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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:OBSCN-CASZ1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: OBSCN-CASZ1
FusionPDB ID: 61304
FusionGDB2.0 ID: 61304
HgeneTgene
Gene symbol

OBSCN

CASZ1

Gene ID

84033

54897

Gene nameobscurin, cytoskeletal calmodulin and titin-interacting RhoGEFcastor zinc finger 1
SynonymsARHGEF30|UNC89CAS11|CST|SRG|ZNF693|dJ734G22.1
Cytomap

1q42.13

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionobscurinobscurin, myosin light chain kinaseobscurin-MLCKzinc finger protein castor homolog 1castor homolog 1, zinc fingercastor-related proteinsurvival-relatedzinc finger protein 693
Modification date2020031320200313
UniProtAcc.

Q86V15

Ensembl transtripts involved in fusion geneENST idsENST00000284548, ENST00000422127, 
ENST00000570156, ENST00000366707, 
ENST00000366709, ENST00000359599, 
ENST00000602685, 		ENST00000478728, 
ENST00000344008, ENST00000377022, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 8 X 3=1446 X 7 X 5=210
# samples 67
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: OBSCN [Title/Abstract] AND CASZ1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)OBSCN(228412435)-CASZ1(10725628), # samples:5
Anticipated loss of major functional domain due to fusion event.OBSCN-CASZ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OBSCN-CASZ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OBSCN-CASZ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
OBSCN-CASZ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCASZ1

GO:0045893

positive regulation of transcription, DNA-templated

27693370


check buttonFusion gene breakpoints across OBSCN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-4223-01AOBSCNchr1

228412435

-CASZ1chr1

10725628

-
ChimerDB4HNSCTCGA-BB-4223-01AOBSCNchr1

228412435

+CASZ1chr1

10725628

-
ChimerDB4HNSCTCGA-BB-4223OBSCNchr1

228412435

+CASZ1chr1

10725628

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000284548OBSCNchr1228412435+ENST00000377022CASZ1chr110725628-1060530037482662730
ENST00000284548OBSCNchr1228412435+ENST00000344008CASZ1chr110725628-707230037464872137
ENST00000570156OBSCNchr1228412435+ENST00000377022CASZ1chr110725628-1088132797485422822
ENST00000570156OBSCNchr1228412435+ENST00000344008CASZ1chr110725628-734832797467632229
ENST00000422127OBSCNchr1228412435+ENST00000377022CASZ1chr110725628-1057529734482362730
ENST00000422127OBSCNchr1228412435+ENST00000344008CASZ1chr110725628-704229734464572137

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000284548ENST00000377022OBSCNchr1228412435+CASZ1chr110725628-0.0028990620.9971009
ENST00000284548ENST00000344008OBSCNchr1228412435+CASZ1chr110725628-0.0035406020.9964594
ENST00000570156ENST00000377022OBSCNchr1228412435+CASZ1chr110725628-0.0029054290.9970945
ENST00000570156ENST00000344008OBSCNchr1228412435+CASZ1chr110725628-0.0035155870.9964844
ENST00000422127ENST00000377022OBSCNchr1228412435+CASZ1chr110725628-0.0028375930.9971624
ENST00000422127ENST00000344008OBSCNchr1228412435+CASZ1chr110725628-0.003459880.9965402

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61304_61304_1_OBSCN-CASZ1_OBSCN_chr1_228412435_ENST00000284548_CASZ1_chr1_10725628_ENST00000344008_length(amino acids)=2137AA_BP=976
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS

--------------------------------------------------------------

>61304_61304_2_OBSCN-CASZ1_OBSCN_chr1_228412435_ENST00000284548_CASZ1_chr1_10725628_ENST00000377022_length(amino acids)=2730AA_BP=976
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS
LEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNC
KYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGFKY
FTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESS
TMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDAACQFSLKVTHYHC
TRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFC
QFSSSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSLSLGAEPGSLLFLQSAAAGL
GLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAE

--------------------------------------------------------------

>61304_61304_3_OBSCN-CASZ1_OBSCN_chr1_228412435_ENST00000422127_CASZ1_chr1_10725628_ENST00000344008_length(amino acids)=2137AA_BP=976
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS

--------------------------------------------------------------

>61304_61304_4_OBSCN-CASZ1_OBSCN_chr1_228412435_ENST00000422127_CASZ1_chr1_10725628_ENST00000377022_length(amino acids)=2730AA_BP=976
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS
LEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNC
KYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGFKY
FTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESS
TMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDAACQFSLKVTHYHC
TRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFC
QFSSSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSLSLGAEPGSLLFLQSAAAGL
GLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAE

--------------------------------------------------------------

>61304_61304_5_OBSCN-CASZ1_OBSCN_chr1_228412435_ENST00000570156_CASZ1_chr1_10725628_ENST00000344008_length(amino acids)=2229AA_BP=1068
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKAVFAKEQPACREV
QAEVGASATLSCEVAQDQMEVTWYKDGKKLSSSSKVHVEAVGCMRRLVVQQVGQADSGEYSCEARGQRVSFRLDVAEPKVVFAKEQLARR
KLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAG
KPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLG
RIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTR
DELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLET
KATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYD
VRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKY
IARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVG
CNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKK
FYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSS
LSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSG
SAASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGEST
GAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWK
VYLRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATV

--------------------------------------------------------------

>61304_61304_6_OBSCN-CASZ1_OBSCN_chr1_228412435_ENST00000570156_CASZ1_chr1_10725628_ENST00000377022_length(amino acids)=2822AA_BP=1068
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKAVFAKEQPACREV
QAEVGASATLSCEVAQDQMEVTWYKDGKKLSSSSKVHVEAVGCMRRLVVQQVGQADSGEYSCEARGQRVSFRLDVAEPKVVFAKEQLARR
KLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAG
KPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLG
RIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTR
DELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLET
KATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYD
VRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKY
IARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVG
CNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKK
FYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSS
LSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSG
SAASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGEST
GAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWK
VYLRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATV
SSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFG
NCKYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGF
KYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSE
SSTMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDAACQFSLKVTHY
HCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAG
FCQFSSSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSLSLGAEPGSLLFLQSAAA
GLGLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAA

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:228412435/chr1:10725628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CASZ1

