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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:OPN3-RGS7

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: OPN3-RGS7
	FusionPDB ID: 61562
	FusionGDB2.0 ID: 61562
		Hgene	Tgene
	Gene symbol	OPN3	RGS7
	Gene ID	23596	6000
	Gene name	opsin 3	regulator of G protein signaling 7
	Synonyms	ECPN\|PPP1R116	-
	Cytomap	1q43	1q43\|1q23.1
	Type of gene	protein-coding	protein-coding
	Description	opsin-3encephalopsinopsin 3 (encephalopsin, panopsin)protein phosphatase 1, regulatory subunit 116	regulator of G-protein signaling 7regulator of G-protein signaling RGS7regulator of G-protein signalling 7
	Modification date	20200329	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000331838, ENST00000366554, ENST00000469376,	ENST00000366562, ENST00000401882, ENST00000407727, ENST00000446183, ENST00000331110, ENST00000348120, ENST00000366563, ENST00000366564, ENST00000366565,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 2 X 3=18	13 X 11 X 8=1144
	# samples	5	14
	** MAII score	log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(14/1144*10)=-3.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: OPN3 [Title/Abstract] AND RGS7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	OPN3(241803184)-RGS7(241262062), # samples:2
Anticipated loss of major functional domain due to fusion event.	OPN3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OPN3-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RGS7	GO:0043547	positive regulation of GTPase activity	10521509

Fusion gene breakpoints across OPN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RGS7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-36-1577-01A	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-
ChimerDB4	OV	TCGA-36-1577	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366554	OPN3	chr1	241803184	-	ENST00000331110	RGS7	chr1	241262062	-	1867	480	480	1835	451
ENST00000366554	OPN3	chr1	241803184	-	ENST00000348120	RGS7	chr1	241262062	-	2382	480	480	1676	398
ENST00000366554	OPN3	chr1	241803184	-	ENST00000366563	RGS7	chr1	241262062	-	2541	480	480	1835	451
ENST00000366554	OPN3	chr1	241803184	-	ENST00000366564	RGS7	chr1	241262062	-	2460	480	480	1811	443
ENST00000366554	OPN3	chr1	241803184	-	ENST00000366565	RGS7	chr1	241262062	-	2514	480	480	1865	461
ENST00000331838	OPN3	chr1	241803184	-	ENST00000331110	RGS7	chr1	241262062	-	1905	518	518	1873	451
ENST00000331838	OPN3	chr1	241803184	-	ENST00000348120	RGS7	chr1	241262062	-	2420	518	518	1714	398
ENST00000331838	OPN3	chr1	241803184	-	ENST00000366563	RGS7	chr1	241262062	-	2579	518	518	1873	451
ENST00000331838	OPN3	chr1	241803184	-	ENST00000366564	RGS7	chr1	241262062	-	2498	518	518	1849	443
ENST00000331838	OPN3	chr1	241803184	-	ENST00000366565	RGS7	chr1	241262062	-	2552	518	518	1903	461
ENST00000366554	OPN3	chr1	241803183	-	ENST00000331110	RGS7	chr1	241262062	-	1867	480	480	1835	451
ENST00000366554	OPN3	chr1	241803183	-	ENST00000348120	RGS7	chr1	241262062	-	2382	480	480	1676	398
ENST00000366554	OPN3	chr1	241803183	-	ENST00000366563	RGS7	chr1	241262062	-	2541	480	480	1835	451
ENST00000366554	OPN3	chr1	241803183	-	ENST00000366564	RGS7	chr1	241262062	-	2460	480	480	1811	443
ENST00000366554	OPN3	chr1	241803183	-	ENST00000366565	RGS7	chr1	241262062	-	2514	480	480	1865	461
ENST00000331838	OPN3	chr1	241803183	-	ENST00000331110	RGS7	chr1	241262062	-	1905	518	518	1873	451
ENST00000331838	OPN3	chr1	241803183	-	ENST00000348120	RGS7	chr1	241262062	-	2420	518	518	1714	398
ENST00000331838	OPN3	chr1	241803183	-	ENST00000366563	RGS7	chr1	241262062	-	2579	518	518	1873	451
ENST00000331838	OPN3	chr1	241803183	-	ENST00000366564	RGS7	chr1	241262062	-	2498	518	518	1849	443
ENST00000331838	OPN3	chr1	241803183	-	ENST00000366565	RGS7	chr1	241262062	-	2552	518	518	1903	461

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366554	ENST00000331110	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.008375027	0.991625
ENST00000366554	ENST00000348120	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.002979545	0.9970204
ENST00000366554	ENST00000366563	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.002789524	0.99721044
ENST00000366554	ENST00000366564	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.003276001	0.99672407
ENST00000366554	ENST00000366565	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.002917592	0.9970824
ENST00000331838	ENST00000331110	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.008178717	0.9918213
ENST00000331838	ENST00000348120	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.002950099	0.9970499
ENST00000331838	ENST00000366563	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.002863866	0.9971361
ENST00000331838	ENST00000366564	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.0033475	0.99665254
ENST00000331838	ENST00000366565	OPN3	chr1	241803184	-	RGS7	chr1	241262062	-	0.002972502	0.9970276
ENST00000366554	ENST00000331110	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.008375027	0.991625
ENST00000366554	ENST00000348120	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.002979545	0.9970204
ENST00000366554	ENST00000366563	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.002789524	0.99721044
ENST00000366554	ENST00000366564	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.003276001	0.99672407
ENST00000366554	ENST00000366565	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.002917592	0.9970824
ENST00000331838	ENST00000331110	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.008178717	0.9918213
ENST00000331838	ENST00000348120	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.002950099	0.9970499
ENST00000331838	ENST00000366563	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.002863866	0.9971361
ENST00000331838	ENST00000366564	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.0033475	0.99665254
ENST00000331838	ENST00000366565	OPN3	chr1	241803183	-	RGS7	chr1	241262062	-	0.002972502	0.9970276

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61562_61562_1_OPN3-RGS7_OPN3_chr1_241803183_ENST00000331838_RGS7_chr1_241262062_ENST00000331110_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

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>61562_61562_2_OPN3-RGS7_OPN3_chr1_241803183_ENST00000331838_RGS7_chr1_241262062_ENST00000348120_length(amino acids)=398AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFM
QAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQ
QQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLK
FLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFI

--------------------------------------------------------------

>61562_61562_3_OPN3-RGS7_OPN3_chr1_241803183_ENST00000331838_RGS7_chr1_241262062_ENST00000366563_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

--------------------------------------------------------------

>61562_61562_4_OPN3-RGS7_OPN3_chr1_241803183_ENST00000331838_RGS7_chr1_241262062_ENST00000366564_length(amino acids)=443AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ

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>61562_61562_5_OPN3-RGS7_OPN3_chr1_241803183_ENST00000331838_RGS7_chr1_241262062_ENST00000366565_length(amino acids)=461AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGKSLT

--------------------------------------------------------------

>61562_61562_6_OPN3-RGS7_OPN3_chr1_241803183_ENST00000366554_RGS7_chr1_241262062_ENST00000331110_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

--------------------------------------------------------------

>61562_61562_7_OPN3-RGS7_OPN3_chr1_241803183_ENST00000366554_RGS7_chr1_241262062_ENST00000348120_length(amino acids)=398AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFM
QAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQ
QQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLK
FLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFI

--------------------------------------------------------------

>61562_61562_8_OPN3-RGS7_OPN3_chr1_241803183_ENST00000366554_RGS7_chr1_241262062_ENST00000366563_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

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>61562_61562_9_OPN3-RGS7_OPN3_chr1_241803183_ENST00000366554_RGS7_chr1_241262062_ENST00000366564_length(amino acids)=443AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ

--------------------------------------------------------------

>61562_61562_10_OPN3-RGS7_OPN3_chr1_241803183_ENST00000366554_RGS7_chr1_241262062_ENST00000366565_length(amino acids)=461AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGKSLT

--------------------------------------------------------------

>61562_61562_11_OPN3-RGS7_OPN3_chr1_241803184_ENST00000331838_RGS7_chr1_241262062_ENST00000331110_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

--------------------------------------------------------------

>61562_61562_12_OPN3-RGS7_OPN3_chr1_241803184_ENST00000331838_RGS7_chr1_241262062_ENST00000348120_length(amino acids)=398AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFM
QAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQ
QQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLK
FLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFI

--------------------------------------------------------------

>61562_61562_13_OPN3-RGS7_OPN3_chr1_241803184_ENST00000331838_RGS7_chr1_241262062_ENST00000366563_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

--------------------------------------------------------------

>61562_61562_14_OPN3-RGS7_OPN3_chr1_241803184_ENST00000331838_RGS7_chr1_241262062_ENST00000366564_length(amino acids)=443AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ

--------------------------------------------------------------

>61562_61562_15_OPN3-RGS7_OPN3_chr1_241803184_ENST00000331838_RGS7_chr1_241262062_ENST00000366565_length(amino acids)=461AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGKSLT

--------------------------------------------------------------

>61562_61562_16_OPN3-RGS7_OPN3_chr1_241803184_ENST00000366554_RGS7_chr1_241262062_ENST00000331110_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

--------------------------------------------------------------

>61562_61562_17_OPN3-RGS7_OPN3_chr1_241803184_ENST00000366554_RGS7_chr1_241262062_ENST00000348120_length(amino acids)=398AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFM
QAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQ
QQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLK
FLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFI

--------------------------------------------------------------

>61562_61562_18_OPN3-RGS7_OPN3_chr1_241803184_ENST00000366554_RGS7_chr1_241262062_ENST00000366563_length(amino acids)=451AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRNIPIFPCHKNCTPTLRASTNL

--------------------------------------------------------------

>61562_61562_19_OPN3-RGS7_OPN3_chr1_241803184_ENST00000366554_RGS7_chr1_241262062_ENST00000366564_length(amino acids)=443AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ

--------------------------------------------------------------

>61562_61562_20_OPN3-RGS7_OPN3_chr1_241803184_ENST00000366554_RGS7_chr1_241262062_ENST00000366565_length(amino acids)=461AA_BP=0
MEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFW
PSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGC
VNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPF
LLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQ
EFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGKSLT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:241803184/chr1:241262062)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

103_117

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

1_40

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

66_77

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

103_117

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

1_40

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

66_77

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

103_117

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

1_40

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

66_77

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

103_117

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

1_40

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

66_77

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

41_65

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D1

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

78_102

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D2

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

41_65

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D1

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

78_102

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D2

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

41_65

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D1

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

78_102

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D2

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

41_65

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D1

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

78_102

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D2

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000348120

255_316

26.0

626.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000348120

333_448

26.0

626.6666666666666

Domain

RGS

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000348120

37_112

26.0

626.6666666666666

Domain

DEP

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366562

255_316

26.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366562

333_448

26.0

470.0

Domain

RGS

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366562

37_112

26.0

470.0

Domain

DEP

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366563

255_316

26.0

689.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366563

333_448

26.0

689.6666666666666

Domain

RGS

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366563

37_112

26.0

689.6666666666666

Domain

DEP

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366564

255_316

26.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366564

333_448

26.0

470.0

Domain

RGS

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366564

37_112

26.0

470.0

Domain

DEP

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366565

255_316

26.0

488.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366565

333_448

26.0

488.0

Domain

RGS

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000366565

37_112

26.0

488.0

Domain

DEP

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000401882

255_316

26.0

425.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000401882

333_448

26.0

425.0

Domain

RGS

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000401882

37_112

26.0

425.0

Domain

DEP

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000407727

255_316

26.0

496.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000407727

333_448

26.0

496.0

Domain

RGS

Tgene

RGS7

chr1:241803183

chr1:241262062

ENST00000407727

37_112

26.0

496.0

Domain

DEP

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000348120

255_316

26.0

626.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000348120

333_448

26.0

626.6666666666666

Domain

RGS

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000348120

37_112

26.0

626.6666666666666

Domain

DEP

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366562

255_316

26.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366562

333_448

26.0

470.0

Domain

RGS

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366562

37_112

26.0

470.0

Domain

DEP

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366563

255_316

26.0

689.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366563

333_448

26.0

689.6666666666666

Domain

RGS

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366563

37_112

26.0

689.6666666666666

Domain

DEP

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366564

255_316

26.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366564

333_448

26.0

470.0

Domain

RGS

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366564

37_112

26.0

470.0

Domain

DEP

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366565

255_316

26.0

488.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366565

333_448

26.0

488.0

Domain

RGS

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000366565

37_112

26.0

488.0

Domain

DEP

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000401882

255_316

26.0

425.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000401882

333_448

26.0

425.0

Domain

RGS

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000401882

37_112

26.0

425.0

Domain

DEP

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000407727

255_316

26.0

496.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000407727

333_448

26.0

496.0

Domain

RGS

Tgene

RGS7

chr1:241803184

chr1:241262062

ENST00000407727

37_112

26.0

496.0

Domain

DEP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

138_153

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

178_201

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

230_255

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

280_287

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

313_402

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

138_153

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

178_201

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

230_255

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

280_287

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

313_402

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

138_153

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

178_201

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

230_255

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

280_287

124.33333333333333

324.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

313_402

124.33333333333333

324.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

138_153

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

178_201

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

230_255

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

280_287

124.33333333333333

403.0

Topological domain

Extracellular

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

313_402

124.33333333333333

403.0

Topological domain

Cytoplasmic

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

118_137

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D3

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

154_177

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D4

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

202_229

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D5

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

256_279

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D6

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000331838

288_312

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D7

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

118_137

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D3

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

154_177

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D4

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

202_229

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D5

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

256_279

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D6

Hgene

OPN3

chr1:241803183

chr1:241262062

ENST00000366554

288_312

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D7

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

118_137

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D3

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

154_177

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D4

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

202_229

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D5

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

256_279

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D6

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000331838

288_312

124.33333333333333

324.0

Transmembrane

Helical%3B Name%3D7

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

118_137

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D3

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

154_177

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D4

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

202_229

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D5

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

256_279

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D6

Hgene

OPN3

chr1:241803184

chr1:241262062

ENST00000366554

288_312

124.33333333333333

403.0

Transmembrane

Helical%3B Name%3D7

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
OPN3
RGS7

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to OPN3-RGS7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to OPN3-RGS7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source