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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PAFAH1B2-GPR137

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PAFAH1B2-GPR137
FusionPDB ID: 62335
FusionGDB2.0 ID: 62335
HgeneTgene
Gene symbol

PAFAH1B2

GPR137

Gene ID

5049

56834

Gene nameplatelet activating factor acetylhydrolase 1b catalytic subunit 2G protein-coupled receptor 137
SynonymsHEL-S-303C11orf4|GPR137A|TM7SF1L1
Cytomap

11q23.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionplatelet-activating factor acetylhydrolase IB subunit betaPAF acetylhydrolase 30 kDa subunitPAF-AH 30 kDa subunitPAF-AH subunit betaPAF-AH1b alpha 2 subunitPAFAH subunit betaepididymis secretory protein Li 303epididymis secretory sperm binding protintegral membrane protein GPR137transmembrane 7 superfamily member 1-like 1 protein
Modification date2020031320200313
UniProtAcc.

Q8N3F9

Ensembl transtripts involved in fusion geneENST idsENST00000419197, ENST00000527958, 
ENST00000529887, ENST00000530272, 
ENST00000526888, 		ENST00000313074, 
ENST00000377702, ENST00000438980, 
ENST00000539851, ENST00000411458, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 7=3787 X 8 X 6=336
# samples 107
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/336*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PAFAH1B2 [Title/Abstract] AND GPR137 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PAFAH1B2(117023244)-GPR137(64053982), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PAFAH1B2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPR137 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-69-7765-01APAFAH1B2chr11

117023244

-GPR137chr11

64053982

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000419197PAFAH1B2chr11117023244-ENST00000411458GPR137chr1164053982+1531223101491493
ENST00000527958PAFAH1B2chr11117023244-ENST00000411458GPR137chr1164053982+1548240271508493
ENST00000529887PAFAH1B2chr11117023244-ENST00000411458GPR137chr1164053982+151720921477491
ENST00000530272PAFAH1B2chr11117023244-ENST00000411458GPR137chr1164053982+1471163821431449

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000419197ENST00000411458PAFAH1B2chr11117023244-GPR137chr1164053982+0.15361360.8463864
ENST00000527958ENST00000411458PAFAH1B2chr11117023244-GPR137chr1164053982+0.14731050.85268945
ENST00000529887ENST00000411458PAFAH1B2chr11117023244-GPR137chr1164053982+0.152331710.84766835
ENST00000530272ENST00000411458PAFAH1B2chr11117023244-GPR137chr1164053982+0.153633980.84636605

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62335_62335_1_PAFAH1B2-GPR137_PAFAH1B2_chr11_117023244_ENST00000419197_GPR137_chr11_64053982_ENST00000411458_length(amino acids)=493AA_BP=70
MLLVLGPEEGRAGAGPTGPSERPTRHPPTPQPLGARTDPLLQCRMSQGDSNPAAIPHAAEDIQGDDRWMSQASLPDMESNLSGLVPAAGL
VPALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVC
LQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACL
CLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWE
LLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTRCQDQAATTTVSTPPHRRDPPPSPTEYPGPS

--------------------------------------------------------------

>62335_62335_2_PAFAH1B2-GPR137_PAFAH1B2_chr11_117023244_ENST00000527958_GPR137_chr11_64053982_ENST00000411458_length(amino acids)=493AA_BP=70
MLLVLGPEEGRAGAGPTGPSERPTRHPPTPQPLGARTDPLLQCRMSQGDSNPAAIPHAAEDIQGDDRWMSQASLPDMESNLSGLVPAAGL
VPALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVC
LQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACL
CLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWE
LLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTRCQDQAATTTVSTPPHRRDPPPSPTEYPGPS

--------------------------------------------------------------

>62335_62335_3_PAFAH1B2-GPR137_PAFAH1B2_chr11_117023244_ENST00000529887_GPR137_chr11_64053982_ENST00000411458_length(amino acids)=491AA_BP=68
LVLGPEEGRAGAGPTGPSERPTRHPPTPQPLGARTDPLLQCRMSQGDSNPAAIPHAAEDIQGDDRWMSQASLPDMESNLSGLVPAAGLVP
ALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVCLQ
FFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCL
VARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELL
PTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTRCQDQAATTTVSTPPHRRDPPPSPTEYPGPSPP

--------------------------------------------------------------

>62335_62335_4_PAFAH1B2-GPR137_PAFAH1B2_chr11_117023244_ENST00000530272_GPR137_chr11_64053982_ENST00000411458_length(amino acids)=449AA_BP=26
MSQGDSNPAAIPHAAEDIQGDDRWMSQASLPDMESNLSGLVPAAGLVPALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSY
QTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVCLQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASL
LFLLVNVLCAVLSHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLT
ALALAPQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:117023244/chr11:64053982)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GPR137

Q8N3F9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. {ECO:0000269|PubMed:31036939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407111_1400418.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407162_1750418.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407197_2180418.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST00000313074071_310418.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407242_2740418.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407296_4170418.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000003130740753_600418.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000003130740782_890418.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207111_1400347.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207162_1750347.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207197_2180347.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST00000377702071_310347.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207242_2740347.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207296_4170347.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000003777020753_600347.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000003777020782_890347.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819111_14053.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819162_17553.0476.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819197_21853.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819242_27453.0476.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819296_41753.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000004114581953_6053.0476.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000004114581982_8953.0476.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007111_1400397.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007162_1750397.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007197_2180397.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST00000438980071_310397.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007242_2740397.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007296_4170397.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000004389800753_600397.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000004389800782_890397.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107111_1400321.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107162_1750321.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107197_2180321.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST00000539851071_310321.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107242_2740321.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107296_4170321.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000005398510753_600321.0Topological domainCytoplasmic
TgeneGPR137chr11:117023244chr11:64053982ENST000005398510782_890321.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407141_1610418.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407176_1960418.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407219_2410418.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:117023244chr11:64053982ENST0000031307407275_2950418.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:117023244chr11:64053982ENST000003130740732_520418.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:117023244chr11:64053982ENST000003130740761_810418.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:117023244chr11:64053982ENST000003130740790_1100418.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207141_1610347.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207176_1960347.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207219_2410347.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:117023244chr11:64053982ENST0000037770207275_2950347.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:117023244chr11:64053982ENST000003777020732_520347.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:117023244chr11:64053982ENST000003777020761_810347.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:117023244chr11:64053982ENST000003777020790_1100347.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819141_16153.0476.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819176_19653.0476.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819219_24153.0476.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:117023244chr11:64053982ENST0000041145819275_29553.0476.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:117023244chr11:64053982ENST000004114581961_8153.0476.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:117023244chr11:64053982ENST000004114581990_11053.0476.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007141_1610397.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007176_1960397.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007219_2410397.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:117023244chr11:64053982ENST0000043898007275_2950397.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:117023244chr11:64053982ENST000004389800732_520397.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:117023244chr11:64053982ENST000004389800761_810397.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:117023244chr11:64053982ENST000004389800790_1100397.0TransmembraneHelical%3B Name%3D3
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107141_1610321.0TransmembraneHelical%3B Name%3D4
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107176_1960321.0TransmembraneHelical%3B Name%3D5
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107219_2410321.0TransmembraneHelical%3B Name%3D6
TgeneGPR137chr11:117023244chr11:64053982ENST0000053985107275_2950321.0TransmembraneHelical%3B Name%3D7
TgeneGPR137chr11:117023244chr11:64053982ENST000005398510732_520321.0TransmembraneHelical%3B Name%3D1
TgeneGPR137chr11:117023244chr11:64053982ENST000005398510761_810321.0TransmembraneHelical%3B Name%3D2
TgeneGPR137chr11:117023244chr11:64053982ENST000005398510790_1100321.0TransmembraneHelical%3B Name%3D3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPR137chr11:117023244chr11:64053982ENST00000411458191_3153.0476.0Topological domainLumenal
TgeneGPR137chr11:117023244chr11:64053982ENST000004114581932_5253.0476.0TransmembraneHelical%3B Name%3D1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PAFAH1B2
GPR137


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PAFAH1B2-GPR137


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PAFAH1B2-GPR137


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource