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Fusion Protein:ARHGDIA-SQSTM1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ARHGDIA-SQSTM1 | FusionPDB ID: 6165 | FusionGDB2.0 ID: 6165 | Hgene | Tgene | Gene symbol | ARHGDIA | SQSTM1 | Gene ID | 396 | 8878 |
| Gene name | Rho GDP dissociation inhibitor alpha | sequestosome 1 | |
| Synonyms | GDIA1|HEL-S-47e|NPHS8|RHOGDI|RHOGDI-1 | A170|DMRV|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62B | |
| Cytomap | 17q25.3 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GDP-dissociation inhibitor 1GDP-dissociation inhibitor, aplysia RAS-related 1Rho GDP dissociation inhibitor (GDI) alphaepididymis secretory sperm binding protein Li 47e | sequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domain | |
| Modification date | 20200327 | 20200327 | |
| UniProtAcc | P52565 | Q13501 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000269321, ENST00000582520, ENST00000400721, ENST00000541078, ENST00000580685, ENST00000581876, ENST00000584461, | ENST00000360718, ENST00000389805, ENST00000402874, ENST00000506690, ENST00000510187, ENST00000376929, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 7 X 4 X 4=112 | 33 X 21 X 17=11781 |
| # samples | 7 | 38 | |
| ** MAII score | log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(38/11781*10)=-4.95431877505661 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ARHGDIA [Title/Abstract] AND SQSTM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ARHGDIA(79825598)-SQSTM1(179250858), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | ARHGDIA-SQSTM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGDIA-SQSTM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGDIA-SQSTM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGDIA-SQSTM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SQSTM1 | GO:0006914 | autophagy | 20452972 |
| Tgene | SQSTM1 | GO:0007032 | endosome organization | 27368102 |
| Tgene | SQSTM1 | GO:0031397 | negative regulation of protein ubiquitination | 20452972 |
| Tgene | SQSTM1 | GO:0061635 | regulation of protein complex stability | 25127057 |
| Tgene | SQSTM1 | GO:1905719 | protein localization to perinuclear region of cytoplasm | 27368102 |
| Fusion gene breakpoints across ARHGDIA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SQSTM1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CR-7398-01A | ARHGDIA | chr17 | 79825598 | - | SQSTM1 | chr5 | 179250858 | + |
| ChimerDB4 | SKCM | TCGA-EB-A1NK-01A | ARHGDIA | chr17 | 79825598 | - | SQSTM1 | chr5 | 179250858 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000582520 | ARHGDIA | chr17 | 79825598 | - | ENST00000376929 | SQSTM1 | chr5 | 179250858 | + | 2749 | 245 | 304 | 1266 | 320 |
| ENST00000269321 | ARHGDIA | chr17 | 79825598 | - | ENST00000376929 | SQSTM1 | chr5 | 179250858 | + | 4410 | 1906 | 1965 | 2927 | 320 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000582520 | ENST00000376929 | ARHGDIA | chr17 | 79825598 | - | SQSTM1 | chr5 | 179250858 | + | 0.022531757 | 0.97746825 |
