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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PAN3-NTRK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PAN3-NTRK2
FusionPDB ID: 62529
FusionGDB2.0 ID: 62529
HgeneTgene
Gene symbol

PAN3

NTRK2

Gene ID

255967

4915

Gene namepoly(A) specific ribonuclease subunit PAN3neurotrophic receptor tyrosine kinase 2
Synonyms-EIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

13q12.2

9q21.33

Type of geneprotein-codingprotein-coding
DescriptionPAN2-PAN3 deadenylation complex subunit PAN3PAB-dependent poly(A)-specific ribonuclease subunit 3PAB-dependent poly(A)-specific ribonuclease subunit PAN3PAB1P-dependent poly(A)-nucleasePAB1P-dependent poly(A)-specific ribonucleasePABP-dependent poly(BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020032020200313
UniProtAcc.

Q16620

Ensembl transtripts involved in fusion geneENST idsENST00000380958, ENST00000399613, 
ENST00000282391, ENST00000483842, 
ENST00000277120, ENST00000304053, 
ENST00000323115, ENST00000359847, 
ENST00000376208, ENST00000395866, 
ENST00000395882, ENST00000376213, 
ENST00000376214, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 9 X 12=205210 X 9 X 7=630
# samples 2010
** MAII scorelog2(20/2052*10)=-3.35895882583233
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PAN3 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PAN3(28713224)-NTRK2(87549077), # samples:3
Anticipated loss of major functional domain due to fusion event.PAN3-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAN3-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAN3-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAN3-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PAN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-4223-01APAN3chr13

28713224

-NTRK2chr9

87549077

+
ChimerDB4HNSCTCGA-BB-4223-01APAN3chr13

28713224

+NTRK2chr9

87549077

+
ChimerDB4HNSCTCGA-BB-4223PAN3chr13

28713224

+NTRK2chr9

87549077

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380958PAN3chr1328713224+ENST00000376214NTRK2chr987549077+36195821521465437
ENST00000380958PAN3chr1328713224+ENST00000376213NTRK2chr987549077+36195821521465437

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380958ENST00000376214PAN3chr1328713224+NTRK2chr987549077+0.0019316730.9980684
ENST00000380958ENST00000376213PAN3chr1328713224+NTRK2chr987549077+0.0019316730.9980684

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62529_62529_1_PAN3-NTRK2_PAN3_chr13_28713224_ENST00000380958_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=437AA_BP=142
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLAL
AGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

--------------------------------------------------------------

>62529_62529_2_PAN3-NTRK2_PAN3_chr13_28713224_ENST00000380958_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=437AA_BP=142
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLAL
AGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:28713224/chr9:87549077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NTRK2

Q16620

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+11943_71143.33333333333334888.0Zinc fingerC3H1-type
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015148_1960554.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015197_2820554.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015295_3650554.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000030405301532_610554.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015538_8070554.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117538_807528.3333333333334823.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000035984701232_610478.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012538_8070478.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014148_1960538.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014197_2820538.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014295_3650538.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000037620801432_610538.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014538_8070538.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420538_807528.3333333333334823.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012148_1960322.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012197_2820322.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012295_3650322.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039586601232_610322.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012538_8070322.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039588201332_610478.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013538_8070478.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319544_552544.3333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015544_5520554.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117544_552528.3333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014544_5520538.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420544_552528.3333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521544_552544.3333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012544_5520322.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015116_1370554.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000030405301592_1130554.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000035984701292_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014116_1370538.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000037620801492_1130538.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012116_1370322.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039586601292_1130322.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039588201392_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST0000030405301532_4300554.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015455_8220554.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000035984701232_4300478.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000037620801432_4300538.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014455_8220538.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039586601232_4300322.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012455_8220322.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039588201332_4300478.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015431_4540554.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012431_4540478.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014431_4540538.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012431_4540322.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013431_4540478.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114751_7890.0576.0Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119751_789143.33333333333334888.0Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118751_7890688.0Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114284_2990.0576.0MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119284_299143.33333333333334888.0MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118284_2990688.0MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114570_5770.0576.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114644_6450.0576.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119570_577143.33333333333334888.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119644_645143.33333333333334888.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118570_5770688.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118644_6450688.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114463_7500.0576.0RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114790_8870.0576.0RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119463_750143.33333333333334888.0RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119790_887143.33333333333334888.0RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118463_7500688.0RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118790_8870688.0RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+11443_710.0576.0Zinc fingerC3H1-type
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+11843_710688.0Zinc fingerC3H1-type
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319148_196544.3333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319197_282544.3333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319295_365544.3333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120131932_61544.3333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319538_807544.3333333333334839.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117148_196528.3333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117197_282528.3333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117295_365528.3333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115111732_61528.3333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420148_196528.3333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420197_282528.3333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420295_365528.3333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213142032_61528.3333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521148_196544.3333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521197_282544.3333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521295_365544.3333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214152132_61544.3333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521538_807544.3333333333334839.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319116_137544.3333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120131992_113544.3333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117116_137528.3333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115111792_113528.3333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420116_137528.3333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213142092_113528.3333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521116_137544.3333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214152192_113544.3333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120131932_430544.3333333333334839.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319455_822544.3333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115111732_430528.3333333333334823.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117455_822528.3333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213142032_430528.3333333333334823.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420455_822528.3333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214152132_430544.3333333333334839.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521455_822544.3333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319431_454544.3333333333334839.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117431_454528.3333333333334823.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420431_454528.3333333333334823.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521431_454544.3333333333334839.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>914_PAN3_28713224_NTRK2_87549077_914_PAN3_28713224_NTRK2_87549077_ranked_0.pdbPAN32871322428713224ENST00000376213NTRK2chr987549077+
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLAL
AGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE
437


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PAN3_pLDDT.png
all structure
all structure
NTRK2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PAN3
NTRK2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319455_466544.3333333333334839.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521455_466544.3333333333334839.0MAPK8IP3/JIP3


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Related Drugs to PAN3-NTRK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PAN3-NTRK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNTRK2C0011570Mental Depression5PSYGENET
TgeneNTRK2C0011581Depressive disorder5PSYGENET
TgeneNTRK2C0041696Unipolar Depression5PSYGENET
TgeneNTRK2C0525045Mood Disorders5PSYGENET
TgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
TgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneNTRK2C4693367EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 583GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0009171Cocaine Abuse2CTD_human
TgeneNTRK2C0036341Schizophrenia2PSYGENET
TgeneNTRK2C0038220Status Epilepticus2CTD_human
TgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
TgeneNTRK2C0270823Petit mal status2CTD_human
TgeneNTRK2C0311335Grand Mal Status Epilepticus2CTD_human
TgeneNTRK2C0393734Complex Partial Status Epilepticus2CTD_human
TgeneNTRK2C0600427Cocaine Dependence2CTD_human
TgeneNTRK2C0751217Hyperkinesia, Generalized2CTD_human
TgeneNTRK2C0751522Status Epilepticus, Subclinical2CTD_human
TgeneNTRK2C0751523Non-Convulsive Status Epilepticus2CTD_human
TgeneNTRK2C0751524Simple Partial Status Epilepticus2CTD_human
TgeneNTRK2C3887506Hyperkinesia2CTD_human
TgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTRK2C0004114Astrocytoma1CTD_human
TgeneNTRK2C0004352Autistic Disorder1CTD_human
TgeneNTRK2C0005587Depression, Bipolar1CTD_human
TgeneNTRK2C0008073Developmental Disabilities1CTD_human
TgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
TgeneNTRK2C0017638Glioma1CTD_human
TgeneNTRK2C0020505Hyperphagia1CTD_human
TgeneNTRK2C0024713Manic Disorder1CTD_human
TgeneNTRK2C0027819Neuroblastoma1CTD_human
TgeneNTRK2C0028754Obesity1CTD_human
TgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
TgeneNTRK2C0037769West Syndrome1ORPHANET
TgeneNTRK2C0085996Child Development Deviations1CTD_human
TgeneNTRK2C0085997Child Development Disorders, Specific1CTD_human
TgeneNTRK2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneNTRK2C0259783mixed gliomas1CTD_human
TgeneNTRK2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0280785Diffuse Astrocytoma1CTD_human
TgeneNTRK2C0334579Anaplastic astrocytoma1CTD_human
TgeneNTRK2C0334580Protoplasmic astrocytoma1CTD_human
TgeneNTRK2C0334581Gemistocytic astrocytoma1CTD_human
TgeneNTRK2C0334582Fibrillary Astrocytoma1CTD_human
TgeneNTRK2C0334583Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0338831Manic1CTD_human
TgeneNTRK2C0547065Mixed oligoastrocytoma1CTD_human
TgeneNTRK2C0555198Malignant Glioma1CTD_human
TgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
TgeneNTRK2C0750935Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0750936Intracranial Astrocytoma1CTD_human
TgeneNTRK2C0752347Lewy Body Disease1CTD_human
TgeneNTRK2C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneNTRK2C1704230Grade I Astrocytoma1CTD_human
TgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET