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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NUP214-ABL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NUP214-ABL1
FusionPDB ID: 61035
FusionGDB2.0 ID: 61035
HgeneTgene
Gene symbol

NUP214

ABL1

Gene ID

8021

25

Gene namenucleoporin 214ABL proto-oncogene 1, non-receptor tyrosine kinase
SynonymsCAIN|CAN|IIAE9ABL|BCR-ABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl
Cytomap

9q34.13

9q34.12

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDatyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1truncated
Modification date2020032220200327
UniProtAcc

P35658

P00519

Ensembl transtripts involved in fusion geneENST idsENST00000359428, ENST00000411637, 
ENST00000451030, ENST00000483497, 
ENST00000465486, 		ENST00000318560, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 15 X 5=82521 X 149 X 8=25032
# samples 14154
** MAII scorelog2(14/825*10)=-2.55896729218821
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(154/25032*10)=-4.02277130765866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NUP214 [Title/Abstract] AND ABL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABL1(133589842)-NUP214(134007983), # samples:2
NUP214(134027281)-ABL1(133747516), # samples:2
NUP214(134027281)-ABL1(133747515), # samples:2
Anticipated loss of major functional domain due to fusion event.NUP214-ABL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP214-ABL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP214-ABL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP214-ABL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ABL1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ABL1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ABL1-NUP214 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ABL1-NUP214 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABL1

GO:0006974

cellular response to DNA damage stimulus

15657060

TgeneABL1

GO:0006975

DNA damage induced protein phosphorylation

18280240

TgeneABL1

GO:0018108

peptidyl-tyrosine phosphorylation

7590236|9144171|10713049|11121037

TgeneABL1

GO:0038083

peptidyl-tyrosine autophosphorylation

10518561

TgeneABL1

GO:0042770

signal transduction in response to DNA damage

9037071|15657060

TgeneABL1

GO:0043065

positive regulation of apoptotic process

9037071

TgeneABL1

GO:0046777

protein autophosphorylation

10713049

TgeneABL1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

15657060

TgeneABL1

GO:0051353

positive regulation of oxidoreductase activity

12893824

TgeneABL1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

20823226

TgeneABL1

GO:0070301

cellular response to hydrogen peroxide

10713049

TgeneABL1

GO:0071103

DNA conformation change

9558345

TgeneABL1

GO:0071901

negative regulation of protein serine/threonine kinase activity

11121037

TgeneABL1

GO:1990051

activation of protein kinase C activity

10713049

TgeneABL1

GO:2001020

regulation of response to DNA damage stimulus

9461559


check buttonFusion gene breakpoints across NUP214 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OQ-01ANUP214chr9

134027281

-ABL1chr9

133747516

+
ChimerDB4ESCATCGA-L5-A4OQ-01ANUP214chr9

134027281

+ABL1chr9

133747516

+
ChimerDB4ESCATCGA-L5-A4OQNUP214chr9

134027281

+ABL1chr9

133747515

+
ChimerKB3..NUP214chr9

134090598

+ABL1chr9

133729450

+
ChimerKB3..NUP214chr9

134090755

+ABL1chr9

133729450

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359428NUP214chr9134090755+ENST00000318560ABL1chr9133729450+1119958932192063061
ENST00000411637NUP214chr9134090755+ENST00000318560ABL1chr9133729450+111445838891513047
ENST00000451030NUP214chr9134090755+ENST00000318560ABL1chr9133729450+111695863091763058
ENST00000483497NUP214chr9134090755+ENST00000318560ABL1chr9133729450+7841253526958481859
ENST00000359428NUP214chr9134027281+ENST00000318560ABL1chr9133747516+714325802151501709
ENST00000411637NUP214chr9134027281+ENST00000318560ABL1chr9133747516+70882525850951695
ENST00000451030NUP214chr9134027281+ENST00000318560ABL1chr9133747516+71132550051201706
ENST00000359428NUP214chr9134027281+ENST00000318560ABL1chr9133747515+714325802151501709
ENST00000411637NUP214chr9134027281+ENST00000318560ABL1chr9133747515+70882525850951695
ENST00000451030NUP214chr9134027281+ENST00000318560ABL1chr9133747515+71132550051201706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359428ENST00000318560NUP214chr9134027281+ABL1chr9133747516+0.0014850830.99851495
ENST00000411637ENST00000318560NUP214chr9134027281+ABL1chr9133747516+0.0016341440.9983658
ENST00000451030ENST00000318560NUP214chr9134027281+ABL1chr9133747516+0.0016276480.9983724
ENST00000359428ENST00000318560NUP214chr9134027281+ABL1chr9133747515+0.0014850830.99851495
ENST00000411637ENST00000318560NUP214chr9134027281+ABL1chr9133747515+0.0016341440.9983658
ENST00000451030ENST00000318560NUP214chr9134027281+ABL1chr9133747515+0.0016276480.9983724

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61035_61035_1_NUP214-ABL1_NUP214_chr9_134027281_ENST00000359428_ABL1_chr9_133747515_ENST00000318560_length(amino acids)=1709AA_BP=851
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG
NLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL
AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS
ISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLL
PKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGF
RSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENR
SDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGA
PGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQP
GEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCL

--------------------------------------------------------------

>61035_61035_2_NUP214-ABL1_NUP214_chr9_134027281_ENST00000359428_ABL1_chr9_133747516_ENST00000318560_length(amino acids)=1709AA_BP=851
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG
NLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL
AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS
ISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLL
PKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGF
RSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENR
SDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGA
PGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQP
GEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCL

--------------------------------------------------------------

>61035_61035_3_NUP214-ABL1_NUP214_chr9_134027281_ENST00000411637_ABL1_chr9_133747515_ENST00000318560_length(amino acids)=1695AA_BP=837
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV
NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF
GVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV
RGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIK
KKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTS
SRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPR
LVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRV
RRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPK
PQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSA

--------------------------------------------------------------

>61035_61035_4_NUP214-ABL1_NUP214_chr9_134027281_ENST00000411637_ABL1_chr9_133747516_ENST00000318560_length(amino acids)=1695AA_BP=837
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV
NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF
GVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV
RGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIK
KKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTS
SRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPR
LVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRV
RRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPK
PQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSA

--------------------------------------------------------------

>61035_61035_5_NUP214-ABL1_NUP214_chr9_134027281_ENST00000451030_ABL1_chr9_133747515_ENST00000318560_length(amino acids)=1706AA_BP=848
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL
DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD
EVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKD
KKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSP
HLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQ
VTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGG
TSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEG
LKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAIS

--------------------------------------------------------------

>61035_61035_6_NUP214-ABL1_NUP214_chr9_134027281_ENST00000451030_ABL1_chr9_133747516_ENST00000318560_length(amino acids)=1706AA_BP=848
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL
DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD
EVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKD
KKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSP
HLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQ
VTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGG
TSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEG
LKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAIS

--------------------------------------------------------------

>61035_61035_7_NUP214-ABL1_NUP214_chr9_134090755_ENST00000359428_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=3061AA_BP=1958
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYG
LVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPF
AYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVI
PCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAA
SAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEP
PSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSE
KFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSP
QAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLK
TTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRN
FLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSH
LVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELK
NNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPS
GTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSK
LETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAP
PAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSA
GRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDART
EAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPS
ATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQP
ASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGS
VFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSKALQRPVASDFEPQGLSEAARWN
SKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEY
LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVS
PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMT
YGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE
SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE
SSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDER
LLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGS
GFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGE
NRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGS
GAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPS
QPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEAL
CLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQ

--------------------------------------------------------------

>61035_61035_8_NUP214-ABL1_NUP214_chr9_134090755_ENST00000411637_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=3047AA_BP=1944
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSV
ATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSV
PYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPS
SNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFP
SSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGS
LPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPE
KPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQ
TAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAP
SLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFG
AASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFG
QQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDP
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRE
SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQ
EVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQ
GVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSAL
IKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTL
TSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPP
PRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEES
RVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPAT
PKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASH

--------------------------------------------------------------

>61035_61035_9_NUP214-ABL1_NUP214_chr9_134090755_ENST00000451030_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=3058AA_BP=1955
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVH
GSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNP
ATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTG
FNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLET
PPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAA
TSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRS
TEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAV
PPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATP
VFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASS
TPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFG
QAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSKALQRPVASDFEPQGLSEAARWNSKE
NLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLS
SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY
DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGN
LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA
YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI
SDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLP
KDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFR
SPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRS
DQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAP
GGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPG
EGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLA

--------------------------------------------------------------

>61035_61035_10_NUP214-ABL1_NUP214_chr9_134090755_ENST00000483497_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=1859AA_BP=756
MQEISEIHHSLLIMKSSLLLRGVHFCFHLPGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQ
PDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQ
ADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTS
LSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQ
QSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVET
SSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATP
QVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSP
NTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGR
GGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLS
ITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV
YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVW
KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM
EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYP
GIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTK
TRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSF
REMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSK
RFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDI
MESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGK
LSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPV
PSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYV

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:133589842/chr9:134007983)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP214

P35658

ABL1

P00519

FUNCTION: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+173641_404812.02091.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736450_586812.02091.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736740_768812.02091.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+173641_404802.02081.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736450_586802.02081.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736740_768802.02081.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+173641_404813.02092.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736450_586813.02092.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736740_768813.02092.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+173641_404812.02091.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736450_586812.02091.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736740_768812.02091.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+173641_404802.02081.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736450_586802.02081.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736740_768802.02081.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+173641_404813.02092.0RegionNote=Seven-bladed beta propeller
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736450_586813.02092.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736740_768813.02092.0RegionNote=Leucine-zipper 1
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736151_193812.02091.0RepeatNote=Blade 3
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736194_239812.02091.0RepeatNote=Blade 4
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736240_303812.02091.0RepeatNote=Blade 5
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736304_359812.02091.0RepeatNote=Blade 6
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736360_404812.02091.0RepeatNote=Blade 7
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+173641_93812.02091.0RepeatNote=Blade 1
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736484_485812.02091.0Repeat1
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736548_549812.02091.0Repeat2
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+173694_150812.02091.0RepeatNote=Blade 2
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736151_193802.02081.0RepeatNote=Blade 3
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736194_239802.02081.0RepeatNote=Blade 4
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736240_303802.02081.0RepeatNote=Blade 5
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736304_359802.02081.0RepeatNote=Blade 6
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736360_404802.02081.0RepeatNote=Blade 7
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+173641_93802.02081.0RepeatNote=Blade 1
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736484_485802.02081.0Repeat1
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736548_549802.02081.0Repeat2
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+173694_150802.02081.0RepeatNote=Blade 2
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736151_193813.02092.0RepeatNote=Blade 3
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736194_239813.02092.0RepeatNote=Blade 4
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736240_303813.02092.0RepeatNote=Blade 5
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736304_359813.02092.0RepeatNote=Blade 6
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736360_404813.02092.0RepeatNote=Blade 7
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+173641_93813.02092.0RepeatNote=Blade 1
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736484_485813.02092.0Repeat1
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736548_549813.02092.0Repeat2
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+173694_150813.02092.0RepeatNote=Blade 2
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736151_193812.02091.0RepeatNote=Blade 3
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736194_239812.02091.0RepeatNote=Blade 4
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736240_303812.02091.0RepeatNote=Blade 5
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736304_359812.02091.0RepeatNote=Blade 6
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736360_404812.02091.0RepeatNote=Blade 7
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+173641_93812.02091.0RepeatNote=Blade 1
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736484_485812.02091.0Repeat1
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736548_549812.02091.0Repeat2
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+173694_150812.02091.0RepeatNote=Blade 2
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736151_193802.02081.0RepeatNote=Blade 3
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736194_239802.02081.0RepeatNote=Blade 4
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736240_303802.02081.0RepeatNote=Blade 5
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736304_359802.02081.0RepeatNote=Blade 6
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736360_404802.02081.0RepeatNote=Blade 7
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+173641_93802.02081.0RepeatNote=Blade 1
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736484_485802.02081.0Repeat1
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736548_549802.02081.0Repeat2
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+173694_150802.02081.0RepeatNote=Blade 2
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736151_193813.02092.0RepeatNote=Blade 3
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736194_239813.02092.0RepeatNote=Blade 4
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736240_303813.02092.0RepeatNote=Blade 5
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736304_359813.02092.0RepeatNote=Blade 6
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736360_404813.02092.0RepeatNote=Blade 7
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+173641_93813.02092.0RepeatNote=Blade 1
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736484_485813.02092.0Repeat1
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736548_549813.02092.0Repeat2
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+173694_150813.02092.0RepeatNote=Blade 2
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311605_609274.01131.0Compositional biasNote=Poly-Lys
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311782_1019274.01131.0Compositional biasNote=Pro-rich
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311897_903274.01131.0Compositional biasNote=Poly-Pro
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311605_609274.01131.0Compositional biasNote=Poly-Lys
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311782_1019274.01131.0Compositional biasNote=Pro-rich
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311897_903274.01131.0Compositional biasNote=Poly-Pro
TgeneABL1chr9:134027281chr9:133747515ENST000003185603111090_1100274.01131.0MotifNuclear export signal
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311381_405274.01131.0MotifNote=Kinase activation loop
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311709_715274.01131.0MotifNuclear localization signal 2
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311762_769274.01131.0MotifNuclear localization signal 3
TgeneABL1chr9:134027281chr9:133747516ENST000003185603111090_1100274.01131.0MotifNuclear export signal
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311381_405274.01131.0MotifNote=Kinase activation loop
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311709_715274.01131.0MotifNuclear localization signal 2
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311762_769274.01131.0MotifNuclear localization signal 3
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311316_322274.01131.0Nucleotide bindingNote=ATP
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311316_322274.01131.0Nucleotide bindingNote=ATP
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311869_968274.01131.0RegionDNA-binding
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311953_1130274.01131.0RegionNote=F-actin-binding
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311869_968274.01131.0RegionDNA-binding
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311953_1130274.01131.0RegionNote=F-actin-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736680_1209812.02091.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736680_1209802.02081.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736680_1209813.02092.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736680_1209812.02091.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736680_1209802.02081.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736680_1209813.02092.0Coiled coilOntology_term=ECO:0000269
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361213_2090812.02091.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361213_2090802.02081.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361213_2090813.02092.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361213_2090812.02091.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361213_2090802.02081.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361213_2090813.02092.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361409_2084812.02091.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361427_2085812.02091.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736236_1418812.02091.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736481_2076812.02091.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+1736861_882812.02091.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361409_2084802.02081.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361427_2085802.02081.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736236_1418802.02081.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736481_2076802.02081.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+1736861_882802.02081.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361409_2084813.02092.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361427_2085813.02092.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736236_1418813.02092.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736481_2076813.02092.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+1736861_882813.02092.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361409_2084812.02091.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361427_2085812.02091.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736236_1418812.02091.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736481_2076812.02091.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+1736861_882812.02091.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361409_2084802.02081.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361427_2085802.02081.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736236_1418802.02081.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736481_2076802.02081.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+1736861_882802.02081.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361409_2084813.02092.0RegionNote=18 X 4 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361427_2085813.02092.0RegionNote=11 X 3 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736236_1418813.02092.0Region44 X 2 AA repeats of F-G
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736481_2076813.02092.0RegionNote=11 X 5 AA approximate repeats
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+1736861_882813.02092.0RegionNote=Leucine-zipper 2
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361225_1226812.02091.0Repeat3
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361411_1412812.02091.0Repeat4
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361427_1428812.02091.0Repeat5
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361441_1442812.02091.0Repeat6
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361473_1474812.02091.0Repeat7
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361635_1636812.02091.0Repeat8
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361674_1675812.02091.0Repeat9
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361686_1687812.02091.0Repeat10
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361713_1714812.02091.0Repeat11
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361721_1722812.02091.0Repeat12
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361726_1727812.02091.0Repeat13
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361732_1733812.02091.0Repeat14
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361756_1757812.02091.0Repeat15
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361772_1773812.02091.0Repeat16
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361786_1787812.02091.0Repeat17
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361798_1799812.02091.0Repeat18
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361806_1807812.02091.0Repeat19
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361812_1813812.02091.0Repeat20
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361819_1820812.02091.0Repeat21
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361842_1843812.02091.0Repeat22
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361851_1852812.02091.0Repeat23
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361862_1863812.02091.0Repeat24
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361874_1875812.02091.0Repeat25
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361910_1911812.02091.0Repeat26
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361922_1923812.02091.0Repeat27
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361930_1931812.02091.0Repeat28
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361938_1939812.02091.0Repeat29
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361959_1960812.02091.0Repeat30
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361970_1971812.02091.0Repeat31
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361976_1977812.02091.0Repeat32
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361982_1983812.02091.0Repeat33
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361988_1989812.02091.0Repeat34
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17361994_1995812.02091.0Repeat35
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362012_2013812.02091.0Repeat36
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362024_2025812.02091.0Repeat37
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362026_2027812.02091.0Repeat38
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362035_2036812.02091.0Repeat39
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362046_2047812.02091.0Repeat40
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362056_2057812.02091.0Repeat41
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362066_2067812.02091.0Repeat42
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362075_2076812.02091.0Repeat43
HgeneNUP214chr9:134027281chr9:133747515ENST00000359428+17362085_2086812.02091.0Repeat44
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361225_1226802.02081.0Repeat3
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361411_1412802.02081.0Repeat4
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361427_1428802.02081.0Repeat5
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361441_1442802.02081.0Repeat6
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361473_1474802.02081.0Repeat7
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361635_1636802.02081.0Repeat8
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361674_1675802.02081.0Repeat9
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361686_1687802.02081.0Repeat10
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361713_1714802.02081.0Repeat11
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361721_1722802.02081.0Repeat12
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361726_1727802.02081.0Repeat13
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361732_1733802.02081.0Repeat14
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361756_1757802.02081.0Repeat15
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361772_1773802.02081.0Repeat16
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361786_1787802.02081.0Repeat17
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361798_1799802.02081.0Repeat18
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361806_1807802.02081.0Repeat19
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361812_1813802.02081.0Repeat20
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361819_1820802.02081.0Repeat21
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361842_1843802.02081.0Repeat22
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361851_1852802.02081.0Repeat23
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361862_1863802.02081.0Repeat24
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361874_1875802.02081.0Repeat25
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361910_1911802.02081.0Repeat26
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361922_1923802.02081.0Repeat27
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361930_1931802.02081.0Repeat28
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361938_1939802.02081.0Repeat29
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361959_1960802.02081.0Repeat30
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361970_1971802.02081.0Repeat31
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361976_1977802.02081.0Repeat32
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361982_1983802.02081.0Repeat33
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361988_1989802.02081.0Repeat34
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17361994_1995802.02081.0Repeat35
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362012_2013802.02081.0Repeat36
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362024_2025802.02081.0Repeat37
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362026_2027802.02081.0Repeat38
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362035_2036802.02081.0Repeat39
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362046_2047802.02081.0Repeat40
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362056_2057802.02081.0Repeat41
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362066_2067802.02081.0Repeat42
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362075_2076802.02081.0Repeat43
HgeneNUP214chr9:134027281chr9:133747515ENST00000411637+17362085_2086802.02081.0Repeat44
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361225_1226813.02092.0Repeat3
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361411_1412813.02092.0Repeat4
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361427_1428813.02092.0Repeat5
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361441_1442813.02092.0Repeat6
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361473_1474813.02092.0Repeat7
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361635_1636813.02092.0Repeat8
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361674_1675813.02092.0Repeat9
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361686_1687813.02092.0Repeat10
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361713_1714813.02092.0Repeat11
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361721_1722813.02092.0Repeat12
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361726_1727813.02092.0Repeat13
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361732_1733813.02092.0Repeat14
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361756_1757813.02092.0Repeat15
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361772_1773813.02092.0Repeat16
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361786_1787813.02092.0Repeat17
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361798_1799813.02092.0Repeat18
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361806_1807813.02092.0Repeat19
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361812_1813813.02092.0Repeat20
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361819_1820813.02092.0Repeat21
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361842_1843813.02092.0Repeat22
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361851_1852813.02092.0Repeat23
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361862_1863813.02092.0Repeat24
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361874_1875813.02092.0Repeat25
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361910_1911813.02092.0Repeat26
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361922_1923813.02092.0Repeat27
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361930_1931813.02092.0Repeat28
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361938_1939813.02092.0Repeat29
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361959_1960813.02092.0Repeat30
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361970_1971813.02092.0Repeat31
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361976_1977813.02092.0Repeat32
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361982_1983813.02092.0Repeat33
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361988_1989813.02092.0Repeat34
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17361994_1995813.02092.0Repeat35
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362012_2013813.02092.0Repeat36
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362024_2025813.02092.0Repeat37
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362026_2027813.02092.0Repeat38
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362035_2036813.02092.0Repeat39
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362046_2047813.02092.0Repeat40
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362056_2057813.02092.0Repeat41
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362066_2067813.02092.0Repeat42
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362075_2076813.02092.0Repeat43
HgeneNUP214chr9:134027281chr9:133747515ENST00000451030+17362085_2086813.02092.0Repeat44
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361225_1226812.02091.0Repeat3
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361411_1412812.02091.0Repeat4
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361427_1428812.02091.0Repeat5
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361441_1442812.02091.0Repeat6
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361473_1474812.02091.0Repeat7
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361635_1636812.02091.0Repeat8
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361674_1675812.02091.0Repeat9
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361686_1687812.02091.0Repeat10
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361713_1714812.02091.0Repeat11
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361721_1722812.02091.0Repeat12
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361726_1727812.02091.0Repeat13
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361732_1733812.02091.0Repeat14
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361756_1757812.02091.0Repeat15
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361772_1773812.02091.0Repeat16
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361786_1787812.02091.0Repeat17
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361798_1799812.02091.0Repeat18
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361806_1807812.02091.0Repeat19
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361812_1813812.02091.0Repeat20
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361819_1820812.02091.0Repeat21
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361842_1843812.02091.0Repeat22
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361851_1852812.02091.0Repeat23
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361862_1863812.02091.0Repeat24
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361874_1875812.02091.0Repeat25
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361910_1911812.02091.0Repeat26
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361922_1923812.02091.0Repeat27
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361930_1931812.02091.0Repeat28
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361938_1939812.02091.0Repeat29
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361959_1960812.02091.0Repeat30
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361970_1971812.02091.0Repeat31
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361976_1977812.02091.0Repeat32
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361982_1983812.02091.0Repeat33
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361988_1989812.02091.0Repeat34
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17361994_1995812.02091.0Repeat35
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362012_2013812.02091.0Repeat36
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362024_2025812.02091.0Repeat37
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362026_2027812.02091.0Repeat38
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362035_2036812.02091.0Repeat39
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362046_2047812.02091.0Repeat40
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362056_2057812.02091.0Repeat41
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362066_2067812.02091.0Repeat42
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362075_2076812.02091.0Repeat43
HgeneNUP214chr9:134027281chr9:133747516ENST00000359428+17362085_2086812.02091.0Repeat44
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361225_1226802.02081.0Repeat3
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361411_1412802.02081.0Repeat4
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361427_1428802.02081.0Repeat5
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361441_1442802.02081.0Repeat6
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361473_1474802.02081.0Repeat7
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361635_1636802.02081.0Repeat8
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361674_1675802.02081.0Repeat9
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361686_1687802.02081.0Repeat10
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361713_1714802.02081.0Repeat11
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361721_1722802.02081.0Repeat12
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361726_1727802.02081.0Repeat13
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361732_1733802.02081.0Repeat14
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361756_1757802.02081.0Repeat15
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361772_1773802.02081.0Repeat16
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361786_1787802.02081.0Repeat17
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361798_1799802.02081.0Repeat18
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361806_1807802.02081.0Repeat19
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361812_1813802.02081.0Repeat20
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361819_1820802.02081.0Repeat21
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361842_1843802.02081.0Repeat22
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361851_1852802.02081.0Repeat23
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361862_1863802.02081.0Repeat24
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361874_1875802.02081.0Repeat25
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361910_1911802.02081.0Repeat26
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361922_1923802.02081.0Repeat27
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361930_1931802.02081.0Repeat28
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361938_1939802.02081.0Repeat29
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361959_1960802.02081.0Repeat30
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361970_1971802.02081.0Repeat31
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361976_1977802.02081.0Repeat32
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361982_1983802.02081.0Repeat33
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361988_1989802.02081.0Repeat34
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17361994_1995802.02081.0Repeat35
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362012_2013802.02081.0Repeat36
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362024_2025802.02081.0Repeat37
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362026_2027802.02081.0Repeat38
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362035_2036802.02081.0Repeat39
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362046_2047802.02081.0Repeat40
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362056_2057802.02081.0Repeat41
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362066_2067802.02081.0Repeat42
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362075_2076802.02081.0Repeat43
HgeneNUP214chr9:134027281chr9:133747516ENST00000411637+17362085_2086802.02081.0Repeat44
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361225_1226813.02092.0Repeat3
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361411_1412813.02092.0Repeat4
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361427_1428813.02092.0Repeat5
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361441_1442813.02092.0Repeat6
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361473_1474813.02092.0Repeat7
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361635_1636813.02092.0Repeat8
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361674_1675813.02092.0Repeat9
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361686_1687813.02092.0Repeat10
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361713_1714813.02092.0Repeat11
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361721_1722813.02092.0Repeat12
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361726_1727813.02092.0Repeat13
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361732_1733813.02092.0Repeat14
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361756_1757813.02092.0Repeat15
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361772_1773813.02092.0Repeat16
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361786_1787813.02092.0Repeat17
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361798_1799813.02092.0Repeat18
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361806_1807813.02092.0Repeat19
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361812_1813813.02092.0Repeat20
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361819_1820813.02092.0Repeat21
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361842_1843813.02092.0Repeat22
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361851_1852813.02092.0Repeat23
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361862_1863813.02092.0Repeat24
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361874_1875813.02092.0Repeat25
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361910_1911813.02092.0Repeat26
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361922_1923813.02092.0Repeat27
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361930_1931813.02092.0Repeat28
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361938_1939813.02092.0Repeat29
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361959_1960813.02092.0Repeat30
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361970_1971813.02092.0Repeat31
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361976_1977813.02092.0Repeat32
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361982_1983813.02092.0Repeat33
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361988_1989813.02092.0Repeat34
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17361994_1995813.02092.0Repeat35
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362012_2013813.02092.0Repeat36
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362024_2025813.02092.0Repeat37
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362026_2027813.02092.0Repeat38
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362035_2036813.02092.0Repeat39
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362046_2047813.02092.0Repeat40
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362056_2057813.02092.0Repeat41
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362066_2067813.02092.0Repeat42
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362075_2076813.02092.0Repeat43
HgeneNUP214chr9:134027281chr9:133747516ENST00000451030+17362085_2086813.02092.0Repeat44
TgeneABL1chr9:134027281chr9:133747515ENST0000031856031118_22274.01131.0Compositional biasNote=Poly-Ser
TgeneABL1chr9:134027281chr9:133747516ENST0000031856031118_22274.01131.0Compositional biasNote=Poly-Ser
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311127_217274.01131.0DomainSH2
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311242_493274.01131.0DomainProtein kinase
TgeneABL1chr9:134027281chr9:133747515ENST0000031856031161_121274.01131.0DomainSH3
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311127_217274.01131.0DomainSH2
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311242_493274.01131.0DomainProtein kinase
TgeneABL1chr9:134027281chr9:133747516ENST0000031856031161_121274.01131.0DomainSH3
TgeneABL1chr9:134027281chr9:133747515ENST00000318560311248_256274.01131.0Nucleotide bindingNote=ATP
TgeneABL1chr9:134027281chr9:133747516ENST00000318560311248_256274.01131.0Nucleotide bindingNote=ATP
TgeneABL1chr9:134027281chr9:133747515ENST000003185603111_60274.01131.0RegionNote=CAP
TgeneABL1chr9:134027281chr9:133747516ENST000003185603111_60274.01131.0RegionNote=CAP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1046)CIF file (1046) >>>1046.cifNUP214chr9134090755+ABL1chr9133729450+
MQEISEIHHSLLIMKSSLLLRGVHFCFHLPGTAKIETAVTSTPSASGQFS
KPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGS
KPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLE
TPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQ
PTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVF
GSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAA
TPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVS
ASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLV
ALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVET
SSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLT
NNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSP
AFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPAS
STPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPG
FGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIV
FGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFG
STATSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYD
FVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNS
LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV
YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRN
KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVK
TLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG
NLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV
GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD
VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYEL
MRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVST
LLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPL
LPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSF
REMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNG
ALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASC
VPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENR
SDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQ
VTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAE
ESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQE
AAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKP
SGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPER
IASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYV
DSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSV
1859
3D view using mol* of 1046 (AA BP:)
PDB file (1245) >>>1245.pdbFusion protein BP residue: 1944
CIF file (1245) >>>1245.cif		NUP214chr9134090755+ABL1chr9133729450+
MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPERE
MKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQIFP
TKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMS
SEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPS
MVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQN
GTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADG
TLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEW
DLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPM
GVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSP
AAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDSSKAAP
GPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVP
SVSAPNIAMKPSFPPSTSAVKVNLSENSSQSAPPMSPFSSASKPAASGPL
SHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPA
AKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKAR
TSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLL
EGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKF
AVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKT
TIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAFL
SQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPS
IQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATK
TVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVV
NVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLK
PSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGF
NFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFP
SSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFN
FTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSG
VISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSF
GSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQS
AQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTG
VPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSI
VAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPV
FGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFG
AASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTS
AATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSV
FGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSKALQRPV
ASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSIT
KGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVS
RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYD
KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF
LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQ
EVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG
LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIA
TYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTR
TSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGG
LNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGA
GEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRS
PHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRS
VTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPP
PRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHK
EEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSE
SPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTK
ATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPS
TLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVL
DSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAF
3047
3D view using mol* of 1245 (AA BP:1944)
PDB file (1247)NUP214chr9134090755+ABL1chr9133729450+
LRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPERE
MKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQIFP
TKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMS
SEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPS
MVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQN
GTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADG
TLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEW
DLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPM
GVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSP
AAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDSSKAAP
GPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVP
SVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFS
SASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSM
VQKSPRITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAH
FQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLH
GDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQ
EIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSD
LESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRST
APASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQA
PRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIP
QGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLT
ESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQ
AKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSK
PFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSK
PSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLET
PPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQP
TKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFG
SLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAAT
PLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSA
SAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVA
LSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETS
STPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTN
NTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPA
FGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASS
TPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGF
GQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVF
GQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGS
TATSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDF
VASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSL
EKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVY
HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK
PTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKT
LKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGN
LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG
ENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDV
WAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELM
RACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTL
LQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLL
PRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFR
EMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGA
LRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCV
PHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRS
DQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQV
TVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEE
SRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEA
AGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPS
GTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERI
ASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVD
SIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVK
3058
PDB file (1249)NUP214chr9134090755+ABL1chr9133729450+
MRGQLRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMI
PEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGL
QIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSA
CMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNP
TVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAV
GKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYA
AADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSY
IEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDD
SLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPG
VKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLP
PSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDSS
KAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLES
TPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPM
SPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPV
PSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEE
IAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTE
SLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEA
QLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFN
TLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSF
DSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPV
RSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAV
VQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASK
IIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVN
TLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVA
ANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQ
FSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGG
GSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSK
LETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTS
TQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTA
VFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTT
AATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSE
VSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTS
LVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAV
ETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQ
LTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFS
SPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQP
ASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQS
PGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGG
IVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGG
FGSTATSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVAL
YDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV
NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEG
RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK
RNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMT
YGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNC
LVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIK
SDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY
ELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAV
STLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVS
PLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS
SFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVP
NGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSA
SCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGE
NRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLR
RQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGP
AEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPS
QEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSA
KPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPP
ERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVS
YVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLS
3061


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NUP214_pLDDT.png
all structure
all structure
ABL1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NUP214_ABL1_1046_pLDDT_and_active_sites.png (AA BP:)
all structure
NUP214_ABL1_1046_violinplot.png (AA BP:)
all structure
NUP214_ABL1_1245_pLDDT.png (AA BP:1944)
all structure
NUP214_ABL1_1245_pLDDT_and_active_sites.png (AA BP:1944)
all structure
NUP214_ABL1_1245_violinplot.png (AA BP:1944)
all structure
NUP214_ABL1_1247_pLDDT_and_active_sites.png (AA BP:)
all structure
NUP214_ABL1_1249_pLDDT_and_active_sites.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
NUP214_ABL1_1245.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
10461.0492141.024549.8290.4990.7711.0180.7791.160.6710.688Chain A: 977,978,979,980,981,982,985,998,999,1000,
1011,1015,1019,1028,1042,1044,1045,1046,1047,1050,
1051,1090,1091,1092,1093,1096,1097,1099,1109,1110,
1111,1113,1115,1122,1124,1125,1126,1128,1129,1130,
1131,1134,1135,1136,1139,1145,1149,1150,1153
12451.0555352621.0906981161.0550.6691920.7405960.8508750.4469130.9007960.4961310.744142Chain A: 75,77,79,80,81,83,134,135,136,137,138,139
,141,190,191,192,193,194,195,196,236,237,238,239,2
40,242,243,255,263,264,282,283,284,285,286,287,288
,289,290,291,312,313,314,315,316,318,320,321,323,3
41,342,343,344,345,346,347,348,349,368,372,373,375
,401,402,403,404,406,737
12451.1051901.066628.3760.4240.8551.1070.461.1870.3870.736Chain A: 77,79,80,81,82,83,84,135,136,137,138,139,
141,192,193,194,196,236,239,240,282,284,341,342,34
3,344,345,346,348,401,402,403,404,406,452,864,867,
868,2946,2996,2998
12471.0391830.982470.2530.5130.7570.9580.5381.2620.4260.622Chain A: 48,49,50,51,52,379,870,1007,1008,1009,101
1,1012,1013,2175,2176,2177,2178,2179,2180,2184,219
7,2199,2202,2218,2227,2241,2243,2244,2245,2246,224
9,2250,2295,2296,2298,2308,2309,2310
12491.0163271.0191094.170.6070.7210.8780.3031.0850.2790.686Chain A: 1080,1081,1082,1083,1084,1085,2000,2001,2
003,2004,2046,2054,2059,2060,2061,2062,2063,2064,2
065,2066,2067,2070,2071,2072,2073,2074,2075,2083,2
084,2085,2086,2087,2091,2092,2093,2104,2105,2106,2
148,2149,2150,2151,2152,2153,2154,2155,2156,2226,2
227,2228,2231,2247,2248,2249,2250,2273,2276,2277,2
280,2283,2284,2287,2303,2304,2305,2306,2307,2309,2
418,2421,2422,2425,2426,2429

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
1245ZINC000003830947DB08947Iopamidol-10.9617-10.9617
1245ZINC000001996784DB08893Mirabegron-8.93449-9.78549
1245ZINC000150339323DB01362Iohexol-9.72866-9.72866
1245ZINC000008143866DB09134Ioversol-9.42136-9.42136
1245ZINC000026985532DB01232Saquinavir-9.10683-9.12003
1245ZINC000003830959DB09156Iopromide-8.7242-8.7242
1245ZINC000003820029DB08882Linagliptin-8.66723-8.66773
1245ZINC000100004345DB06708Lumefantrine-6.75631-8.65751
1245ZINC000242548690DB00390Digoxin-8.65411-8.65411
1245ZINC000001530775DB00738Pentamidine-8.62669-8.62669
1245ZINC000003830943DB01362Iohexol-8.57149-8.57149
1245ZINC000058581064DB08930Dolutegravir-7.9343-8.5596
1245ZINC000003860453DB00693Fluorescein-8.28436-8.50036
1245ZINC000003810860DB00973Ezetimibe-8.48201-8.48261
1245ZINC000003816292DB09078Lenvatinib-8.47087-8.47087
1245ZINC000022851765DB08884Gadoxetic acid-7.41127-8.46447
1245ZINC000096006023DB06590Ceftaroline fosamil-7.85702-8.40212
1245ZINC000000897085DB00358Mefloquine-8.34383-8.34633
1245ZINC000035801098DB05039Indacaterol-8.28347-8.32567
1245ZINC000011681534DB04861Nebivolol-8.2858-8.3056

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000003830947DB08947IopamidolSmall moleculeC[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1IApproved
ZINC000001996784DB08893MirabegronSmall moleculeNC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1Approved
ZINC000003820029DB08882LinagliptinSmall moleculeCC#CCN1C(=NC2=C1C(=O)N(CC1=NC3=C(C=CC=C3)C(C)=N1)C(=O)N2C)N1CCC[C@@H](N)C1Approved
ZINC000100004345DB06708LumefantrineSmall moleculeCCCCN(CCCC)CC(O)C1=C2C(=CC(Cl)=C1)C(=C/C1=CC=C(Cl)C=C1)C1=C2C=CC(Cl)=C1Approved
ZINC000242548690DB00390DigoxinSmall molecule[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](O)[C@H](O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](O)[C@H](O)[C@@H](C)O3)[C@@H](C)O2)[C@@H](C)O1Approved
ZINC000001530775DB00738PentamidineSmall moleculeNC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1Approved|Investigational
ZINC000058581064DB08930DolutegravirSmall molecule[H][C@]12CN3C=C(C(=O)NCC4=CC=C(F)C=C4F)C(=O)C(O)=C3C(=O)N1[C@H](C)CCO2Approved
ZINC000003860453DB00693FluoresceinSmall moleculeOC1=CC=C2C(OC3=CC(O)=CC=C3C22OC(=O)C3=C2C=CC=C3)=C1Approved
ZINC000003810860DB00973EzetimibeSmall molecule[H][C@]1(CC[C@H](O)C2=CC=C(F)C=C2)C(=O)N(C2=CC=C(F)C=C2)[C@]1([H])C1=CC=C(O)C=C1Approved
ZINC000003816292DB09078LenvatinibSmall moleculeCOC1=C(C=C2C(OC3=CC=C(NC(=O)NC4CC4)C(Cl)=C3)=CC=NC2=C1)C(N)=OApproved|Investigational
ZINC000035801098DB05039IndacaterolSmall moleculeCCC1=C(CC)C=C2CC(CC2=C1)NC[C@H](O)C1=C2C=CC(=O)NC2=C(O)C=C1Approved
ZINC000011681534DB04861NebivololSmall moleculeOC(CNCC(O)C1CCC2=C(O1)C=CC(F)=C2)C1CCC2=C(O1)C=CC(F)=C2Approved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000003830947777.096.063732.513308.58284.54921.693117.6911366.3938168.95316.98331
ZINC000001996784396.5065.759766.121167.737163.909381.05653.421313.34757.78.494375.07100
ZINC000001996784396.5065.465768.333168.285165.496381.31553.2371317.85557.78.411374.8900
ZINC000150339323821.1435.122799.098320.899354.9098.481114.811490.915818.29.4751031
ZINC000008143866807.11612.43787.226281.425372.62910.876122.2951453.064818.29.4221031
ZINC000026985532670.852.9921090.203522.841198.112369.2502103.734513.78.881223.06232
ZINC000026985532670.858.5931062.24515.596176.807369.83702085.965513.79.245225.69832
ZINC000026985532670.852.7191077.343520.688191.958364.69702094.541513.78.97622532
ZINC000003830959791.1166.881795.56367.606272.46115.444140.0491453.578616.59.227212.54630
ZINC000003820029472.5497.164801.508461.193134.309206.00601483.36928.58.355386.44100
ZINC000100004345528.9482.263895.882363.3924.837296.21211.4441663.73313.78.994110021
ZINC000100004345528.9484.318860.588352.43925.843270.986211.3211610.68313.78.86110021
ZINC000242548690780.94815.0021107.32807.732281.00618.58202219.681622.4510.316219.64533
ZINC000001530775340.4248.052698.011179.111218.326300.57401179.9564.58.662263.34410
ZINC000003830943821.1432.11797.152329.149341.9798.796117.2271489.14818.29.3561031
ZINC000058581064419.38410.752671.499281.937165.698150.48573.3791193.65208.458.755383.67200
ZINC000058581064419.38410.808670.317276.157165.522158.3170.3281193.76108.458.94383.69800
ZINC000003860453332.3125.245542.950160.245382.7060950.991259.081385.30100
ZINC000003860453332.3125.244542.9510160.245382.7060950.991259.081385.30100
ZINC000003860453332.3128.156540.0140169.567370.4470949.498259.238383.47100
ZINC000003810860409.4325.656707.47174.233136.697402.90893.6341265.98724.458.806191.96111
ZINC000003816292426.8589.862742.101255.781187.765232.78565.771281.53246.758.841378.40300
ZINC000022851765527.5274.811790.247292.846398.04999.35201523.16516.758.8631022
ZINC000022851765527.5275.593797.913294.327427.40176.18601526.281516.758.9141022
ZINC000022851765527.5277.566772.204272.194408.26191.74901508.668516.759.1561022
ZINC000022851765527.5278.214830.92302.781440.21487.92501547.591516.758.6791022
ZINC000022851765527.5277.606823.168293.536442.5787.06201542.8516.759.0471022
ZINC000022851765527.5278.854764.332291.138373.48799.70701494.407516.759.0741022
ZINC000000897085378.3177.557589.939192.62654.6122.313220.4011034.64724.29.439310000
ZINC000035801098392.4976.567723.38351.978176.028195.37401302.33846.458.773273.75101
ZINC000035801098392.4973.839725.07357.079176.515191.47501297.13446.458.801273.41201
ZINC000035801098392.4976.636719.071347.003176.457195.6101289.86946.458.766273.21401
ZINC000011681534405.4412.335727.789280.70885.7267.62193.761272.95136.49.228395.43300
ZINC000011681534405.4416.385707.131273.32277.744262.30193.7651256.16536.49.073396.54300