| ENST00000269321 | ENST00000376929 | ARHGDIA | chr17 | 79825598 | - | SQSTM1 | chr5 | 179250858 | + | 0.037863262 | 0.9621368 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >6165_6165_1_ARHGDIA-SQSTM1_ARHGDIA_chr17_79825598_ENST00000269321_SQSTM1_chr5_179250858_ENST00000376929_length(amino acids)=320AA_BP= MVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRP PRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA -------------------------------------------------------------- >6165_6165_2_ARHGDIA-SQSTM1_ARHGDIA_chr17_79825598_ENST00000582520_SQSTM1_chr5_179250858_ENST00000376929_length(amino acids)=320AA_BP= MVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRP PRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79825598/chr5:179250858) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGDIA | SQSTM1 |
| FUNCTION: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. | FUNCTION: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215). {ECO:0000250|UniProtKB:O08623, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:33393215}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 272_294 | 16.333333333333332 | 357.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 272_294 | 16.333333333333332 | 357.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 272_294 | 100.33333333333333 | 441.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 272_294 | 16.333333333333332 | 357.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 389_434 | 16.333333333333332 | 357.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 389_434 | 16.333333333333332 | 357.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 389_434 | 100.33333333333333 | 441.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 389_434 | 16.333333333333332 | 357.0 | Domain | UBA | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 228_233 | 16.333333333333332 | 357.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 336_341 | 16.333333333333332 | 357.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 228_233 | 16.333333333333332 | 357.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 336_341 | 16.333333333333332 | 357.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 228_233 | 100.33333333333333 | 441.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 336_341 | 100.33333333333333 | 441.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 228_233 | 16.333333333333332 | 357.0 | Motif | Note=TRAF6-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 336_341 | 16.333333333333332 | 357.0 | Motif | Note=LIR | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 170_220 | 16.333333333333332 | 357.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 321_342 | 16.333333333333332 | 357.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 170_220 | 16.333333333333332 | 357.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 321_342 | 16.333333333333332 | 357.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 170_220 | 100.33333333333333 | 441.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 321_342 | 100.33333333333333 | 441.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 170_220 | 16.333333333333332 | 357.0 | Region | Note=LIM protein-binding (LB) | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 321_342 | 16.333333333333332 | 357.0 | Region | MAP1LC3B-binding | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 122_167 | 16.333333333333332 | 357.0 | Zinc finger | ZZ-type | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 122_167 | 16.333333333333332 | 357.0 | Zinc finger | ZZ-type | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 122_167 | 100.33333333333333 | 441.0 | Zinc finger | ZZ-type | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 122_167 | 16.333333333333332 | 357.0 | Zinc finger | ZZ-type |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 3_102 | 16.333333333333332 | 357.0 | Domain | PB1 | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 3_102 | 16.333333333333332 | 357.0 | Domain | PB1 | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 3_102 | 100.33333333333333 | 441.0 | Domain | PB1 | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 3_102 | 16.333333333333332 | 357.0 | Domain | PB1 |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>588_ARHGDIA_79825598_SQSTM1_179250858_ranked_0.pdb | ARHGDIA | 79825598 | 79825598 | ENST00000376929 | SQSTM1 | chr5 | 179250858 | + | MVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRP PRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA | 320 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
ARHGDIA_pLDDT.png  |
SQSTM1_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| SQSTM1 | GABARAPL2, RAD23A, GABARAPL1, SQSTM1, LINC00341, MAP1LC3B, TRAF6, PRKCZ, IRAK1, PRKCI, NTRK1, RIPK1, NTRK2, NTRK3, LCK, MAP1LC3A, Shank1, Dlg4, Grin2a, Gria1, Chrna7, KEAP1, GABARAP, C10orf2, ABHD10, CEP78, DIP2B, BLOC1S5, EMILIN3, NSUN4, OSBPL8, INA, NIPSNAP1, GBAS, LLGL1, HADHA, GPC4, HADHB, CTNND1, ASPH, ENPP1, TRMT61B, GLG1, MRPL38, NEFM, GTF3C3, SRRM2, MYD88, MYC, MAP3K3, MAP2K5, IRF8, TRIM21, CYLD, Cep78, Poc1b, CALM1, BNIP1, NFE2L2, CUL3, PIK3CA, PPHLN1, BPTF, UBC, DAZAP2, CDC37, TRIM13, CASP8, PCK1, STAT5A, PDE4A, MAPT, ATG4B, CHMP2B, TARDBP, CUL1, CUL2, HDAC6, ATG7, FUS, CSNK2A1, ZFAND5, TUBA1A, WDFY3, ATG8, BAG3, NBR1, SNCA, TRIM63, TRIM55, TTN, RARA, PSMC2, PSMD4, MAP1LC3C, TRIM50, ARHGEF28, TGM2, PAWR, RPTOR, MTOR, AKT1S1, MLST8, RPS6KB1, RRAGC, RRAGB, CDK9, tat, SPRED2, TRIM5, AJUBA, LIMD1, MAPK14, PARP10, vif, nef, TNFRSF10A, HTT, HNRNPA2B1, SDHA, CAV1, BID, FAS, SESN2, SESN1, MALT1, IKBKG, FHOD3, NOD2, SYNPO2, PYCARD, MLH1, PARK2, BCL2, PAN2, NPM1, MBP, YWHAZ, STXBP1, FKBP4, MEIS2, TKT, HSPA4, RELN, CAMK2A, ULK2, NCOR1, NGFR, env, HIV2gp7, CALCOCO2, Prkci, CDK1, CCNB1, PRKCD, MAPK1, SMAD3, EEF1D, RPL37, GEMIN4, DVL2, CHAF1A, TP53, CASP9, HIF1A, PSMD12, PSMD3, FLNB, PSMD10, TXNL1, TNK2, LGALS3, EDEM1, CFTR, CSNK2A2, DCP2, EGLN3, EPAS1, ULK1, TOLLIP, OPTN, ATXN3, STUB1, ISG15, MOV10, NXF1, CUL7, PIK3R1, PIK3R2, AGAP1, INSR, Ubc, TBK1, CRHBP, SCCPDH, DNAI1, DNAI2, TP53INP1, LLGL2, HSPB1, Ripk3, Nr2f2, IFI16, KIAA0753, MED4, CEP135, CNTRL, SASS6, TMEM17, XPO1, CD44, KIF5B, PML, Mgp, Poc1a, Fgfr1op, ENC1, SKI, TRIB3, RBM45, MAPK13, CHDH, EPDR1, GAS6, NDUFS2, NDUFS3, GFM2, NDUFA5, CD48, LDHA, RCN2, TRAF1, GBP2, KLHL3, EPM2A, RAD54L2, HSPA5, GRIA1, UBXN1, PEX5, BCL10, ATG5, CSNK1A1, VANGL2, SERPINA1, RNF168, LRRK2, VHL, TCEB2, TCEB1, RNF166, NOTCH1, RETN, KERA, INSL5, TMX1, VWCE, CD96, HTR3A, RNF26, INO80B, DLST, TRIM25, PLIN1, TES, WDR81, PSMA6, TRIM23, PGI1, UBE2D2, UBE2D3, ID1, ID2, TAX1BP1, Map1lc3b, UBD, RMND5A, RIPK4, MAPK6, TMPO, AIM2, TRIM11, TNFAIP3, VDR, NEDD4, CNOT2, WDR77, KRAS, RXRA, TGFB1, TRIP4, C19orf80, CCNF, VIM, FLNA, RAD51, NR4A1, RAD18, REL, RELA, RNF4, RNF31, PARK7, MYO6, XIAP, DDX5, CCND1, BPLF1, ESR2, BBC3, CDC6, BRCA1, CRYAB, DNAJC10, PADI1, CALCR, USP14, DDX58, Gabarapl1, MB21D1, SMN1, CRBN, FBL, ELAVL1, KIAA1429, AMBRA1, VCP, LAMP2, ATG16L1, LRRK1, PHB, BECN1, SOX2, PARP1, USP10, MTDH, FUNDC1, GBF1, MECOM, DCAF15, asp, SHMT2, CCT7, SLIRP, SND1, FADD, BIRC2, DYRK1A, PINK1, RB1CC1, IFITM3, P2RY6, GCH1, NUB1, PPP1CA, Casp8, FBXW7, BIRC3, LMBR1L, IGF2BP1, SERPINE2, MYO5A, FN1, CTHRC1, CD59, ITIH5, TNC, SNTB1, ROBO1, TUBB2A, GDF15, CNP, RAI14, ACSL3, CEP170, TAOK2, CNST, SSR3, SLC25A11, SPATA20, FARP1, UTRN, DHX33, CHCHD3, HS2ST1, PTRH2, SOD3, BCKDK, CCDC77, IQGAP1, FKBP11, CEP350, SCO1, SNTB2, MTX2, MYO1B, PWP1, SRPR, ATAD3A, ACTR1A, SLC25A1, MOGS, GOLGA2, SMG8, DYNC1LI2, UQCRH, SRPK2, CAPZA2, POLRMT, SMARCD1, GNB1, HSD17B12, DYNC1LI1, AIFM1, DARS2, GNAI2, TUBA1C, TUBA1B, MRPS28, CEP131, WDR82, PAFAH1B1, TUBB, MRPS34, ATP5A1, NOL9, ZC3H4, ATP5B, MRPS26, MRPS18B, ERAL1, PNKP, MIB1, SRP14, SLC25A3, MRPS22, CEP250, CCDC61, CKAP4, RPS16, BICD1, RPS15, ATP5H, AP2B1, NFIX, CDK5RAP2, RRBP1, SLC25A4, RPS5, TPX2, AP2A2, IK, PPP2R1A, GOLGB1, MPRIP, AHNAK, PCNT, RPS24, CETN2, HNRNPUL1, PRRC2A, DAP3, PIBF1, TJP1, RFC4, NOL8, CEP290, MAGI1, ZNF384, IQSEC1, TAOK1, PGAM5, SMG1, GAPVD1, MRPS9, ATAD3B, CSTF3, FRYL, EPRS, ARHGEF18, SNAP23, PRPF38A, RBM12B, SLC25A10, UTP23, FGFR1OP, SMU1, RAPGEF2, OFD1, PARD3, S100A9, EIF4B, EIF5B, IGF2BP3, ATXN1, HCVgp1, IKBKB, SKP2, PHB2, PLN, MAVS, APAF1, ECSIT, G3BP1, G3BP2, BNIP3, BNIP3L, CALR, DAXX, LINC01554, HMOX1, KAT5, PDPK1, PXN, RAF1, SH3BGRL, ORF7a, E, nsp6, ORF6, ORF8, ESR1, TRIM32, RQCD1, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, PDCD4, BRD1, FIS1, MARCH5, MFN2, OCIAD1, ABL1, Rnf183, AGR2, HULC, NLRP3, NUPR1, USP8, GSK3B, UCHL5, FAM20C, GJA1, CCDC88C, PRDM9, PPIA, USP20, USP19, OTUD7B, JOSD1, IRF3, STK17A, OGT, BAG5, PSMB2, PSMD14, TRIM37, AR, MCL1, AMOT, B3GAT1, GJD3, GOLGA1, IMPDH2, KRT8, PXMP2, AMER1, ARHGAP32, BCR, C1orf198, CC2D1A, CCDC85C, CDC27, CENPB, CEP85, CNOT1, CNOT10, CSTF2T, DNAJA2, EDRF1, FAM193A, FARSA, FLJ44635, GGA3, HGS, HIST1H2BD, HIST1H3F, HSPA1B, IARS2, IFT172, IFT74, IQGAP2, JADE3, KIF7, KPNA3, LZTS2, MAGED1, NAE1, NAV1, NUDT19, OCRL, PAPD7, PDLIM7, PEBP1, PIK3C2B, PJA2, PPP1R13B, PPP2R3B, PPP2R5D, RC3H1, RIPK2, SCYL2, SEC16A, SIRT2, SMG7, SNRPE, SYNJ1, TNIP1, TNRC6A, TNRC6B, TP53BP2, TRIM26, TRIP6, TTK, UBB, VWA8, ZCCHC14, ZCCHC2, ZFP36L2, ABLIM1, KIAA1244, ASNS, CEP152, DIAPH3, DNAAF2, DRG1, DVL3, EXOC4, KIAA1671, LPP, NELFCD, NRBF2, PAK4, PDLIM3, PDLIM5, RPAP2, SDCCAG3, SIPA1L3, SLAIN2, SYNJ2, TAB2, TANC1, TTC28, TTF2, UCHL1, WRAP73, YEATS2, SYNE3, VASP, JUN, UBQLN2, CCDC50, IFIH1, VDAC1, MOAP1, CHRNB4, ZCCHC10, PRR27, IL7R, IL17F, BAGE2, HFE, CST8, POGLUT1, EDDM3B, LY6G5C, ST14, TNFSF18, GREM2, C1QTNF1, CST11, HLA-DPB1, FIBIN, ADAMTS12, GLIPR1L2, FAM46C, BTF3, ZRANB1, UXT, WBP4, IFITM1, KDR, NEDD8, KDM1A, AARS, ACLY, ACTB, ARF4, ATG9A, ATP2A2, BZW1, CACYBP, CAD, CALCOCO1, CCAR2, CCPG1, CCT2, CCT3, CCT4, CCT5, CCT6A, CEP112, CKB, CLTC, CTPS1, DDX3X, DNM1L, DYNC1H1, EEF2, EIF2S3, EIF3A, EIF4A1, ERLIN1, FASN, FASTKD2, FTL, GART, GPC1, HEXB, HIST1H2BN, HMGB1, HSP90AA1, HSP90AB1, HSPA8, HSPH1, IPO5, IPO7, KLHL8, KPNA2, KPNA4, KPNB1, LPL, LRRC59, MAT2A, MFF, MTHFD1, MTMR4, NCOA4, NPR3, NUP155, PABPC1, PAICS, PAIP1, PDCD6, PFKM, PFKP, PGD, PHGDH, PRKACA, PRKAR1A, PSMC1, PSMC3, PSMC4, PSMC5, PSMC6, PSMD2, RAB18, RAB1A, RAB21, RAB2A, RAB5C, RAB7A, RAB8A, RHEB, RPS17, RRM1, RTN4, S100A6, SAR1B, SDC2, SDC4, SDCBP, SEPT7, SMC4, SPG20, ST13P5, STIP1, SYNGR2, TAGLN2, TBC1D15, TCP1, TFRC, TM9SF2, TMEM59, TNPO1, TPP1, TRAF2, TRAF3, TRIP13, TUBB4B, VAPA, VAPB, YBX1, YWHAB, YWHAE, TRIO, HECTD1, WNK1, SPATA5L1, CTNNB1, LUZP1, MTCL1, STAM, TMEM160, POLR2B, TNKS1BP1, PPP6R3, KIF11, RTN3, ADAR, RACGAP1, BUB3, CORO1B, PABPC4, MAP7, DCXR, TSR1, DNMT1, ZC3HAV1, RPS27A, RAB6A, ADRM1, DHX9, UBA1, GSTP1, ACTG1, CISD2, DNAJA4, SETX, KIAA0101, TYSND1, STARD7, RNF114, ALKBH5, LGALS1, ARPC1A, TPM2, MRPS11, NT5C2, ACOT1, MRPS21, ARHGEF1, UBAP2L, SLC38A2, RPP38, MAP7D3, BAG1, MMS19, EARS2, SPATS2L, LGALS3BP, OXSR1, ARHGEF40, IGF2R, TUBG1, NUP188, TNPO3, PTRF, TDRD3, MORF4L2, NIF3L1, NIPBL, FTH1, CHEK2, FBXO3, RPL37A, METAP2, MRPS23, RPS19, SART1, APRT, WBSCR22, HMGB2, RPL12, PSIP1, RPS7, STRBP, ZC3H15, MAGT1, DHX37, RFC1, SRP72, PRPF31, SEMA3C, HNRNPA0, SCAMP3, SRPK1, UPF3B, ZFR, SYNCRIP, ILF2, SLK, AP3D1, ARPC4-TTLL3, RPS26, SSBP1, HNRNPAB, TMEM192, SCAP, CNR2, KLF15, SAMM50, IMMT, MTX1, MAP1LC3B2, VPS29, TOMM40, PSMB4, TRIM44, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ARHGDIA | |
| SQSTM1 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000360718 | 0 | 7 | 2_50 | 16.333333333333332 | 357.0 | LCK | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000376929 | 2 | 9 | 2_50 | 16.333333333333332 | 357.0 | LCK | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 2_50 | 100.33333333333333 | 441.0 | LCK | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000402874 | 1 | 8 | 2_50 | 16.333333333333332 | 357.0 | LCK | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 50_80 | 100.33333333333333 | 441.0 | PAWR | |
| Tgene | SQSTM1 | chr17:79825598 | chr5:179250858 | ENST00000389805 | 1 | 8 | 43_107 | 100.33333333333333 | 441.0 | PRKCZ and dimerization |
Top |
Related Drugs to ARHGDIA-SQSTM1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to ARHGDIA-SQSTM1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SQSTM1 | C4085252 | PAGET DISEASE OF BONE 3 | 9 | GENOMICS_ENGLAND;UNIPROT |
| Tgene | SQSTM1 | C0002736 | Amyotrophic Lateral Sclerosis | 5 | CTD_human;ORPHANET |
| Tgene | SQSTM1 | C4225326 | FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 3 | 4 | CTD_human;UNIPROT |
| Tgene | SQSTM1 | C0029463 | Osteosarcoma | 2 | GENOMICS_ENGLAND |
| Tgene | SQSTM1 | C0221054 | Welander Distal Myopathy | 1 | ORPHANET |
| Tgene | SQSTM1 | C0242383 | Age related macular degeneration | 1 | CTD_human |
| Tgene | SQSTM1 | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human |
| Tgene | SQSTM1 | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human |
| Tgene | SQSTM1 | C1853926 | NONAKA MYOPATHY | 1 | CTD_human;GENOMICS_ENGLAND |
| Tgene | SQSTM1 | C2931290 | Welander distal myopathy, Swedish type | 1 | ORPHANET |
| Tgene | SQSTM1 | C3888102 | Frontotemporal Dementia With Motor Neuron Disease | 1 | ORPHANET |
| Tgene | SQSTM1 | C4011788 | Behavioral variant of frontotemporal dementia | 1 | ORPHANET |
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