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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ARHGAP5-NUBPL

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ARHGAP5-NUBPL
	FusionPDB ID: 6143
	FusionGDB2.0 ID: 6143
		Hgene	Tgene
	Gene symbol	ARHGAP5	NUBPL
	Gene ID	394	80224
	Gene name	Rho GTPase activating protein 5	nucleotide binding protein like
	Synonyms	GFI2\|RhoGAP5\|p190-B\|p190BRhoGAP	C14orf127\|IND1\|MC1DN21\|huInd1
	Cytomap	14q12	14q12
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 5growth factor independent 2p100 RasGAP-associated p105 proteinp105 RhoGAPrho-type GTPase-activating protein 5	iron-sulfur protein NUBPLIND1 homologiron-sulfur protein required for NADH dehydrogenase
	Modification date	20200313	20200313
	UniProtAcc	Q13017	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000345122, ENST00000432921, ENST00000433497, ENST00000539826, ENST00000556611, ENST00000396582,	ENST00000418681, ENST00000281081, ENST00000536705,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 4 X 7=280	17 X 14 X 7=1666
	# samples	12	17
	** MAII score	log2(12/280*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1666*10)=-3.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ARHGAP5 [Title/Abstract] AND NUBPL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ARHGAP5(32586493)-NUBPL(32142561), # samples:2
Anticipated loss of major functional domain due to fusion event.	ARHGAP5-NUBPL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP5-NUBPL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP5-NUBPL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP5-NUBPL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARHGAP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUBPL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-66-2795-01A	ARHGAP5	chr14	32586493	-	NUBPL	chr14	32142561	+
ChimerDB4	LUSC	TCGA-66-2795-01A	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000556611	ARHGAP5	chr14	32586493	+	ENST00000281081	NUBPL	chr14	32142561	+	6739	4117	255	4694	1479
ENST00000556611	ARHGAP5	chr14	32586493	+	ENST00000536705	NUBPL	chr14	32142561	+	6708	4117	255	4694	1479
ENST00000539826	ARHGAP5	chr14	32586493	+	ENST00000281081	NUBPL	chr14	32142561	+	6724	4102	237	4679	1480
ENST00000539826	ARHGAP5	chr14	32586493	+	ENST00000536705	NUBPL	chr14	32142561	+	6693	4102	237	4679	1480
ENST00000432921	ARHGAP5	chr14	32586493	+	ENST00000281081	NUBPL	chr14	32142561	+	6799	4177	315	4754	1479
ENST00000432921	ARHGAP5	chr14	32586493	+	ENST00000536705	NUBPL	chr14	32142561	+	6768	4177	315	4754	1479
ENST00000345122	ARHGAP5	chr14	32586493	+	ENST00000281081	NUBPL	chr14	32142561	+	6802	4180	315	4757	1480
ENST00000345122	ARHGAP5	chr14	32586493	+	ENST00000536705	NUBPL	chr14	32142561	+	6771	4180	315	4757	1480
ENST00000433497	ARHGAP5	chr14	32586493	+	ENST00000281081	NUBPL	chr14	32142561	+	2894	272	190	849	219
ENST00000433497	ARHGAP5	chr14	32586493	+	ENST00000536705	NUBPL	chr14	32142561	+	2863	272	190	849	219

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000556611	ENST00000281081	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.00012048	0.9998795
ENST00000556611	ENST00000536705	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.000123228	0.99987674
ENST00000539826	ENST00000281081	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	9.98E-05	0.9999001
ENST00000539826	ENST00000536705	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.000102609	0.99989736
ENST00000432921	ENST00000281081	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.000130136	0.9998698
ENST00000432921	ENST00000536705	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.000133264	0.9998667
ENST00000345122	ENST00000281081	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.000109394	0.99989057
ENST00000345122	ENST00000536705	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.000112723	0.9998872
ENST00000433497	ENST00000281081	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.000376609	0.9996234
ENST00000433497	ENST00000536705	ARHGAP5	chr14	32586493	+	NUBPL	chr14	32142561	+	0.00039305	0.999607

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6143_6143_1_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000345122_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=1480AA_BP=1288
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYF
GMPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTG
DVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLN

--------------------------------------------------------------

>6143_6143_2_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000345122_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=1480AA_BP=1288
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYF
GMPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTG
DVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLN

--------------------------------------------------------------

>6143_6143_3_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000432921_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=1479AA_BP=1287
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKKKKTKNFNPPTRRNWESNYFG
MPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGD
VQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNI

--------------------------------------------------------------

>6143_6143_4_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000432921_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=1479AA_BP=1287
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKKKKTKNFNPPTRRNWESNYFG
MPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGD
VQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNI

--------------------------------------------------------------

>6143_6143_5_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000433497_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=219AA_BP=27
MPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGD
VQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNI

--------------------------------------------------------------

>6143_6143_6_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000433497_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=219AA_BP=27
MPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGD
VQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNI

--------------------------------------------------------------

>6143_6143_7_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000539826_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=1480AA_BP=1288
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYF
GMPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTG
DVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLN

--------------------------------------------------------------

>6143_6143_8_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000539826_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=1480AA_BP=1288
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYF
GMPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTG
DVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLN

--------------------------------------------------------------

>6143_6143_9_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000556611_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=1479AA_BP=1287
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKKKKTKNFNPPTRRNWESNYFG
MPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGD
VQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNI

--------------------------------------------------------------

>6143_6143_10_ARHGAP5-NUBPL_ARHGAP5_chr14_32586493_ENST00000556611_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=1479AA_BP=1287
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKI
HVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVV
TATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIY
ELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQA
GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP
YSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRR
THSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKKKKTKNFNPPTRRNWESNYFG
MPLQDLVTAEKPIPLFVEKCVEFIEDTGNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGD
VQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:32586493/chr14:32142561)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP5 Q13017	.
FUNCTION: GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269\|PubMed:8537347}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

1225_1245

1288.3333333333333

1503.0

Compositional bias

Note=Lys-rich

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

1225_1245

1287.3333333333333

1502.0

Compositional bias

Note=Lys-rich

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

1225_1245

1288.3333333333333

1503.0

Compositional bias

Note=Lys-rich

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

1225_1245

1287.3333333333333

1502.0

Compositional bias

Note=Lys-rich

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

267_325

1288.3333333333333

1503.0

Domain

Note=FF 1

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

366_420

1288.3333333333333

1503.0

Domain

Note=FF 2

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

427_481

1288.3333333333333

1503.0

Domain

Note=FF 3

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

482_548

1288.3333333333333

1503.0

Domain

Note=FF 4

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

590_763

1288.3333333333333

1503.0

Domain

pG1 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

779_944

1288.3333333333333

1503.0

Domain

pG2 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

267_325

1287.3333333333333

1502.0

Domain

Note=FF 1

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

366_420

1287.3333333333333

1502.0

Domain

Note=FF 2

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

427_481

1287.3333333333333

1502.0

Domain

Note=FF 3

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

482_548

1287.3333333333333

1502.0

Domain

Note=FF 4

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

590_763

1287.3333333333333

1502.0

Domain

pG1 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

779_944

1287.3333333333333

1502.0

Domain

pG2 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

267_325

1288.3333333333333

1503.0

Domain

Note=FF 1

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

366_420

1288.3333333333333

1503.0

Domain

Note=FF 2

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

427_481

1288.3333333333333

1503.0

Domain

Note=FF 3

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

482_548

1288.3333333333333

1503.0

Domain

Note=FF 4

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

590_763

1288.3333333333333

1503.0

Domain

pG1 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

779_944

1288.3333333333333

1503.0

Domain

pG2 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

267_325

1287.3333333333333

1502.0

Domain

Note=FF 1

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

366_420

1287.3333333333333

1502.0

Domain

Note=FF 2

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

427_481

1287.3333333333333

1502.0

Domain

Note=FF 3

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

482_548

1287.3333333333333

1502.0

Domain

Note=FF 4

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

590_763

1287.3333333333333

1502.0

Domain

pG1 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

779_944

1287.3333333333333

1502.0

Domain

pG2 pseudoGTPase

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

1225_1245

238.0

Compositional bias

Note=Lys-rich

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

1225_1245

27.333333333333332

242.0

Compositional bias

Note=Lys-rich

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000345122

1262_1449

1288.3333333333333

1503.0

Domain

Rho-GAP

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

1262_1449

238.0

Domain

Rho-GAP

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

267_325

238.0

Domain

Note=FF 1

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

366_420

238.0

Domain

Note=FF 2

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

427_481

238.0

Domain

Note=FF 3

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

482_548

238.0

Domain

Note=FF 4

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

590_763

238.0

Domain

pG1 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000396582

779_944

238.0

Domain

pG2 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000432921

1262_1449

1287.3333333333333

1502.0

Domain

Rho-GAP

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

1262_1449

27.333333333333332

242.0

Domain

Rho-GAP

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

267_325

27.333333333333332

242.0

Domain

Note=FF 1

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

366_420

27.333333333333332

242.0

Domain

Note=FF 2

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

427_481

27.333333333333332

242.0

Domain

Note=FF 3

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

482_548

27.333333333333332

242.0

Domain

Note=FF 4

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

590_763

27.333333333333332

242.0

Domain

pG1 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000433497

779_944

27.333333333333332

242.0

Domain

pG2 pseudoGTPase

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000539826

1262_1449

1288.3333333333333

1503.0

Domain

Rho-GAP

Hgene

ARHGAP5

chr14:32586493

chr14:32142561

ENST00000556611

1262_1449

1287.3333333333333

1502.0

Domain

Rho-GAP

Tgene

NUBPL

chr14:32586493

chr14:32142561

ENST00000281081

75_82

127.33333333333333

320.0

Nucleotide binding

ATP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ARHGAP5
NUBPL

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ARHGAP5-NUBPL

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ARHGAP5-NUBPL

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source