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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PARD3-HTRA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PARD3-HTRA1
FusionPDB ID: 62708
FusionGDB2.0 ID: 62708
HgeneTgene
Gene symbol

PARD3

HTRA1

Gene ID

56288

5654

Gene namepar-3 family cell polarity regulatorHtrA serine peptidase 1
SynonymsASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2ARMD7|CADASIL2|CARASIL|HtrA|L56|ORF480|PRSS11
Cytomap

10p11.22-p11.21

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118serine protease HTRA1IGFBP5-proteasehigh-temperature requirement A serine peptidase 1protease, serine, 11 (IGF binding)
Modification date2020032720200322
UniProtAcc.

Q92743

Ensembl transtripts involved in fusion geneENST idsENST00000466092, ENST00000544292, 
ENST00000340077, ENST00000346874, 
ENST00000350537, ENST00000374773, 
ENST00000374776, ENST00000374788, 
ENST00000374789, ENST00000374790, 
ENST00000374794, ENST00000545260, 
ENST00000545693, ENST00000374768, 
ENST00000368984, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score33 X 20 X 14=92404 X 5 X 4=80
# samples 495
** MAII scorelog2(49/9240*10)=-4.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PARD3 [Title/Abstract] AND HTRA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PARD3(34620045)-HTRA1(124248418), # samples:1
Anticipated loss of major functional domain due to fusion event.PARD3-HTRA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-HTRA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-HTRA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-HTRA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-HTRA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PARD3-HTRA1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PARD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTRA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6953-01APARD3chr10

34620045

-HTRA1chr10

124248418

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545260PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4422290219838721224
ENST00000545693PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4644312419840941298
ENST00000350537PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4550303019440001268
ENST00000346874PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4688316819441381314
ENST00000374789PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4688316819441381314
ENST00000374790PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4508298819439581254
ENST00000374794PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4463294319439131239
ENST00000374788PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4679315919441291311
ENST00000374776PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4550303019440001268
ENST00000340077PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4683316319841331311
ENST00000374773PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4589306919440391281

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545260ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0016074040.9983925
ENST00000545693ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015035810.9984964
ENST00000350537ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0014372760.99856275
ENST00000346874ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015807660.9984193
ENST00000374789ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015807660.9984193
ENST00000374790ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015947610.9984053
ENST00000374794ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0012658220.9987342
ENST00000374788ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0019236080.99807644
ENST00000374776ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0014372760.99856275
ENST00000340077ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.001911380.99808854
ENST00000374773ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0012911250.99870884

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62708_62708_1_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000340077_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1311AA_BP=989
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVL
PPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIAD
ETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQ
EDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKA
DIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEV
IGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLK

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>62708_62708_2_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000346874_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1314AA_BP=992
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRL
PVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLG
IADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGME
TWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVD
EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLD
GEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG

--------------------------------------------------------------

>62708_62708_3_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000350537_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1268AA_BP=946
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSA
GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNE
LKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSH
DDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTL
NGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVA
SGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTV
TTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKY
IGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMIT

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>62708_62708_4_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374773_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1281AA_BP=959
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVL
PPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSS
LESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELF
RKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFV
VAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHD
RQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLN

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>62708_62708_5_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374776_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1268AA_BP=946
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSA
GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNE
LKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSH
DDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTL
NGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVA
SGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTV
TTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKY
IGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMIT

--------------------------------------------------------------

>62708_62708_6_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374788_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1311AA_BP=989
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVL
PPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIAD
ETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQ
EDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKA
DIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEV
IGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLK

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>62708_62708_7_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374789_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1314AA_BP=992
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRL
PVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLG
IADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGME
TWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVD
EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLD
GEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG

--------------------------------------------------------------

>62708_62708_8_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374790_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1254AA_BP=932
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDD
MVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG
YNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
SLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI
AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA
ALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQ
SMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRII
RGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIV
TNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKE
LGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAK

--------------------------------------------------------------

>62708_62708_9_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374794_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1239AA_BP=917
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDD
MVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG
YNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
SLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI
AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA
ALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQ
SMSEKRTKQFSDASQLDFVKTRKSKSMDLGSSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDK
SYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVE
LKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDA
IINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISG

--------------------------------------------------------------

>62708_62708_10_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000545260_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1224AA_BP=902
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDD
MVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG
YNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
SLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI
AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA
ALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQ
IADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGME
TWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVD
EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLD
GEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG

--------------------------------------------------------------

>62708_62708_11_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000545693_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1298AA_BP=976
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSA
GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNE
LKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSH
DDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAG
SPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFI
ADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKL
PVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGIS
FAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:34620045/chr10:124248418)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HTRA1

Q92743

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:20671064, ECO:0000269|PubMed:9852107}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921271_359944.33333333333341032.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921461_546944.33333333333341032.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921590_677944.33333333333341032.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924271_359947.33333333333341320.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924461_546947.33333333333341320.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924590_677947.33333333333341320.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824271_359901.33333333333341311.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824461_546901.33333333333341311.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824590_677901.33333333333341311.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820271_359901.3333333333334989.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820461_546901.3333333333334989.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820590_677901.3333333333334989.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925271_359944.33333333333341354.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925461_546944.33333333333341354.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925590_677944.33333333333341354.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925271_359947.33333333333341357.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925461_546947.33333333333341357.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925590_677947.33333333333341357.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621271_359872.33333333333341245.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621461_546872.33333333333341245.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621590_677872.33333333333341245.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723271_359857.33333333333341267.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723461_546857.33333333333341267.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723590_677857.33333333333341267.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824271_359931.33333333333341341.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824461_546931.33333333333341341.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824590_677931.33333333333341341.0DomainPDZ 3
TgeneHTRA1chr10:34620045chr10:124248418ENST0000036898409365_467157.33333333333334481.0DomainPDZ
TgeneHTRA1chr10:34620045chr10:124248418ENST0000036898409204_364157.33333333333334481.0RegionNote=Serine protease

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211049_1077944.33333333333341032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211151_1174944.33333333333341032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211201_1224944.33333333333341032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211280_1301944.33333333333341032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241049_1077947.33333333333341320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241151_1174947.33333333333341320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241201_1224947.33333333333341320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241280_1301947.33333333333341320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241049_1077901.33333333333341311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241151_1174901.33333333333341311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241201_1224901.33333333333341311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241280_1301901.33333333333341311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201049_1077901.3333333333334989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201151_1174901.3333333333334989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201201_1224901.3333333333334989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201280_1301901.3333333333334989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251049_1077944.33333333333341354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251151_1174944.33333333333341354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251201_1224944.33333333333341354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251280_1301944.33333333333341354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251049_1077947.33333333333341357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251151_1174947.33333333333341357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251201_1224947.33333333333341357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251280_1301947.33333333333341357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211049_1077872.33333333333341245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211151_1174872.33333333333341245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211201_1224872.33333333333341245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211280_1301872.33333333333341245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231049_1077857.33333333333341267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231151_1174857.33333333333341267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231201_1224857.33333333333341267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231280_1301857.33333333333341267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241049_1077931.33333333333341341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241151_1174931.33333333333341341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241201_1224931.33333333333341341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241280_1301931.33333333333341341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921984_1042944.33333333333341032.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924984_1042947.33333333333341320.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824984_1042901.33333333333341311.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820984_1042901.3333333333334989.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925984_1042944.33333333333341354.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925984_1042947.33333333333341357.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621984_1042872.33333333333341245.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723984_1042857.33333333333341267.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824984_1042931.33333333333341341.0Compositional biasNote=Lys-rich
TgeneHTRA1chr10:34620045chr10:124248418ENST000003689840933_100157.33333333333334481.0DomainIGFBP N-terminal
TgeneHTRA1chr10:34620045chr10:124248418ENST000003689840998_157157.33333333333334481.0DomainKazal-like


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PARD3
HTRA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921935_1356944.33333333333341032.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924935_1356947.33333333333341320.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824935_1356901.33333333333341311.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820935_1356901.3333333333334989.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925935_1356944.33333333333341354.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925935_1356947.33333333333341357.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621935_1356872.33333333333341245.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723935_1356857.33333333333341267.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824935_1356931.33333333333341341.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824712_936901.33333333333341311.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820712_936901.3333333333334989.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621712_936872.33333333333341245.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723712_936857.33333333333341267.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824712_936931.33333333333341341.0PRKCI and PRKCZ


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Related Drugs to PARD3-HTRA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PARD3-HTRA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource