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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:OSTF1-SMARCA4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: OSTF1-SMARCA4
FusionPDB ID: 61926
FusionGDB2.0 ID: 61926
HgeneTgene
Gene symbol

OSTF1

SMARCA4

Gene ID

26578

6597

Gene nameosteoclast stimulating factor 1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SynonymsOSF|SH3P2|bA235O14.1BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2-beta|SNF2L4|SNF2LB|SWI2|hSNF2b
Cytomap

9q21.13

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionosteoclast-stimulating factor 1transcription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and transcription a
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000346234, ENST00000538456, 
ENST00000344626, ENST00000358026, 
ENST00000413806, ENST00000429416, 
ENST00000444061, ENST00000450717, 
ENST00000541122, ENST00000589677, 
ENST00000590574, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 3 X 3=4520 X 28 X 15=8400
# samples 632
** MAII scorelog2(6/45*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(32/8400*10)=-4.71424551766612
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: OSTF1 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)OSTF1(77703642)-SMARCA4(11141406), # samples:2
Anticipated loss of major functional domain due to fusion event.OSTF1-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OSTF1-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OSTF1-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
OSTF1-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMARCA4

GO:0006337

nucleosome disassembly

8895581

TgeneSMARCA4

GO:0006338

chromatin remodeling

10943845|11726552

TgeneSMARCA4

GO:0045892

negative regulation of transcription, DNA-templated

12065415

TgeneSMARCA4

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904|17938176

TgeneSMARCA4

GO:0051091

positive regulation of DNA-binding transcription factor activity

11950834|17938176

TgeneSMARCA4

GO:1902661

positive regulation of glucose mediated signaling pathway

22368283


check buttonFusion gene breakpoints across OSTF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMARCA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48N-01AOSTF1chr9

77703642

-SMARCA4chr19

11141406

+
ChimerDB4SARCTCGA-DX-A48N-01AOSTF1chr9

77703642

+SMARCA4chr19

11141406

+
ChimerDB4SARCTCGA-DX-A48NOSTF1chr9

77703642

+SMARCA4chr19

11141405

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346234OSTF1chr977703642+ENST00000358026SMARCA4chr1911141406+23081841501841563
ENST00000346234OSTF1chr977703642+ENST00000344626SMARCA4chr1911141406+19891841501745531
ENST00000346234OSTF1chr977703642+ENST00000429416SMARCA4chr1911141406+22121841501745531
ENST00000346234OSTF1chr977703642+ENST00000541122SMARCA4chr1911141406+16561841501655501
ENST00000346234OSTF1chr977703642+ENST00000589677SMARCA4chr1911141406+16531841501652500
ENST00000346234OSTF1chr977703642+ENST00000444061SMARCA4chr1911141406+16441841501643497
ENST00000346234OSTF1chr977703642+ENST00000590574SMARCA4chr1911141406+16471841501646498
ENST00000346234OSTF1chr977703642+ENST00000413806SMARCA4chr1911141406+21221841501655501
ENST00000346234OSTF1chr977703642+ENST00000450717SMARCA4chr1911141406+21191841501652500
ENST00000346234OSTF1chr977703642+ENST00000358026SMARCA4chr1911141405+23081841501841563
ENST00000346234OSTF1chr977703642+ENST00000344626SMARCA4chr1911141405+19891841501745531
ENST00000346234OSTF1chr977703642+ENST00000429416SMARCA4chr1911141405+22121841501745531
ENST00000346234OSTF1chr977703642+ENST00000541122SMARCA4chr1911141405+16561841501655501
ENST00000346234OSTF1chr977703642+ENST00000589677SMARCA4chr1911141405+16531841501652500
ENST00000346234OSTF1chr977703642+ENST00000444061SMARCA4chr1911141405+16441841501643497
ENST00000346234OSTF1chr977703642+ENST00000590574SMARCA4chr1911141405+16471841501646498
ENST00000346234OSTF1chr977703642+ENST00000413806SMARCA4chr1911141405+21221841501655501
ENST00000346234OSTF1chr977703642+ENST00000450717SMARCA4chr1911141405+21191841501652500

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346234ENST00000358026OSTF1chr977703642+SMARCA4chr1911141406+0.0140035150.98599654
ENST00000346234ENST00000344626OSTF1chr977703642+SMARCA4chr1911141406+0.0108685610.98913145
ENST00000346234ENST00000429416OSTF1chr977703642+SMARCA4chr1911141406+0.0097553070.9902446
ENST00000346234ENST00000541122OSTF1chr977703642+SMARCA4chr1911141406+0.0069710990.99302894
ENST00000346234ENST00000589677OSTF1chr977703642+SMARCA4chr1911141406+0.0076834720.9923165
ENST00000346234ENST00000444061OSTF1chr977703642+SMARCA4chr1911141406+0.0060900330.99390996
ENST00000346234ENST00000590574OSTF1chr977703642+SMARCA4chr1911141406+0.0058864680.9941135
ENST00000346234ENST00000413806OSTF1chr977703642+SMARCA4chr1911141406+0.0073061050.9926939
ENST00000346234ENST00000450717OSTF1chr977703642+SMARCA4chr1911141406+0.0077585170.9922415
ENST00000346234ENST00000358026OSTF1chr977703642+SMARCA4chr1911141405+0.0140035150.98599654
ENST00000346234ENST00000344626OSTF1chr977703642+SMARCA4chr1911141405+0.0108685610.98913145
ENST00000346234ENST00000429416OSTF1chr977703642+SMARCA4chr1911141405+0.0097553070.9902446
ENST00000346234ENST00000541122OSTF1chr977703642+SMARCA4chr1911141405+0.0069710990.99302894
ENST00000346234ENST00000589677OSTF1chr977703642+SMARCA4chr1911141405+0.0076834720.9923165
ENST00000346234ENST00000444061OSTF1chr977703642+SMARCA4chr1911141405+0.0060900330.99390996
ENST00000346234ENST00000590574OSTF1chr977703642+SMARCA4chr1911141405+0.0058864680.9941135
ENST00000346234ENST00000413806OSTF1chr977703642+SMARCA4chr1911141405+0.0073061050.9926939
ENST00000346234ENST00000450717OSTF1chr977703642+SMARCA4chr1911141405+0.0077585170.9922415

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61926_61926_1_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000344626_length(amino acids)=531AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEV
PDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEK
QWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSS
SGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEK

--------------------------------------------------------------

>61926_61926_2_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000358026_length(amino acids)=563AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEV
PDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEK
QWLKKITGKDIHDTASSVARGLQFQRGLQFCTRASKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRG
RPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQ
NAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKP

--------------------------------------------------------------

>61926_61926_3_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000413806_length(amino acids)=501AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVD
FKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVK

--------------------------------------------------------------

>61926_61926_4_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000429416_length(amino acids)=531AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEV
PDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEK
QWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSS
SGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEK

--------------------------------------------------------------

>61926_61926_5_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000444061_length(amino acids)=497AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDA
GSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKI
KERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLG

--------------------------------------------------------------

>61926_61926_6_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000450717_length(amino acids)=500AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDF
KKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKI

--------------------------------------------------------------

>61926_61926_7_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000541122_length(amino acids)=501AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVD
FKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVK

--------------------------------------------------------------

>61926_61926_8_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000589677_length(amino acids)=500AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDF
KKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKI

--------------------------------------------------------------

>61926_61926_9_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141405_ENST00000590574_length(amino acids)=498AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDA
GSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKK
IKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKL

--------------------------------------------------------------

>61926_61926_10_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000344626_length(amino acids)=531AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEV
PDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEK
QWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSS
SGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEK

--------------------------------------------------------------

>61926_61926_11_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000358026_length(amino acids)=563AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEV
PDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEK
QWLKKITGKDIHDTASSVARGLQFQRGLQFCTRASKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRG
RPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQ
NAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKP

--------------------------------------------------------------

>61926_61926_12_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000413806_length(amino acids)=501AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVD
FKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVK

--------------------------------------------------------------

>61926_61926_13_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000429416_length(amino acids)=531AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEV
PDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEK
QWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSS
SGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEK

--------------------------------------------------------------

>61926_61926_14_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000444061_length(amino acids)=497AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDA
GSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKI
KERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLG

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>61926_61926_15_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000450717_length(amino acids)=500AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDF
KKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKI

--------------------------------------------------------------

>61926_61926_16_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000541122_length(amino acids)=501AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVD
FKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVK

--------------------------------------------------------------

>61926_61926_17_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000589677_length(amino acids)=500AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRD
SDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDF
KKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKI

--------------------------------------------------------------

>61926_61926_18_OSTF1-SMARCA4_OSTF1_chr9_77703642_ENST00000346234_SMARCA4_chr19_11141406_ENST00000590574_length(amino acids)=498AA_BP=11
MSKPPPKPVKPGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCT
VNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEAR
NPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDA
GSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKK
IKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKL

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:77703642/chr19:11141406)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSTF1chr9:77703642chr19:11141405ENST00000346234+1104_1111.333333333333334215.0Compositional biasNote=Pro-rich
HgeneOSTF1chr9:77703642chr19:11141406ENST00000346234+1104_1111.333333333333334215.0Compositional biasNote=Pro-rich
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000034462623351360_13641127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000034462623351571_15841127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000041380622331360_13641127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000041380622331571_15841127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000042941624361360_13641127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000042941624361571_15841127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000044406124351360_13641127.33333333333331614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000044406124351571_15841127.33333333333331614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000045071722331360_13641127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000045071722331571_15841127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000054112224351360_13641127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000054112224351571_15841127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000058967724351360_13641127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000058967724351571_15841127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000059057423341360_13641127.33333333333331615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000059057423341571_15841127.33333333333331615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000034462623351360_13641127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000034462623351571_15841127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000041380622331360_13641127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000041380622331571_15841127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000042941624361360_13641127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000042941624361571_15841127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000044406124351360_13641127.33333333333331614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000044406124351571_15841127.33333333333331614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000045071722331360_13641127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000045071722331571_15841127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000054112224351360_13641127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000054112224351571_15841127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000058967724351360_13641127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000058967724351571_15841127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000059057423341360_13641127.33333333333331615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000059057423341571_15841127.33333333333331615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000034462623351477_15471127.33333333333331648.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000041380622331477_15471127.33333333333331618.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000042941624361477_15471127.33333333333331648.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000044406124351477_15471127.33333333333331614.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000045071722331477_15471127.33333333333331617.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000054112224351477_15471127.33333333333331618.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000058967724351477_15471127.33333333333331617.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000059057423341477_15471127.33333333333331615.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000034462623351477_15471127.33333333333331648.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000041380622331477_15471127.33333333333331618.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000042941624361477_15471127.33333333333331648.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000044406124351477_15471127.33333333333331614.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000045071722331477_15471127.33333333333331617.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000054112224351477_15471127.33333333333331618.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000058967724351477_15471127.33333333333331617.0DomainBromo
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000059057423341477_15471127.33333333333331615.0DomainBromo

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSTF1chr9:77703642chr19:11141405ENST00000346234+11012_7111.333333333333334215.0DomainSH3
HgeneOSTF1chr9:77703642chr19:11141406ENST00000346234+11012_7111.333333333333334215.0DomainSH3
HgeneOSTF1chr9:77703642chr19:11141405ENST00000346234+110105_13511.333333333333334215.0RepeatNote=ANK 2
HgeneOSTF1chr9:77703642chr19:11141405ENST00000346234+110139_16811.333333333333334215.0RepeatNote=ANK 3
HgeneOSTF1chr9:77703642chr19:11141405ENST00000346234+11072_10111.333333333333334215.0RepeatNote=ANK 1
HgeneOSTF1chr9:77703642chr19:11141406ENST00000346234+110105_13511.333333333333334215.0RepeatNote=ANK 2
HgeneOSTF1chr9:77703642chr19:11141406ENST00000346234+110139_16811.333333333333334215.0RepeatNote=ANK 3
HgeneOSTF1chr9:77703642chr19:11141406ENST00000346234+11072_10111.333333333333334215.0RepeatNote=ANK 1
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335578_5881127.33333333333331648.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335663_6721127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233578_5881127.33333333333331618.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233663_6721127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436578_5881127.33333333333331648.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436663_6721127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435578_5881127.33333333333331614.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435663_6721127.33333333333331614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233578_5881127.33333333333331617.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233663_6721127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435578_5881127.33333333333331618.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435663_6721127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435578_5881127.33333333333331617.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435663_6721127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334578_5881127.33333333333331615.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334663_6721127.33333333333331615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335578_5881127.33333333333331648.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335663_6721127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233578_5881127.33333333333331618.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233663_6721127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436578_5881127.33333333333331648.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436663_6721127.33333333333331648.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435578_5881127.33333333333331614.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435663_6721127.33333333333331614.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233578_5881127.33333333333331617.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233663_6721127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435578_5881127.33333333333331618.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435663_6721127.33333333333331618.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435578_5881127.33333333333331617.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435663_6721127.33333333333331617.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334578_5881127.33333333333331615.0Compositional biasNote=Poly-Lys
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334663_6721127.33333333333331615.0Compositional biasNote=Poly-Glu
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000034462623351084_12461127.33333333333331648.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335171_2061127.33333333333331648.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335460_5321127.33333333333331648.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335766_9311127.33333333333331648.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000041380622331084_12461127.33333333333331618.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233171_2061127.33333333333331618.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233460_5321127.33333333333331618.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233766_9311127.33333333333331618.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000042941624361084_12461127.33333333333331648.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436171_2061127.33333333333331648.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436460_5321127.33333333333331648.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436766_9311127.33333333333331648.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000044406124351084_12461127.33333333333331614.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435171_2061127.33333333333331614.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435460_5321127.33333333333331614.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435766_9311127.33333333333331614.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000045071722331084_12461127.33333333333331617.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233171_2061127.33333333333331617.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233460_5321127.33333333333331617.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233766_9311127.33333333333331617.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000054112224351084_12461127.33333333333331618.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435171_2061127.33333333333331618.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435460_5321127.33333333333331618.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435766_9311127.33333333333331618.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000058967724351084_12461127.33333333333331617.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435171_2061127.33333333333331617.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435460_5321127.33333333333331617.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435766_9311127.33333333333331617.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST0000059057423341084_12461127.33333333333331615.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334171_2061127.33333333333331615.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334460_5321127.33333333333331615.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334766_9311127.33333333333331615.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000034462623351084_12461127.33333333333331648.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335171_2061127.33333333333331648.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335460_5321127.33333333333331648.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335766_9311127.33333333333331648.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000041380622331084_12461127.33333333333331618.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233171_2061127.33333333333331618.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233460_5321127.33333333333331618.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233766_9311127.33333333333331618.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000042941624361084_12461127.33333333333331648.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436171_2061127.33333333333331648.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436460_5321127.33333333333331648.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436766_9311127.33333333333331648.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000044406124351084_12461127.33333333333331614.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435171_2061127.33333333333331614.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435460_5321127.33333333333331614.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435766_9311127.33333333333331614.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000045071722331084_12461127.33333333333331617.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233171_2061127.33333333333331617.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233460_5321127.33333333333331617.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233766_9311127.33333333333331617.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000054112224351084_12461127.33333333333331618.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435171_2061127.33333333333331618.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435460_5321127.33333333333331618.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435766_9311127.33333333333331618.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000058967724351084_12461127.33333333333331617.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435171_2061127.33333333333331617.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435460_5321127.33333333333331617.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435766_9311127.33333333333331617.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141406ENST0000059057423341084_12461127.33333333333331615.0DomainHelicase C-terminal
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334171_2061127.33333333333331615.0DomainQLQ
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334460_5321127.33333333333331615.0DomainHSA
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334766_9311127.33333333333331615.0DomainHelicase ATP-binding
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335881_8841127.33333333333331648.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233881_8841127.33333333333331618.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436881_8841127.33333333333331648.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435881_8841127.33333333333331614.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233881_8841127.33333333333331617.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435881_8841127.33333333333331618.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435881_8841127.33333333333331617.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334881_8841127.33333333333331615.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335881_8841127.33333333333331648.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233881_8841127.33333333333331618.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436881_8841127.33333333333331648.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435881_8841127.33333333333331614.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233881_8841127.33333333333331617.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435881_8841127.33333333333331618.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435881_8841127.33333333333331617.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334881_8841127.33333333333331615.0MotifNote=DEGH box
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335779_7861127.33333333333331648.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233779_7861127.33333333333331618.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436779_7861127.33333333333331648.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435779_7861127.33333333333331614.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233779_7861127.33333333333331617.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435779_7861127.33333333333331618.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435779_7861127.33333333333331617.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334779_7861127.33333333333331615.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335779_7861127.33333333333331648.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233779_7861127.33333333333331618.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436779_7861127.33333333333331648.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435779_7861127.33333333333331614.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233779_7861127.33333333333331617.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435779_7861127.33333333333331618.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435779_7861127.33333333333331617.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334779_7861127.33333333333331615.0Nucleotide bindingATP
TgeneSMARCA4chr9:77703642chr19:11141405ENST000003446262335462_7281127.33333333333331648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004138062233462_7281127.33333333333331618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004294162436462_7281127.33333333333331648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004440612435462_7281127.33333333333331614.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141405ENST000004507172233462_7281127.33333333333331617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005411222435462_7281127.33333333333331618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005896772435462_7281127.33333333333331617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141405ENST000005905742334462_7281127.33333333333331615.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000003446262335462_7281127.33333333333331648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004138062233462_7281127.33333333333331618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004294162436462_7281127.33333333333331648.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004440612435462_7281127.33333333333331614.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000004507172233462_7281127.33333333333331617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005411222435462_7281127.33333333333331618.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005896772435462_7281127.33333333333331617.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2
TgeneSMARCA4chr9:77703642chr19:11141406ENST000005905742334462_7281127.33333333333331615.0RegionRNA-binding region which is sufficient for binding to lncRNA Evf2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
OSTF1
SMARCA4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to OSTF1-SMARCA4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to OSTF1-SMARCA4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource