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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PAPD4-NUP214

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PAPD4-NUP214
FusionPDB ID: 62576
FusionGDB2.0 ID: 62576
HgeneTgene
Gene symbol

PAPD4

NUP214

Gene ID

167153

8021

Gene nameterminal nucleotidyltransferase 2nucleoporin 214
SynonymsAPD4|GLD2|PAPD4|TUT2CAIN|CAN|IIAE9
Cytomap

5q14.1

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionpoly(A) RNA polymerase GLD2PAP associated domain containing 4PAP-associated domain-containing protein 4TUTase 2hGLD-2poly(A) RNA polymerase D4, non-canonicalterminal uridylyltransferase 2nuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDa
Modification date2020032220200322
UniProtAcc.

P35658

Ensembl transtripts involved in fusion geneENST idsENST00000296783, ENST00000423041, 
ENST00000428308, ENST00000453514, 
ENST00000504233, ENST00000502269, 
ENST00000465486, ENST00000359428, 
ENST00000411637, ENST00000451030, 
ENST00000483497, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 3 X 3=3619 X 26 X 11=5434
# samples 429
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/5434*10)=-4.22788976020704
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PAPD4 [Title/Abstract] AND NUP214 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PAPD4(78952824)-NUP214(134090599), # samples:1
Anticipated loss of major functional domain due to fusion event.PAPD4-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAPD4-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAPD4-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAPD4-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPD4

GO:0043489

RNA stabilization

23200856

HgenePAPD4

GO:0043631

RNA polyadenylation

15070731

HgenePAPD4

GO:2000626

negative regulation of miRNA catabolic process

23200856


check buttonFusion gene breakpoints across PAPD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP214 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315488PAPD4chr5

78952824

+NUP214chr9

134090599

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000453514PAPD4chr578952824+ENST00000359428NUP214chr9134090599+362817646932444583
ENST00000453514PAPD4chr578952824+ENST00000411637NUP214chr9134090599+362117646932444583
ENST00000453514PAPD4chr578952824+ENST00000451030NUP214chr9134090599+265917646932444583
ENST00000453514PAPD4chr578952824+ENST00000483497NUP214chr9134090599+266117646932444583
ENST00000423041PAPD4chr578952824+ENST00000359428NUP214chr9134090599+332814644052144579
ENST00000423041PAPD4chr578952824+ENST00000411637NUP214chr9134090599+332114644052144579
ENST00000423041PAPD4chr578952824+ENST00000451030NUP214chr9134090599+235914644052144579
ENST00000423041PAPD4chr578952824+ENST00000483497NUP214chr9134090599+236114644052144579
ENST00000504233PAPD4chr578952824+ENST00000359428NUP214chr9134090599+348416206782300540
ENST00000504233PAPD4chr578952824+ENST00000411637NUP214chr9134090599+347716206782300540
ENST00000504233PAPD4chr578952824+ENST00000451030NUP214chr9134090599+251516206782300540
ENST00000504233PAPD4chr578952824+ENST00000483497NUP214chr9134090599+251716206782300540
ENST00000428308PAPD4chr578952824+ENST00000359428NUP214chr9134090599+337715134422193583
ENST00000428308PAPD4chr578952824+ENST00000411637NUP214chr9134090599+337015134422193583
ENST00000428308PAPD4chr578952824+ENST00000451030NUP214chr9134090599+240815134422193583
ENST00000428308PAPD4chr578952824+ENST00000483497NUP214chr9134090599+241015134422193583
ENST00000296783PAPD4chr578952824+ENST00000359428NUP214chr9134090599+323413702992050583
ENST00000296783PAPD4chr578952824+ENST00000411637NUP214chr9134090599+322713702992050583
ENST00000296783PAPD4chr578952824+ENST00000451030NUP214chr9134090599+226513702992050583
ENST00000296783PAPD4chr578952824+ENST00000483497NUP214chr9134090599+226713702992050583