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000003830947C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I0.0734655710.438210227
ZINC000001996784Nc1nc(CC(=O)Nc2ccc(CCNC[C@H](O)c3ccccc3)cc2)cs10.205681060.138337618
ZINC000150339323CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NC[C@@H](O)CO)c(I)c(C(=O)NC[C@@H](O)CO)c1I0.0423322430.211666342
ZINC000008143866O=C(NC[C@H](O)CO)c1c(I)c(C(=O)NC[C@@H](O)CO)c(I)c(N(CCO)C(=O)CO)c1I0.0517806690.23149478
ZINC000026985532CC(C)(C)NC(=O)[C@@H]1C[C@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n10.0392487760.333476835
ZINC000003830959COCC(=O)Nc1c(I)c(C(=O)NC[C@@H](O)CO)c(I)c(C(=O)N(C)C[C@H](O)CO)c1I0.0609495530.263153665
ZINC000003820029CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C0.0894362030.296948997
ZINC000100004345CCCCN(CCCC)C[C@@H](O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc10.1159179020.321524005
ZINC000242548690C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@]5(C)[C@H]6C[C@@H](O)[C@]7(C)[C@@H](C8=CC(=O)OC8)CC[C@]7(O)[C@@H]6CC[C@@H]5C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O0.0059617660.497688486
ZINC000001530775N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc10.370358210.393925825
ZINC000003830943CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0423322430.211666342
ZINC000058581064C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N210.072657050.3133548
ZINC000003860453O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccccc210.1402051550.611363322
ZINC000003810860O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc10.1137834410.30369071
ZINC000003816292COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O0.2628364030.170435147
ZINC000022851765CCOc1ccc(C[C@H](CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O)cc10.1078831610.343921729
ZINC000096006023CCO/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n10.0272335820.191312451
ZINC000000897085O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCCN10.0827248270.290697747
ZINC000035801098CCc1cc2c(cc1CC)CC(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C20.1052921910.180827637
ZINC000011681534O[C@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, CRM1, KAP104, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, Plk1, Nup88, Nup188, Nup214, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, rev, NUPL2, NUP214, MEX67, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, Ranbp2, Ube2i, Rcc1, Nup107, Kifc1, Nup155, Nup98, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1, ORF10, CTNNB1, CUL4B, RNF31, ESR2, EZH2, SUZ12, MYC, CDK9, VCP, KIAA1429, NR2C2, HIST1H4A, PTPDC1, RHBDD1, RHBDF2, nsp9, BIRC3, LMBR1L, PLEKHA4, CYLD, ORF6, IMMP1L, IMMP2L, CTIF, DDX19B, GLE1, FARP1, Myo9b, ITSN1, PLEKHG6, ACACA, SUMO2, NFX1, NUPR1, DYRK1A, NUP155, SYNE3, NAA40, NXT2, SLFN11, CCNF, TAX1BP1, SIRT6, DVL2, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NUP214all structure
ABL1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NUP214-ABL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
NUP214ABL1Tyrosine Kinase Inhibitor (Tki)PubMed30936193

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Related Diseases to NUP214-ABL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
NUP214ABL1T-Cell Acute Lymphoblastic Leukemia (T-All)PubMed30936193

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP214C0025958Microcephaly1GENOMICS_ENGLAND
HgeneNUP214C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
HgeneNUP214C1836830Developmental regression1GENOMICS_ENGLAND
HgeneNUP214C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET
TgeneABL1C0023473Myeloid Leukemia, Chronic3CGI;CTD_human;ORPHANET
TgeneABL1C0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
TgeneABL1C0023453L2 Acute Lymphoblastic Leukemia2CTD_human
TgeneABL1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CGI;CTD_human
TgeneABL1C0001418Adenocarcinoma1CTD_human
TgeneABL1C0003706Arachnodactyly1GENOMICS_ENGLAND
TgeneABL1C0005941Bone Diseases, Developmental1CTD_human
TgeneABL1C0006142Malignant neoplasm of breast1CTD_human
TgeneABL1C0006413Burkitt Lymphoma1ORPHANET
TgeneABL1C0014859Esophageal Neoplasms1CTD_human
TgeneABL1C0015544Failure to Thrive1CTD_human
TgeneABL1C0018798Congenital Heart Defects1CTD_human
TgeneABL1C0023903Liver neoplasms1CTD_human
TgeneABL1C0027659Neoplasms, Experimental1CTD_human
TgeneABL1C0032927Precancerous Conditions1CTD_human
TgeneABL1C0039075Syndactyly1GENOMICS_ENGLAND
TgeneABL1C0151491Congenital musculoskeletal anomalies1CTD_human
TgeneABL1C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneABL1C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneABL1C0205643Carcinoma, Cribriform1CTD_human
TgeneABL1C0205644Carcinoma, Granular Cell1CTD_human
TgeneABL1C0205645Adenocarcinoma, Tubular1CTD_human
TgeneABL1C0265610Clinodactyly of fingers1GENOMICS_ENGLAND
TgeneABL1C0282313Condition, Preneoplastic1CTD_human
TgeneABL1C0345904Malignant neoplasm of liver1CTD_human
TgeneABL1C0546837Malignant neoplasm of esophagus1CTD_human
TgeneABL1C0596263Carcinogenesis1CTD_human
TgeneABL1C0678222Breast Carcinoma1CTD_human
TgeneABL1C1257931Mammary Neoplasms, Human1CTD_human
TgeneABL1C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
TgeneABL1C1458155Mammary Neoplasms1CTD_human
TgeneABL1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CGI;ORPHANET
TgeneABL1C4539857CONGENITAL HEART DEFECTS AND SKELETAL MALFORMATIONS SYNDROME1GENOMICS_ENGLAND;UNIPROT
TgeneABL1C4551485Clinodactyly1GENOMICS_ENGLAND
TgeneABL1C4704874Mammary Carcinoma, Human1CTD_human