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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PARD3-CUL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PARD3-CUL2
FusionPDB ID: 62700
FusionGDB2.0 ID: 62700
HgeneTgene
Gene symbol

PARD3

CUL2

Gene ID

56288

8453

Gene namepar-3 family cell polarity regulatorcullin 2
SynonymsASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2-
Cytomap

10p11.22-p11.21

10p11.21

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118cullin-2CUL-2testis secretory sperm-binding protein Li 238E
Modification date2020032720200327
UniProtAcc.

Q13617

Ensembl transtripts involved in fusion geneENST idsENST00000340077, ENST00000346874, 
ENST00000350537, ENST00000374773, 
ENST00000374776, ENST00000374788, 
ENST00000374789, ENST00000374790, 
ENST00000374794, ENST00000545260, 
ENST00000545693, ENST00000374768, 
ENST00000466092, ENST00000544292, 
ENST00000374742, ENST00000374748, 
ENST00000374749, ENST00000374751, 
ENST00000478044, ENST00000537177, 
ENST00000602371, ENST00000374746, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score33 X 20 X 14=92409 X 9 X 8=648
# samples 4916
** MAII scorelog2(49/9240*10)=-4.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/648*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PARD3 [Title/Abstract] AND CUL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CUL2(35333494)-PARD3(34806087), # samples:2
PARD3(35103803)-CUL2(35360267), # samples:2
Anticipated loss of major functional domain due to fusion event.PARD3-CUL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-CUL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CUL2-PARD3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CUL2-PARD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CUL2-PARD3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CUL2-PARD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PARD3-CUL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PARD3-CUL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PARD3-CUL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PARD3-CUL2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PARD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CUL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA87-01APARD3chr10

34985246

-CUL2chr10

35360267

-
ChimerDB4BRCATCGA-OL-A66P-01APARD3chr10

34985246

-CUL2chr10

35305322

-
ChimerDB4HNSCTCGA-CR-7404PARD3chr10

35103803

-CUL2chr10

35360267

-
ChimerDB4OVTCGA-59-2348-01APARD3chr10

35103804

-CUL2chr10

35305322

-
ChimerDB4OVTCGA-59-2348PARD3chr10

35103803

-CUL2chr10

35305322

-
ChimerDB4OVTCGA-61-2000-01APARD3chr10

34985246

-CUL2chr10

35324224

-
ChimerDB4OVTCGA-61-2000PARD3chr10

34985245

-CUL2chr10

35324224

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545260PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43534504722592706
ENST00000545693PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43534504722592706
ENST00000350537PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000346874PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000374789PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000374790PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000374794PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000374788PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000374776PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000340077PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43534504722592706
ENST00000374773PARD3chr1035103803-ENST00000374746CUL2chr1035360267-43494464682588706
ENST00000545260PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44555525742694706
ENST00000545693PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44555525742694706
ENST00000350537PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706
ENST00000346874PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706
ENST00000374789PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706
ENST00000374790PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706
ENST00000374794PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706
ENST00000374788PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706
ENST00000374776PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706
ENST00000340077PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44555525742694706
ENST00000374773PARD3chr1034985246-ENST00000374746CUL2chr1035360267-44515485702690706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545260ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002681680.99973184
ENST00000545693ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002681680.99973184
ENST00000350537ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000346874ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000374789ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000374790ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000374794ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000374788ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000374776ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000340077ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002681680.99973184
ENST00000374773ENST00000374746PARD3chr1035103803-CUL2chr1035360267-0.0002685740.99973136
ENST00000545260ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002870130.999713
ENST00000545693ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002870130.999713
ENST00000350537ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205
ENST00000346874ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205
ENST00000374789ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205
ENST00000374790ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205
ENST00000374794ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205
ENST00000374788ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205
ENST00000374776ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205
ENST00000340077ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002870130.999713
ENST00000374773ENST00000374746PARD3chr1034985246-CUL2chr1035360267-0.0002879760.99971205

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62700_62700_1_PARD3-CUL2_PARD3_chr10_34985246_ENST00000340077_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_2_PARD3-CUL2_PARD3_chr10_34985246_ENST00000346874_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_3_PARD3-CUL2_PARD3_chr10_34985246_ENST00000350537_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_4_PARD3-CUL2_PARD3_chr10_34985246_ENST00000374773_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_5_PARD3-CUL2_PARD3_chr10_34985246_ENST00000374776_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_6_PARD3-CUL2_PARD3_chr10_34985246_ENST00000374788_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_7_PARD3-CUL2_PARD3_chr10_34985246_ENST00000374789_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_8_PARD3-CUL2_PARD3_chr10_34985246_ENST00000374790_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_9_PARD3-CUL2_PARD3_chr10_34985246_ENST00000374794_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_10_PARD3-CUL2_PARD3_chr10_34985246_ENST00000545260_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_11_PARD3-CUL2_PARD3_chr10_34985246_ENST00000545693_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_12_PARD3-CUL2_PARD3_chr10_35103803_ENST00000340077_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_13_PARD3-CUL2_PARD3_chr10_35103803_ENST00000346874_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_14_PARD3-CUL2_PARD3_chr10_35103803_ENST00000350537_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_15_PARD3-CUL2_PARD3_chr10_35103803_ENST00000374773_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_16_PARD3-CUL2_PARD3_chr10_35103803_ENST00000374776_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_17_PARD3-CUL2_PARD3_chr10_35103803_ENST00000374788_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_18_PARD3-CUL2_PARD3_chr10_35103803_ENST00000374789_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_19_PARD3-CUL2_PARD3_chr10_35103803_ENST00000374790_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_20_PARD3-CUL2_PARD3_chr10_35103803_ENST00000374794_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_21_PARD3-CUL2_PARD3_chr10_35103803_ENST00000545260_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

>62700_62700_22_PARD3-CUL2_PARD3_chr10_35103803_ENST00000545693_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:35333494/chr10:34806087)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CUL2

Q13617

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). {ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:9122164}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-2211049_107774.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-2211151_117474.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-2211201_122474.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-2211280_130174.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-2241049_107774.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-2241151_117474.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-2241201_122474.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-2241280_130174.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-2241049_107774.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-2241151_117474.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-2241201_122474.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-2241280_130174.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-2201049_107774.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-2201151_117474.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-2201201_122474.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-2201280_130174.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-2251049_107774.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-2251151_117474.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-2251201_122474.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-2251280_130174.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-2251049_107774.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-2251151_117474.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-2251201_122474.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-2251280_130174.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-2211049_107774.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-2211151_117474.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-2211201_122474.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-2211280_130174.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-2231049_107774.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-2231151_117474.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-2231201_122474.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-2231280_130174.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-2241049_107774.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-2241151_117474.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-2241201_122474.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-2241280_130174.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-1211049_107740.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-1211151_117440.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-1211201_122440.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-1211280_130140.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-1241049_107740.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-1241151_117440.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-1241201_122440.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-1241280_130140.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-1241049_107740.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-1241151_117440.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-1241201_122440.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-1241280_130140.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-1201049_107740.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-1201151_117440.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-1201201_122440.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-1201280_130140.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-1251049_107740.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-1251151_117440.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-1251201_122440.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-1251280_130140.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-1251049_107740.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-1251151_117440.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-1251201_122440.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-1251280_130140.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-1211049_107740.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-1211151_117440.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-1211201_122440.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-1211280_130140.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-1231049_107740.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-1231151_117440.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-1231201_122440.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-1231280_130140.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-1241049_107740.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-1241151_117440.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-1241201_122440.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-1241280_130140.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-221984_104274.01032.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-224984_104274.01320.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-224984_104274.01311.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-220984_104274.0989.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-225984_104274.01354.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-225984_104274.01357.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-221984_104274.01245.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-223984_104274.01267.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-224984_104274.01341.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-121984_104240.01032.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-124984_104240.01320.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-124984_104240.01311.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-120984_104240.0989.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-125984_104240.01354.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-125984_104240.01357.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-121984_104240.01245.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-123984_104240.01267.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-124984_104240.01341.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-221271_35974.01032.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-221461_54674.01032.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-221590_67774.01032.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-224271_35974.01320.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-224461_54674.01320.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-224590_67774.01320.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-224271_35974.01311.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-224461_54674.01311.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-224590_67774.01311.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-220271_35974.0989.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-220461_54674.0989.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-220590_67774.0989.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-225271_35974.01354.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-225461_54674.01354.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-225590_67774.01354.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-225271_35974.01357.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-225461_54674.01357.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-225590_67774.01357.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-221271_35974.01245.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-221461_54674.01245.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-221590_67774.01245.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-223271_35974.01267.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-223461_54674.01267.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-223590_67774.01267.0DomainPDZ 3
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-224271_35974.01341.0DomainPDZ 1
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-224461_54674.01341.0DomainPDZ 2
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-224590_67774.01341.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-121271_35940.01032.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-121461_54640.01032.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-121590_67740.01032.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-124271_35940.01320.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-124461_54640.01320.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-124590_67740.01320.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-124271_35940.01311.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-124461_54640.01311.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-124590_67740.01311.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-120271_35940.0989.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-120461_54640.0989.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-120590_67740.0989.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-125271_35940.01354.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-125461_54640.01354.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-125590_67740.01354.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-125271_35940.01357.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-125461_54640.01357.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-125590_67740.01357.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-121271_35940.01245.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-121461_54640.01245.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-121590_67740.01245.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-123271_35940.01267.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-123461_54640.01267.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-123590_67740.01267.0DomainPDZ 3
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-124271_35940.01341.0DomainPDZ 1
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-124461_54640.01341.0DomainPDZ 2
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-124590_67740.01341.0DomainPDZ 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PARD3
CUL2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-221935_135674.01032.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-224935_135674.01320.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-224935_135674.01311.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-220935_135674.0989.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-225935_135674.01354.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-225935_135674.01357.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-221935_135674.01245.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-223935_135674.01267.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-224935_135674.01341.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-121935_135640.01032.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-124935_135640.01320.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-124935_135640.01311.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-120935_135640.0989.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-125935_135640.01354.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-125935_135640.01357.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-121935_135640.01245.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-123935_135640.01267.0FRMD4A
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-124935_135640.01341.0FRMD4A
HgenePARD3chr10:34985246chr10:35360267ENST00000340077-221712_93674.01032.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000346874-224712_93674.01320.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000350537-224712_93674.01311.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000374776-220712_93674.0989.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000374788-225712_93674.01354.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000374789-225712_93674.01357.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000374794-221712_93674.01245.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000545260-223712_93674.01267.0PRKCI and PRKCZ
HgenePARD3chr10:34985246chr10:35360267ENST00000545693-224712_93674.01341.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000340077-121712_93640.01032.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000346874-124712_93640.01320.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000350537-124712_93640.01311.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000374776-120712_93640.0989.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000374788-125712_93640.01354.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000374789-125712_93640.01357.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000374794-121712_93640.01245.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000545260-123712_93640.01267.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr10:35360267ENST00000545693-124712_93640.01341.0PRKCI and PRKCZ


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Related Drugs to PARD3-CUL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PARD3-CUL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource