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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:OCIAD1-KIT

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: OCIAD1-KIT
	FusionPDB ID: 61324
	FusionGDB2.0 ID: 61324
		Hgene	Tgene
	Gene symbol	OCIAD1	KIT
	Gene ID	54940	3815
	Gene name	OCIA domain containing 1	KIT proto-oncogene, receptor tyrosine kinase
	Synonyms	ASRIJ\|OCIA\|TPA018	C-Kit\|CD117\|MASTC\|PBT\|SCFR
	Cytomap	4p11	4q12
	Type of gene	protein-coding	protein-coding
	Description	OCIA domain-containing protein 1ovarian cancer immunoreactive antigen domain containing 1ovarian cancer immunoreactive antigen domain containing 1Aovarian carcinoma immunoreactive antigen	mast/stem cell growth factor receptor Kitc-Kit protooncogenep145 c-kitpiebald trait proteinproto-oncogene c-Kitproto-oncogene tyrosine-protein kinase Kitsoluble KIT variant 1tyrosine-protein kinase Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral o
	Modification date	20200313	20200313
	UniProtAcc	.	P21583
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264312, ENST00000381473, ENST00000508293, ENST00000509122, ENST00000513391, ENST00000396448, ENST00000425583, ENST00000444354, ENST00000506801, ENST00000512981,	ENST00000288135,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 6 X 3=90	4 X 4 X 3=48
	# samples	6	4
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: OCIAD1 [Title/Abstract] AND KIT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	OCIAD1(48859382)-KIT(55589750), # samples:3
Anticipated loss of major functional domain due to fusion event.	OCIAD1-KIT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OCIAD1-KIT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OCIAD1-KIT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. OCIAD1-KIT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KIT	GO:0000187	activation of MAPK activity	21640708
Tgene	KIT	GO:0002551	mast cell chemotaxis	20100931
Tgene	KIT	GO:0018108	peptidyl-tyrosine phosphorylation	21640708
Tgene	KIT	GO:0019221	cytokine-mediated signaling pathway	21640708
Tgene	KIT	GO:0031532	actin cytoskeleton reorganization	1721869
Tgene	KIT	GO:0032762	mast cell cytokine production	20100931
Tgene	KIT	GO:0038093	Fc receptor signaling pathway	20100931
Tgene	KIT	GO:0038109	Kit signaling pathway	17662946
Tgene	KIT	GO:0046777	protein autophosphorylation	21640708
Tgene	KIT	GO:0060326	cell chemotaxis	1721869
Tgene	KIT	GO:1905065	positive regulation of vascular smooth muscle cell differentiation	19088079

Fusion gene breakpoints across OCIAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UVM	TCGA-V4-A9F7-01A	OCIAD1	chr4	48859382	-	KIT	chr4	55589750	+
ChimerDB4	UVM	TCGA-V4-A9F7-01A	OCIAD1	chr4	48859382	+	KIT	chr4	55589750	+
ChimerDB4	UVM	TCGA-V4-A9F7	OCIAD1	chr4	48859382	+	KIT	chr4	55589750	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000509122

OCIAD1

chr4

48859382

ENST00000288135

KIT

chr4

55589750

4537

679

2378

789

ENST00000264312

OCIAD1

chr4

48859382

ENST00000288135

KIT

chr4

55589750

4748

890

166

2589

807

ENST00000381473

OCIAD1

chr4

48859382

ENST00000288135

KIT

chr4

55589750

4976

1118

319

2817

832

ENST00000508293

OCIAD1

chr4

48859382

ENST00000288135

KIT

chr4

55589750

4789

931

216

2630

804

ENST00000513391

OCIAD1

chr4

48859382

ENST00000288135

KIT

chr4

55589750

4620

762

2461

818

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000509122	ENST00000288135	OCIAD1	chr4	48859382	+	KIT	chr4	55589750	+	0.000552071	0.9994479
ENST00000264312	ENST00000288135	OCIAD1	chr4	48859382	+	KIT	chr4	55589750	+	0.000756241	0.99924374
ENST00000381473	ENST00000288135	OCIAD1	chr4	48859382	+	KIT	chr4	55589750	+	0.00071878	0.9992812
ENST00000508293	ENST00000288135	OCIAD1	chr4	48859382	+	KIT	chr4	55589750	+	0.00045887	0.99954116
ENST00000513391	ENST00000288135	OCIAD1	chr4	48859382	+	KIT	chr4	55589750	+	0.00072003	0.99928004

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61324_61324_1_OCIAD1-KIT_OCIAD1_chr4_48859382_ENST00000264312_KIT_chr4_55589750_ENST00000288135_length(amino acids)=807AA_BP=241
MLLSSGGKMNGRADFREPNAEVPRPIPHIGPDYIPTEEERRVFAECNDESFWFRSVPLAATSMLITQGLISKGILSSHPKYGSIPKLILA
CIMGYFAGKLSYVKTCQEKFKKLENSPLGEALRSGQARRSSPPGHYYQKSKYDSSVSGQSSFVTSPAADNIEMLPHYEPIPFSSSMNESA
PTGITDHIVQGPDPNLEESPKRKNITYEELRNKNRESYEVSLTQKTDPSVRPMHERVPKKEAKPEILTYDRLVNGMLQCVAAGFPEPTID
WYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGF
VIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMT
VAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHS
KESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNIL
LTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRM

--------------------------------------------------------------

>61324_61324_2_OCIAD1-KIT_OCIAD1_chr4_48859382_ENST00000381473_KIT_chr4_55589750_ENST00000288135_length(amino acids)=832AA_BP=266
MREATECFWGCELGKFVVTDACGVAAQSVTAGKMNGRADFREPNAEVPRPIPHIGPDYIPTEEERRVFAECNDESFWFRSVPLAATSMLI
TQGLISKGILSSHPKYGSIPKLILACIMGYFAGKLSYVKTCQEKFKKLENSPLGEALRSGQARRSSPPGHYYQKSKYDSSVSGQSSFVTS
PAADNIEMLPHYEPIPFSSSMNESAPTGITDHIVQGPDPNLEESPKRKNITYEELRNKNRESYEVSLTQKTDPSVRPMHERVPKKEAKPE
ILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYF
NFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKT
LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRR
KRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSY
QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFS
LGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHS

--------------------------------------------------------------

>61324_61324_3_OCIAD1-KIT_OCIAD1_chr4_48859382_ENST00000508293_KIT_chr4_55589750_ENST00000288135_length(amino acids)=804AA_BP=238
MECGKMNGRADFREPNAEVPRPIPHIGPDYIPTEEERRVFAECNDESFWFRSVPLAATSMLITQGLISKGILSSHPKYGSIPKLILACIM
GYFAGKLSYVKTCQEKFKKLENSPLGEALRSGQARRSSPPGHYYQKSKYDSSVSGQSSFVTSPAADNIEMLPHYEPIPFSSSMNESAPTG
ITDHIVQGPDPNLEESPKRKNITYEELRNKNRESYEVSLTQKTDPSVRPMHERVPKKEAKPEILTYDRLVNGMLQCVAAGFPEPTIDWYF
CPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIV
AGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAV
KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKES
SCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH
GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSP

--------------------------------------------------------------

>61324_61324_4_OCIAD1-KIT_OCIAD1_chr4_48859382_ENST00000509122_KIT_chr4_55589750_ENST00000288135_length(amino acids)=789AA_BP=223
MLALRPAVRSDVISCRKMNGRADFREPNAEVPRPIPPVPLAATSMLITQGLISKGILSSHPKYGSIPKLILACIMGYFAGKLSYVKTCQE
KFKKLENSPLGEALRSGQARRSSPPGHYYQKSKYDSSVSGQSSFVTSPAADNIEMLPHYEPIPFSSSMNESAPTGITDHIVQGPDPNLEE
SPKRKNITYEELRNKNRESYEVSLTQKTDPSVRPMHERVPKKEAKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPV
DVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKY
LQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREAL
MSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPG
VSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI
KNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCW

--------------------------------------------------------------

>61324_61324_5_OCIAD1-KIT_OCIAD1_chr4_48859382_ENST00000513391_KIT_chr4_55589750_ENST00000288135_length(amino acids)=818AA_BP=252
MPVRVDRSRSGLGLLSAGKMNGRADFREPNAEVPRPIPHIGPDYIPTEEERRVFAECNDESFWFRSVPLAATSMLITQGLISKGILSSHP
KYGSIPKLILACIMGYFAGKLSYVKTCQEKFKKLENSPLGEALRSGQARRSSPPGHYYQKSKYDSSVSGQSSFVTSPAADNIEMLPHYEP
IPFSSSMNESAPTGITDHIVQGPDPNLEESPKRKNITYEELRNKNRESYEVSLTQKTDPSVRPMHERVPKKEAKPEILTYDRLVNGMLQC
VAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHP
HTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATA
YGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHA
EAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNC
IHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSK
FYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:48859382/chr4:55589750)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KIT P21583
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OCIAD1

chr4:48859382

chr4:55589750

ENST00000264312

1_112

233.33333333333334

246.0

Domain

Note=OCIA

Hgene

OCIAD1

chr4:48859382

chr4:55589750

ENST00000381473

1_112

233.33333333333334

246.0

Domain

Note=OCIA

Hgene

OCIAD1

chr4:48859382

chr4:55589750

ENST00000508293

1_112

233.33333333333334

246.0

Domain

Note=OCIA

Hgene

OCIAD1

chr4:48859382

chr4:55589750

ENST00000513391

1_112

233.33333333333334

246.0

Domain

Note=OCIA

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

413_507

410.3333333333333

977.0

Domain

Note=Ig-like C2-type 5

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

589_937

410.3333333333333

977.0

Domain

Protein kinase

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

596_603

410.3333333333333

977.0

Nucleotide binding

Note=ATP

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

671_677

410.3333333333333

977.0

Nucleotide binding

Note=ATP

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

546_976

410.3333333333333

977.0

Topological domain

Cytoplasmic

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

525_545

410.3333333333333

977.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OCIAD1

chr4:48859382

chr4:55589750

ENST00000396448

1_112

301.0

Domain

Note=OCIA

Hgene

OCIAD1

chr4:48859382

chr4:55589750

ENST00000425583

1_112

195.0

Domain

Note=OCIA

Hgene

OCIAD1

chr4:48859382

chr4:55589750

ENST00000444354

1_112

195.0

Domain

Note=OCIA

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

121_205

410.3333333333333

977.0

Domain

Note=Ig-like C2-type 2

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

212_308

410.3333333333333

977.0

Domain

Note=Ig-like C2-type 3

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

27_112

410.3333333333333

977.0

Domain

Note=Ig-like C2-type 1

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

317_410

410.3333333333333

977.0

Domain

Note=Ig-like C2-type 4

Tgene

KIT

chr4:48859382

chr4:55589750

ENST00000288135

26_524

410.3333333333333

977.0

Topological domain

Extracellular

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1619_OCIAD1_48859382_KIT_55589750_ranked_0.pdb	OCIAD1	48859382	48859382	ENST00000288135	KIT	chr4	55589750	+	MREATECFWGCELGKFVVTDACGVAAQSVTAGKMNGRADFREPNAEVPRPIPHIGPDYIPTEEERRVFAECNDESFWFRSVPLAATSMLI TQGLISKGILSSHPKYGSIPKLILACIMGYFAGKLSYVKTCQEKFKKLENSPLGEALRSGQARRSSPPGHYYQKSKYDSSVSGQSSFVTS PAADNIEMLPHYEPIPFSSSMNESAPTGITDHIVQGPDPNLEESPKRKNITYEELRNKNRESYEVSLTQKTDPSVRPMHERVPKKEAKPE ILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYF NFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKT LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRR KRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSY QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFS LGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHS	832

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

OCIAD1_pLDDT.png

KIT_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
OCIAD1
KIT

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to OCIAD1-KIT

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to OCIAD1-KIT

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source