294.0 | 455.0 | Domain | WW 2 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | 3 | 7 | 171_204 | 290.0 | 451.0 | Domain | WW 1 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | 3 | 7 | 230_263 | 290.0 | 451.0 | Domain | WW 2 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | 4 | 8 | 171_204 | 328.0 | 489.0 | Domain | WW 1 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | 4 | 8 | 230_263 | 328.0 | 489.0 | Domain | WW 2 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | 4 | 8 | 171_204 | 332.0 | 493.0 | Domain | WW 1 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | 4 | 8 | 230_263 | 332.0 | 493.0 | Domain | WW 2 | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | 5 | 9 | 291_504 | 344.0 | 505.0 | Region | Note=Transactivation domain | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | 4 | 8 | 291_504 | 328.0 | 489.0 | Region | Note=Transactivation domain | |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | 4 | 8 | 291_504 | 332.0 | 493.0 | Region | Note=Transactivation domain |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| NUMA1 | EPB41, EPB41L1, YEATS4, GPSM2, TNKS, ACTR1A, SMC1A, SMC3, EPB41L2, NCOA6, PIM1, RPAP1, NPM1, BANF1, tat, HDAC5, Ranbp2, SMARCAD1, SIRT7, TERF1, TERF2IP, TERF2, CDK2, EMILIN1, RAE1, NUP98, DYNLL1, NCSTN, DDB1, ESR1, ECT2, MDC1, TP53BP1, SMURF1, VCP, HSP90AB1, HSP90AA1, CDK6, CBX6, KIAA0101, CCDC57, LMNA, YWHAQ, RPA3, RPA2, RPA1, ERG, LGR4, BRAP, DVL1, DVL2, DVL3, GMCL1, ENO1, MOV10, NXF1, BRCA1, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, SUMO2, ABCE1, WDR83, GPSM1, EPB41L3, BRD4, EIF3H, CDC73, EIF3E, EIF3I, EIF3L, RPS13, SRRM1, RPL35A, RTF1, RUVBL1, ZC3H18, NTRK1, SCARNA22, PTTG1, IFI16, SSX2IP, CRK, MATR3, KIF20A, MPHOSPH8, CBX8, PAPD5, ASPM, Cbx1, Tnks, Srp72, Tnks2, DYNC1H1, KPNB1, FAM175B, BRCC3, U2AF2, SCOC, TCP10L, PDHA1, YAP1, TXNIP, MED12, CTNNB1, TCF7L2, EFTUD2, CHD3, CHD4, AGR2, MYC, CDK9, WDR76, HIST1H4A, HIST1H2BB, HIST1H2AB, HIST1H3A, KIAA1429, ACTC1, Bach1, CCND1, NR2C2, PPP1CC, ZFYVE21, XRCC6, DCAF15, BMH1, BMH2, ALYREF, SCARB2, FUS, EWSR1, TAF15, HMGB1, LRWD1, BIRC3, STAU1, WWP2, TRIM28, PLEKHA4, PINK1, WHSC1, FANCD2, GOLGA6L2, HIST1H1A, EIF5B, LYPLA2, NPR2, DDX10, LRRFIP1, RIBC1, HELZ2, MACF1, SDR42E2, VPS4B, MLYCD, LRPAP1, MMEL1, ZFYVE27, DMBX1, BIRC6, TLN1, PHIP, ORF14, LRRC31, CIT, ANLN, CHMP4B, KIF14, PRC1, PYHIN1, DEPDC1B, ARHGAP44, ARHGEF1, LRRC59, NDN, NUPR1, RBM39, nsp2, APEX1, ASF1A, HIST1H2BG, UBC, NAA40, ZBTB2, KRT4, KRT75, KRT72, KRT78, KXD1, TCP10, BTF3, EP300, FBXW7, nsp15, CCNB1, KPNA2, CCNF, TAX1BP1, SIRT6, YY1, PIGR, BRD2, BRD3, BRDT, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| NUMA1 |  |
| YAP1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to NUMA1-YAP1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to NUMA1-YAP1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NUMA1 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human;ORPHANET |
| Hgene | NUMA1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
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