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000453514ENST00000359428PAPD4chr578952824+NUP214chr9134090599+0.0077508480.99224913
ENST00000453514ENST00000411637PAPD4chr578952824+NUP214chr9134090599+0.0075914610.9924085
ENST00000453514ENST00000451030PAPD4chr578952824+NUP214chr9134090599+0.0057218090.9942782
ENST00000453514ENST00000483497PAPD4chr578952824+NUP214chr9134090599+0.0055906990.99440926
ENST00000423041ENST00000359428PAPD4chr578952824+NUP214chr9134090599+0.0091349070.99086505
ENST00000423041ENST00000411637PAPD4chr578952824+NUP214chr9134090599+0.0088844540.99111557
ENST00000423041ENST00000451030PAPD4chr578952824+NUP214chr9134090599+0.0063315250.9936685
ENST00000423041ENST00000483497PAPD4chr578952824+NUP214chr9134090599+0.0061446260.9938553
ENST00000504233ENST00000359428PAPD4chr578952824+NUP214chr9134090599+0.0087219080.9912781
ENST00000504233ENST00000411637PAPD4chr578952824+NUP214chr9134090599+0.0085443030.99145573
ENST00000504233ENST00000451030PAPD4chr578952824+NUP214chr9134090599+0.0064033630.9935967
ENST00000504233ENST00000483497PAPD4chr578952824+NUP214chr9134090599+0.0062109770.993789
ENST00000428308ENST00000359428PAPD4chr578952824+NUP214chr9134090599+0.0097222570.9902777
ENST00000428308ENST00000411637PAPD4chr578952824+NUP214chr9134090599+0.0094120120.99058795
ENST00000428308ENST00000451030PAPD4chr578952824+NUP214chr9134090599+0.0069760620.9930239
ENST00000428308ENST00000483497PAPD4chr578952824+NUP214chr9134090599+0.0067181130.99328184
ENST00000296783ENST00000359428PAPD4chr578952824+NUP214chr9134090599+0.0085511930.9914488
ENST00000296783ENST00000411637PAPD4chr578952824+NUP214chr9134090599+0.008301740.99169827
ENST00000296783ENST00000451030PAPD4chr578952824+NUP214chr9134090599+0.0057501220.99424994
ENST00000296783ENST00000483497PAPD4chr578952824+NUP214chr9134090599+0.0056239630.99437606

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62576_62576_1_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000296783_NUP214_chr9_134090599_ENST00000359428_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_2_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000296783_NUP214_chr9_134090599_ENST00000411637_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_3_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000296783_NUP214_chr9_134090599_ENST00000451030_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_4_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000296783_NUP214_chr9_134090599_ENST00000483497_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_5_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000423041_NUP214_chr9_134090599_ENST00000359428_length(amino acids)=579AA_BP=353
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVS
CVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSSSSSG
SVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGF
SSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQ

--------------------------------------------------------------

>62576_62576_6_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000423041_NUP214_chr9_134090599_ENST00000411637_length(amino acids)=579AA_BP=353
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVS
CVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSSSSSG
SVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGF
SSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQ

--------------------------------------------------------------

>62576_62576_7_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000423041_NUP214_chr9_134090599_ENST00000451030_length(amino acids)=579AA_BP=353
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVS
CVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSSSSSG
SVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGF
SSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQ

--------------------------------------------------------------

>62576_62576_8_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000423041_NUP214_chr9_134090599_ENST00000483497_length(amino acids)=579AA_BP=353
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVS
CVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSSSSSG
SVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGF
SSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQ

--------------------------------------------------------------

>62576_62576_9_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000428308_NUP214_chr9_134090599_ENST00000359428_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_10_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000428308_NUP214_chr9_134090599_ENST00000411637_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_11_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000428308_NUP214_chr9_134090599_ENST00000451030_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_12_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000428308_NUP214_chr9_134090599_ENST00000483497_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_13_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000453514_NUP214_chr9_134090599_ENST00000359428_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_14_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000453514_NUP214_chr9_134090599_ENST00000411637_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_15_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000453514_NUP214_chr9_134090599_ENST00000451030_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_16_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000453514_NUP214_chr9_134090599_ENST00000483497_length(amino acids)=583AA_BP=357
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPQSS
SSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQ
GFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFG

--------------------------------------------------------------

>62576_62576_17_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000504233_NUP214_chr9_134090599_ENST00000359428_length(amino acids)=540AA_BP=314
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYPLPEPILPSLQKIYPQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGF
GSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAF
TSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS

--------------------------------------------------------------

>62576_62576_18_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000504233_NUP214_chr9_134090599_ENST00000411637_length(amino acids)=540AA_BP=314
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYPLPEPILPSLQKIYPQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGF
GSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAF
TSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS

--------------------------------------------------------------

>62576_62576_19_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000504233_NUP214_chr9_134090599_ENST00000451030_length(amino acids)=540AA_BP=314
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYPLPEPILPSLQKIYPQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGF
GSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAF
TSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS

--------------------------------------------------------------

>62576_62576_20_PAPD4-NUP214_PAPD4_chr5_78952824_ENST00000504233_NUP214_chr9_134090599_ENST00000483497_length(amino acids)=540AA_BP=314
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKR
QRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFR
DKVSCVEFDLNVNNIVGIRNTFLLRTYAYPLPEPILPSLQKIYPQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGF
GSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAF
TSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:78952824/chr9:134090599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NUP214

P35658

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPD4chr5:78952824chr9:134090599ENST00000296783+121676_92357.0485.0MotifNuclear localization signal
HgenePAPD4chr5:78952824chr9:134090599ENST00000423041+121676_92353.0481.0MotifNuclear localization signal
HgenePAPD4chr5:78952824chr9:134090599ENST00000428308+131776_92357.0485.0MotifNuclear localization signal
HgenePAPD4chr5:78952824chr9:134090599ENST00000453514+111576_92357.0485.0MotifNuclear localization signal
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361862_18631864.02091.0Repeat24
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361874_18751864.02091.0Repeat25
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361910_19111864.02091.0Repeat26
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361922_19231864.02091.0Repeat27
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361930_19311864.02091.0Repeat28
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361938_19391864.02091.0Repeat29
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361959_19601864.02091.0Repeat30
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361970_19711864.02091.0Repeat31
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361976_19771864.02091.0Repeat32
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361982_19831864.02091.0Repeat33
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361988_19891864.02091.0Repeat34
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361994_19951864.02091.0Repeat35
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362012_20131864.02091.0Repeat36
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362024_20251864.02091.0Repeat37
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362026_20271864.02091.0Repeat38
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362035_20361864.02091.0Repeat39
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362046_20471864.02091.0Repeat40
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362056_20571864.02091.0Repeat41
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362066_20671864.02091.0Repeat42
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362075_20761864.02091.0Repeat43
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829362085_20861864.02091.0Repeat44
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361851_18521854.02081.0Repeat23
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361862_18631854.02081.0Repeat24
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361874_18751854.02081.0Repeat25
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361910_19111854.02081.0Repeat26
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361922_19231854.02081.0Repeat27
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361930_19311854.02081.0Repeat28
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361938_19391854.02081.0Repeat29
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361959_19601854.02081.0Repeat30
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361970_19711854.02081.0Repeat31
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361976_19771854.02081.0Repeat32
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361982_19831854.02081.0Repeat33
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361988_19891854.02081.0Repeat34
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361994_19951854.02081.0Repeat35
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362012_20131854.02081.0Repeat36
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362024_20251854.02081.0Repeat37
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362026_20271854.02081.0Repeat38
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362035_20361854.02081.0Repeat39
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362046_20471854.02081.0Repeat40
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362056_20571854.02081.0Repeat41
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362066_20671854.02081.0Repeat42
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362075_20761854.02081.0Repeat43
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729362085_20861854.02081.0Repeat44
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361862_18631865.02092.0Repeat24
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361874_18751865.02092.0Repeat25
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361910_19111865.02092.0Repeat26
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361922_19231865.02092.0Repeat27
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361930_19311865.02092.0Repeat28
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361938_19391865.02092.0Repeat29
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361959_19601865.02092.0Repeat30
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361970_19711865.02092.0Repeat31
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361976_19771865.02092.0Repeat32
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361982_19831865.02092.0Repeat33
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361988_19891865.02092.0Repeat34
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361994_19951865.02092.0Repeat35
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362012_20131865.02092.0Repeat36
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362024_20251865.02092.0Repeat37
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362026_20271865.02092.0Repeat38
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362035_20361865.02092.0Repeat39
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362046_20471865.02092.0Repeat40
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362056_20571865.02092.0Repeat41
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362066_20671865.02092.0Repeat42
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362075_20761865.02092.0Repeat43
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029362085_20861865.02092.0Repeat44

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPD4chr5:78952824chr9:134090599ENST00000296783+1216386_440357.0485.0DomainNote=PAP-associated
HgenePAPD4chr5:78952824chr9:134090599ENST00000423041+1216386_440353.0481.0DomainNote=PAP-associated
HgenePAPD4chr5:78952824chr9:134090599ENST00000428308+1317386_440357.0485.0DomainNote=PAP-associated
HgenePAPD4chr5:78952824chr9:134090599ENST00000453514+1115386_440357.0485.0DomainNote=PAP-associated
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936680_12091864.02091.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936680_12091854.02081.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936680_12091865.02092.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361213_20901864.02091.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361213_20901854.02081.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361213_20901865.02092.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361409_20841864.02091.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361427_20851864.02091.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936236_14181864.02091.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr5:78952824chr9:134090599ENST00000359428293641_4041864.02091.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936450_5861864.02091.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936481_20761864.02091.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936740_7681864.02091.0RegionNote=Leucine-zipper 1
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936861_8821864.02091.0RegionNote=Leucine-zipper 2
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361409_20841854.02081.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361427_20851854.02081.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936236_14181854.02081.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr5:78952824chr9:134090599ENST00000411637293641_4041854.02081.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936450_5861854.02081.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936481_20761854.02081.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936740_7681854.02081.0RegionNote=Leucine-zipper 1
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936861_8821854.02081.0RegionNote=Leucine-zipper 2
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361409_20841865.02092.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361427_20851865.02092.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936236_14181865.02092.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr5:78952824chr9:134090599ENST00000451030293641_4041865.02092.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936450_5861865.02092.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936481_20761865.02092.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936740_7681865.02092.0RegionNote=Leucine-zipper 1
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936861_8821865.02092.0RegionNote=Leucine-zipper 2
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361225_12261864.02091.0Repeat3
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361411_14121864.02091.0Repeat4
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361427_14281864.02091.0Repeat5
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361441_14421864.02091.0Repeat6
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361473_14741864.02091.0Repeat7
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936151_1931864.02091.0RepeatNote=Blade 3
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361635_16361864.02091.0Repeat8
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361674_16751864.02091.0Repeat9
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361686_16871864.02091.0Repeat10
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361713_17141864.02091.0Repeat11
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361721_17221864.02091.0Repeat12
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361726_17271864.02091.0Repeat13
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361732_17331864.02091.0Repeat14
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361756_17571864.02091.0Repeat15
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361772_17731864.02091.0Repeat16
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361786_17871864.02091.0Repeat17
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361798_17991864.02091.0Repeat18
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361806_18071864.02091.0Repeat19
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361812_18131864.02091.0Repeat20
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361819_18201864.02091.0Repeat21
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361842_18431864.02091.0Repeat22
TgeneNUP214chr5:78952824chr9:134090599ENST0000035942829361851_18521864.02091.0Repeat23
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936194_2391864.02091.0RepeatNote=Blade 4
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936240_3031864.02091.0RepeatNote=Blade 5
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936304_3591864.02091.0RepeatNote=Blade 6
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936360_4041864.02091.0RepeatNote=Blade 7
TgeneNUP214chr5:78952824chr9:134090599ENST00000359428293641_931864.02091.0RepeatNote=Blade 1
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936484_4851864.02091.0Repeat1
TgeneNUP214chr5:78952824chr9:134090599ENST000003594282936548_5491864.02091.0Repeat2
TgeneNUP214chr5:78952824chr9:134090599ENST00000359428293694_1501864.02091.0RepeatNote=Blade 2
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361225_12261854.02081.0Repeat3
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361411_14121854.02081.0Repeat4
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361427_14281854.02081.0Repeat5
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361441_14421854.02081.0Repeat6
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361473_14741854.02081.0Repeat7
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936151_1931854.02081.0RepeatNote=Blade 3
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361635_16361854.02081.0Repeat8
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361674_16751854.02081.0Repeat9
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361686_16871854.02081.0Repeat10
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361713_17141854.02081.0Repeat11
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361721_17221854.02081.0Repeat12
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361726_17271854.02081.0Repeat13
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361732_17331854.02081.0Repeat14
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361756_17571854.02081.0Repeat15
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361772_17731854.02081.0Repeat16
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361786_17871854.02081.0Repeat17
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361798_17991854.02081.0Repeat18
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361806_18071854.02081.0Repeat19
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361812_18131854.02081.0Repeat20
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361819_18201854.02081.0Repeat21
TgeneNUP214chr5:78952824chr9:134090599ENST0000041163729361842_18431854.02081.0Repeat22
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936194_2391854.02081.0RepeatNote=Blade 4
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936240_3031854.02081.0RepeatNote=Blade 5
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936304_3591854.02081.0RepeatNote=Blade 6
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936360_4041854.02081.0RepeatNote=Blade 7
TgeneNUP214chr5:78952824chr9:134090599ENST00000411637293641_931854.02081.0RepeatNote=Blade 1
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936484_4851854.02081.0Repeat1
TgeneNUP214chr5:78952824chr9:134090599ENST000004116372936548_5491854.02081.0Repeat2
TgeneNUP214chr5:78952824chr9:134090599ENST00000411637293694_1501854.02081.0RepeatNote=Blade 2
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361225_12261865.02092.0Repeat3
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361411_14121865.02092.0Repeat4
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361427_14281865.02092.0Repeat5
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361441_14421865.02092.0Repeat6
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361473_14741865.02092.0Repeat7
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936151_1931865.02092.0RepeatNote=Blade 3
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361635_16361865.02092.0Repeat8
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361674_16751865.02092.0Repeat9
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361686_16871865.02092.0Repeat10
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361713_17141865.02092.0Repeat11
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361721_17221865.02092.0Repeat12
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361726_17271865.02092.0Repeat13
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361732_17331865.02092.0Repeat14
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361756_17571865.02092.0Repeat15
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361772_17731865.02092.0Repeat16
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361786_17871865.02092.0Repeat17
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361798_17991865.02092.0Repeat18
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361806_18071865.02092.0Repeat19
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361812_18131865.02092.0Repeat20
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361819_18201865.02092.0Repeat21
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361842_18431865.02092.0Repeat22
TgeneNUP214chr5:78952824chr9:134090599ENST0000045103029361851_18521865.02092.0Repeat23
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936194_2391865.02092.0RepeatNote=Blade 4
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936240_3031865.02092.0RepeatNote=Blade 5
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936304_3591865.02092.0RepeatNote=Blade 6
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936360_4041865.02092.0RepeatNote=Blade 7
TgeneNUP214chr5:78952824chr9:134090599ENST00000451030293641_931865.02092.0RepeatNote=Blade 1
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936484_4851865.02092.0Repeat1
TgeneNUP214chr5:78952824chr9:134090599ENST000004510302936548_5491865.02092.0Repeat2
TgeneNUP214chr5:78952824chr9:134090599ENST00000451030293694_1501865.02092.0RepeatNote=Blade 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, CRM1, KAP104, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, Plk1, Nup88, Nup188, Nup214, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, rev, NUPL2, NUP214, MEX67, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, Ranbp2, Ube2i, Rcc1, Nup107, Kifc1, Nup155, Nup98, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1, ORF10, CTNNB1, CUL4B, RNF31, ESR2, EZH2, SUZ12, MYC, CDK9, VCP, KIAA1429, NR2C2, HIST1H4A, PTPDC1, RHBDD1, RHBDF2, nsp9, BIRC3, LMBR1L, PLEKHA4, CYLD, ORF6, IMMP1L, IMMP2L, CTIF, DDX19B, GLE1, FARP1, Myo9b, ITSN1, PLEKHG6, ACACA, SUMO2, NFX1, NUPR1, DYRK1A, NUP155, SYNE3, NAA40, NXT2, SLFN11, CCNF, TAX1BP1, SIRT6, DVL2, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PAPD4
NUP214all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PAPD4-NUP214


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PAPD4-NUP214


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP214C0025958Microcephaly1GENOMICS_ENGLAND
TgeneNUP214C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneNUP214C1836830Developmental regression1GENOMICS_ENGLAND
TgeneNUP214C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET