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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ARHGEF10L-GPR137B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ARHGEF10L-GPR137B
	FusionPDB ID: 6180
	FusionGDB2.0 ID: 6180
		Hgene	Tgene
	Gene symbol	ARHGEF10L	GPR137B
	Gene ID	55160	7107
	Gene name	Rho guanine nucleotide exchange factor 10 like	G protein-coupled receptor 137B
	Synonyms	GrinchGEF	TM7SF1
	Cytomap	1p36.13	1q42.3
	Type of gene	protein-coding	protein-coding
	Description	rho guanine nucleotide exchange factor 10-like proteinRho guanine nucleotide exchange factor (GEF) 10-like	integral membrane protein GPR137Btransmembrane 7 superfamily member 1 (upregulated in kidney)transmembrane 7 superfamily member 1 protein
	Modification date	20200313	20200313
	UniProtAcc	Q9HCE6	O60478
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000469726, ENST00000167825, ENST00000361221, ENST00000375408, ENST00000375415, ENST00000434513, ENST00000452522, ENST00000375420,	ENST00000366592, ENST00000477559, ENST00000366591,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 12 X 12=1728	4 X 3 X 2=24
	# samples	17	4
	** MAII score	log2(17/1728*10)=-3.34549656602577 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ARHGEF10L [Title/Abstract] AND GPR137B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ARHGEF10L(17991090)-GPR137B(236368426), # samples:1
Anticipated loss of major functional domain due to fusion event.	ARHGEF10L-GPR137B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF10L-GPR137B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARHGEF10L	GO:0032933	SREBP signaling pathway	16112081
Hgene	ARHGEF10L	GO:0051496	positive regulation of stress fiber assembly	16112081

Fusion gene breakpoints across ARHGEF10L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GPR137B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A922-01A	ARHGEF10L	chr1	17991090	+	GPR137B	chr1	236368426	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000434513	ARHGEF10L	chr1	17991090	+	ENST00000366592	GPR137B	chr1	236368426	+	4135	3153	156	3386	1076
ENST00000361221	ARHGEF10L	chr1	17991090	+	ENST00000366592	GPR137B	chr1	236368426	+	4150	3168	156	3401	1081
ENST00000452522	ARHGEF10L	chr1	17991090	+	ENST00000366592	GPR137B	chr1	236368426	+	4033	3051	156	3284	1042
ENST00000375415	ARHGEF10L	chr1	17991090	+	ENST00000366592	GPR137B	chr1	236368426	+	3917	2935	40	3168	1042
ENST00000375408	ARHGEF10L	chr1	17991090	+	ENST00000366592	GPR137B	chr1	236368426	+	3348	2366	38	2599	853
ENST00000167825	ARHGEF10L	chr1	17991090	+	ENST00000366592	GPR137B	chr1	236368426	+	3100	2118	0	2351	783

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000434513	ENST00000366592	ARHGEF10L	chr1	17991090	+	GPR137B	chr1	236368426	+	0.001156483	0.99884343
ENST00000361221	ENST00000366592	ARHGEF10L	chr1	17991090	+	GPR137B	chr1	236368426	+	0.002153787	0.99784625
ENST00000452522	ENST00000366592	ARHGEF10L	chr1	17991090	+	GPR137B	chr1	236368426	+	0.001462639	0.9985374
ENST00000375415	ENST00000366592	ARHGEF10L	chr1	17991090	+	GPR137B	chr1	236368426	+	0.001272399	0.9987276
ENST00000375408	ENST00000366592	ARHGEF10L	chr1	17991090	+	GPR137B	chr1	236368426	+	0.006961115	0.99303895
ENST00000167825	ENST00000366592	ARHGEF10L	chr1	17991090	+	GPR137B	chr1	236368426	+	0.01222341	0.98777664

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6180_6180_1_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000167825_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=783AA_BP=706
MLPSSSWGKRKLRGRLGWVRSDARGVMWARQEGLHHPHPHAVIRCPSSSSSSVSCSGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSP
QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASDM
LKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRV
FLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQ
DLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWV
NRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGG
QVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPV
LCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPR

--------------------------------------------------------------

>6180_6180_2_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000361221_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1081AA_BP=1004
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKV
SFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKC
QVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRV
TLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLL
CETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQH
SGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLP
GKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNC
PLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQ
DGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCG
PWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGGFAPDYYDWGQQTNSFLAQAGTLQDSTLDPDKPSL

--------------------------------------------------------------

>6180_6180_3_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000375408_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=853AA_BP=776
MLPSSSWGKRKLRGRLGWVRSDARGVMWARQEGLHHPHPHAVIRCPSSSSSSVSCSGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSP
QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFS
KSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE
LETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEI
SSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLH
GTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLC
PDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPL
AAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLA
AYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNI

--------------------------------------------------------------

>6180_6180_4_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000375415_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1042AA_BP=965
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPE
GLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFV
ASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQL
ALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKP
ANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQ
ITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLR
EENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPS
PRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLL
AGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYD

--------------------------------------------------------------

>6180_6180_5_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000434513_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1076AA_BP=999
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKV
SFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKC
QVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRV
TLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLL
CETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKK
ASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDK
SGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGF
SAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSIL
LYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTV

--------------------------------------------------------------

>6180_6180_6_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000452522_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1042AA_BP=965
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPE
GLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFV
ASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQL
ALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKP
ANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQ
ITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLR
EENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPS
PRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLL
AGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:17991090/chr1:236368426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGEF10L Q9HCE6	GPR137B O60478
FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269\|PubMed:16112081}.	FUNCTION: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). {ECO:0000269\|PubMed:31036939}.; FUNCTION: Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity). {ECO:0000250\|UniProtKB:Q8BNQ3}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGEF10L

chr1:17991090

chr1:236368426

ENST00000167825

316_503

706.0

983.0

Domain

Hgene

ARHGEF10L

chr1:17991090

chr1:236368426

ENST00000361221

316_503

1003.0

1280.0

Domain

Hgene

ARHGEF10L

chr1:17991090

chr1:236368426

ENST00000375415

316_503

964.0

1241.0

Domain

Hgene

ARHGEF10L

chr1:17991090

chr1:236368426

ENST00000434513

316_503

998.0

1068.0

Domain

Hgene

ARHGEF10L

chr1:17991090

chr1:236368426

ENST00000452522

316_503

964.0

1241.0

Domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

101_111

322.0

400.0

Topological domain

Lumenal

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

133_159

322.0

400.0

Topological domain

Cytoplasmic

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

181_188

322.0

400.0

Topological domain

Lumenal

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

1_46

322.0

400.0

Topological domain

Lumenal

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

210_237

322.0

400.0

Topological domain

Cytoplasmic

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

259_292

322.0

400.0

Topological domain

Lumenal

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

314_399

322.0

400.0

Topological domain

Cytoplasmic

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

68_79

322.0

400.0

Topological domain

Cytoplasmic

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

112_132

322.0

400.0

Transmembrane

Helical%3B Name%3D3

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

160_180

322.0

400.0

Transmembrane

Helical%3B Name%3D4

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

189_209

322.0

400.0

Transmembrane

Helical%3B Name%3D5

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

238_258

322.0

400.0

Transmembrane

Helical%3B Name%3D6

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

293_313

322.0

400.0

Transmembrane

Helical%3B Name%3D7

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

47_67

322.0

400.0

Transmembrane

Helical%3B Name%3D1

Tgene

GPR137B

chr1:17991090

chr1:236368426

ENST00000366592

80_100

322.0

400.0

Transmembrane

Helical%3B Name%3D2

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ARHGEF10L
GPR137B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ARHGEF10L-GPR137B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ARHGEF10L-GPR137B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source