Q86V15

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981192_198976.33333333333346621.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981710_713976.33333333333346621.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981931_934976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105192_198976.33333333333347969.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105710_713976.33333333333347969.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105931_934976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+98110_100976.33333333333346621.0DomainNote=Ig-like 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981110_202976.33333333333346621.0DomainNote=Ig-like 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981236_322976.33333333333346621.0DomainNote=Ig-like 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981331_414976.33333333333346621.0DomainNote=Ig-like 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981420_508976.33333333333346621.0DomainNote=Ig-like 5
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981515_612976.33333333333346621.0DomainFibronectin type-III 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981619_698976.33333333333346621.0DomainNote=Ig-like 6
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981701_790976.33333333333346621.0DomainNote=Ig-like 7
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981798_884976.33333333333346621.0DomainNote=Ig-like 8
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981886_977976.33333333333346621.0DomainNote=Ig-like 9
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+910510_100976.33333333333347969.0DomainNote=Ig-like 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105110_202976.33333333333347969.0DomainNote=Ig-like 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105236_322976.33333333333347969.0DomainNote=Ig-like 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105331_414976.33333333333347969.0DomainNote=Ig-like 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105420_508976.33333333333347969.0DomainNote=Ig-like 5
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105515_612976.33333333333347969.0DomainFibronectin type-III 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105619_698976.33333333333347969.0DomainNote=Ig-like 6
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105701_790976.33333333333347969.0DomainNote=Ig-like 7
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105798_884976.33333333333347969.0DomainNote=Ig-like 8
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105886_977976.33333333333347969.0DomainNote=Ig-like 9
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161080_11435.3333333333333331167.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161635_16705.3333333333333331167.0Compositional biasNote=Ala-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161672_17295.3333333333333331167.0Compositional biasNote=Glu-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161691_17185.3333333333333331167.0Compositional biasNote=Asp-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316384_4175.3333333333333331167.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211080_11435.3333333333333331760.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211635_16705.3333333333333331760.0Compositional biasNote=Ala-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211672_17295.3333333333333331760.0Compositional biasNote=Glu-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211691_17185.3333333333333331760.0Compositional biasNote=Asp-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321384_4175.3333333333333331760.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161031_10555.3333333333333331167.0Zinc fingerC2H2-type 4
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161300_13245.3333333333333331167.0Zinc fingerC2H2-type 5
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161457_14815.3333333333333331167.0Zinc fingerC2H2-type 6
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161515_15375.3333333333333331167.0Zinc fingerC2H2-type 7
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161571_15955.3333333333333331167.0Zinc fingerC2H2-type 8
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316551_5755.3333333333333331167.0Zinc fingerC2H2-type 1
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316610_6345.3333333333333331167.0Zinc fingerC2H2-type 2
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316668_6925.3333333333333331167.0Zinc fingerC2H2-type 3
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211031_10555.3333333333333331760.0Zinc fingerC2H2-type 4
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211300_13245.3333333333333331760.0Zinc fingerC2H2-type 5
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211457_14815.3333333333333331760.0Zinc fingerC2H2-type 6
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211515_15375.3333333333333331760.0Zinc fingerC2H2-type 7
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211571_15955.3333333333333331760.0Zinc fingerC2H2-type 8
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321551_5755.3333333333333331760.0Zinc fingerC2H2-type 1
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321610_6345.3333333333333331760.0Zinc fingerC2H2-type 2
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321668_6925.3333333333333331760.0Zinc fingerC2H2-type 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811115_1118976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811207_1210976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811299_1302976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811391_1394976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811575_1578976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811667_1670976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814398_4401976.33333333333346621.0Compositional biasNote=Poly-Leu
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814846_4849976.33333333333346621.0Compositional biasNote=Poly-Gln
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816789_6796976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816969_7117976.33333333333346621.0Compositional biasNote=Pro-rich
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051115_1118976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051207_1210976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051299_1302976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051391_1394976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051575_1578976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051667_1670976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054398_4401976.33333333333347969.0Compositional biasNote=Poly-Leu
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054846_4849976.33333333333347969.0Compositional biasNote=Poly-Gln
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056789_6796976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056969_7117976.33333333333347969.0Compositional biasNote=Pro-rich
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811070_1161976.33333333333346621.0DomainNote=Ig-like 11
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811162_1252976.33333333333346621.0DomainNote=Ig-like 12
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811254_1345976.33333333333346621.0DomainNote=Ig-like 13
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811346_1432976.33333333333346621.0DomainNote=Ig-like 14
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811438_1524976.33333333333346621.0DomainNote=Ig-like 15
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811530_1621976.33333333333346621.0DomainNote=Ig-like 16
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811622_1719976.33333333333346621.0DomainNote=Ig-like 17
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811731_1808976.33333333333346621.0DomainFibronectin type-III 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811809_1894976.33333333333346621.0DomainNote=Ig-like 18
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811896_1982976.33333333333346621.0DomainNote=Ig-like 19
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811987_2071976.33333333333346621.0DomainNote=Ig-like 20
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812077_2162976.33333333333346621.0DomainNote=Ig-like 21
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812165_2249976.33333333333346621.0DomainNote=Ig-like 22
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812289_2380976.33333333333346621.0DomainNote=Ig-like 23
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812468_2559976.33333333333346621.0DomainNote=Ig-like 24
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812564_2643976.33333333333346621.0DomainNote=Ig-like 25
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812646_2730976.33333333333346621.0DomainNote=Ig-like 26
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812736_2823976.33333333333346621.0DomainNote=Ig-like 27
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812826_2908976.33333333333346621.0DomainNote=Ig-like 28
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812920_2999976.33333333333346621.0DomainNote=Ig-like 29
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813003_3092976.33333333333346621.0DomainNote=Ig-like 30
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813095_3183976.33333333333346621.0DomainNote=Ig-like 31
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813184_3268976.33333333333346621.0DomainNote=Ig-like 32
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813273_3356976.33333333333346621.0DomainNote=Ig-like 33
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813359_3444976.33333333333346621.0DomainNote=Ig-like 34
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813449_3532976.33333333333346621.0DomainNote=Ig-like 35
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813537_3620976.33333333333346621.0DomainNote=Ig-like 36
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813625_3708976.33333333333346621.0DomainNote=Ig-like 37
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813713_3796976.33333333333346621.0DomainNote=Ig-like 38
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813801_3884976.33333333333346621.0DomainNote=Ig-like 39
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813890_3973976.33333333333346621.0DomainNote=Ig-like 40
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813978_4062976.33333333333346621.0DomainNote=Ig-like 41
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814068_4160976.33333333333346621.0DomainNote=Ig-like 42
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814171_4239976.33333333333346621.0DomainNote=Ig-like 43
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814248_4337976.33333333333346621.0DomainNote=Ig-like 44
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814340_4427976.33333333333346621.0DomainNote=Ig-like 45
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814430_4518976.33333333333346621.0DomainNote=Ig-like 46
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814525_4619976.33333333333346621.0DomainFibronectin type-III 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814624_4714976.33333333333346621.0DomainNote=Ig-like 47
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814872_4901976.33333333333346621.0DomainIQ
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814898_4989976.33333333333346621.0DomainNote=Ig-like 48
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815126_5215976.33333333333346621.0DomainNote=Ig-like 49
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815260_5349976.33333333333346621.0DomainNote=Ig-like 50
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815371_5467976.33333333333346621.0DomainNote=Ig-like 51
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815600_5667976.33333333333346621.0DomainSH3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815693_5877976.33333333333346621.0DomainDH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815895_6004976.33333333333346621.0DomainPH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816014_6097976.33333333333346621.0DomainNote=Ig-like 52
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816108_6200976.33333333333346621.0DomainNote=Ig-like 53
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816357_6445976.33333333333346621.0DomainNote=Ig-like 54
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816468_6721976.33333333333346621.0DomainProtein kinase 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817463_7552976.33333333333346621.0DomainNote=Ig-like 55
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817557_7649976.33333333333346621.0DomainFibronectin type-III 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817672_7924976.33333333333346621.0DomainProtein kinase 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981978_1066976.33333333333346621.0DomainNote=Ig-like 10
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051070_1161976.33333333333347969.0DomainNote=Ig-like 11
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051162_1252976.33333333333347969.0DomainNote=Ig-like 12
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051254_1345976.33333333333347969.0DomainNote=Ig-like 13
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051346_1432976.33333333333347969.0DomainNote=Ig-like 14
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051438_1524976.33333333333347969.0DomainNote=Ig-like 15
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051530_1621976.33333333333347969.0DomainNote=Ig-like 16
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051622_1719976.33333333333347969.0DomainNote=Ig-like 17
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051731_1808976.33333333333347969.0DomainFibronectin type-III 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051809_1894976.33333333333347969.0DomainNote=Ig-like 18
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051896_1982976.33333333333347969.0DomainNote=Ig-like 19
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051987_2071976.33333333333347969.0DomainNote=Ig-like 20
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052077_2162976.33333333333347969.0DomainNote=Ig-like 21
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052165_2249976.33333333333347969.0DomainNote=Ig-like 22
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052289_2380976.33333333333347969.0DomainNote=Ig-like 23
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052468_2559976.33333333333347969.0DomainNote=Ig-like 24
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052564_2643976.33333333333347969.0DomainNote=Ig-like 25
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052646_2730976.33333333333347969.0DomainNote=Ig-like 26
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052736_2823976.33333333333347969.0DomainNote=Ig-like 27
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052826_2908976.33333333333347969.0DomainNote=Ig-like 28
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052920_2999976.33333333333347969.0DomainNote=Ig-like 29
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053003_3092976.33333333333347969.0DomainNote=Ig-like 30
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053095_3183976.33333333333347969.0DomainNote=Ig-like 31
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053184_3268976.33333333333347969.0DomainNote=Ig-like 32
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053273_3356976.33333333333347969.0DomainNote=Ig-like 33
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053359_3444976.33333333333347969.0DomainNote=Ig-like 34
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053449_3532976.33333333333347969.0DomainNote=Ig-like 35
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053537_3620976.33333333333347969.0DomainNote=Ig-like 36
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053625_3708976.33333333333347969.0DomainNote=Ig-like 37
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053713_3796976.33333333333347969.0DomainNote=Ig-like 38
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053801_3884976.33333333333347969.0DomainNote=Ig-like 39
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053890_3973976.33333333333347969.0DomainNote=Ig-like 40
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053978_4062976.33333333333347969.0DomainNote=Ig-like 41
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054068_4160976.33333333333347969.0DomainNote=Ig-like 42
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054171_4239976.33333333333347969.0DomainNote=Ig-like 43
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054248_4337976.33333333333347969.0DomainNote=Ig-like 44
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054340_4427976.33333333333347969.0DomainNote=Ig-like 45
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054430_4518976.33333333333347969.0DomainNote=Ig-like 46
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054525_4619976.33333333333347969.0DomainFibronectin type-III 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054624_4714976.33333333333347969.0DomainNote=Ig-like 47
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054872_4901976.33333333333347969.0DomainIQ
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054898_4989976.33333333333347969.0DomainNote=Ig-like 48
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055126_5215976.33333333333347969.0DomainNote=Ig-like 49
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055260_5349976.33333333333347969.0DomainNote=Ig-like 50
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055371_5467976.33333333333347969.0DomainNote=Ig-like 51
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055600_5667976.33333333333347969.0DomainSH3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055693_5877976.33333333333347969.0DomainDH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055895_6004976.33333333333347969.0DomainPH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056014_6097976.33333333333347969.0DomainNote=Ig-like 52
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056108_6200976.33333333333347969.0DomainNote=Ig-like 53
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056357_6445976.33333333333347969.0DomainNote=Ig-like 54
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056468_6721976.33333333333347969.0DomainProtein kinase 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057463_7552976.33333333333347969.0DomainNote=Ig-like 55
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057557_7649976.33333333333347969.0DomainFibronectin type-III 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057672_7924976.33333333333347969.0DomainProtein kinase 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105978_1066976.33333333333347969.0DomainNote=Ig-like 10
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816474_6482976.33333333333346621.0Nucleotide bindingATP
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817678_7686976.33333333333346621.0Nucleotide bindingATP
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056474_6482976.33333333333347969.0Nucleotide bindingATP
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057678_7686976.33333333333347969.0Nucleotide bindingATP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
OBSCN_pLDDT.png
all structure
all structure
CASZ1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
OBSCN
CASZ1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to OBSCN-CASZ1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to OBSCN-CASZ1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource