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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NVL-NEK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NVL-NEK2
FusionPDB ID: 61188
FusionGDB2.0 ID: 61188
HgeneTgene
Gene symbol

NVL

NEK2

Gene ID

4931

4751

Gene namenuclear VCP likeNIMA related kinase 2
SynonymsNVL2HsPK21|NEK2A|NLK1|PPP1R111|RP67
Cytomap

1q42.11

1q32.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear valosin-containing protein-likeNVLpserine/threonine-protein kinase Nek2NIMA (never in mitosis gene a)-related kinase 2nimA-like protein kinase 1nimA-related protein kinase 2protein phosphatase 1, regulatory subunit 111
Modification date2020031320200313
UniProtAcc.

P51955

Ensembl transtripts involved in fusion geneENST idsENST00000361463, ENST00000281701, 
ENST00000340871, ENST00000391875, 
ENST00000469075, ENST00000482491, 
ENST00000468673, 		ENST00000366999, 
ENST00000540251, ENST00000366998, 
ENST00000462283, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 11 X 8=9683 X 4 X 3=36
# samples 124
** MAII scorelog2(12/968*10)=-3.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NVL [Title/Abstract] AND NEK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NVL(224437914)-NEK2(211847855), # samples:3
Anticipated loss of major functional domain due to fusion event.NVL-NEK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NEK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NVL-NEK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NVL-NEK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NVL-NEK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNVL

GO:0006364

rRNA processing

29107693

HgeneNVL

GO:0032092

positive regulation of protein binding

29107693

HgeneNVL

GO:0042273

ribosomal large subunit biogenesis

26166824

HgeneNVL

GO:1904749

regulation of protein localization to nucleolus

29107693

TgeneNEK2

GO:0006468

protein phosphorylation

21076410

TgeneNEK2

GO:0007059

chromosome segregation

14978040

TgeneNEK2

GO:0046777

protein autophosphorylation

17626005

TgeneNEK2

GO:0051299

centrosome separation

18086858


check buttonFusion gene breakpoints across NVL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NEK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09Q-01ANVLchr1

224437914

-NEK2chr1

211847855

-
ChimerDB4BRCATCGA-A8-A09QNVLchr1

224437913

-NEK2chr1

211847855

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391875NVLchr1224437914-ENST00000366999NEK2chr1211847855-415422585634991147
ENST00000281701NVLchr1224437914-ENST00000366999NEK2chr1211847855-4445254922437901188
ENST00000469075NVLchr1224437914-ENST00000366999NEK2chr1211847855-392320271132681085
ENST00000391875NVLchr1224437913-ENST00000366999NEK2chr1211847855-415422585634991147
ENST00000281701NVLchr1224437913-ENST00000366999NEK2chr1211847855-4445254922437901188
ENST00000469075NVLchr1224437913-ENST00000366999NEK2chr1211847855-392320271132681085

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391875ENST00000366999NVLchr1224437914-NEK2chr1211847855-0.0002621490.9997378
ENST00000281701ENST00000366999NVLchr1224437914-NEK2chr1211847855-0.0002301010.99976987
ENST00000469075ENST00000366999NVLchr1224437914-NEK2chr1211847855-0.0002870450.9997129
ENST00000391875ENST00000366999NVLchr1224437913-NEK2chr1211847855-0.0002621490.9997378
ENST00000281701ENST00000366999NVLchr1224437913-NEK2chr1211847855-0.0002301010.99976987
ENST00000469075ENST00000366999NVLchr1224437913-NEK2chr1211847855-0.0002870450.9997129

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61188_61188_1_NVL-NEK2_NVL_chr1_224437913_ENST00000281701_NEK2_chr1_211847855_ENST00000366999_length(amino acids)=1188AA_BP=775
MAVRAVAWKTDAMKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTEL
EDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKD
SEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQ
ISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRE
LFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA
SRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDEL
QRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGV
LLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTE
MDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI
VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKL
GDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEI
ITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVR
ERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQAL

--------------------------------------------------------------

>61188_61188_2_NVL-NEK2_NVL_chr1_224437913_ENST00000391875_NEK2_chr1_211847855_ENST00000366999_length(amino acids)=1147AA_BP=734
MQGSWIINSSSESSSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHM
NSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKD
SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPR
GVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL
TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR
EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR
EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGES
ERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLP
PPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYL
DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSD
IWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGR
QLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSS

--------------------------------------------------------------

>61188_61188_3_NVL-NEK2_NVL_chr1_224437913_ENST00000469075_NEK2_chr1_211847855_ENST00000366999_length(amino acids)=1085AA_BP=672
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG
EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGND
MTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCII
FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKL
RLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPL
SEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL
AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIM
AATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNT
TLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDT
SFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRP
SVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAEN
LLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQ

--------------------------------------------------------------

>61188_61188_4_NVL-NEK2_NVL_chr1_224437914_ENST00000281701_NEK2_chr1_211847855_ENST00000366999_length(amino acids)=1188AA_BP=775
MAVRAVAWKTDAMKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTEL
EDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKD
SEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQ
ISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRE
LFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA
SRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDEL
QRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGV
LLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTE
MDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI
VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKL
GDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEI
ITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVR
ERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQAL

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>61188_61188_5_NVL-NEK2_NVL_chr1_224437914_ENST00000391875_NEK2_chr1_211847855_ENST00000366999_length(amino acids)=1147AA_BP=734
MQGSWIINSSSESSSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHM
NSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKD
SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPR
GVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL
TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR
EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR
EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGES
ERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLP
PPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYL
DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSD
IWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGR
QLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSS

--------------------------------------------------------------

>61188_61188_6_NVL-NEK2_NVL_chr1_224437914_ENST00000469075_NEK2_chr1_211847855_ENST00000366999_length(amino acids)=1085AA_BP=672
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG
EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGND
MTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCII
FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKL
RLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPL
SEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL
AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIM
AATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNT
TLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDT
SFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRP
SVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAEN
LLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:224437914/chr1:211847855)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NEK2

P51955

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-1923218_232763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-192349_52763.0857.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-192385_88763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-1721218_232574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-172149_52574.0668.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-172185_88574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-1822218_232657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-182249_52657.0751.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-182285_88657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-1822218_232672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-182249_52672.0766.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-182285_88672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-1923218_232763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-192349_52763.0857.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-192385_88763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-1721218_232574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-172149_52574.0668.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-172185_88574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-1822218_232657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-182249_52657.0751.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-182285_88657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-1822218_232672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-182249_52672.0766.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-182285_88672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-1923305_312763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-1923622_629763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-1721305_312574.0668.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-1822305_312657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-1822622_629657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-1822305_312672.0766.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-1822622_629672.0766.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-1923305_312763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-1923622_629763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-1721305_312574.0668.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-1822305_312657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-1822622_629657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-1822305_312672.0766.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-1822622_629672.0766.0Nucleotide bindingATP
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807303_36232.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807406_43032.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908303_36232.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908406_43032.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807303_36232.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807406_43032.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908303_36232.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908406_43032.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807306_33432.0385.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807333_37032.0385.0RegionNote=Required for microtubule binding and for localization to the centrosomes
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908306_33432.0446.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908333_37032.0446.0RegionNote=Required for microtubule binding and for localization to the centrosomes
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807306_33432.0385.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807333_37032.0385.0RegionNote=Required for microtubule binding and for localization to the centrosomes
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908306_33432.0446.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908333_37032.0446.0RegionNote=Required for microtubule binding and for localization to the centrosomes

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-1721622_629574.0668.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-1721622_629574.0668.0Nucleotide bindingATP
TgeneNEK2chr1:224437913chr1:211847855ENST00000366998078_27132.0385.0DomainProtein kinase
TgeneNEK2chr1:224437913chr1:211847855ENST00000366999088_27132.0446.0DomainProtein kinase
TgeneNEK2chr1:224437914chr1:211847855ENST00000366998078_27132.0385.0DomainProtein kinase
TgeneNEK2chr1:224437914chr1:211847855ENST00000366999088_27132.0446.0DomainProtein kinase
TgeneNEK2chr1:224437913chr1:211847855ENST000003669980714_2232.0385.0Nucleotide bindingATP
TgeneNEK2chr1:224437913chr1:211847855ENST000003669990814_2232.0446.0Nucleotide bindingATP
TgeneNEK2chr1:224437914chr1:211847855ENST000003669980714_2232.0385.0Nucleotide bindingATP
TgeneNEK2chr1:224437914chr1:211847855ENST000003669990814_2232.0446.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NVL
NEK2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NVL-NEK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NVL-NEK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource