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Fusion Protein:NUTM1-BRD4 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: NUTM1-BRD4 | FusionPDB ID: 61178 | FusionGDB2.0 ID: 61178 | Hgene | Tgene | Gene symbol | NUTM1 | BRD4 | Gene ID | 256646 | 23476 |
| Gene name | NUT midline carcinoma family member 1 | bromodomain containing 4 | |
| Synonyms | C15orf55|FAM22H|NUT | CAP|HUNK1|HUNKI|MCAP | |
| Cytomap | 15q14 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NUT family member 1nuclear protein in testis | bromodomain-containing protein 4chromosome-associated proteinmitotic chromosome-associated protein | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | Q86Y26 | O60885 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000333756, ENST00000438749, ENST00000537011, | ENST00000602230, ENST00000263377, ENST00000360016, ENST00000371835, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 1 X 1 X 1=1 | 15 X 19 X 13=3705 |
| # samples | 1 | 28 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(28/3705*10)=-3.72597481024823 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: NUTM1 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BRD4(15391262)-NUTM1(34640165), # samples:1 BRD4(15364963)-NUTM1(34640165), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | BRD4-NUTM1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. BRD4-NUTM1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. BRD4-NUTM1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BRD4-NUTM1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. BRD4-NUTM1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BRD4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 19103749|23086925 |
| Tgene | BRD4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19103749 |
| Tgene | BRD4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23086925|23317504|24360279 |
| Tgene | BRD4 | GO:0050727 | regulation of inflammatory response | 19103749 |
| Tgene | BRD4 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain | 23086925 |
| Fusion gene breakpoints across NUTM1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across BRD4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000537011 | NUTM1 | chr15 | 34640878 | + | ENST00000263377 | BRD4 | chr19 | 15366403 | - | 5070 | 1191 | 382 | 3528 | 1048 |
| ENST00000537011 | NUTM1 | chr15 | 34640878 | + | ENST00000371835 | BRD4 | chr19 | 15366403 | - | 3832 | 1191 | 382 | 1608 | 408 |
| ENST00000537011 | NUTM1 | chr15 | 34640878 | + | ENST00000360016 | BRD4 | chr19 | 15366403 | - | 2390 | 1191 | 382 | 1824 | 480 |
| ENST00000438749 | NUTM1 | chr15 | 34640878 | + | ENST00000263377 | BRD4 | chr19 | 15366403 | - | 4881 | 1002 | 223 | 3339 | 1038 |
| ENST00000438749 | NUTM1 | chr15 | 34640878 | + | ENST00000371835 | BRD4 | chr19 | 15366403 | - | 3643 | 1002 | 223 | 1419 | 398 |
| ENST00000438749 | NUTM1 | chr15 | 34640878 | + | ENST00000360016 | BRD4 | chr19 | 15366403 | - | 2201 | 1002 | 223 | 1635 | 470 |
| ENST00000333756 | NUTM1 | chr15 | 34640878 | + | ENST00000263377 | BRD4 | chr19 | 15366403 | - | 4759 | 880 | 56 | 3217 | 1053 |
| ENST00000333756 | NUTM1 | chr15 | 34640878 | + | ENST00000371835 | BRD4 | chr19 | 15366403 | - | 3521 | 880 | 56 | 1297 | 413 |
| ENST00000333756 | NUTM1 | chr15 | 34640878 | + | ENST00000360016 | BRD4 | chr19 | 15366403 | - | 2079 | 880 | 56 | 1513 | 485 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >61178_61178_1_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000333756_BRD4_chr19_15366403_ENST00000263377_length(amino acids)=1053AA_BP=663 MCTYWSQVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSP DNPLMLSAFPSSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKA VGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEAL SCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELER YVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPP PPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPP HLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQ PPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPP PPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPI IRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKH PTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQ -------------------------------------------------------------- >61178_61178_2_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000333756_BRD4_chr19_15366403_ENST00000360016_length(amino acids)=485AA_BP=275 MCTYWSQVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSP DNPLMLSAFPSSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKA VGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEAL SCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELER YVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTA -------------------------------------------------------------- >61178_61178_3_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000333756_BRD4_chr19_15366403_ENST00000371835_length(amino acids)=413AA_BP=275 MCTYWSQVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSP DNPLMLSAFPSSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKA VGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEAL SCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELER -------------------------------------------------------------- >61178_61178_4_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000438749_BRD4_chr19_15366403_ENST00000263377_length(amino acids)=1038AA_BP=648 MFQRSNQDLKLGPYRKFSALSYGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLV TGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQP PPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLIKKEPAPMKSK PPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAE KVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQ QPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHN ALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQP PPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHH SPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPP KHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSF EQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQS -------------------------------------------------------------- >61178_61178_5_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000438749_BRD4_chr19_15366403_ENST00000360016_length(amino acids)=470AA_BP=260 MFQRSNQDLKLGPYRKFSALSYGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLV TGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQP PPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLIKKEPAPMKSK PPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAE KVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPHRQSAAGPAIT -------------------------------------------------------------- >61178_61178_6_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000438749_BRD4_chr19_15366403_ENST00000371835_length(amino acids)=398AA_BP=260 MFQRSNQDLKLGPYRKFSALSYGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLV TGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQP PPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLIKKEPAPMKSK PPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAE -------------------------------------------------------------- >61178_61178_7_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000537011_BRD4_chr19_15366403_ENST00000263377_length(amino acids)=1048AA_BP=658 MVVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLM LSAFPSSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQ EGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLI KKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC LRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQP PPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQH AVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPL LPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPA KPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEP FSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPS STAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAV -------------------------------------------------------------- >61178_61178_8_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000537011_BRD4_chr19_15366403_ENST00000360016_length(amino acids)=480AA_BP=270 MVVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLM LSAFPSSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQ EGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLI KKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC LRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPH -------------------------------------------------------------- >61178_61178_9_NUTM1-BRD4_NUTM1_chr15_34640878_ENST00000537011_BRD4_chr19_15366403_ENST00000371835_length(amino acids)=408AA_BP=270 MVVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLM LSAFPSSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQ EGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLI KKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:15391262/chr19:34640165) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUTM1 | BRD4 |
| FUNCTION: Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. {ECO:0000269|PubMed:30447097}. | FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file (157) >>>157.pdbFusion protein BP residue: 260 CIF file (157) >>>157.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MFQRSNQDLKLGPYRKFSALSYGASALPGPDMSMKPSAAPSPSPALPFLP PTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLVTGDGGPCLSG AGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPP FVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGP HGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSP DTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINK LPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC | 398 |
| 3D view using mol* of 157 (AA BP:260) | ||||||||||
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| PDB file (172) >>>172.pdbFusion protein BP residue: 270 CIF file (172) >>>172.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MVVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAP SPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLV TGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTP CGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPI VPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKA LARRHLSQSPDTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEE KRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTL RELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDS | 408 |
| 3D view using mol* of 172 (AA BP:270) | ||||||||||
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| PDB file (177) >>>177.pdbFusion protein BP residue: 275 CIF file (177) >>>177.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MCTYWSQVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMK PSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFP SSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNST APGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVA QLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQW QRYKALARRHLSQSPDTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKP MSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETL KPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSES | 413 |
| 3D view using mol* of 177 (AA BP:275) | ||||||||||
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| PDB file (248) >>>248.pdbFusion protein BP residue: 260 CIF file (248) >>>248.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MFQRSNQDLKLGPYRKFSALSYGASALPGPDMSMKPSAAPSPSPALPFLP PTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLVTGDGGPCLSG AGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPP FVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGP HGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSP DTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINK LPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC LRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTS GDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPHRQSAAGPAIT | 470 |
| 3D view using mol* of 248 (AA BP:260) | ||||||||||
| ||||||||||
| PDB file (266) >>>266.pdbFusion protein BP residue: 270 CIF file (266) >>>266.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MVVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAP SPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLV TGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTP CGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPI VPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKA LARRHLSQSPDTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEE KRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTL RELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDS EDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPH | 480 |
| 3D view using mol* of 266 (AA BP:270) | ||||||||||
| ||||||||||
| PDB file (275) >>>275.pdbFusion protein BP residue: 275 CIF file (275) >>>275.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MCTYWSQVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMK PSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFP SSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNST APGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVA QLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQW QRYKALARRHLSQSPDTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKP MSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETL KPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSES SSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTA | 485 |
| 3D view using mol* of 275 (AA BP:275) | ||||||||||
| ||||||||||
| PDB file (766) >>>766.pdbFusion protein BP residue: 648 CIF file (766) >>>766.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MFQRSNQDLKLGPYRKFSALSYGASALPGPDMSMKPSAAPSPSPALPFLP PTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLVTGDGGPCLSG AGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPP FVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGP HGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSP DTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINK LPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC LRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPK SKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQ QPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFT QPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPS NRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLT SMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQP PPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPP GQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMS QFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEP FSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGA PDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSF EQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARR AHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQ | 1038 |
| 3D view using mol* of 766 (AA BP:648) | ||||||||||
| ||||||||||
| PDB file (772) >>>772.pdbFusion protein BP residue: 658 CIF file (772) >>>772.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MVVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMKPSAAP SPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLV TGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTP CGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPI VPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKA LARRHLSQSPDTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKPMSYEE KRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTL RELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDS EDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQP PPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPG SVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHN ALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLE DEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHP SVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPP QGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPS PLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEK IHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRP PEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPS STAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSRE DEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQS | 1048 |
| 3D view using mol* of 772 (AA BP:658) | ||||||||||
| ||||||||||
| PDB file (777) >>>777.pdbFusion protein BP residue: 663 CIF file (777) >>>777.cif | NUTM1 | chr15 | 34640878 | + | BRD4 | chr19 | 15366403 | - | MCTYWSQVTLGPGPDCLILEASRQPQLVPKPERMASDGASALPGPDMSMK PSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFP SSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNST APGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVA QLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQW QRYKALARRHLSQSPDTEALSCFLIKKEPAPMKSKPPPTYESEEEDKCKP MSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETL KPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSES SSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPP PPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLE PQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSP PALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPP QVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLP PPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQ QPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHL REAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVV VKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGR PVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKH PTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQER MRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAAT PQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEE | 1053 |
| 3D view using mol* of 777 (AA BP:663) | ||||||||||
| ||||||||||
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
NUTM1_pLDDT.png  |
BRD4_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
NUTM1_BRD4_157_PAE.png (AA BP:260) |
NUTM1_BRD4_157_pLDDT.png (AA BP:260) |
NUTM1_BRD4_157_pLDDT_and_active_sites.png (AA BP:260) |
NUTM1_BRD4_157_violinplot.png (AA BP:260) |
NUTM1_BRD4_172_PAE.png (AA BP:270) |
NUTM1_BRD4_172_pLDDT.png (AA BP:270) |
NUTM1_BRD4_172_pLDDT_and_active_sites.png (AA BP:270) |
NUTM1_BRD4_172_violinplot.png (AA BP:270) |
NUTM1_BRD4_177_PAE.png (AA BP:275) |
NUTM1_BRD4_177_pLDDT.png (AA BP:275) |
NUTM1_BRD4_177_pLDDT_and_active_sites.png (AA BP:275) |
NUTM1_BRD4_177_violinplot.png (AA BP:275) |
NUTM1_BRD4_248_PAE.png (AA BP:260) |
NUTM1_BRD4_248_pLDDT.png (AA BP:260) |
NUTM1_BRD4_248_pLDDT_and_active_sites.png (AA BP:260) |
NUTM1_BRD4_248_violinplot.png (AA BP:260) |
NUTM1_BRD4_266_PAE.png (AA BP:270) |
NUTM1_BRD4_266_pLDDT.png (AA BP:270) |
NUTM1_BRD4_266_pLDDT_and_active_sites.png (AA BP:270) |
NUTM1_BRD4_266_violinplot.png (AA BP:270) |
NUTM1_BRD4_275_pLDDT.png (AA BP:275) |
NUTM1_BRD4_275_pLDDT_and_active_sites.png (AA BP:275) |
NUTM1_BRD4_275_violinplot.png (AA BP:275) |
NUTM1_BRD4_766_pLDDT.png (AA BP:648) |
NUTM1_BRD4_766_pLDDT_and_active_sites.png (AA BP:648) |
NUTM1_BRD4_766_violinplot.png (AA BP:648) |
NUTM1_BRD4_772_pLDDT.png (AA BP:658) |
NUTM1_BRD4_772_pLDDT_and_active_sites.png (AA BP:658) |
NUTM1_BRD4_772_violinplot.png (AA BP:658) |
NUTM1_BRD4_777_pLDDT.png (AA BP:663) |
NUTM1_BRD4_777_pLDDT_and_active_sites.png (AA BP:663) |
NUTM1_BRD4_777_violinplot.png (AA BP:663) |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
| NUTM1_BRD4_157.png |
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| NUTM1_BRD4_172.png |
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| NUTM1_BRD4_177.png |
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| NUTM1_BRD4_248.png |
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| NUTM1_BRD4_266.png |
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| NUTM1_BRD4_275.png |
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| NUTM1_BRD4_766.png |
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| NUTM1_BRD4_772.png |
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| NUTM1_BRD4_777.png |
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Potential Active Site Information |
| The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
| Fusion AA seq ID in FusionPDB | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| 157 | 0.766 | 25 | 0.767 | 114.562 | 0.554 | 0.713 | 0.928 | 2.061 | 0.402 | 5.124 | 1.923 | Chain A: 238,241,242,245,246,252,255,256,259,268 |
| 172 | 0.706 | 27 | 0.557 | 79.576 | 0.534 | 0.785 | 1.212 | 0.63 | 1.235 | 0.51 | 0.799 | Chain A: 5,9,10,12,298,301,302,305,306,342 |
| 177 | 0.921 | 97 | 0.957 | 166.012 | 0.536 | 0.572 | 0.863 | 0.288 | 0.957 | 0.301 | 0.889 | Chain A: 118,119,120,121,122,123,124,125,126,137,1 38,139,140,141,142,143,144 |
| 248 | 1.04 | 269 | 1.07 | 493.234 | 0.37 | 0.728 | 0.987 | 0.74 | 0.941 | 0.787 | 0.919 | Chain A: 103,104,105,106,107,108,109,110,111,112,2 88,291,292,295,296,298,299,306,309,310,325,326,327 ,328,329,330,331,332,333 |
| 266 | 1.077 | 169 | 1.182 | 624.603 | 0.626 | 0.636 | 0.838 | 1.448 | 0.427 | 3.389 | 1.632 | Chain A: 261,263,264,265,267,268,269,272,423,424,4 26,427,428,429,430,431,432,433,434,436,437,438,459 ,461,462,463,468,469,470,472,473,475,476 |
| 275 | 1.055 | 152 | 1.138 | 430.465 | 0.625 | 0.65 | 0.851 | 1.379 | 0.589 | 2.341 | 0.867 | Chain A: 242,243,246,247,250,269,272,273,275,276,4 31,434,435,437,438,439,441,442,443,445 |
| 766 | 1.055 | 91 | 1.105 | 250.733 | 0.513 | 0.739 | 0.983 | 1.388 | 0.722 | 1.922 | 0.76 | Chain A: 104,105,106,108,288,291,292,295,296,298,2 99,306,309,328,329,330,331,332,333 |
| 772 | 0.9355 | 70 | 0.9847 | 282.632 | 0.6847 | 0.651 | 0.8335 | 1.1137 | 0.5898 | 1.8882 | 0.7574 | Chain A: 1,2,3,115,116,118,119,298,301,302,305,308 ,309,316,319,338,339,340,341,342,343 |
| 777 | 0.9919 | 86 | 1.0345 | 207.172 | 0.5401 | 0.6851 | 0.951 | 1.2064 | 0.7616 | 1.5841 | 0.8054 | Chain A: 118,119,120,121,123,303,306,307,310,311,3 13,314,321,324,343,344,345,346,347,348 |
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Potentially Interacting Small Molecules through Virtual Screening |
| The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide. |
| Fusion AA seq ID in FusionPDB | ZINC ID | DrugBank ID | Drug name | Docking score | Glide gscore |
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| Drug information from DrugBank of the top 20 interacting small molecules. |
| ZINC ID | DrugBank ID | Drug name | Drug type | SMILES | Drug group |
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Biochemical Features of Small Molecules |
| ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9) |
| ZINC ID | mol_MW | dipole | SASA | FOSA | FISA | PISA | WPSA | volume | donorHB | accptHB | IP | Human Oral Absorption | Percent Human Oral Absorption | Rule Of Five | Rule Of Three |
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Drug Toxicity Information |
| Toxicity information of individual drugs using eToxPred |
| ZINC ID | Smile | Surface Accessibility | Toxicity |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| NUTM1 | EP300, ALOX5, IFIT2, KPNA2, LMO1, LMO2, PRKAA2, TP53BP2, NEBL, ZNF277, SAMD4A, PSME4, ZMYND10, CCHCR1, LMO3, RIC8A, SH2D4A, HSPBAP1, FAM161A, MORN4, P4HA3, KANSL1, LHX8, AXIN1, SMARCD1, MBD3, TXN2, TTC23, AES, CHCHD3, CDK18, RCOR3, ENKD1, ARHGEF6, PRKAB2, OSTF1, SOGA1, ALS2CR11, CCDC116, SCNM1, CDC20B, PRPF18, METTL17, TBC1D21, LRRC8E, TSGA10IP, PLEKHF2, CCDC185, SAMD4B, GADD45GIP1, KANK2, TEAD4, SH2D1B, GPANK1, AQP1, E7, nsp8, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| NUTM1 |  |
| BRD4 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to NUTM1-BRD4 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to NUTM1-BRD4 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NUTM1 | C1707291 | NUT midline carcinoma | 1 | ORPHANET |
| Tgene | BRD4 | C0017636 | Glioblastoma | 2 | CTD_human |
| Tgene | BRD4 | C0334588 | Giant Cell Glioblastoma | 2 | CTD_human |
| Tgene | BRD4 | C1621958 | Glioblastoma Multiforme | 2 | CTD_human |
| Tgene | BRD4 | C0002170 | Alopecia | 1 | CTD_human |
| Tgene | BRD4 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| Tgene | BRD4 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | BRD4 | C0018798 | Congenital Heart Defects | 1 | GENOMICS_ENGLAND |
| Tgene | BRD4 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| Tgene | BRD4 | C0020507 | Hyperplasia | 1 | CTD_human |
| Tgene | BRD4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| Tgene | BRD4 | C0025149 | Medulloblastoma | 1 | CTD_human |
| Tgene | BRD4 | C0025958 | Microcephaly | 1 | GENOMICS_ENGLAND |
| Tgene | BRD4 | C0029463 | Osteosarcoma | 1 | CTD_human |
| Tgene | BRD4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | BRD4 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| Tgene | BRD4 | C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | CTD_human |
| Tgene | BRD4 | C0086873 | Pseudopelade | 1 | CTD_human |
| Tgene | BRD4 | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human |
| Tgene | BRD4 | C0162311 | Androgenetic Alopecia | 1 | CTD_human |
| Tgene | BRD4 | C0205833 | Medullomyoblastoma | 1 | CTD_human |
| Tgene | BRD4 | C0263477 | Female pattern alopecia (disorder) | 1 | CTD_human |
| Tgene | BRD4 | C0270972 | Cornelia De Lange Syndrome | 1 | CTD_human |
| Tgene | BRD4 | C0278510 | Childhood Medulloblastoma | 1 | CTD_human |
| Tgene | BRD4 | C0278876 | Adult Medulloblastoma | 1 | CTD_human |
| Tgene | BRD4 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Tgene | BRD4 | C0549473 | Thyroid carcinoma | 1 | CTD_human |
| Tgene | BRD4 | C0751291 | Desmoplastic Medulloblastoma | 1 | CTD_human |
| Tgene | BRD4 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| Tgene | BRD4 | C0887850 | Polycystic Kidney, Type 1 Autosomal Dominant Disease | 1 | CTD_human |
| Tgene | BRD4 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| Tgene | BRD4 | C1275668 | Melanotic medulloblastoma | 1 | CTD_human |
| Tgene | BRD4 | C1707291 | NUT midline carcinoma | 1 | ORPHANET |
| Tgene | BRD4 | C1802395 | Congenital muscular hypertrophy-cerebral syndrome | 1 | CTD_human |
| Tgene | BRD4 | C1853099 | Cornelia de Lange Syndrome 3 | 1 | CTD_human |
| Tgene | BRD4 | C2751306 | Polycystic kidney disease, type 2 | 1 | CTD_human |
| Tgene | BRD4 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| Tgene | BRD4 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
| Tgene | BRD4 | C4025871 | Abnormality of the face | 1 | GENOMICS_ENGLAND |
| Tgene | BRD4 | C4083212 | Alopecia, Male Pattern | 1 | CTD_human |
| Tgene | BRD4 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | BRD4 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
| Tgene | BRD4 | C4551851 | Cornelia de Lange Syndrome 1 | 1 | CTD_human |
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