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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PARD3B-WWOX

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PARD3B-WWOX
FusionPDB ID: 62693
FusionGDB2.0 ID: 62693
HgeneTgene
Gene symbol

PARD3B

WWOX

Gene ID

117583

51741

Gene namepar-3 family cell polarity regulator betaWW domain containing oxidoreductase
SynonymsALS2CR19|PAR3B|PAR3L|PAR3betaD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

2q33.3

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homolog BPAR3-L proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 proteinpar-3 partitioning defective 3 homolog BpartitioningWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000349953, ENST00000351153, 
ENST00000358768, ENST00000406610, 
ENST00000462231, ENST00000488622, 
ENST00000355860, ENST00000408984, 
ENST00000565791, ENST00000569818, 
ENST00000402655, ENST00000406884, 
ENST00000566780, ENST00000539474, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 15 X 9=243030 X 23 X 10=6900
# samples 2036
** MAII scorelog2(20/2430*10)=-3.60288440871842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PARD3B [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PARD3B(205990461)-WWOX(79245505), # samples:3
Anticipated loss of major functional domain due to fusion event.PARD3B-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3B-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3B-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3B-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3B-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PARD3B-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across PARD3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-6744-01APARD3Bchr2

205990461

-WWOXchr16

79245505

+
ChimerDB4LUADTCGA-49-6744-01APARD3Bchr2

205990461

+WWOXchr16

79245505

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406610PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+270116411081829573
ENST00000462231PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+26541594611782573
ENST00000349953PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+2494143401622540
ENST00000358768PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+2494143401622540
ENST00000351153PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+2494143401622540

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406610ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001004350.9989956
ENST00000462231ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.0009229920.99907696
ENST00000349953ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001015390.99898463
ENST00000358768ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001015390.99898463
ENST00000351153ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001015390.99898463

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62693_62693_1_PARD3B-WWOX_PARD3B_chr2_205990461_ENST00000349953_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=540AA_BP=478
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIES
PSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA
QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
AMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG

--------------------------------------------------------------

>62693_62693_2_PARD3B-WWOX_PARD3B_chr2_205990461_ENST00000351153_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=540AA_BP=478
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIES
PSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA
QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
AMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG

--------------------------------------------------------------

>62693_62693_3_PARD3B-WWOX_PARD3B_chr2_205990461_ENST00000358768_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=540AA_BP=478
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIES
PSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA
QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
AMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG

--------------------------------------------------------------

>62693_62693_4_PARD3B-WWOX_PARD3B_chr2_205990461_ENST00000406610_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=573AA_BP=511
MGPPAPGVLREWGLRPRGQTPVRPGPAWSPGARMKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGG
ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGP
PADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIE
DNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG
LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILP
KGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCR

--------------------------------------------------------------

>62693_62693_5_PARD3B-WWOX_PARD3B_chr2_205990461_ENST00000462231_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=573AA_BP=511
MGPPAPGVLREWGLRPRGQTPVRPGPAWSPGARMKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGG
ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGP
PADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIE
DNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG
LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILP
KGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:205990461/chr16:79245505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022201_289478.01105.0DomainPDZ 1
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022383_468478.01105.0DomainPDZ 2
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022201_289478.01144.0DomainPDZ 1
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022383_468478.01144.0DomainPDZ 2
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023201_289478.01206.0DomainPDZ 1
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023383_468478.01206.0DomainPDZ 2
TgeneWWOXchr2:205990461chr16:79245505ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST0000040265535209_273136.33333333333334312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST0000040688446209_273172.0235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+10221144_1149478.01105.0Compositional biasNote=Poly-Pro
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022830_896478.01105.0Compositional biasNote=Lys-rich
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+10221144_1149478.01144.0Compositional biasNote=Poly-Pro
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022830_896478.01144.0Compositional biasNote=Lys-rich
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+10231144_1149478.01206.0Compositional biasNote=Poly-Pro
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023830_896478.01206.0Compositional biasNote=Lys-rich
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022498_585478.01105.0DomainPDZ 3
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022498_585478.01144.0DomainPDZ 3
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023498_585478.01206.0DomainPDZ 3
TgeneWWOXchr2:205990461chr16:79245505ENST000004026553516_49136.33333333333334312.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000004026553557_90136.33333333333334312.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000004068844616_49172.0235.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000004068844657_90172.0235.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000005667807916_49352.0415.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000005667807957_90352.0415.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000004026553550_55136.33333333333334312.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST000004068844650_55172.0235.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST000005667807950_55352.0415.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST0000040265535131_137136.33333333333334312.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000040688446131_137172.0235.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000056678079131_137352.0415.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000056678079209_273352.0415.0RegionMediates targeting to the mitochondria


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PARD3B
WWOX


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr2:205990461chr16:79245505ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr2:205990461chr16:79245505ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr2:205990461chr16:79245505ENST0000056678079125_414352.0415.0MAPT


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Related Drugs to PARD3B-WWOX


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PARD3B-WWOX


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource