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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:OCLN-ARHGAP26

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: OCLN-ARHGAP26
FusionPDB ID: 61330
FusionGDB2.0 ID: 61330
HgeneTgene
Gene symbol

OCLN

ARHGAP26

Gene ID

100506658

23092

Gene nameoccludinRho GTPase activating protein 26
SynonymsBLCPMG|PPP1R115|PTORCH1GRAF|GRAF1|OPHN1L|OPHN1L1
Cytomap

5q13.2

5q31.3

Type of geneprotein-codingprotein-coding
Descriptionoccludinphosphatase 1, regulatory subunit 115tight junction protein occludinrho GTPase-activating protein 26GTPase regulator associated with focal adhesion kinase pp125(FAK)oligophrenin-1-like protein
Modification date2020031320200313
UniProtAcc.

Q9UNA1

Ensembl transtripts involved in fusion geneENST idsENST00000355237, ENST00000396442, 
ENST00000538151, ENST00000380766, 
ENST00000514370, ENST00000542132, 
ENST00000486650, ENST00000274498, 
ENST00000378004, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 7=37823 X 27 X 10=6210
# samples 1330
** MAII scorelog2(13/378*10)=-1.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/6210*10)=-4.37155886261196
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: OCLN [Title/Abstract] AND ARHGAP26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)OCLN(68809936)-ARHGAP26(142393645), # samples:2
Anticipated loss of major functional domain due to fusion event.OCLN-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OCLN-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OCLN-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
OCLN-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across OCLN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8528-01AOCLNchr5

68809936

+ARHGAP26chr5

142393645

+
ChimerDB4STADTCGA-CD-8528OCLNchr5

68809936

+ARHGAP26chr5

142393644

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355237OCLNchr568809936+ENST00000378004ARHGAP26chr5142393645+906513274362499687
ENST00000355237OCLNchr568809936+ENST00000274498ARHGAP26chr5142393645+670413274362664742
ENST00000396442OCLNchr568809936+ENST00000378004ARHGAP26chr5142393645+880810701792242687
ENST00000396442OCLNchr568809936+ENST00000274498ARHGAP26chr5142393645+644710701792407742
ENST00000538151OCLNchr568809936+ENST00000378004ARHGAP26chr5142393645+79942561091428439
ENST00000538151OCLNchr568809936+ENST00000274498ARHGAP26chr5142393645+56332561091593494
ENST00000355237OCLNchr568809936+ENST00000378004ARHGAP26chr5142393644+906513274362499687
ENST00000355237OCLNchr568809936+ENST00000274498ARHGAP26chr5142393644+670413274362664742
ENST00000396442OCLNchr568809936+ENST00000378004ARHGAP26chr5142393644+880810701792242687
ENST00000396442OCLNchr568809936+ENST00000274498ARHGAP26chr5142393644+644710701792407742
ENST00000538151OCLNchr568809936+ENST00000378004ARHGAP26chr5142393644+79942561091428439
ENST00000538151OCLNchr568809936+ENST00000274498ARHGAP26chr5142393644+56332561091593494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355237ENST00000378004OCLNchr568809936+ARHGAP26chr5142393645+0.0017576420.9982424
ENST00000355237ENST00000274498OCLNchr568809936+ARHGAP26chr5142393645+0.0028154140.9971846
ENST00000396442ENST00000378004OCLNchr568809936+ARHGAP26chr5142393645+0.0016181510.99838185
ENST00000396442ENST00000274498OCLNchr568809936+ARHGAP26chr5142393645+0.002618360.9973816
ENST00000538151ENST00000378004OCLNchr568809936+ARHGAP26chr5142393645+0.0006403590.99935967
ENST00000538151ENST00000274498OCLNchr568809936+ARHGAP26chr5142393645+0.0013745320.9986255
ENST00000355237ENST00000378004OCLNchr568809936+ARHGAP26chr5142393644+0.0017576420.9982424
ENST00000355237ENST00000274498OCLNchr568809936+ARHGAP26chr5142393644+0.0028154140.9971846
ENST00000396442ENST00000378004OCLNchr568809936+ARHGAP26chr5142393644+0.0016181510.99838185
ENST00000396442ENST00000274498OCLNchr568809936+ARHGAP26chr5142393644+0.002618360.9973816
ENST00000538151ENST00000378004OCLNchr568809936+ARHGAP26chr5142393644+0.0006403590.99935967
ENST00000538151ENST00000274498OCLNchr568809936+ARHGAP26chr5142393644+0.0013745320.9986255

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61330_61330_1_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000355237_ARHGAP26_chr5_142393644_ENST00000274498_length(amino acids)=742AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSV
AGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEP

--------------------------------------------------------------

>61330_61330_2_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000355237_ARHGAP26_chr5_142393644_ENST00000378004_length(amino acids)=687AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVSTP

--------------------------------------------------------------

>61330_61330_3_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000355237_ARHGAP26_chr5_142393645_ENST00000274498_length(amino acids)=742AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSV
AGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEP

--------------------------------------------------------------

>61330_61330_4_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000355237_ARHGAP26_chr5_142393645_ENST00000378004_length(amino acids)=687AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVSTP

--------------------------------------------------------------

>61330_61330_5_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000396442_ARHGAP26_chr5_142393644_ENST00000274498_length(amino acids)=742AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSV
AGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEP

--------------------------------------------------------------

>61330_61330_6_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000396442_ARHGAP26_chr5_142393644_ENST00000378004_length(amino acids)=687AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVSTP

--------------------------------------------------------------

>61330_61330_7_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000396442_ARHGAP26_chr5_142393645_ENST00000274498_length(amino acids)=742AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSV
AGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEP

--------------------------------------------------------------

>61330_61330_8_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000396442_ARHGAP26_chr5_142393645_ENST00000378004_length(amino acids)=687AA_BP=297
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT
ASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNL
MTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEK
QEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVSTP

--------------------------------------------------------------

>61330_61330_9_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000538151_ARHGAP26_chr5_142393644_ENST00000274498_length(amino acids)=494AA_BP=49
MGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGL
YRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKN
RQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSD
SKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMF
SAPSSPMPTSSTSSDSSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAE

--------------------------------------------------------------

>61330_61330_10_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000538151_ARHGAP26_chr5_142393644_ENST00000378004_length(amino acids)=439AA_BP=49
MGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGL
YRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKN
RQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSD
SKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMF

--------------------------------------------------------------

>61330_61330_11_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000538151_ARHGAP26_chr5_142393645_ENST00000274498_length(amino acids)=494AA_BP=49
MGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGL
YRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKN
RQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSD
SKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMF
SAPSSPMPTSSTSSDSSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAE

--------------------------------------------------------------

>61330_61330_12_OCLN-ARHGAP26_OCLN_chr5_68809936_ENST00000538151_ARHGAP26_chr5_142393645_ENST00000378004_length(amino acids)=439AA_BP=49
MGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGL
YRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKN
RQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSD
SKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:68809936/chr5:142393645)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP26

Q9UNA1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: GTPase-activating protein for RHOA and CDC42.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+4992_131297.0523.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+4992_131297.0523.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+4992_131297.0523.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+4992_131297.0523.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+4960_269297.0523.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+4960_269297.0523.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+4960_269297.0523.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+4960_269297.0523.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+49161_170297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+49196_243297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+491_66297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+4990_135297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+49161_170297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+49196_243297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+491_66297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+4990_135297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+49161_170297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+49196_243297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+491_66297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+4990_135297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+49161_170297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+49196_243297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+491_66297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+4990_135297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+49136_160297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+49171_195297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+49244_265297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+4967_89297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+49136_160297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+49171_195297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+49244_265297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+4967_89297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+49136_160297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+49171_195297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+49244_265297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+4967_89297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+49136_160297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+49171_195297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+49244_265297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+4967_89297.0523.0TransmembraneHelical
TgeneARHGAP26chr5:68809936chr5:142393644ENST000002744981023584_701369.0815.0Compositional biasNote=Ser-rich
TgeneARHGAP26chr5:68809936chr5:142393644ENST000003780041023584_701369.0760.0Compositional biasNote=Ser-rich
TgeneARHGAP26chr5:68809936chr5:142393645ENST000002744981023584_701369.0815.0Compositional biasNote=Ser-rich
TgeneARHGAP26chr5:68809936chr5:142393645ENST000003780041023584_701369.0760.0Compositional biasNote=Ser-rich
TgeneARHGAP26chr5:68809936chr5:142393644ENST000002744981023383_568369.0815.0DomainRho-GAP
TgeneARHGAP26chr5:68809936chr5:142393644ENST000002744981023756_814369.0815.0DomainSH3
TgeneARHGAP26chr5:68809936chr5:142393644ENST000003780041023383_568369.0760.0DomainRho-GAP
TgeneARHGAP26chr5:68809936chr5:142393644ENST000003780041023756_814369.0760.0DomainSH3
TgeneARHGAP26chr5:68809936chr5:142393645ENST000002744981023383_568369.0815.0DomainRho-GAP
TgeneARHGAP26chr5:68809936chr5:142393645ENST000002744981023756_814369.0815.0DomainSH3
TgeneARHGAP26chr5:68809936chr5:142393645ENST000003780041023383_568369.0760.0DomainRho-GAP
TgeneARHGAP26chr5:68809936chr5:142393645ENST000003780041023756_814369.0760.0DomainSH3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+49426_489297.0523.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+18426_4890469.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+49426_489297.0523.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+27426_48946.0272.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+16426_4890201.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+49426_489297.0523.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+18426_4890469.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+49426_489297.0523.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+27426_48946.0272.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+16426_4890201.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+1892_1310469.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+2792_13146.0272.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+1692_1310201.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+1892_1310469.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+2792_13146.0272.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+1692_1310201.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+1860_2690469.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+2760_26946.0272.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+1660_2690201.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+1860_2690469.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+2760_26946.0272.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+1660_2690201.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:142393644ENST00000355237+49266_522297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+18161_1700469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+18196_2430469.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+181_660469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+18266_5220469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+1890_1350469.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000396442+49266_522297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+27161_17046.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+27196_24346.0272.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+271_6646.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+27266_52246.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+2790_13546.0272.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+16161_1700201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+16196_2430201.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+161_660201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+16266_5220201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+1690_1350201.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000355237+49266_522297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+18161_1700469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+18196_2430469.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+181_660469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+18266_5220469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+1890_1350469.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000396442+49266_522297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+27161_17046.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+27196_24346.0272.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+271_6646.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+27266_52246.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+2790_13546.0272.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+16161_1700201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+16196_2430201.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+161_660201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+16266_5220201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+1690_1350201.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+18136_1600469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+18171_1950469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+18244_2650469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000380766+1867_890469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+27136_16046.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+27171_19546.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+27244_26546.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000538151+2767_8946.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+16136_1600201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+16171_1950201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+16244_2650201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393644ENST00000542132+1667_890201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+18136_1600469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+18171_1950469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+18244_2650469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000380766+1867_890469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+27136_16046.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+27171_19546.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+27244_26546.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000538151+2767_8946.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+16136_1600201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+16171_1950201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+16244_2650201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:142393645ENST00000542132+1667_890201.0TransmembraneHelical
TgeneARHGAP26chr5:68809936chr5:142393644ENST000002744981023265_369369.0815.0DomainPH
TgeneARHGAP26chr5:68809936chr5:142393644ENST000003780041023265_369369.0760.0DomainPH
TgeneARHGAP26chr5:68809936chr5:142393645ENST000002744981023265_369369.0815.0DomainPH
TgeneARHGAP26chr5:68809936chr5:142393645ENST000003780041023265_369369.0760.0DomainPH


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
OCLN
ARHGAP26all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to OCLN-ARHGAP26


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to OCLN-ARHGAP26


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARHGAP26C0033975Psychotic Disorders1PSYGENET